Nociceptin (BioDeep_00000843700)
Main id: BioDeep_00000181739
代谢物信息卡片
Nociceptin
化学式: C79H129N27O22 (1807.9805014)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(C)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)O)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=CC=C2)N
InChI: InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
描述信息
A seventenn-membered polypeptide consisting of Phe, Gly, Gly, Phe, Thr, Gly, Ala, Arg, Lys, Ser, Ala, Arg, Lys, Leu, Ala, Asn and Gln residue joined in sequence.
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D018377 - Neurotransmitter Agents > D018847 - Opioid Peptides
Nociceptin, a heptadecapeptide, is the endogenous ligand of the nociceptin receptor, acting as a potent anti-analgesic.
同义名列表
2 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:80266
- PubChem: 16131448
- ChEMBL: CHEMBL396460
- CAS: 170713-75-4
- MetaboLights: MTBLC80266
- PubChem: 47205354
- NIKKAJI: J764.295D
- KEGG: C16044
- medchemexpress: HY-P0183
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Marco Raffaele, Kristina Kovacovicova, Tommaso Biagini, Oriana Lo Re, Jan Frohlich, Sebastiano Giallongo, James D Nhan, Antonino Giulio Giannone, Daniela Cabibi, Martin Ivanov, Anton B Tonchev, Martin Mistrik, Matthew Lacey, Petr Dzubak, Sona Gurska, Marian Hajduch, Jiri Bartek, Tommaso Mazza, Vincenzo Micale, Sean P Curran, Manlio Vinciguerra. Nociceptin/orphanin FQ opioid receptor (NOP) selective ligand MCOPPB links anxiolytic and senolytic effects.
GeroScience.
2022 02; 44(1):463-483. doi:
10.1007/s11357-021-00487-y. [PMID: 34820764] - Sonny H J Sliepen, Johanna Korioth, Thomas Christoph, Thomas M Tzschentke, Marta Diaz-delCastillo, Anne-Marie Heegaard, Kris Rutten. The nociceptin/orphanin FQ receptor system as a target to alleviate cancer-induced bone pain in rats: Model validation and pharmacological evaluation.
British journal of pharmacology.
2021 05; 178(9):1995-2007. doi:
10.1111/bph.14899. [PMID: 31724155] - Thomas A Verbeek, Nancy Ruth Jarbadan, Charles Davis, Julia Caldwell. Nociceptin is present in synovial fluid of patients undergoing total knee arthroplasty.
Journal of orthopaedic surgery and research.
2020 Jul; 15(1):266. doi:
10.1186/s13018-020-01789-1. [PMID: 32677997] - Margaret Flanigan, Savannah Tollefson, Michael L Himes, Rehima Jordan, Katherine Roach, Clara Stoughton, Brian Lopresti, N Scott Mason, Roberto Ciccocioppo, Rajesh Narendran. Acute Elevations in Cortisol Increase the In Vivo Binding of [11C]NOP-1A to Nociceptin Receptors: A Novel Imaging Paradigm to Study the Interaction Between Stress- and Antistress-Regulating Neuropeptides.
Biological psychiatry.
2020 03; 87(6):570-576. doi:
10.1016/j.biopsych.2019.09.013. [PMID: 31706582] - Yidi Wang, Zhanfeng Li, Yi Han. [Endogenous nocciceptin/orphanin FQ affect ischemic arrhythmias in rats through Raf kinase inhibitor protein].
Zhonghua wei zhong bing ji jiu yi xue.
2019 Dec; 31(12):1474-1478. doi:
10.3760/cma.j.issn.2095-4352.2019.12.008. [PMID: 32029032] - Reema Tominna, Sima Chokr, Micah Feri, Timbora Chuon, Kevin Sinchak. Plasma membrane G protein-coupled estrogen receptor 1 (GPER) mediates rapid estradiol facilitation of sexual receptivity through the orphanin-FQ-ORL-1 system in estradiol primed female rats.
Hormones and behavior.
2019 06; 112(?):89-99. doi:
10.1016/j.yhbeh.2019.04.004. [PMID: 30981690] - Signe B Munksgaard, Csaba Ertsey, Erik Frandsen, Lars Bendtsen, Kornelia Tekes, Rigmor H Jensen. Circulating nociceptin and CGRP in medication-overuse headache.
Acta neurologica Scandinavica.
2019 Mar; 139(3):269-275. doi:
10.1111/ane.13053. [PMID: 30457160] - Patrizia Angelico, Marco Barchielli, Massimo Lazzeri, Remo Guerrini, Girolamo Caló. Nociceptin/Orphanin FQ and Urinary Bladder.
Handbook of experimental pharmacology.
2019; 254(?):347-365. doi:
10.1007/164_2018_182. [PMID: 30430260] - Rajesh Narendran, Roberto Ciccocioppo, Brian Lopresti, Jennifer Paris, Michael L Himes, N Scott Mason. Nociceptin Receptors in Alcohol Use Disorders: A Positron Emission Tomography Study Using [11C]NOP-1A.
