(R)-paliperidone (BioDeep_00000843668)
代谢物信息卡片
(R)-paliperidone
化学式: C23H27FN4O3 (426.2067084)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C(=O)N2CCCC(C2=N1)O)CCN3CCC(CC3)C4=NOC5=C4C=CC(=C5)F
InChI: InChI=1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3/t19-/m1/s1
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Angela C Doran, Sarah M Osgood, Jessica Y Mancuso, Christopher L Shaffer. An evaluation of using rat-derived single-dose neuropharmacokinetic parameters to project accurately large animal unbound brain drug concentrations.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Nov; 40(11):2162-73. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 907(?):101-7. doi:
10.1016/j.jchromb.2012.09.009. [PMID: 23026228] - Tomoko Inoue, Kenichi Osada, Masaaki Tagawa, Yuriko Ogawa, Toshiaki Haga, Yoshihisa Sogame, Takanori Hashizume, Takashi Watanabe, Atsushi Taguchi, Takashi Katsumata, Masashi Yabuki, Noboru Yamaguchi. Blonanserin, a novel atypical antipsychotic agent not actively transported as substrate by P-glycoprotein.
Progress in neuro-psychopharmacology & biological psychiatry.
2012 Oct; 39(1):156-62. doi:
10.1016/j.pnpbp.2012.06.005. [PMID: 22691713] - Marc De Hert, Weiping Yu, Johan Detraux, Kim Sweers, Ruud van Winkel, Christoph U Correll. Body weight and metabolic adverse effects of asenapine, iloperidone, lurasidone and paliperidone in the treatment of schizophrenia and bipolar disorder: a systematic review and exploratory meta-analysis.
CNS drugs.
2012 Sep; 26(9):733-59. doi:
10.2165/11634500-000000000-00000. [PMID: 22900950] - Yasuhisa Nagasaka, Kazuo Oda, Takafumi Iwatsubo, Akio Kawamura, Takashi Usui. Effects of aripiprazole and its active metabolite dehydroaripiprazole on the activities of drug efflux transporters expressed both in the intestine and at the blood-brain barrier.
Biopharmaceutics & drug disposition.
2012 Sep; 33(6):304-15. doi:
10.1002/bdd.1801. [PMID: 22847220] - Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Chi-Un Pae, W Wolfgang Fleischhacker. Paliperidone: a review of clinical trial data and clinical implications.
Clinical drug investigation.
2012 Aug; 32(8):497-512. doi:
10.2165/11634440-000000000-00000. [PMID: 22747259] - Saeko Ikai, Gary Remington, Takefumi Suzuki, Hiroyoshi Takeuchi, Takashi Tsuboi, Ryosuke Den, Jinichi Hirano, Kenichi Tsunoda, Masahiko Nishimoto, Koichiro Watanabe, Masaru Mimura, David Mamo, Hiroyuki Uchida. A cross-sectional study of plasma risperidone levels with risperidone long-acting injectable: implications for dopamine D2 receptor occupancy during maintenance treatment in schizophrenia.
The Journal of clinical psychiatry.
2012 Aug; 73(8):1147-52. doi:
10.4088/jcp.12m07638. [PMID: 22967779] - Magdalena Kozielska, Martin Johnson, Venkatesh Pilla Reddy, An Vermeulen, Cheryl Li, Sarah Grimwood, Rik de Greef, Geny M M Groothuis, Meindert Danhof, Johannes H Proost. Pharmacokinetic-pharmacodynamic modeling of the D₂ and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats.
Pharmaceutical research.
2012 Jul; 29(7):1932-48. doi:
10.1007/s11095-012-0722-8. [PMID: 22437487] - Leslie Citrome. Oral paliperidone extended-release: chemistry, pharmacodynamics, pharmacokinetics and metabolism, clinical efficacy, safety and tolerability.
Expert opinion on drug metabolism & toxicology.
2012 Jul; 8(7):873-88. doi:
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The Cochrane database of systematic reviews.
2012 Jun; ?(6):CD008296. doi:
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Therapeutic drug monitoring.
2012 Jun; 34(3):349-55. doi:
10.1097/ftd.0b013e3182577c43. [PMID: 22569353] - Mingzhu Huang, Jianzhong Shen-Tu, Xingjiang Hu, Junchun Chen, Jian Liu, Lihua Wu. Comparative fasting bioavailability of dispersible and conventional tablets of risperidone: a single-dose, randomized-sequence, open-label, two-period crossover study in healthy male Chinese volunteers.
