Hydergine (BioDeep_00000843653)

   


代谢物信息卡片


Hydergine

化学式: C32H45N5O8S (659.2989)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)C1C(=O)N2CCCC2C3(N1C(=O)C(O3)(C(C)C)NC(=O)C4CC5C(CC6=CNC7=CC=CC5=C67)N(C4)C)O.CS(=O)(=O)O
InChI: /m1./s1

描述信息

C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D002491 - Central Nervous System Agents > D018697 - Nootropic Agents > D004877 - Ergoloid Mesylates
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018491 - Dopamine Agonists
C78272 - Agent Affecting Nervous System > C66884 - Dopamine Agonist
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

2 个代谢物同义名

Hydergine; 9,10-Dihydroergocornine methanesulfonate



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jian Chen, Xiaomei Wang, Juan Wang, Guangli Liu, Xing Tang. Evaluation of brain-targeting for the nasal delivery of ergoloid mesylate by the microdialysis method in rats. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2008 Mar; 68(3):694-700. doi: 10.1016/j.ejpb.2007.08.013. [PMID: 17945473]
  • Beatriz Bicalho, Juliana Marconi Giolo, Sergio Lilla, Gilberto De Nucci. Identification and human pharmacokinetics of dihydroergotoxine metabolites in man: preliminary results. Biopharmaceutics & drug disposition. 2008 Jan; 29(1):17-28. doi: 10.1002/bdd.585. [PMID: 17941060]
  • Wen-Jen Lu, Jin-Ding Huang, Ming-Liang Lai. The effects of ergoloid mesylates and ginkgo biloba on the pharmacokinetics of ticlopidine. Journal of clinical pharmacology. 2006 Jun; 46(6):628-34. doi: 10.1177/0091270006287024. [PMID: 16707409]
  • Ursula Werneke, Trevor Turner, Stefan Priebe. Complementary medicines in psychiatry: review of effectiveness and safety. The British journal of psychiatry : the journal of mental science. 2006 Feb; 188(?):109-21. doi: 10.1192/bjp.188.2.109. [PMID: 16449696]
  • Jun-shan Huang, Qiu-cheng Lin, Rong-zhang Huang. [Clinical study on effect of yuantong capsule in treating vascular dementia]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2003 Nov; 23(11):815-8. doi: ". [PMID: 14666760]
  • A Gomaa, M Eissa, A El-Gebaley. The effect of topically applied vasoactive agents and testosterone versus testosterone in the treatment of erectile dysfunction in aged men with low sexual interest. International journal of impotence research. 2001 Apr; 13(2):93-9. doi: 10.1038/sj.ijir.3900643. [PMID: 11426345]
  • G Coppi, S Silingardi. Pharmacokinetics of alpha-dihydroergocriptine in rats after single intravenous and single and repeated oral administrations. Biopharmaceutics & drug disposition. 1995 May; 16(4):333-42. doi: 10.1002/bdd.2510160409. [PMID: 7548782]
  • J Kleijnen, P Knipschild. Ginkgo biloba for cerebral insufficiency. British journal of clinical pharmacology. 1992 Oct; 34(4):352-8. doi: 10.1111/j.1365-2125.1992.tb05642.x. [PMID: 1457269]
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  • W Kirch, A Nokhodian, A Halabi, G Weidinger. Clinical pharmacokinetics of the nifedipine/co-dergocrine combination in impaired liver and renal function. European journal of drug metabolism and pharmacokinetics. 1992 Jan; 17(1):33-8. doi: 10.1007/bf03189985. [PMID: 1499595]
  • W H Aellig, E Nüesch. Comparative pharmacokinetic investigations with tritium-labeled ergot alkaloids after oral and intravenous administration man. International journal of clinical pharmacology and biopharmacy. 1977 Mar; 15(3):106-12. doi: NULL. [PMID: 403149]
  • A Marzo, P Ghirardi, M A Parenti, L Merlo, G Marchetti. [Plasma levels and biliary and urinary elimination of raubasine, dehydroergocristine and dihydroergotamine after venous administration in anesthetized dogs]. Bollettino della Societa italiana di biologia sperimentale. 1975 Jun; 51(11):684-6. doi: NULL. [PMID: 816365]
  • C Weisse, K Kühns. [Effect of Briserin on hypertensive patients with and without diabetes and hypertensive patients with normal and disordered kidney function]. Die Medizinische Welt. 1975 Jan; 26(2):82-3. doi: NULL. [PMID: 803604]
  • V V Buianov. [Effect of dihydroergotoxin and phentolamine on the alpha--adrenoreceptors of the vessels of the kidney and intestines]. Farmakologiia i toksikologiia. 1974 Nov; 37(6):674-6. doi: NULL. [PMID: 4219191]
  • I C Campbell, A Todrick. On the pharmacology and biochemistry of the amine-uptake mechanism in human blood platelets. British journal of pharmacology. 1973 Oct; 49(2):279-87. doi: 10.1111/j.1476-5381.1973.tb08373.x. [PMID: 4152219]