Biological psychiatry.
2018 11; 84(10):708-714. doi:
10.1016/j.biopsych.2017.05.019. [PMID: 28711193] - Anna I Erdei, Adina Borbély, Anna Magyar, Nóra Taricska, András Perczel, Ottó Zsíros, Győző Garab, Edina Szűcs, Ferenc Ötvös, Ferenc Zádor, Mihály Balogh, Mahmoud Al-Khrasani, Sándor Benyhe. Biochemical and pharmacological characterization of three opioid-nociceptin hybrid peptide ligands reveals substantially differing modes of their actions.
Peptides.
2018 01; 99(?):205-216. doi:
10.1016/j.peptides.2017.10.005. [PMID: 29038035] - Y Zhang, C D Simpson-Durand, K M Standifer. Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder.
British journal of pharmacology.
2015 Jan; 172(2):571-82. doi:
10.1111/bph.12701. [PMID: 24666365] - Rink-Jan Lohman, Rosemary S Harrison, Gloria Ruiz-Gómez, Huy N Hoang, Nicholas E Shepherd, Shiao Chow, Timothy A Hill, Praveen K Madala, David P Fairlie. Helix-constrained nociceptin peptides are potent agonists and antagonists of ORL-1 and nociception.
Vitamins and hormones.
2015; 97(?):1-55. doi:
10.1016/bs.vh.2014.10.001. [PMID: 25677767] - Ko Eto. Nociceptin and meiosis during spermatogenesis in postnatal testes.
Vitamins and hormones.
2015; 97(?):167-86. doi:
10.1016/bs.vh.2014.10.003. [PMID: 25677772] - L Granholm, E Roman, I Nylander. Single housing during early adolescence causes time-, area- and peptide-specific alterations in endogenous opioids of rat brain.
British journal of pharmacology.
2015 Jan; 172(2):606-14. doi:
10.1111/bph.12753. [PMID: 24821004] - J Fichna, M Sobczak, A Mokrowiecka, A I Cygankiewicz, P K Zakrzewski, N Cenac, M Sałaga, J-P Timmermans, N Vergnolle, E Małecka-Panas, W M Krajewska, M Storr. Activation of the endogenous nociceptin system by selective nociceptin receptor agonist SCH 221510 produces antitransit and antinociceptive effect: a novel strategy for treatment of diarrhea-predominant IBS.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2014 Nov; 26(11):1539-50. doi:
10.1111/nmo.12390. [PMID: 25041572] - Roisin C Thomas, Michael F Bath, Cordula M Stover, David G Lambert, Jonathan P Thompson. Exploring LPS-induced sepsis in rats and mice as a model to study potential protective effects of the nociceptin/orphanin FQ system.
Peptides.
2014 Nov; 61(?):56-60. doi:
10.1016/j.peptides.2014.08.009. [PMID: 25161013] - Elaine Cristina Gavioli, Girolamo Calo'. Nociceptin/orphanin FQ receptor antagonists as innovative antidepressant drugs.
Pharmacology & therapeutics.
2013 Oct; 140(1):10-25. doi:
10.1016/j.pharmthera.2013.05.008. [PMID: 23711793] - Beáta H Deák, Anna Klukovits, Kornélia Tekes, Eszter Ducza, George Falkay, Róbert Gáspár. Nocistatin inhibits pregnant rat uterine contractions in vitro: roles of calcitonin gene-related peptide and calcium-dependent potassium channel.
European journal of pharmacology.
2013 Aug; 714(1-3):96-104. doi:
10.1016/j.ejphar.2013.05.037. [PMID: 23792038] - Ko Eto, Masahiro Shiotsuki, Shin-Ichi Abe. Nociceptin induces Rec8 phosphorylation and meiosis in postnatal murine testes.
Endocrinology.
2013 Aug; 154(8):2891-9. doi:
10.1210/en.2012-1977. [PMID: 23720425] - Nikol Sullo, Fiorentina Roviezzo, Maria Matteis, Angela Ianaro, Girolamo Calò, Remo Guerrini, Luana De Gruttola, Giuseppe Spaziano, Giuseppe Cirino, Francesco Rossi, Bruno D'Agostino. Nociceptin/orphanin FQ receptor activation decreases the airway hyperresponsiveness induced by allergen in sensitized mice.
American journal of physiology. Lung cellular and molecular physiology.
2013 May; 304(10):L657-64. doi:
10.1152/ajplung.00358.2012. [PMID: 23502511] - Jonathan P Thompson, Alcira Serrano-Gomez, John McDonald, Nadia Ladak, Sarah Bowrey, David G Lambert. The Nociceptin/Orphanin FQ system is modulated in patients admitted to ICU with sepsis and after cardiopulmonary bypass.