Clinical therapeutics.
2012 Jun; 34(6):1432-9. doi:
10.1016/j.clinthera.2012.04.027. [PMID: 22595151] - Hiroyuki Uchida, David C Mamo, Bruce G Pollock, Takefumi Suzuki, Kenichi Tsunoda, Koichiro Watanabe, Masaru Mimura, Robert R Bies. Predicting plasma concentration of risperidone associated with dosage change: a population pharmacokinetic study.
Therapeutic drug monitoring.
2012 Apr; 34(2):182-7. doi:
10.1097/ftd.0b013e3182489a6f. [PMID: 22377743] - W Mahatthanatrakul, S Sriwiriyajan, W Ridtitid, J Boonleang, M Wongnawa, N Rujimamahasan, W Pipatrattanaseree. Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers.
Journal of clinical pharmacy and therapeutics.
2012 Apr; 37(2):221-5. doi:
10.1111/j.1365-2710.2011.01271.x. [PMID: 21518375] - E C Muly, J R Votaw, J Ritchie, L L Howell. Relationship between dose, drug levels, and D2 receptor occupancy for the atypical antipsychotics risperidone and paliperidone.
The Journal of pharmacology and experimental therapeutics.
2012 Apr; 341(1):81-9. doi:
10.1124/jpet.111.189076. [PMID: 22214649] - Danielle Coppola, Yanning Liu, Srihari Gopal, Bart Remmerie, Mahesh N Samtani, David W Hough, Isaac Nuamah, Ahmad Sulaiman, Gahan Pandina. A one-year prospective study of the safety, tolerability and pharmacokinetics of the highest available dose of paliperidone palmitate in patients with schizophrenia.
BMC psychiatry.
2012 Mar; 12(?):26. doi:
10.1186/1471-244x-12-26. [PMID: 22455454] - Andrea Reed, Keith Huie, Elke S Perloff, James V Cassella, Lori H Takahashi. Loxapine P-glycoprotein interactions in vitro.
Drug metabolism letters.
2012 Mar; 6(1):26-32. doi:
10.2174/187231212800229255. [PMID: 22300294] - Christoffer Bundgaard, Christian Jes Nyberg Jensen, Mats Garmer. Species comparison of in vivo P-glycoprotein-mediated brain efflux using mdr1a-deficient rats and mice.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Mar; 40(3):461-6. doi:
10.1124/dmd.111.043083. [PMID: 22112383] - Chih-Sung Liang, Ya-Mei Bai, Ying-Jay Liou, Yuan Hwa Chou. Acute renal failure after paliperidone overdose: a case report.
Journal of clinical psychopharmacology.
2012 Feb; 32(1):128. doi:
10.1097/jcp.0b013e31823f9101. [PMID: 22217944] - Cesario Bellantuono, Giovanni Santone. [Efficacy, tolerability and safety of paliperidone extended-release in the treatment of schizophrenia and schizoaffective disorder].
Rivista di psichiatria.
2012 Jan; 47(1):5-20. doi:
10.1708/1034.11287. [PMID: 22358213] - Yutaro Suzuki, Naoki Fukui, Junzo Watanabe, Shin Ono, Takuro Sugai, Nobuto Tsuneyama, Mami Saito, Yoshimasa Inoue, Toshiyuki Someya. QT prolongation of the antipsychotic risperidone is predominantly related to its 9-hydroxy metabolite paliperidone.
Human psychopharmacology.
2012 Jan; 27(1):39-42. doi:
10.1002/hup.1258. [PMID: 22144033] - Yutaro Suzuki, Naoki Fukui, Nobuto Tsuneyama, Junzo Watanabe, Shin Ono, Takuro Sugai, Mami Saito, Yoshimasa Inoue, Toshiyuki Someya. Effect of the cytochrome P450 2D6*10 allele on risperidone metabolism in Japanese psychiatric patients.
Human psychopharmacology.
2012 Jan; 27(1):43-6. doi:
10.1002/hup.1260. [PMID: 22745940] - Mahesh N Samtani, John J Sheehan, Dong-Jing Fu, Bart Remmerie, Jennifer Kern Sliwa, Larry Alphs. Management of antipsychotic treatment discontinuation and interruptions using model-based simulations.
