meso-Tetrakis(2-N-methylpyridyl)porphine (BioDeep_00000843839)
代谢物信息卡片
meso-Tetrakis(2-N-methylpyridyl)porphine
化学式: C44H38N8+4 (678.3219268)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C[N+]1=CC=C(C=C1)C2=C3C=CC(=C(C4=NC(=C(C5=CC=C(N5)C(=C6C=CC2=N6)C7=CC=[N+](C=C7)C)C8=CC=[N+](C=C8)C)C=C4)C9=CC=[N+](C=C9)C)N3
InChI: InChI=1S/C44H37N8/c1-49-21-13-29(14-22-49)41-33-5-7-35(45-33)42(30-15-23-50(2)24-16-30)37-9-11-39(47-37)44(32-19-27-52(4)28-20-32)40-12-10-38(48-40)43(36-8-6-34(41)46-36)31-17-25-51(3)26-18-31/h5-28H,1-4H3,(H,45,46,47,48)/q+3/p+1
描述信息
D011838 - Radiation-Sensitizing Agents > D017319 - Photosensitizing Agents
D006133 - Growth Substances > D043924 - Angiogenesis Modulating Agents
D000970 - Antineoplastic Agents > D020533 - Angiogenesis Inhibitors
D006133 - Growth Substances > D006131 - Growth Inhibitors
D000890 - Anti-Infective Agents
D003879 - Dermatologic Agents
D004791 - Enzyme Inhibitors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Susanta Haldar, Yashu Zhang, Ying Xia, Barira Islam, Sisi Liu, Francesco L Gervasio, Adrian J Mulholland, Zoë A E Waller, Dengguo Wei, Shozeb Haider. Mechanistic Insights into the Ligand-Induced Unfolding of an RNA G-Quadruplex.
Journal of the American Chemical Society.
2022 01; 144(2):935-950. doi:
10.1021/jacs.1c11248. [PMID: 34989224] - Natalya E Sannikova, Ivan O Timofeev, Alexey S Chubarov, Natalya Sh Lebedeva, Aleksandr S Semeikin, Igor A Kirilyuk, Yuri P Tsentalovich, Matvey V Fedin, Elena G Bagryanskaya, Olesya A Krumkacheva. Application of EPR to porphyrin-protein agents for photodynamic therapy.
Journal of photochemistry and photobiology. B, Biology.
2020 Oct; 211(?):112008. doi:
10.1016/j.jphotobiol.2020.112008. [PMID: 32932136] - Li Liu, Zafar Iqbal Tanveer, Keqiu Jiang, Qingwen Huang, Jinghui Zhang, Yongjiang Wu, Zheng Han. Label-Free Fluorescent Aptasensor for Ochratoxin-A Detection Based on CdTe Quantum Dots and (N-Methyl-4-pyridyl) Porphyrin.
Toxins.
2019 07; 11(8):. doi:
10.3390/toxins11080447. [PMID: 31357671] - Alexey V Solomonov, Maria K Shipitsyna, Arthur S Vashurin, Evgeniy V Rumyantsev, Alexander S Timin, Sergey P Ivanov. Analysis of binding ability of two tetramethylpyridylporphyrins to albumin and its complex with bilirubin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2016 Nov; 168(?):12-20. doi:
10.1016/j.saa.2016.05.044. [PMID: 27267279] - Tomoyuki Watanabe, Masao Saotome, Mamoru Nobuhara, Atsushi Sakamoto, Tsuyoshi Urushida, Hideki Katoh, Hiroshi Satoh, Makoto Funaki, Hideharu Hayashi. Roles of mitochondrial fragmentation and reactive oxygen species in mitochondrial dysfunction and myocardial insulin resistance.
Experimental cell research.
2014 May; 323(2):314-25. doi:
10.1016/j.yexcr.2014.02.027. [PMID: 24631294] - Supratim Ghosh, Kamil B Ucer, Ralph D'Agostino, Ken Grant, Joseph Sirintrapun, Michael J Thomas, Roy Hantgan, Manish Bharadwaj, William H Gmeiner. Non-covalent assembly of meso-tetra-4-pyridyl porphine with single-stranded DNA to form nano-sized complexes with hydrophobicity-dependent DNA release and anti-tumor activity.
Nanomedicine : nanotechnology, biology, and medicine.
2014 Feb; 10(2):451-61. doi:
10.1016/j.nano.2013.07.019. [PMID: 23988714] - Birute Pudziuvyte, Elena Bakiene, Raymond Bonnett, Pavel A Shatunov, Michela Magaraggia, Giulio Jori. Alterations of Escherichia coli envelope as a consequence of photosensitization with tetrakis(N-ethylpyridinium-4-yl)porphyrin tetratosylate.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology.