PloS one.
2013; 8(10):e76682. doi:
10.1371/journal.pone.0076682. [PMID: 24124588] - Yong Zhang, Priyam R Gandhi, Kelly M Standifer. Increased nociceptive sensitivity and nociceptin/orphanin FQ levels in a rat model of PTSD.
Molecular pain.
2012 Oct; 8(?):76. doi:
10.1186/1744-8069-8-76. [PMID: 23082795] - Paola Nativio, Esterina Pascale, Angelo Maffei, Sergio Scaccianoce, Francesca Passarelli. Effect of stress on hippocampal nociceptin expression in the rat.
Stress (Amsterdam, Netherlands).
2012 Jul; 15(4):378-84. doi:
10.3109/10253890.2011.627071. [PMID: 22074385] - Cs Csobay-Novák, P Sótonyi, M Krepuska, E Zima, N Szilágyi, Sz Tóth, Z Szeberin, Gy Acsády, B Merkely, Kornélia Tekes. Decreased plasma nociceptin/orphanin FQ levels after acute coronary syndromes.
Acta physiologica Hungarica.
2012 Jun; 99(2):99-110. doi:
10.1556/aphysiol.99.2012.2.2. [PMID: 22849833] - Swetha S Murali, Ian A Napier, Beth K Rycroft, MacDonald J Christie. Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels.
The Journal of physiology.
2012 Apr; 590(7):1655-67. doi:
10.1113/jphysiol.2012.228429. [PMID: 22371475] - Talakad G Lohith, Sami S Zoghbi, Cheryl L Morse, Maria F Araneta, Vanessa N Barth, Nancy A Goebl, Johannes T Tauscher, Victor W Pike, Robert B Innis, Masahiro Fujita. Brain and whole-body imaging of nociceptin/orphanin FQ peptide receptor in humans using the PET ligand 11C-NOP-1A.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2012 Mar; 53(3):385-92. doi:
10.2967/jnumed.111.097162. [PMID: 22312136] - Cynthia Wei-Sheng Lee, Jia-Ying Yan, Yao-Chang Chiang, Tsai-Wei Hung, Hung-Li Wang, Lih-Chu Chiou, Ing-Kang Ho. Differential pharmacological actions of methadone and buprenorphine in human embryonic kidney 293 cells coexpressing human μ-opioid and opioid receptor-like 1 receptors.
Neurochemical research.
2011 Nov; 36(11):2008-21. doi:
10.1007/s11064-011-0525-z. [PMID: 21671107] - Miklós Krepuska, Péter Sótonyi, Csaba Csobay-Novák, Zoltán Szeberin, István Hartyánszky, Endre Zima, Nóra Szilágyi, Ferenc Horkay, Béla Merkely, György Acsády, Kornélia Tekes. Plasma nociceptin/orphanin FQ levels are lower in patients with chronic ischemic cardiovascular diseases--A pilot study.
Regulatory peptides.
2011 Aug; 169(1-3):1-5. doi:
10.1016/j.regpep.2011.01.007. [PMID: 21310194] - Kornélia Tekes, P Szegi, R Laufer, M Hantos, G Csaba. Effect of perinatal stress on the biogenic amine neurotransmitter level of the adult rat's brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2011 Apr; 29(2):171-5. doi:
10.1016/j.ijdevneu.2010.11.004. [PMID: 21126566] - Gyöngyi Horváth, László Mécs. Antinociception by endogenous ligands at peripheral level.
Ideggyogyaszati szemle.
2011 Mar; 64(5-6):193-207. doi:
". [PMID: 21688721] - Elina Tzvetanova, Galina Nenkova, Almira Georgieva, Albena Alexandrova, Radoslav Girchev, Margarita Kirkova. Effects of structural analogues of nociceptin(1-13)NH₂ on brain antioxidant status in kainic acid-treated rats.
Cell biochemistry and function.
2011 Mar; 29(2):135-41. doi:
10.1002/cbf.1733. [PMID: 21287579] - A Serrano-Gomez, J P Thompson, D G Lambert. Nociceptin/orphanin FQ in inflammation and sepsis.
British journal of anaesthesia.
2011 Jan; 106(1):6-12. doi:
10.1093/bja/aeq337. [PMID: 21138900] - Richard D Wainford, Daniel R Kapusta. Hypothalamic paraventricular nucleus G alpha q subunit protein pathways mediate vasopressin dysregulation and fluid retention in salt-sensitive rats.
Endocrinology.
2010 Nov; 151(11):5403-14. doi:
10.1210/en.2010-0345. [PMID: 20861238] - Fiorella Fontana, Carmine Pizzi, Pasquale Bernardi, Emilio Merlo Pich, Andrea Bedini, Santi Spampinato. Plasma nociceptin/orphanin FQ levels in response to the hyperventilation test in healthy subjects.