Clinical pharmacology : advances and applications.
2012; 4(?):25-40. doi:
10.2147/cpaa.s32735. [PMID: 22888277] - Manuel Maria de Carvalho, Carlos Góis. [Hyperprolactinemia in mentally ill patients].
Acta medica portuguesa.
2011 Nov; 24(6):1005-12. doi:
. [PMID: 22713195] - Norio Yasui-Furukori, Shoko Tsuchimine, Manabu Saito, Taku Nakagami, Norio Sugawara, Akira Fujii, Sunao Kaneko. Comparing the influence of dopamine D₂ polymorphisms and plasma drug concentrations on the clinical response to risperidone.
Journal of clinical psychopharmacology.
2011 Oct; 31(5):633-7. doi:
10.1097/jcp.0b013e31822c09a7. [PMID: 21869689] - Martin Johnson, Magdalena Kozielska, Venkatesh Pilla Reddy, An Vermeulen, Cheryl Li, Sarah Grimwood, Rik de Greef, Geny M M Groothuis, Meindert Danhof, Johannes H Proost. Mechanism-based pharmacokinetic-pharmacodynamic modeling of the dopamine D2 receptor occupancy of olanzapine in rats.
Pharmaceutical research.
2011 Oct; 28(10):2490-504. doi:
10.1007/s11095-011-0477-7. [PMID: 21647790] - Hee-Doo Yoo, Sang-No Lee, Hyun-Ah Kang, Hea-Young Cho, Il-Kwon Lee, Yong-Bok Lee. Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of risperidone in healthy subjects with CYP2D6*10/*10.
British journal of pharmacology.
2011 Sep; 164(2b):433-43. doi:
10.1111/j.1476-5381.2011.01385.x. [PMID: 21449914] - Tim Moons, Mariska de Roo, Stephan Claes, Geert Dom. Relationship between P-glycoprotein and second-generation antipsychotics.
Pharmacogenomics.
2011 Aug; 12(8):1193-211. doi:
10.2217/pgs.11.55. [PMID: 21843066] - Hua-Lin Cai, Rong-Hua Zhu, Huan-De Li, Jun Zhang, Lan-Fang Li. MultiSimplex optimization of chromatographic separation and dansyl derivatization conditions in the ultra performance liquid chromatography-tandem mass spectrometry analysis of risperidone, 9-hydroxyrisperidone, monoamine and amino acid neurotransmitters in human urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jul; 879(21):1993-9. doi:
10.1016/j.jchromb.2011.05.006. [PMID: 21621490] - Robert K McNamara, Ronald Jandacek, Therese Rider, Patrick Tso, Allyson Cole-Strauss, Jack W Lipton. Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity.
Schizophrenia research.
2011 Jun; 129(1):66-73. doi:
10.1016/j.schres.2011.03.016. [PMID: 21474290] - Amir Badshah, Fazal Subhan, Khalid Rauf, Nadeem Irfan Bukhari, Kifayatullah Shah, Samiullah Khan, Zia Ahmed, Ihsanullah Khan. Development of controlled-release matrix tablet of risperidone: influence of Methocel®- and Ethocel®-based novel polymeric blend on in vitro drug release and bioavailability.
AAPS PharmSciTech.
2011 Jun; 12(2):525-33. doi:
10.1208/s12249-011-9613-2. [PMID: 21494924] - Robert K McNamara, Ronald Jandacek, Therese Rider, Patrick Tso, Allyson Cole-Strauss, Jack W Lipton. Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression.
Schizophrenia research.
2011 Jun; 129(1):57-65. doi:
10.1016/j.schres.2011.03.006. [PMID: 21458237] - N Khorana, S Maphanta, O Lohitnavy, A Srichaiya, J Sayasathid. Comparative pharmacokinetics and bioequivalence of two tablet formulations of 2 mg risperidone in healthy Thai male volunteers.
International journal of clinical pharmacology and therapeutics.
2011 Jun; 49(6):409-14. doi:
10.5414/cp201509. [PMID: 21612749] - Ricarda Jantos, Markus Schuhmacher, Janet L Veldstra, Wendy M Bosker, Ineke Klöpping-Ketelaars, Katerina Touliou, Gian Marco Sardi, Karel A Brookhuis, Johannes G Ramaekers, Rainer Mattern, Gisela Skopp. [Determination of blood/serum ratios of different forensically relevant analytes in authentic samples].
