Ladostigil (BioDeep_00000843707)
代谢物信息卡片
化学式: C16H20N2O2 (272.15247)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(C)C(=O)OC1=CC2=C(CCC2NCC#C)C=C1
InChI: InChI=1S/C16H20N2O2/c1-4-10-17-15-9-7-12-6-8-13(11-14(12)15)20-16(19)18(3)5-2/h1,6,8,11,15,17H,5,7,9-10H2,2-3H3/t15-/m1/s1
描述信息
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
C471 - Enzyme Inhibitor > C667 - Monoamine Oxidase Inhibitor
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dorit Moradov, Efrat Finkin-Groner, Corina Bejar, Priyashree Sunita, Donna Schorer-Apelbaum, Dinorah Barasch, Alina Nemirovski, Marganit Cohen, Marta Weinstock. Dose-limiting inhibition of acetylcholinesterase by ladostigil results from the rapid formation and fast hydrolysis of the drug-enzyme complex formed by its major metabolite, R-MCPAI.
Biochemical pharmacology.
2015 Mar; 94(2):164-72. doi:
10.1016/j.bcp.2015.01.017. [PMID: 25662585] - Inessa Yanovsky, Efrat Finkin-Groner, Andrey Zaikin, Lena Lerman, Hila Shalom, Shani Zeeli, Tehilla Weill, Isaac Ginsburg, Abraham Nudelman, Marta Weinstock. Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Journal of medicinal chemistry.
2012 Dec; 55(23):10700-15. doi:
10.1021/jm301411g. [PMID: 23151013] - Rony Panarsky, Lisandro Luques, Marta Weinstock. Anti-inflammatory effects of ladostigil and its metabolites in aged rat brain and in microglial cells.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.
2012 Jun; 7(2):488-98. doi:
10.1007/s11481-012-9358-z. [PMID: 22454040] - Tatyana Poltyrev, Elena Gorodetsky, Corina Bejar, Donna Schorer-Apelbaum, Marta Weinstock. Effect of chronic treatment with ladostigil (TV-3326) on anxiogenic and depressive-like behaviour and on activity of the hypothalamic-pituitary-adrenal axis in male and female prenatally stressed rats.
Psychopharmacology.
2005 Aug; 181(1):118-25. doi:
10.1007/s00213-005-2229-z. [PMID: 15830235] - Moussa B H Youdim, Mati Fridkin, Hailin Zheng. Bifunctional drug derivatives of MAO-B inhibitor rasagiline and iron chelator VK-28 as a more effective approach to treatment of brain ageing and ageing neurodegenerative diseases.
Mechanisms of ageing and development.
2005 Feb; 126(2):317-26. doi:
10.1016/j.mad.2004.08.023. [PMID: 15621213] - Songbai Zhang, Akihiro Mizutani, Chihiro Hisatsune, Takayasu Higo, Hiroko Bannai, Tomohiro Nakayama, Mitsuharu Hattori, Katsuhiko Mikoshiba. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.
The Journal of biological chemistry.
2003 Feb; 278(6):4048-56. doi:
10.1074/jbc.m209960200. [PMID: 12444087]