Fatostatin (BioDeep_00000843746)
代谢物信息卡片
Fatostatin
化学式: C18H18N2S (294.11906280000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCC1=NC=CC(=C1)C2=NC(=CS2)C3=CC=C(C=C3)C
InChI: InChI=1S/C18H18N2S/c1-3-4-16-11-15(9-10-19-16)18-20-17(12-21-18)14-7-5-13(2)6-8-14/h5-12H,3-4H2,1-2H3
描述信息
Fatostatin (125B11), a specific inhibitor of SREBP activation, impairs the activation of SREBP-1 and SREBP-2. Fatostatin binds to SCAP (SREBP cleavage-activating protein), and inhibits the ER-Golgi translocation of SREBPs. Fatostatin decreases the transcription of lipogenic genes in cells. Fatostatin possesses antitumor properties, and lowers hyperglycemia in ob/ob mice[1][2].
同义名列表
2 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:95052
- PubChem: 1889993
- ChEMBL: CHEMBL1621019
- CAS: 125256-00-0
- medchemexpress: HY-14452
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lei Zhu, Yilin Shi, Zhelong Feng, Dingyi Yuan, Shiduo Guo, Yuxia Wang, Haowen Shen, Yan Li, Fang Yan, Yajing Wang. Fatostatin promotes anti-tumor immunity by reducing SREBP2 mediated cholesterol metabolism in tumor-infiltrating T lymphocytes.
European journal of pharmacology.
2024 May; 971(?):176519. doi:
10.1016/j.ejphar.2024.176519. [PMID: 38522641] - Jiayang Cai, Zhang Ye, Yuanyuan Hu, Liguo Ye, Lun Gao, Yixuan Wang, Qian Sun, Shiao Tong, Shenqi Zhang, Liquan Wu, Ji'an Yang, Qianxue Chen. Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cell death & disease.
2023 03; 14(3):211. doi:
10.1038/s41419-023-05738-8. [PMID: 36966152] - Munki Choo, Van-Hieu Mai, Han Sun Kim, Dong-Hwa Kim, Ja-Lok Ku, Sang Kook Lee, Chul-Kee Park, Yong Jin An, Sunghyouk Park. Involvement of cell shape and lipid metabolism in glioblastoma resistance to temozolomide.
Acta pharmacologica Sinica.
2023 Mar; 44(3):670-679. doi:
10.1038/s41401-022-00984-6. [PMID: 36100765] - Miao Li, Qian Lu, Yangping Zhu, Xue Fan, Wen Zhao, Luyong Zhang, Zhenzhou Jiang, Qinwei Yu. Fatostatin inhibits SREBP2-mediated cholesterol uptake via LDLR against selective estrogen receptor α modulator-induced hepatic lipid accumulation.
Chemico-biological interactions.
2022 Sep; 365(?):110091. doi:
10.1016/j.cbi.2022.110091. [PMID: 35944649] - Shuhe Ma, Kosaku Murakami, Kazune Tanaka, Motomu Hashimoto, Masao Tanaka, Koji Kitagori, Shuji Akizuki, Ran Nakashima, Hajime Yoshifuji, Koichiro Ohmura, Akio Morinobu, Tsuneyo Mimori. Fatostatin ameliorates inflammation without affecting cell viability.
FEBS open bio.
2022 03; 12(3):594-604. doi:
10.1002/2211-5463.13364. [PMID: 35015380] - Lan Yao, Shucheng Chen, Wansheng Li. Fatostatin inhibits the development of endometrial carcinoma in endometrial carcinoma cells and a xenograft model by targeting lipid metabolism.
Archives of biochemistry and biophysics.
2020 05; 684(?):108327. doi:
10.1016/j.abb.2020.108327. [PMID: 32142890] - Ya-Xiong Pan, Mei-Qing Zhuo, Dan-Dan Li, Yi-Huan Xu, Kun Wu, Zhi Luo. SREBP-1 and LXRα pathways mediated Cu-induced hepatic lipid metabolism in zebrafish Danio rerio.
Chemosphere.