Archiv fur Kriminologie.
2011 May; 227(5-6):188-203. doi:
NULL. [PMID: 21805908] - Chadi Albert Calarge, Del D Miller. Predictors of risperidone and 9-hydroxyrisperidone serum concentration in children and adolescents.
Journal of child and adolescent psychopharmacology.
2011 Apr; 21(2):163-9. doi:
10.1089/cap.2010.0038. [PMID: 21486167] - H Y Meltzer, B W Massey. The role of serotonin receptors in the action of atypical antipsychotic drugs.
Current opinion in pharmacology.
2011 Feb; 11(1):59-67. doi:
10.1016/j.coph.2011.02.007. [PMID: 21420906] - Roberto Mandrioli, Laura Mercolini, Domenico Lateana, Giancarlo Boncompagni, Maria Augusta Raggi. Analysis of risperidone and 9-hydroxyrisperidone in human plasma, urine and saliva by MEPS-LC-UV.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2011 Jan; 879(2):167-73. doi:
10.1016/j.jchromb.2010.11.033. [PMID: 21183412] - Frédérique Lancelin, Elsa Bourcier, Valérie Le Masson, Yolande Lemeille, Sophie Brovedani, Pascal Paubel, Marie-Liesse Piketty. Effect of cyamemazine on the steady-state plasma concentrations of risperidone and 9-hydroxyrisperidone: a preliminary retrospective study.
Therapeutic drug monitoring.
2010 Dec; 32(6):757-61. doi:
10.1097/ftd.0b013e3181fa57fe. [PMID: 21068648] - Igor Locatelli, Matej Kastelic, Jure Koprivsek, Blanka Kores-Plesnicar, Ales Mrhar, Vita Dolzan, Iztok Grabnar. A population pharmacokinetic evaluation of the influence of CYP2D6 genotype on risperidone metabolism in patients with acute episode of schizophrenia.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2010 Oct; 41(2):289-98. doi:
10.1016/j.ejps.2010.06.016. [PMID: 20599499] - Hua-Lin Cai, Rong-Hua Zhu, Huan-De Li, Xiang-Hui Zhang, Li Hu, Wen Yang, Hai-Sen Ye. Elevated plasma γ-aminobutyrate/glutamate ratio and responses to risperidone antipsychotic treatment in schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Oct; 34(7):1273-8. doi:
10.1016/j.pnpbp.2010.07.006. [PMID: 20637820] - Jutima Boonleang, Weerachai Pipatrattanaseree, Chanpa Tanthana, Werawath Mahatthanatrakul. Relative bioavailability and pharmacokinetic comparison of two 2-mg risperidone tablet formulations: A single dose, randomized-sequence, double-blind, 2-way crossover study in healthy male volunteers in Thailand.
Clinical therapeutics.
2010 Sep; 32(10):1842-53. doi:
10.1016/j.clinthera.2010.09.013. [PMID: 21194608] - W Tassaneeyakul, S Kumar, D Gaysonsiri, T Kaewkamson, A Khuroo, P Tangsucharit, K Phunikhom, S Vannaprasaht, S Kanjanawart, N Rao Thudi, R Jain, S Reyar, T Monif. Comparative bioavailability of two risperidone orodispersible tablet products after single dose administration.
International journal of clinical pharmacology and therapeutics.
2010 Sep; 48(9):614-20. doi:
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Pharmacotherapy.
2010 Sep; 30(9):942-51. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2010 Aug; 67(15):1254-9. doi:
10.2146/ajhp090243. [PMID: 20651315] - Yasmin Nazirizadeh, Friederike Vogel, Wolfgang Bader, Ekkehard Haen, Bruno Pfuhlmann, Gerhard Gründer, Michael Paulzen, Markus Schwarz, Gerald Zernig, Christoph Hiemke. Serum concentrations of paliperidone versus risperidone and clinical effects.
European journal of clinical pharmacology.
2010 Aug; 66(8):797-803. doi:
10.1007/s00228-010-0812-7. [PMID: 20358189] - Claudine M Chwieduk, Gillian M Keating. Paliperidone extended release: a review of its use in the management of schizophrenia.
