(S)-1-(Sec-Butyl)-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide (BioDeep_00000843703)
代谢物信息卡片
化学式: C31H38N6O2 (526.3056088)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
InChI: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1
数据库引用编号
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相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lingling Wu, Xiaoyue Jiang, Chaojun Qi, Chunyan Zhang, Bo Qu, Nan Shen. EZH2 Inhibition Interferes With the Activation of Type I Interferon Signaling Pathway and Ameliorates Lupus Nephritis in NZB/NZW F1 Mice.
Frontiers in immunology.
2021; 12(?):653989. doi:
10.3389/fimmu.2021.653989. [PMID: 33868295] - Harikrishnan Kaipananickal, Abdul Waheed Khan, Jun Okabe, Susan J Corcoran, Murray D Esler, Assam El-Osta. Targeting Treatment Refractory NET by EZH2 Inhibition in Postural Tachycardia Syndrome.
Circulation research.
2020 04; 126(8):1058-1060. doi:
10.1161/circresaha.119.315654. [PMID: 32122262] - Timothy A Yap, Jane N Winter, Lisa Giulino-Roth, Jemma Longley, Juanita Lopez, Jean-Marie Michot, John P Leonard, Vincent Ribrag, Michael T McCabe, Caretha L Creasy, Melissa Stern, Teodora Pene Dumitrescu, Xiaowei Wang, Steve Frey, Jennifer Carver, Thierry Horner, Choon Oh, Ahmed Khaled, Arindam Dhar, Peter W M Johnson. Phase I Study of the Novel Enhancer of Zeste Homolog 2 (EZH2) Inhibitor GSK2816126 in Patients with Advanced Hematologic and Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 12; 25(24):7331-7339. doi:
10.1158/1078-0432.ccr-18-4121. [PMID: 31471312] - Nicole K H Yiew, Charlotte Greenway, Abdalrahman Zarzour, Samah Ahmadieh, Brandee Goo, David Kim, Tyler W Benson, Mourad Ogbi, Yao Liang Tang, Weiqin Chen, David Stepp, Vijay Patel, Renee Hilton, Xin-Yun Lu, David Y Hui, Ha Won Kim, Neal L Weintraub. Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E.
The Journal of biological chemistry.
2019 05; 294(21):8577-8591. doi:
10.1074/jbc.ra118.006871. [PMID: 30971429] - Yuan Wei, Xiang-Ming Lao, Xiao Xiao, Xu-Yan Wang, Zong-Jian Wu, Qiu-Hui Zeng, Cai-Yuan Wu, Rui-Qi Wu, Zhen-Xin Chen, Limin Zheng, Bo Li, Dong-Ming Kuang. Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice.
Gastroenterology.
2019 05; 156(6):1890-1904.e16. doi:
10.1053/j.gastro.2019.01.250. [PMID: 30711627] - Ping Zhang, Mark C de Gooijer, Levi C M Buil, Jos H Beijnen, Gang Li, Olaf van Tellingen. ABCB1 and ABCG2 restrict the brain penetration of a panel of novel EZH2-Inhibitors.
International journal of cancer.
2015 Oct; 137(8):2007-18. doi:
10.1002/ijc.29566. [PMID: 25868794]