2011 Jun; 10(6):1046-55. doi:
10.1039/c1pp05028a. [PMID: 21409226] - Wanhua Lei, Guoyu Jiang, Qianxiong Zhou, Baowen Zhang, Xuesong Wang. Greatly enhanced binding of a cationic porphyrin towards bovine serum albumin by cucurbit[8]uril.
Physical chemistry chemical physics : PCCP.
2010 Oct; 12(40):13255-60. doi:
10.1039/c001013h. [PMID: 20824256] - Junichi Odo, Manabu Sumihiro, Takuma Okadome, Masahiko Inoguchi, Haruo Akashi, Kazunori Nakagoe. Peroxidase-like catalytic activity of water-insoluble complex linked Fe(III)-thiacalix[4]arenetetrasulfonate with tetrakis(1-methylpyridinium-4-yl)porphine via ionic interaction.
Chemical & pharmaceutical bulletin.
2009 Dec; 57(12):1400-4. doi:
10.1248/cpb.57.1400. [PMID: 19952452] - Ryan F Donnelly, Corona M Cassidy, Ryan G Loughlin, Anthony Brown, Michael M Tunney, Mark G Jenkins, Paul A McCarron. Delivery of Methylene Blue and meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate from cross-linked poly(vinyl alcohol) hydrogels: a potential means of photodynamic therapy of infected wounds.
Journal of photochemistry and photobiology. B, Biology.
2009 Sep; 96(3):223-31. doi:
10.1016/j.jphotobiol.2009.06.010. [PMID: 19651522] - Daekyu Sun, Wei-Jun Liu, Kexiao Guo, Jadrian J Rusche, Scot Ebbinghaus, Vijay Gokhale, Laurence H Hurley. The proximal promoter region of the human vascular endothelial growth factor gene has a G-quadruplex structure that can be targeted by G-quadruplex-interactive agents.
Molecular cancer therapeutics.
2008 Apr; 7(4):880-9. doi:
10.1158/1535-7163.mct-07-2119. [PMID: 18413801] - M B Vrouenraets, G W Visser, C Loup, B Meunier, M Stigter, H Oppelaar, F A Stewart, G B Snow, G A van Dongen. Targeting of a hydrophilic photosensitizer by use of internalizing monoclonal antibodies: A new possibility for use in photodynamic therapy.
International journal of cancer.
2000 Oct; 88(1):108-14. doi:
10.1002/1097-0215(20001001)88:1<108::aid-ijc17>3.0.co;2-h. [PMID: 10962447] - E Izbicka, E Sommer, E Skopinska-Rozewska, K Davidson, R S Wu, T Orlowski, K Pastewka. Tetracationic porphyrins inhibit angiogenesis induced by human tumor cells in vivo.
Anticancer research.
2000 Sep; 20(5A):3205-10. doi:
NULL. [PMID: 11062744] - Y Nitzan, A Balzam-Sudakevitz, H Ashkenazi. Eradication of Acinetobacter baumannii by photosensitized agents in vitro.
Journal of photochemistry and photobiology. B, Biology.
1998 Mar; 42(3):211-8. doi:
10.1016/s1011-1344(98)00073-6. [PMID: 9595710] - J A Silvester, G S Timmins, M J Davies. Detection of protein radicals formed by the photodynamic action of porphyrin sensitizers.
Biochemical Society transactions.
1995 May; 23(2):261S. doi:
10.1042/bst023261s. [PMID: 7672285] - A Villanueva, G Jori. Pharmacokinetic and tumour-photosensitizing properties of the cationic porphyrin meso-tetra(4N-methylpyridyl)porphine.
Cancer letters.
1993 Sep; 73(1):59-64. doi:
10.1016/0304-3835(93)90188-f. [PMID: 8402599] - A Villanueva, M Cañete, M J Hazen. Uptake and DNA photodamage induced in plant cells in vivo by two cationic porphyrins.
Mutagenesis.
1989 Mar; 4(2):157-9. doi:
10.1093/mutage/4.2.157. [PMID: 2659928] - N Datta-Gupta, D Malakar, E Walters, B Thompson. Binding studies of three water-soluble polycationic porphyrins with human serum albumin.
Research communications in chemical pathology and pharmacology.
1988 Jun; 60(3):347-60. doi:
NULL. [PMID: 3175333] - N Maric, S M Chan, P B Hoffer, P Duray. Radiolabeled porphyrin vs gallium-67 citrate for the detection of human melanoma in athymic mice.
International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.
1988; 15(5):543-51. doi:
10.1016/s0969-8051(88)80013-1. [PMID: 3254877]