Drugs.
2010 Jul; 70(10):1295-317. doi:
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Current drug metabolism.
2010 Jul; 11(6):516-25. doi:
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Journal of psychopharmacology (Oxford, England).
2010 Jul; 24(7):1115-20. doi:
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Journal of psychopharmacology (Oxford, England).
2010 Jul; 24(7):1011-8. doi:
10.1177/0269881109106914. [PMID: 19825908] - Tianmei Si, Liang Shu, Yi Liu, Yun' Ai Su, Chunmei Guo, Hongyan Zhang. Single-dose pharmacokinetics of paliperidone extended-release tablets in healthy Chinese subjects.
Human psychopharmacology.
2010 Jul; 25(5):404-9. doi:
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Neuropsychiatric disease and treatment.
2010 Jun; 6(?):261-7. doi:
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Talanta.
2010 Jun; 81(4-5):1547-53. doi:
10.1016/j.talanta.2010.02.067. [PMID: 20441937] - Qian Xiang, Xia Zhao, Ying Zhou, Jing Li Duan, Yi Min Cui. Effect of CYP2D6, CYP3A5, and MDR1 genetic polymorphisms on the pharmacokinetics of risperidone and its active moiety.
Journal of clinical pharmacology.
2010 Jun; 50(6):659-66. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2010 Mar; 34(2):387-92. doi:
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European psychiatry : the journal of the Association of European Psychiatrists.
2010 Mar; 25(2):92-100. doi:
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Pharmacopsychiatry.
2010 Mar; 43(2):58-65. doi:
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Current medical research and opinion.
2010 Feb; 26(2):377-87. doi:
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Psychosomatics.
2010 Jan; 51(1):80-8. doi:
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International journal of clinical practice.
2010 Jan; 64(2):216-39. doi:
10.1111/j.1742-1241.2009.02240.x. [PMID: 19886879] - Arlan L Rosenbloom. Hyperprolactinemia with antipsychotic drugs in children and adolescents.
International journal of pediatric endocrinology.
2010; 2010(?):. doi:
10.1155/2010/159402. [PMID: 20871665] - Igor Locatelli, Ales Mrhar, Iztok Grabnar. Simultaneous determination of risperidone and 9-hydroxyrisperidone enantiomers in human blood plasma by liquid chromatography with electrochemical detection.
Journal of pharmaceutical and biomedical analysis.
2009 Dec; 50(5):905-10. doi:
10.1016/j.jpba.2009.06.013. [PMID: 19589654] - Magnhild Hendset, Espen Molden, Helge Refsum, Monica Hermann. Impact of CYP2D6 genotype on steady-state serum concentrations of risperidone and 9-hydroxyrisperidone in patients using long-acting injectable risperidone.
Journal of clinical psychopharmacology.
2009 Dec; 29(6):537-41. doi:
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The Psychiatric clinics of North America.
2009 Dec; 32(4):775-94. doi:
10.1016/j.psc.2009.08.003. [PMID: 19944883] - Gaetana Migliardi, Edoardo Spina, Concetta D'Arrigo, Antonella Gagliano, Eva Germanò, Rosamaria Siracusano, Francisco J Diaz, Jose de Leon. Short- and long-term effects on prolactin of risperidone and olanzapine treatments in children and adolescents.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Nov; 33(8):1496-501. doi:
10.1016/j.pnpbp.2009.08.009. [PMID: 19706318] - Sandra Boom, Krishna Talluri, Luc Janssens, Bart Remmerie, Marc De Meulder, Stefaan Rossenu, Nancy van Osselaer, Marielle Eerdekens, Adriaan Cleton. Single- and multiple-dose pharmacokinetics and dose proportionality of the psychotropic agent paliperidone extended release.
Journal of clinical pharmacology.
2009 Nov; 49(11):1318-30. doi:
10.1177/0091270009339190. [PMID: 19713555] - An Thyssen, Adriaan Cleton, Krishna Talluri, Jos Leempoels, Luc Janssens, Sandra Boom, Marielle Eerdekens. No pharmacokinetic interaction between paliperidone extended-release tablets and trimethoprim in healthy subjects.
Human psychopharmacology.