Peptides.
2010 Apr; 31(4):720-2. doi:
10.1016/j.peptides.2010.01.005. [PMID: 20100531] - Kumi Moriyama, Jia Liu, Yeon Jang, Yun Jeong Chae, Yan Wang, James Mitchell, Stefan Grond, Xiaokang Han, Yilei Xing, Guo-xi Xie, Pamela Pierce Palmer. Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2009 Dec; 58(12):873-80. doi:
10.1007/s00011-009-0058-y. [PMID: 19544046] - J D Leggett, K L Dawe, D S Jessop, A J Fulford. Endogenous nociceptin / orphanin FQ system involvement in hypothalamic-pituitary-adrenal axis responses: relevance to models of inflammation.
Journal of neuroendocrinology.
2009 Nov; 21(11):888-97. doi:
10.1111/j.1365-2826.2009.01912.x. [PMID: 19732291] - Fiorella Fontana, Pasquale Bernardi, Carmine Pizzi, Santi Spampinato, Andrea Bedini, Emilio Merlo Pich. Plasma nociceptin/orphanin FQ levels rise after spontaneous episodes of angina, but not during induced myocardial ischemia.
Peptides.
2009 Sep; 30(9):1705-9. doi:
10.1016/j.peptides.2009.06.018. [PMID: 19560501] - Jomo A Claiborne, Subodh Nag, Sukhbir S Mokha. Estrogen-dependent, sex-specific modulation of mustard oil-induced secondary thermal hyperalgesia by orphanin FQ in the rat.
Neuroscience letters.
2009 Jun; 456(2):59-63. doi:
10.1016/j.neulet.2009.03.106. [PMID: 19429134] - Hiroko Matsushita, Akane Ishihara, Satoshi Mashiko, Takeshi Tanaka, Tetsuya Kanno, Hisashi Iwaasa, Hisashi Ohta, Akio Kanatani. Chronic intracerebroventricular infusion of nociceptin/orphanin FQ produces body weight gain by affecting both feeding and energy metabolism in mice.
Endocrinology.
2009 Jun; 150(6):2668-73. doi:
10.1210/en.2008-1515. [PMID: 19196798] - Kelly L Prince-Zullig, Emily Murphree, Rainer K Reinscheid, James Janik, Phyllis Callahan. Effect of Nociceptin/Orphanin FQ (N/OFQ) and isoflurane on the corticosterone secretory response in mice lacking the N/OFQ prepropeptide (ppN/OFQ-/-).
Neuropeptides.
2009 Jun; 43(3):201-5. doi:
10.1016/j.npep.2009.04.002. [PMID: 19457551] - Miwako Koizumi, Barbara Cagniard, Niall P Murphy. Endogenous nociceptin modulates diet preference independent of motivation and reward.
Physiology & behavior.
2009 Apr; 97(1):1-13. doi:
10.1016/j.physbeh.2008.12.008. [PMID: 19138695] - Li-na Wang, Lan-fen Liu, Jing-xuan Zhang, Gui-fang Zhao. [Plasma levels of nociceptin/orphanin FQ in patients with bipolar disorders and health adults].
Zhonghua yi xue za zhi.
2009 Apr; 89(13):916-8. doi:
NULL. [PMID: 19671295] - Richard D Wainford, Daniel R Kapusta. Chronic high-NaCl intake prolongs the cardiorenal responses to central N/OFQ and produces regional changes in the endogenous brain NOP receptor system.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Feb; 296(2):R280-8. doi:
10.1152/ajpregu.00096.2008. [PMID: 18987291] - Melissa A Burmeister, Michael A Ansonoff, John E Pintar, Daniel R Kapusta. Nociceptin/orphanin FQ (N/OFQ)-evoked bradycardia, hypotension, and diuresis are absent in N/OFQ peptide (NOP) receptor knockout mice.
The Journal of pharmacology and experimental therapeutics.
2008 Sep; 326(3):897-904. doi:
10.1124/jpet.107.135905. [PMID: 18539652] - Richard D Wainford, Kristine Kurtz, Daniel R Kapusta. Central G-alpha subunit protein-mediated control of cardiovascular function, urine output, and vasopressin secretion in conscious Sprague-Dawley rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Aug; 295(2):R535-42. doi:
10.1152/ajpregu.00043.2008. [PMID: 18525017] - Xiao-Fei An, Yun-Fei Niu, Shi-Chao Ten, Jing-Shun Liu, Hao Feng, Ming He, Xiao-Jun Shen. Orphanin FQ and glutamate connection in the regulation of gonadotropin-releasing hormone secretion in the preoptic area of conscious male rats.
Neuroscience letters.