2019 Jan; 215(?):370-379. doi:
10.1016/j.chemosphere.2018.10.058. [PMID: 30336314] - Guang-Hui Chen, Zhi Luo, Christer Hogstrand, Kun Wu, Shi-Cheng Ling. SREBP1, PPARG and AMPK pathways mediated the Cu-induced change in intestinal lipogenesis and lipid transport of yellow catfish Pelteobagrus fulvidraco.
Food chemistry.
2018 Dec; 269(?):595-602. doi:
10.1016/j.foodchem.2018.07.048. [PMID: 30100477] - Angela Kwok-Fung Lo, Raymond Wai-Ming Lung, Christopher W Dawson, Lawrence S Young, Chuen-Wai Ko, Walter Wai Yeung, Wei Kang, Ka-Fai To, Kwok-Wai Lo. Activation of sterol regulatory element-binding protein 1 (SREBP1)-mediated lipogenesis by the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) promotes cell proliferation and progression of nasopharyngeal carcinoma.
The Journal of pathology.
2018 10; 246(2):180-190. doi:
10.1002/path.5130. [PMID: 29968360] - Viktor Brovkovych, Yasir Izhar, Jeanne M Danes, Oleskii Dubrovskyi, Isin T Sakallioglu, Lauren M Morrow, G Ekin Atilla-Gokcumen, Jonna Frasor. Fatostatin induces pro- and anti-apoptotic lipid accumulation in breast cancer.
Oncogenesis.
2018 Aug; 7(8):66. doi:
10.1038/s41389-018-0076-0. [PMID: 30140005] - Ali Talebi, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, David Nittner, Rita Derua, Frank Vanderhoydonc, Joao A G Duarte, Francesca Bosisio, Kathleen Van den Eynde, Kris Nys, Mónica Vara Pérez, Patrizia Agostinis, Etienne Waelkens, Joost Van den Oord, Sarah-Maria Fendt, Jean-Christophe Marine, Johannes V Swinnen. Sustained SREBP-1-dependent lipogenesis as a key mediator of resistance to BRAF-targeted therapy.
Nature communications.
2018 06; 9(1):2500. doi:
10.1038/s41467-018-04664-0. [PMID: 29950559] - Raja Gopoju, Sravya Panangipalli, Srigiridhar Kotamraju. Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis.
Free radical biology & medicine.
2018 04; 118(?):85-97. doi:
10.1016/j.freeradbiomed.2018.02.031. [PMID: 29499335] - Richard Van Krieken, Mandeep Marway, Pavithra Parthasarathy, Neel Mehta, Alistar J Ingram, Bo Gao, Joan C Krepinsky. Inhibition of SREBP With Fatostatin Does Not Attenuate Early Diabetic Nephropathy in Male Mice.
Endocrinology.
2018 03; 159(3):1479-1495. doi:
10.1210/en.2018-00093. [PMID: 29420703] - Ming Chen, Jiangwen Zhang, Katia Sampieri, John G Clohessy, Lourdes Mendez, Enrique Gonzalez-Billalabeitia, Xue-Song Liu, Yu-Ru Lee, Jacqueline Fung, Jesse M Katon, Archita Venugopal Menon, Kaitlyn A Webster, Christopher Ng, Maria Dilia Palumbieri, Moussa S Diolombi, Susanne B Breitkopf, Julie Teruya-Feldstein, Sabina Signoretti, Roderick T Bronson, John M Asara, Mireia Castillo-Martin, Carlos Cordon-Cardo, Pier Paolo Pandolfi. An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer.
Nature genetics.
2018 02; 50(2):206-218. doi:
10.1038/s41588-017-0027-2. [PMID: 29335545] - Teresa Merino-Ramos, Nereida Jiménez de Oya, Juan-Carlos Saiz, Miguel A Martín-Acebes. Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra-O-Methyl Nordihydroguaiaretic Acid against West Nile Virus and Zika Virus.
Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
10.1128/aac.00376-17. [PMID: 28507114] - Guang-Hui Chen, Zhi Luo, Feng Chen, Xi Shi, Yu-Feng Song, Wen-Jing You, Xu Liu. PPARα, PPARγ and SREBP-1 pathways mediated waterborne iron (Fe)-induced reduction in hepatic lipid deposition of javelin goby Synechogobius hasta.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2017 Jul; 197(?):8-18. doi:
10.1016/j.cbpc.2017.04.003. [PMID: 28411055] - Siqingaowa, Sathiya Sekar, Venkat Gopalakrishnan, Changiz Taghibiglou. Sterol regulatory element-binding protein 1 inhibitors decrease pancreatic cancer cell viability and proliferation.
Biochemical and biophysical research communications.
2017 06; 488(1):136-140. doi:
10.1016/j.bbrc.2017.05.023. [PMID: 28483521] - Richard Van Krieken, Guang Chen, Bo Gao, Jolene Read, Hassan A Al Saleh, Renzhong Li, Khalid Al-Nedawi, Joan C Krepinsky. Sterol Regulatory Element Binding Protein (SREBP)-1 is a novel regulator of the Transforming Growth Factor (TGF)-β receptor I (TβRI) through exosomal secretion.
Cellular signalling.
2017 01; 29(?):158-167. doi:
10.1016/j.cellsig.2016.11.004. [PMID: 27826032] - Maria Mustafa, Tony N Wang, Xing Chen, Bo Gao, Joan C Krepinsky. SREBP inhibition ameliorates renal injury after unilateral ureteral obstruction.
American journal of physiology. Renal physiology.
2016 09; 311(3):F614-25. doi:
10.1152/ajprenal.00140.2016. [PMID: 27385736] - Ankur A Gholkar, Keith Cheung, Kevin J Williams, Yu-Chen Lo, Shadia A Hamideh, Chelsea Nnebe, Cindy Khuu, Steven J Bensinger, Jorge Z Torres. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division.
The Journal of biological chemistry.
2016 08; 291(33):17001-8. doi:
10.1074/jbc.c116.737346. [PMID: 27378817] - Jiajin Li, Hui Yan, Li Zhao, Wenzhi Jia, Hao Yang, Liu Liu, Xiang Zhou, Ping Miao, Xiaoguang Sun, Shaoli Song, Xiaoping Zhao, Jianjun Liu, Gang Huang. Inhibition of SREBP increases gefitinib sensitivity in non-small cell lung cancer cells.
Oncotarget.
2016 Aug; 7(32):52392-52403. doi:
10.18632/oncotarget.10721. [PMID: 27447558] - Wei Shao, Carolyn E Machamer, Peter J Espenshade. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner.
Journal of lipid research.
2016 08; 57(8):1564-73. doi:
10.1194/jlr.m069583. [PMID: 27324795] - Isabel R Schlaepfer, Dhanya K Nambiar, Anand Ramteke, Rahul Kumar, Deepanshi Dhar, Chapla Agarwal, Bryan Bergman, Michael Graner, Paul Maroni, Rana P Singh, Rajesh Agarwal, Gagan Deep. Hypoxia induces triglycerides accumulation in prostate cancer cells and extracellular vesicles supporting growth and invasiveness following reoxygenation.
Oncotarget.
2015 Sep; 6(26):22836-56. doi:
10.18632/oncotarget.4479. [PMID: 26087400] - Tony N Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G Dickhout, Joan C Krepinsky. SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis.
Journal of the American Society of Nephrology : JASN.
2015 Aug; 26(8):1839-54. doi:
10.1681/asn.2013121332. [PMID: 25398788] - Uma Kant Misra, Salvatore Vincent Pizzo. Activated α2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses.
The Journal of biological chemistry.
2015 Apr; 290(15):9571-87. doi:
10.1074/jbc.m114.617837. [PMID: 25720493] - Dhanya K Nambiar, Gagan Deep, Rana P Singh, Chapla Agarwal, Rajesh Agarwal. Silibinin inhibits aberrant lipid metabolism, proliferation and emergence of androgen-independence in prostate cancer cells via primarily targeting the sterol response element binding protein 1.
Oncotarget.
2014 Oct; 5(20):10017-33. doi:
10.18632/oncotarget.2488. [PMID: 25294820]