2009 Oct; 24(7):532-9. doi:
10.1002/hup.1049. [PMID: 19693799] - S Boom, A Thyssen, H Crauwels, K H Molz, A Cleton, L Janssens, K Talluri, M Eerdekens. The influence of hepatic impairment on the pharmacokinetics of paliperidone.
International journal of clinical pharmacology and therapeutics.
2009 Oct; 47(10):606-16. doi:
10.5414/cpp47606. [PMID: 19825324] - Tanya Jones, Karin Van Breda, Bruce Charles, Angela J Dean, Brett M McDermott, Ross Norris. Determination of risperidone and 9-Hydroxyrisperidone using HPLC, in plasma of children and adolescents with emotional and behavioural disorders.
Biomedical chromatography : BMC.
2009 Sep; 23(9):929-34. doi:
10.1002/bmc.1204. [PMID: 19353731] - David Hough, Jean-Pierre Lindenmayer, Srihari Gopal, Rama Melkote, Pilar Lim, Virginie Herben, Eric Yuen, Marielle Eerdekens. Safety and tolerability of deltoid and gluteal injections of paliperidone palmitate in schizophrenia.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Aug; 33(6):1022-31. doi:
10.1016/j.pnpbp.2009.05.014. [PMID: 19481579] - Alfonso M Lostia, Lorenzo Mazzarini, Isabella Pacchiarotti, Luana Lionetto, Pietro De Rossi, Livia Sanna, Gabriele Sani, Giorgio D Kotzalidis, Paolo Girardi, Maurizio Simmaco, Roberto Tatarelli. Serum levels of risperidone and its metabolite, 9-hydroxyrisperidone: correlation between drug concentration and clinical response.
Therapeutic drug monitoring.
2009 Aug; 31(4):475-81. doi:
10.1097/ftd.0b013e3181aa4780. [PMID: 19531984] - Rhee-Hun Kang, Sun-Min Jung, Kyoung-Ah Kim, Duk-Ki Lee, Hyun-Kee Cho, Bong-Joo Jung, Young-Ku Kim, Seung-Hyun Kim, Changsu Han, Min-Soo Lee, Ji-Young Park. Effects of CYP2D6 and CYP3A5 genotypes on the plasma concentrations of risperidone and 9-hydroxyrisperidone in Korean schizophrenic patients.
Journal of clinical psychopharmacology.
2009 Jun; 29(3):272-7. doi:
10.1097/jcp.0b013e3181a289e0. [PMID: 19440082] - Xingrong Liu, Kristine Van Natta, Helen Yeo, Olga Vilenski, Paul E Weller, Philip D Worboys, Mario Monshouwer. Unbound drug concentration in brain homogenate and cerebral spinal fluid at steady state as a surrogate for unbound concentration in brain interstitial fluid.
Drug metabolism and disposition: the biological fate of chemicals.
2009 Apr; 37(4):787-93. doi:
10.1124/dmd.108.024125. [PMID: 19116265] - Hiroyuki Uchida, Shitij Kapur, Benoit H Mulsant, Ariel Graff-Guerrero, Bruce G Pollock, David C Mamo. Sensitivity of older patients to antipsychotic motor side effects: a PET study examining potential mechanisms.
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.
2009 Mar; 17(3):255-63. doi:
10.1097/jgp.0b013e318198776d. [PMID: 19225277] - Luca Pani, Giorgio Marchese. Expected clinical benefits of paliperidone extended-release formulation when compared with risperidone immediate-release.
Expert opinion on drug delivery.
2009 Mar; 6(3):319-31. doi:
10.1517/17425240902780158. [PMID: 19317589] - Nada Bozina, Nikolina Jovanović, Mila Lovrić, Vesna Medved. Clinical significance of a CYP2D6 poor metabolizer--a patient with schizophrenia on risperidone treatment.
Therapeutic drug monitoring.
2008 Dec; 30(6):748-51. doi:
10.1097/ftd.0b013e3181896afc. [PMID: 18806696] - Arzu Gunes, Edoardo Spina, Marja-Liisa Dahl, Maria Gabriella Scordo. ABCB1 polymorphisms influence steady-state plasma levels of 9-hydroxyrisperidone and risperidone active moiety.
Therapeutic drug monitoring.