2008 Aug; 440(2):109-12. doi:
10.1016/j.neulet.2008.05.059. [PMID: 18562103] - M Broccardo, S Agostini, C Petrella, R Guerrini, G Improta. Central and peripheral role of the nociceptin/orphaninFQ system on normal and disturbed colonic motor function and faecal pellet output in the rat.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2008 Aug; 20(8):939-48. doi:
10.1111/j.1365-2982.2008.01120.x. [PMID: 18410266] - J P Williams, J P Thompson, S P Young, S J Gold, J McDonald, D J Rowbotham, D G Lambert. Nociceptin and urotensin-II concentrations in critically ill patients with sepsis.
British journal of anaesthesia.
2008 Jun; 100(6):810-4. doi:
10.1093/bja/aen093. [PMID: 18430746] - Arnulfo Quesada, Paul Micevych. Estrogen and progesterone modulate [35S]GTPgammaS binding to nociceptin receptors.
Neuroendocrinology.
2008; 88(1):35-42. doi:
10.1159/000113933. [PMID: 18212517] - Sheila A Doggrell. Cardiovascular and renal effects of nociceptin/orphanin FQ: a new mediator to target?.
Current opinion in investigational drugs (London, England : 2000).
2007 Sep; 8(9):742-9. doi:
. [PMID: 17729186] - Xiao-fei An, Jiang-yi Yu, Yi Feng, Bo-ying Chen, Su-lin Zhang. Role of hypothalamus nociceptin/orphanin FQ in pre-ovulatory luteinizing hormone surge of estrogen and progesterone-primed, ovariectomized rats.
Acta pharmacologica Sinica.
2007 Aug; 28(8):1189-97. doi:
10.1111/j.1745-7254.2007.00587.x. [PMID: 17640482] - Tessy Joseph, Tat-Leang Lee, Chunmei Li, Chiang Siau, Yuji Nishiuchi, Terutoshi Kimura, Shinro Tachibana. Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model.
Peptides.
2007 Jul; 28(7):1433-40. doi:
10.1016/j.peptides.2007.05.009. [PMID: 17583384] - H B Gottlieb, T M Fleming, L Ji, J T Cunningham. Identification of central nervous system sites involved in the water diuresis response elicited by central microinjection of nociceptin/ Orphanin FQ in conscious rats via c-Fos and inducible cAMP early repressor immunocytochemistry.
Journal of neuroendocrinology.
2007 Jul; 19(7):531-42. doi:
10.1111/j.1365-2826.2007.01559.x. [PMID: 17532793] - Melissa A Burmeister, Daniel R Kapusta. Centrally administered nociceptin/orphanin FQ (N/OFQ) evokes bradycardia, hypotension, and diuresis in mice via activation of central N/OFQ peptide receptors.
The Journal of pharmacology and experimental therapeutics.
2007 Jul; 322(1):324-31. doi:
10.1124/jpet.107.120394. [PMID: 17452419] - L-C Chiou, Y-Y Liao, P-C Fan, P-H Kuo, C-H Wang, C Riemer, E P Prinssen. Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications.
Current drug targets.
2007 Jan; 8(1):117-35. doi:
10.2174/138945007779315605. [PMID: 17266536] - Massimo Lazzeri, Girolamo Calò, Michele Spinelli, Silvia Malaguti, Remo Guerrini, Severo Salvadori, Patrizia Beneforti, Domenico Regoli, Damiano Turini. Daily intravesical instillation of 1 mg nociceptin/orphanin FQ for the control of neurogenic detrusor overactivity: a multicenter, placebo controlled, randomized exploratory study.
The Journal of urology.
2006 Nov; 176(5):2098-102. doi:
10.1016/j.juro.2006.07.025. [PMID: 17070267] - J D Leggett, M S Harbuz, D S Jessop, A J Fulford. The nociceptin receptor antagonist [Nphe1,Arg14,Lys15]nociceptin/orphanin FQ-NH2 blocks the stimulatory effects of nociceptin/orphanin FQ on the HPA axis in rats.
Neuroscience.
2006 Sep; 141(4):2051-7. doi:
10.1016/j.neuroscience.2006.05.036. [PMID: 16784820] - Daniela Alberati, Dominik Hainzl, Synèse Jolidon, Eva A Krafft, Anke Kurt, Axel Maier, Emmanuel Pinard, Andrew W Thomas, Daniel Zimmerli. Discovery of 4-substituted-8-(2-hydroxy-2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with improved metabolic stability.
Bioorganic & medicinal chemistry letters.
2006 Aug; 16(16):4311-5. doi:
10.1016/j.bmcl.2006.05.058. [PMID: 16757170] - Daniela Alberati, Simona M Ceccarelli, Synèse Jolidon, Eva A Krafft, Anke Kurt, Axel Maier, Emmanuel Pinard, Henri Stalder, Deborah Studer, Andrew W Thomas, Daniel Zimmerli. Design and synthesis of 4-substituted-8-(2-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of GlyT1 inhibitors: achieving selectivity against the mu opioid and nociceptin/orphanin FQ peptide (NOP) receptors.
