Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (BioDeep_00000843740)

   


代谢物信息卡片


Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone

化学式: C22H30FN3O7 (467.2067682)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C(C(=O)NC(C)C(=O)NC(CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1
InChI: InChI=1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D009676 - Noxae > D000477 - Alkylating Agents > D000590 - Amino Acid Chloromethyl Ketones

同义名列表

1 个代谢物同义名

Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mercè Garcia-Belinchón, María Sánchez-Osuna, Laura Martínez-Escardó, Carla Granados-Colomina, Sònia Pascual-Guiral, Victoria Iglesias-Guimarais, Elisenda Casanelles, Judit Ribas, Victor J Yuste. An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death. The Journal of biological chemistry. 2015 Aug; 290(34):20841-20855. doi: 10.1074/jbc.m115.644179. [PMID: 26124276]
  • Iyo Matsuda, Kentaro Matsuo, Yuka Matsushita, Yasushi Haruna, Masamitsu Niwa, Takao Kataoka. The C-terminal domain of the long form of cellular FLICE-inhibitory protein (c-FLIPL) inhibits the interaction of the caspase 8 prodomain with the receptor-interacting protein 1 (RIP1) death domain and regulates caspase 8-dependent nuclear factor κB (NF-κB) activation. The Journal of biological chemistry. 2014 Feb; 289(7):3876-87. doi: 10.1074/jbc.m113.506485. [PMID: 24398693]
  • N Podechard, X Tekpli, D Catheline, J A Holme, V Rioux, P Legrand, M Rialland, O Fardel, D Lagadic-Gossmann, V Lecureur. Mechanisms involved in lipid accumulation and apoptosis induced by 1-nitropyrene in Hepa1c1c7 cells. Toxicology letters. 2011 Oct; 206(3):289-99. doi: 10.1016/j.toxlet.2011.07.024. [PMID: 21872649]
  • Marina N Semenova, Alex S Kiselyov, Dmitry V Tsyganov, Leonid D Konyushkin, Sergei I Firgang, Roman V Semenov, Oleg R Malyshev, Mikhail M Raihstat, Fabian Fuchs, Anne Stielow, Margareta Lantow, Alex A Philchenkov, Michael P Zavelevich, Nikolay S Zefirov, Sergei A Kuznetsov, Victor V Semenov. Polyalkoxybenzenes from plants. 5. Parsley seed extract in synthesis of azapodophyllotoxins featuring strong tubulin destabilizing activity in the sea urchin embryo and cell culture assays. Journal of medicinal chemistry. 2011 Oct; 54(20):7138-49. doi: 10.1021/jm200737s. [PMID: 21916509]
  • S Ivanova, U Gregorc, N Vidergar, R Javier, D S Bredt, P Vandenabeele, J Pardo, M M Simon, V Turk, L Banks, B Turk. MAGUKs, scaffolding proteins at cell junctions, are substrates of different proteases during apoptosis. Cell death & disease. 2011 Jan; 2(?):e116. doi: 10.1038/cddis.2010.92. [PMID: 21368887]
  • Daniel J Antoine, Dominic P Williams, Anja Kipar, Rosalind E Jenkins, Sophie L Regan, Jean G Sathish, Neil R Kitteringham, B Kevin Park. High-mobility group box-1 protein and keratin-18, circulating serum proteins informative of acetaminophen-induced necrosis and apoptosis in vivo. Toxicological sciences : an official journal of the Society of Toxicology. 2009 Dec; 112(2):521-31. doi: 10.1093/toxsci/kfp235. [PMID: 19783637]
  • S Steiger-Barraissoul, A Rami. Serum deprivation induced autophagy and predominantly an AIF-dependent apoptosis in hippocampal HT22 neurons. Apoptosis : an international journal on programmed cell death. 2009 Nov; 14(11):1274-88. doi: 10.1007/s10495-009-0396-9. [PMID: 19757066]