2008 Oct; 30(5):628-33. doi:
10.1097/ftd.0b013e3181858ca9. [PMID: 18708991] - Hiroyuki Uchida, David C Mamo, Shitij Kapur, Alain Labelle, Chekkera Shammi, Erik J L Mannaert, Steve W Mann, Gary Remington. Monthly administration of long-acting injectable risperidone and striatal dopamine D2 receptor occupancy for the management of schizophrenia.
The Journal of clinical psychiatry.
2008 Aug; 69(8):1281-6. doi:
10.4088/jcp.v69n0811. [PMID: 18642974] - Marc De Meulder, Bart M M Remmerie, Ronald de Vries, Luc L A Sips, Sandra Boom, Edwin W J Hooijschuur, Nico C van de Merbel, Philip M M B L Timmerman. Validated LC-MS/MS methods for the determination of risperidone and the enantiomers of 9-hydroxyrisperidone in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jul; 870(1):8-16. doi:
10.1016/j.jchromb.2008.04.041. [PMID: 18571483] - Abraham M Nussbaum, T Scott Stroup. Paliperidone for treatment of schizophrenia.
Schizophrenia bulletin.
2008 May; 34(3):419-22. doi:
10.1093/schbul/sbn015. [PMID: 18375569] - Herbert Y Meltzer, William V Bobo, Isaac F Nuamah, Rosanne Lane, David Hough, Michelle Kramer, Marielle Eerdekens. Efficacy and tolerability of oral paliperidone extended-release tablets in the treatment of acute schizophrenia: pooled data from three 6-week, placebo-controlled studies.
The Journal of clinical psychiatry.
2008 May; 69(5):817-29. doi:
10.4088/jcp.v69n0515. [PMID: 18466043] - A Nussbaum, T S Stroup. Paliperidone for schizophrenia.
The Cochrane database of systematic reviews.
2008 Apr; ?(2):CD006369. doi:
10.1002/14651858.cd006369.pub2. [PMID: 18425951] - Marc Vermeir, Ineke Naessens, Bart Remmerie, Geert Mannens, Jan Hendrickx, Patrick Sterkens, Krishna Talluri, Sandra Boom, Marielle Eerdekens, Nancy van Osselaer, Adriaan Cleton. Absorption, metabolism, and excretion of paliperidone, a new monoaminergic antagonist, in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Apr; 36(4):769-79. doi:
10.1124/dmd.107.018275. [PMID: 18227146] - Ryosuke Arakawa, Hiroshi Ito, Akihiro Takano, Hidehiko Takahashi, Takuya Morimoto, Takeshi Sassa, Katsuya Ohta, Motoichiro Kato, Yoshiro Okubo, Tetsuya Suhara. Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia.
Psychopharmacology.
2008 Apr; 197(2):229-35. doi:
10.1007/s00213-007-1029-z. [PMID: 18058087] - Marion Lautenschlager, Andreas Heinz. Paliperidone-ER: first atypical antipsychotic with oral extended release formulation.
Expert review of neurotherapeutics.
2008 Feb; 8(2):193-200. doi:
10.1586/14737175.8.2.193. [PMID: 18271706] - Bo Feng, Jessica B Mills, Ralph E Davidson, Rouchelle J Mireles, John S Janiszewski, Matthew D Troutman, Sonia M de Morais. In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Feb; 36(2):268-75. doi:
10.1124/dmd.107.017434. [PMID: 17962372] - Fabrice Duval, Marie-Sabine Guillon, Marie-Claude Mokrani, Marc-Antoine Crocq, Frederico Garcia Duarte. Relationship between prolactin secretion, and plasma risperidone and 9-hydroxyrisperidone concentrations in adolescents with schizophreniform disorder.
Psychoneuroendocrinology.
2008 Feb; 33(2):255-9. doi:
10.1016/j.psyneuen.2007.10.010. [PMID: 18053652] - Kyoung-Ah Kim, Pil-Whan Park, Kwang-Hyeon Liu, Kwon-Bok Kim, Heon-Jeong Lee, Jae-Gook Shin, Ji-Young Park. Effect of rifampin, an inducer of CYP3A and P-glycoprotein, on the pharmacokinetics of risperidone.
Journal of clinical pharmacology.