Bioorganic & medicinal chemistry letters.
2006 Aug; 16(16):4305-10. doi:
10.1016/j.bmcl.2006.05.064. [PMID: 16762548] - Daniela Alberati, Dominik Hainzl, Synèse Jolidon, Anke Kurt, Emmanuel Pinard, Andrew W Thomas, Daniel Zimmerli. 4-Substituted-8-(1-phenyl-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one as a novel class of highly selective GlyT1 inhibitors with superior pharmacological and pharmacokinetic parameters.
Bioorganic & medicinal chemistry letters.
2006 Aug; 16(16):4321-5. doi:
10.1016/j.bmcl.2006.05.063. [PMID: 16762550] - Aldo Spadaro, Antonino Ajello, Carmelo Luigiano, Carmela Morace, Maria Letizia Resta, Grazia Berlinghieri, Salvatore Campo, Claudio Scisca, Angela Alibrandi, Graziella D'Arrigo, Nunziata Alessi, Oscar Ferrau, Maria Antonietta Freni. Low utility of plasma Nociceptin/orphanin FQ in the diagnosis of hepatocellular carcinoma.
World journal of gastroenterology.
2006 Aug; 12(29):4716-20. doi:
10.3748/wjg.v12.i29.4716. [PMID: 16937445] - Kornélia Tekes, Mónika Hantos, György Bátor, Melinda Gyenge, Rudolf Laufer, András Folyovich. [Endogenous nociceptin level in ischemic stroke: connection to serotonin system].
Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology.
2006 Jun; 8(2):53-9. doi:
NULL. [PMID: 17073212] - M Broccardo, S Scaccianoce, P Del Bianco, S Agostini, C Petrella, G Improta. Nociceptin/orphanin FQ-induced delay in gastric emptying: role of central corticotropin-releasing factor and glucocorticoid receptors.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2005 Dec; 17(6):871-7. doi:
10.1111/j.1365-2982.2005.00717.x. [PMID: 16336503] - Xiao-fei An, Hai-ping Chen, Shu-lan Ma, Yi Feng, Jun-wei Hao, Bo-ying Chen. Involvement of nociceptin/orphanin FQ in release of hypothalamic GnRH mediated by ORL1 receptor in ovariectomized rats.
Acta pharmacologica Sinica.
2005 Sep; 26(9):1039-44. doi:
10.1111/j.1745-7254.2005.00172.x. [PMID: 16115368] - Daniel R Kapusta, Melissa A Burmeister, Girolamo Calo', Remo Guerrini, Helmut B Gottlieb, Velga A Kenigs. Functional selectivity of nociceptin/orphanin FQ peptide receptor partial agonists on cardiovascular and renal function.
The Journal of pharmacology and experimental therapeutics.
2005 Aug; 314(2):643-51. doi:
10.1124/jpet.104.082768. [PMID: 15855356] - Fredrick Lindström, Philip T F Williamson, Gerhard Gröbner. Molecular insight into the electrostatic membrane surface potential by 14n/31p MAS NMR spectroscopy: nociceptin-lipid association.
Journal of the American Chemical Society.
2005 May; 127(18):6610-6. doi:
10.1021/ja042325b. [PMID: 15869282] - C Ertsey, M Hantos, G Bozsik, K Tekes. Plasma nociceptin levels are reduced in migraine without aura.
Cephalalgia : an international journal of headache.
2005 Apr; 25(4):261-6. doi:
10.1111/j.1468-2982.2004.00849.x. [PMID: 15773823] - Bruno D'Agostino, Giuseppina Marrocco, Marilisa De Nardo, Girolamo Calò, Remo Guerrini, Luca Gallelli, Charles Advenier, Francesco Rossi. Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux.
British journal of pharmacology.
2005 Mar; 144(6):813-20. doi:
10.1038/sj.bjp.0706066. [PMID: 15685213] - Niels Hadrup, Jørgen S Petersen, Jeppe Praetorius, Eddi Meier, Martin Graebe, Lone Brønd, Dennis Staahltoft, Søren Nielsen, Sten Christensen, Daniel R Kapusta, Thomas E N Jonassen. Opioid receptor-like 1 stimulation in the collecting duct induces aquaresis through vasopressin-independent aquaporin-2 downregulation.
American journal of physiology. Renal physiology.
2004 Jul; 287(1):F160-8. doi:
10.1152/ajprenal.00329.2003. [PMID: 15010357] - Johannes Oehlke, Gerd Wallukat, Yvonne Wolf, Angelika Ehrlich, Burkhard Wiesner, Hartmut Berger, Michael Bienert. Enhancement of intracellular concentration and biological activity of PNA after conjugation with a cell-penetrating synthetic model peptide.
European journal of biochemistry.