  • Li Yu, Fengyi Wan, Sudeshna Dutta, Sarah Welsh, ZhiHua Liu, Eric Freundt, Eric H Baehrecke, Michael Lenardo. Autophagic programmed cell death by selective catalase degradation. Proceedings of the National Academy of Sciences of the United States of America. 2006 Mar; 103(13):4952-7. doi: 10.1073/pnas.0511288103. [PMID: 16547133]
  • Ling Wei, Ai Ying Xiao, Chun Jin, Aizhen Yang, Zhong Yang Lu, Shan Ping Yu. Effects of chloride and potassium channel blockers on apoptotic cell shrinkage and apoptosis in cortical neurons. Pflugers Archiv : European journal of physiology. 2004 Jun; 448(3):325-34. doi: 10.1007/s00424-004-1277-2. [PMID: 15057559]
  • Naoko Shimma, Nobuteru Akiyama, Michiko Umezawa, Yasunobu Okuma, Yasuyuki Nomura, Takeshi Saito, Syunji Horie, Toshihiko Murayama. Possible role of interleukin-6 in PC12 cell death induced by MPP+ and tetrahydroisoquinoline. Journal of pharmacological sciences. 2003 Dec; 93(4):471-7. doi: 10.1254/jphs.93.471. [PMID: 14737019]
  • Grazyna Nowak, Peter M Price, Rick G Schnellmann. Lack of a functional p21WAF1/CIP1 gene accelerates caspase-independent apoptosis induced by cisplatin in renal cells. American journal of physiology. Renal physiology. 2003 Sep; 285(3):F440-50. doi: 10.1152/ajprenal.00233.2002. [PMID: 12746256]
  • Carole Ferraro-Peyret, Laurence Quemeneur, Monique Flacher, Jean-Pierre Revillard, Laurent Genestier. Caspase-independent phosphatidylserine exposure during apoptosis of primary T lymphocytes. Journal of immunology (Baltimore, Md. : 1950). 2002 Nov; 169(9):4805-10. doi: 10.4049/jimmunol.169.9.4805. [PMID: 12391190]
  • Chapla Agarwal, Rana P Singh, Rajesh Agarwal. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis. 2002 Nov; 23(11):1869-76. doi: 10.1093/carcin/23.11.1869. [PMID: 12419835]
  • Defeng Wu, Arthur I Cederbaum. Cyclosporine A protects against arachidonic acid toxicity in rat hepatocytes: role of CYP2E1 and mitochondria. Hepatology (Baltimore, Md.). 2002 Jun; 35(6):1420-30. doi: 10.1053/jhep.2002.33639. [PMID: 12029627]
  • H Yang, W M Miller, E T Papoutsakis. Higher pH promotes megakaryocytic maturation and apoptosis. Stem cells (Dayton, Ohio). 2002; 20(4):320-8. doi: 10.1634/stemcells.20-4-320. [PMID: 12110701]
  • M A Daemen, B de Vries, C van't Veer, T G Wolfs, W A Buurman. Apoptosis and chemokine induction after renal ischemia-reperfusion. Transplantation. 2001 Apr; 71(7):1007-11. doi: 10.1097/00007890-200104150-00032. [PMID: 11349710]
  • Y Segawa, Y Itokazu, N Inoue, T Saito, K Suzuki. Possible changes in expression of chemotaxin LECT2 mRNA in mouse liver after concanavalin A-induced hepatic injury. Biological & pharmaceutical bulletin. 2001 Apr; 24(4):425-8. doi: 10.1248/bpb.24.425. [PMID: 11305608]
  • K Xu, P J Thornalley. Studies on the mechanism of the inhibition of human leukaemia cell growth by dietary isothiocyanates and their cysteine adducts in vitro. Biochemical pharmacology. 2000 Jul; 60(2):221-31. doi: 10.1016/s0006-2952(00)00319-1. [PMID: 10825467]
  • T Miyashita, K Nagao, S Krajewski, G S Salvesen, J C Reed, T Inoue, M Yamada. Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3. Cell death and differentiation. 1998 Dec; 5(12):1034-41. doi: 10.1038/sj.cdd.4400442. [PMID: 9894610]