2008 Jan; 48(1):66-72. doi:
10.1177/0091270007309888. [PMID: 18094221] - Stephen R Marder, Michelle Kramer, Lisa Ford, Els Eerdekens, Pilar Lim, Mariëlle Eerdekens, Adam Lowy. Efficacy and safety of paliperidone extended-release tablets: results of a 6-week, randomized, placebo-controlled study.
Biological psychiatry.
2007 Dec; 62(12):1363-70. doi:
10.1016/j.biopsych.2007.01.017. [PMID: 17601495] - Philip G Janicak, Elizabeth A Winans. Paliperidone ER: a review of the clinical trial data.
Neuropsychiatric disease and treatment.
2007 Dec; 3(6):869-97. doi:
10.2147/ndt.s1365. [PMID: 19300622] - Edoardo Spina, Roberto Cavallaro. The pharmacology and safety of paliperidone extended-release in the treatment of schizophrenia.
Expert opinion on drug safety.
2007 Nov; 6(6):651-62. doi:
10.1517/14740338.6.6.651. [PMID: 17967154] - Lei Wang, Lan Yu, Ai-Ping Zhang, Chao Fang, Jing Du, Niu-Fan Gu, Sheng-Ying Qin, Guo-Yin Feng, Xing-Wang Li, Qing-He Xing, Lin He. Serum prolactin levels, plasma risperidone levels, polymorphism of cytochrome P450 2D6 and clinical response in patients with schizophrenia.
Journal of psychopharmacology (Oxford, England).
2007 Nov; 21(8):837-42. doi:
10.1177/0269881107077357. [PMID: 17715206] - Guodong Zhang, Alvin V Terry, Michael G Bartlett. Sensitive liquid chromatography/tandem mass spectrometry method for the simultaneous determination of olanzapine, risperidone, 9-hydroxyrisperidone, clozapine, haloperidol and ziprasidone in rat brain tissue.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Oct; 858(1-2):276-81. doi:
10.1016/j.jchromb.2007.08.007. [PMID: 17766202] - Aiping Zhang, Qinghe Xing, Lei Wang, Jing Du, Lan Yu, Zhiguang Lin, Xingwang Li, Guoyin Feng, Lin He. Dopamine transporter polymorphisms and risperidone response in Chinese schizophrenia patients: an association study.
Pharmacogenomics.
2007 Oct; 8(10):1337-45. doi:
10.2217/14622416.8.10.1337. [PMID: 17979508] - Wolfgang Aichhorn, Josef Marksteiner, Thomas Walch, Gerald Zernig, Hartmann Hinterhuber, Christoph Stuppaeck, Georg Kemmler. Age and gender effects on olanzapine and risperidone plasma concentrations in children and adolescents.
Journal of child and adolescent psychopharmacology.
2007 Oct; 17(5):665-74. doi:
10.1089/cap.2006.0045. [PMID: 17979586] - Heather Dlugosz, Henry A Nasrallah. Paliperidone: a new extended-release oral atypical antipsychotic.
Expert opinion on pharmacotherapy.
2007 Oct; 8(14):2307-13. doi:
10.1517/14656566.8.14.2307. [PMID: 17927485] - Guodong Zhang, Alvin V Terry, Michael G Bartlett. Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Sep; 856(1-2):20-8. doi:
10.1016/j.jchromb.2007.05.015. [PMID: 17588832] - Michael Davidson, Robin Emsley, Michelle Kramer, Lisa Ford, Guohua Pan, Pilar Lim, Mariëlle Eerdekens. Efficacy, safety and early response of paliperidone extended-release tablets (paliperidone ER): results of a 6-week, randomized, placebo-controlled study.
Schizophrenia research.
2007 Jul; 93(1-3):117-30. doi:
10.1016/j.schres.2007.03.003. [PMID: 17466492] - B Cabovska, S L Cox, A A Vinks. Determination of risperidone and enantiomers of 9-hydroxyrisperidone in plasma by LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):497-504. doi:
10.1016/j.jchromb.2007.02.007. [PMID: 17344104] - Jun-Jie Ding, Zheng Jiao, Yun-Qiu Yu, Xiao-Jin Shi. [Development and identifiability analysis of parent-metabolite pharmacokinetic model for risperidone and its main active metabolite 9-hydroxyrisperidone].
Yao xue xue bao = Acta pharmaceutica Sinica.
2007 Jun; 42(6):631-8. doi:
NULL. [PMID: 17702401]