2004 Jul; 271(14):3043-9. doi:
10.1111/j.1432-1033.2004.04236.x. [PMID: 15233801] - Yan-Yan Sun, Ceng Luo, Zhen Li, Jun Chen. Differential actions of intrathecal nociceptin on persistent spontaneous nociception, hyperalgesia and inflammation produced by subcutaneous bee venom injection in conscious rats.
Sheng li xue bao : [Acta physiologica Sinica].
2004 Jun; 56(3):321-7. doi:
NULL. [PMID: 15224144] - Maithé Corbani, Christophe Gonindard, Jean-Claude Meunier. Ligand-regulated internalization of the opioid receptor-like 1: a confocal study.
Endocrinology.
2004 Jun; 145(6):2876-85. doi:
10.1210/en.2004-0062. [PMID: 15016723] - Céline Rouget, Yong Yao Cui, Bruno D'Agostino, Christophe Faisy, Emmanuel Naline, Marc Bardou, Charles Advenier. Nociceptin inhibits airway microvascular leakage induced by HCl intra-oesophageal instillation.
British journal of pharmacology.
2004 Mar; 141(6):1077-83. doi:
10.1038/sj.bjp.0705704. [PMID: 14993101] - Ferenc Szalay, Monika B Hantos, Andrea Horvath, Peter L Lakatos, Aniko Folhoffer, Kinga Dunkel, Dalma Hegedus, Kornelia Tekes. Increased nociceptin/orphanin FQ plasma levels in hepatocellular carcinoma.
World journal of gastroenterology.
2004 Jan; 10(1):42-5. doi:
10.3748/wjg.v10.i1.42. [PMID: 14695766] - Andrea Horvath, Aniko Folhoffer, Peter Laszlo Lakatos, Judit Halosz, Gyorgy Illyes, Zsuzsa Schaff, Monika Beatrix Hantos, Kornelia Tekes, Ferenc Szalay. Rising plasma nociceptin level during development of HCC: a case report.
World journal of gastroenterology.
2004 Jan; 10(1):152-4. doi:
10.3748/wjg.v10.i1.152. [PMID: 14695788] - Hang Gu, Dian Hu, Xin-ru Hong, Jie Mao, Ying Cui, Ning Hui, Jin-yan Sha. [Changes and significance of orphanin and serotonin in patients with postpartum depression].
Zhonghua fu chan ke za zhi.
2003 Dec; 38(12):727-8. doi:
NULL. [PMID: 14728841] - Luisa Bracci, Chiara Falciani, Barbara Lelli, Luisa Lozzi, Ylenia Runci, Alessandro Pini, Maria Graziella De Montis, Alessandro Tagliamonte, Paolo Neri. Synthetic peptides in the form of dendrimers become resistant to protease activity.
The Journal of biological chemistry.
2003 Nov; 278(47):46590-5. doi:
10.1074/jbc.m308615200. [PMID: 12972419] - D P Devine, M T Hoversten, Y Ueda, H Akil. Nociceptin/orphanin FQ content is decreased in forebrain neurones during acute stress.
Journal of neuroendocrinology.
2003 Jan; 15(1):69-74. doi:
10.1046/j.1365-2826.2003.00868.x. [PMID: 12535171] - S Spampinato, R Di Toro, M Alessandri, G Murari. Agonist-induced internalization and desensitization of the human nociceptin receptor expressed in CHO cells.
Cellular and molecular life sciences : CMLS.
2002 Dec; 59(12):2172-83. doi:
10.1007/s000180200016. [PMID: 12568343] - Kenneth W L Kam, David C New, Yung H Wong. Constitutive activation of the opioid receptor-like (ORL1) receptor by mutation of Asn133 to tryptophan in the third transmembrane region.
Journal of neurochemistry.
2002 Dec; 83(6):1461-70. doi:
10.1046/j.1471-4159.2002.01231.x. [PMID: 12472900] - C Le Cudennec, B Naudin, J-C Do Rego, J Costentin. Nociceptin/orphanin FQ and related peptides reduce the increase in plasma corticosterone elicited in mice by an intracerebroventricular injection.
Life sciences.
2002 Nov; 72(2):163-71. doi:
10.1016/s0024-3205(02)02218-x. [PMID: 12417250] - Myoung-Hwan Ko, Yun-Hee Kim, Ran-Sook Woo, Kee-Won Kim. Quantitative analysis of nociceptin in blood of patients with acute and chronic pain.
Neuroreport.
2002 Sep; 13(13):1631-3. doi:
10.1097/00001756-200209160-00012. [PMID: 12352616] - Mónika B Hantos, Ferenc Szalay, Péter L Lakatos, Dalma Hegedus, Gábor Firneisz, Jeno Reiczigel, Tamás Török, Kornélia Tekes. Elevated plasma nociceptin level in patients with Wilson disease.
Brain research bulletin.
2002 Jul; 58(3):311-3. doi:
10.1016/s0361-9230(02)00795-5. [PMID: 12128158] - Daniel R Kapusta, Lisa A Dayan, Velga A Kenigs. Nociceptin/orphanin FQ modulates the cardiovascular, but not renal, responses to stress in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology.
2002 Mar; 29(3):254-9. doi:
10.1046/j.1440-1681.2002.03639.x. [PMID: 11906494] - Mónika Beatrix Hantos, Kornélia Tekes, Ferenc Szalay. [Peripheral nociceptin levels in Wilson disease].
Acta pharmaceutica Hungarica.
2002; 72(4):260-4. doi:
NULL. [PMID: 12812047] - J R Nicholson, H Akil, S J Watson. Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors.
Neuroscience.
2002; 115(2):637-43. doi:
10.1016/s0306-4522(02)00290-7. [PMID: 12421628] - B M Prasad, S G Amara. The dopamine transporter in mesencephalic cultures is refractory to physiological changes in membrane voltage.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2001 Oct; 21(19):7561-7. doi:
10.1523/jneurosci.21-19-07561.2001. [PMID: 11567046] - F M Dautzenberg, J Wichmann, J Higelin, G Py-Lang, C Kratzeisen, P Malherbe, G J Kilpatrick, F Jenck. Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.
The Journal of pharmacology and experimental therapeutics.
2001 Aug; 298(2):812-9. doi:
NULL. [PMID: 11454946] - Z Liu, Y Wang, J Zhang, J Ding, L Guo, D Cui, J Fei. Orphanin FQ: an endogenous antagonist of rat brain dopamine transporter.
Neuroreport.
2001 Mar; 12(4):699-702. doi:
10.1097/00001756-200103260-00017. [PMID: 11277567] - C N Serhan, I M Fierro, N Chiang, M Pouliot. Cutting edge: nociceptin stimulates neutrophil chemotaxis and recruitment: inhibition by aspirin-triggered-15-epi-lipoxin A4.
Journal of immunology (Baltimore, Md. : 1950).
2001 Mar; 166(6):3650-4. doi:
10.4049/jimmunol.166.6.3650. [PMID: 11238602] - K Shieh, J Pan. Effects of orphanin FQ on central dopaminergic neuronal activities and prolactin secretion.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Mar; 280(3):R705-12. doi:
10.1152/ajpregu.2001.280.3.r705. [PMID: 11171648] - S Grond, A Gabriel, C Pietruck, L C Yu, G X Xie, P Pierce Palmer. Bi-directional modulation of 5-hydroxytryptamine-induced plasma extravasation in the rat knee joint by nociceptin.
Neuroscience.
2001; 103(4):1085-92. doi:
10.1016/s0306-4522(01)00040-9. [PMID: 11301215] - D P Devine, S J Watson, H Akil. Nociceptin/orphanin FQ regulates neuroendocrine function of the limbic-hypothalamic-pituitary-adrenal axis.
Neuroscience.
2001; 102(3):541-53. doi:
10.1016/s0306-4522(00)00517-0. [PMID: 11226692] - S Kakiya, T Murase, H Arima, H Yokoi, Y Iwasaki, Y Miura, Y Oiso. Role of endogenous nociceptin in the regulation of arginine vasopressin release in conscious rats.
Endocrinology.
2000 Dec; 141(12):4466-71. doi:
10.1210/endo.141.12.7809. [PMID: 11108256] - L Y Yung, K W Tsim, G Pei, Y H Wong. Immunoglobulin G1 Fc fragment-tagged human opioid receptor-like receptor retains the ability to inhibit cAMP accumulation.
Biological signals and receptors.
2000 Sep; 9(5):240-7. doi:
10.1159/000014645. [PMID: 10965058] - L Terenius, J Sandin, T Sakurada. Nociceptin/orphanin FQ metabolism and bioactive metabolites.
Peptides.
2000 Jul; 21(7):919-22. doi:
10.1016/s0196-9781(00)00228-x. [PMID: 10998525] - D R Kapusta. Neurohumoral effects of orphanin FQ/nociceptin: relevance to cardiovascular and renal function.
Peptides.
2000 Jul; 21(7):1081-99. doi:
10.1016/s0196-9781(00)00246-1. [PMID: 10998543] - G Calo', R Guerrini, A Rizzi, S Salvadori, D Regoli. Pharmacology of nociceptin and its receptor: a novel therapeutic target.
British journal of pharmacology.
2000 Apr; 129(7):1261-83. doi:
10.1038/sj.bjp.0703219. [PMID: 10742280] - D R Kapusta, V A Kenigs. Cardiovascular and renal responses produced by central orphanin FQ/nociceptin occur independent of renal nerves.
The American journal of physiology.
1999 10; 277(4):R987-95. doi:
10.1152/ajpregu.1999.277.4.r987. [PMID: 10516236]