  • R Iwangoff, A Enz. Inhibition of phosphodiesterase by dihydroergotamine and hydergine in various organs of the cat in vitro. Experientia. 1973 Sep; 29(9):1067-9. doi: 10.1007/bf01946723. [PMID: 4355415]
  • E Kiesewetter, F X Wohlzogen, A Mostbeck. [Kidney function during therapy of hypertension]. International journal of clinical pharmacology, therapy and toxicology. 1973 Jul; 7(4):316-22. doi: NULL. [PMID: 4199251]
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  • W Habermann, K O Stumpe, F Krück. [Glomerular filtrate, renal plasma flow, and sodium excretion in hypertensive patients before and following antihypertensive treatment with combination preparations]. Medizinische Klinik. 1972 Oct; 67(42):1363-7. doi: NULL. [PMID: 4629612]
  • F H Franken. [Therapy of functional intestinal disorders]. Deutsche medizinische Wochenschrift (1946). 1971 Aug; 96(32):1310-1. doi: 10.1055/s-0028-1110131. [PMID: 4998627]
  • E Stampfer. [Experiences with a new antihypertensive agent]. Wiener klinische Wochenschrift. 1971 Jan; 83(4):66-9. doi: NULL. [PMID: 4994618]
  • A Kotãsek, J Cervenka, J Bastecky, M Cernã. Further experience with Forrest tests in obstetrics. Activitas nervosa superior. 1971; 13(3):222-4. doi: NULL. [PMID: 5001128]
  • A Morra, U Pettinelli. [The use of sympatholytics (hydergine) in association with other drugs in the prevention and treatment of post-operative acute renal insufficiency]. Minerva chirurgica. 1970 Dec; 25(23):1600-6. doi: NULL. [PMID: 4994489]
  • O H Arnold. [Therapy of arterial hypertension. Results, possibilities, methods]. Experimentelle Medizin, Pathologie und Klinik. 1970; 30(?):1-202. doi: NULL. [PMID: 4398695]
  • M F Lockett, R Wadley. Renal actions of dihydroergocristine and of phentolamine in anaesthetized cats. British journal of pharmacology. 1969 Nov; 37(3):595-608. doi: 10.1111/j.1476-5381.1969.tb08498.x. [PMID: 4390677]
  • A Gras, A Jouve. [Study of the association of a diuretic and a sympatholitic agent and its application in the treatment of hypertension]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1969 Feb; 45(7):455-9. doi: NULL. [PMID: 4307117]
  • H Tronnier. [Internal treatment of chronic venous insufficiency. Clinico-pharmacological studies]. Munchener medizinische Wochenschrift (1950). 1968 Oct; 110(40):2303-7. doi: ". [PMID: 4998528]
  • J Concha, B Norris. Studies on renal vasomotion. British journal of pharmacology. 1968 Oct; 34(2):277-90. doi: 10.1111/j.1476-5381.1968.tb07051.x. [PMID: 4972068]
  • G Deutsch, P Drăgan, D Drugărin. Intrarenal redistribution of the organ blood flow, induced by bleeding or hemorrhagic shock. Experientia. 1968 Aug; 24(8):816-7. doi: 10.1007/bf02144889. [PMID: 4971620]
  • A Scriabine, S Bellet, A Kershbaum, L J Feinberg. Effect of dihydroergotamine on plasma free fatty acids (FFA) in dogs. Life sciences. 1968 May; 7(9):453-63. doi: 10.1016/0024-3205(68)90047-7. [PMID: 4967825]
  • R Hummel, E Flückiger. [The antihypertensive combination DCR (dihydroergocristine, clopamide, reserpine)]. Medizinische Klinik. 1968 Apr; 63(14):536-40. doi: NULL. [PMID: 4972528]
  • T Longo, A Santa. The effects of catecholamines on renal artery flow before and after alpha-receptor blockade. Comparative experimental research on the conscious and anesthetized dog. The Journal of cardiovascular surgery. 1968 Mar; 9(2):195-200. doi: NULL. [PMID: 4969213]
  • E Kirchner. [Shock and central venous pressure]. Munchener medizinische Wochenschrift (1950). 1967 Sep; 109(36):1846-50. doi: NULL. [PMID: 4969765]
  • A Aradas. [Preliminary observations on the changes of renal function and blood coagulation processes in normal aged subjects and those with vascular diseases treated with large subintrant doses of hydergine]. Giornale di gerontologia. 1966 Dec; 14(12):1155-62. doi: NULL. [PMID: 4966651]
  • E Passaggio, A Calcagno, M Quercio. [Etiopathogenetic and therapeutic criteria of shock in gravely injured subjects]. Pathologica. 1966 Nov; 58(867):523-8. doi: NULL. [PMID: 4968468]
  • G Agrifoglio, P Belardi, E Berti-Riboli. [Quantitative determination of blood flow of the legs by means of radioactive tracings. Effect of intra-arterial administration of a vasodilating drug in peripheral artery diseases]. Minerva cardioangiologica. 1965 Oct; 13(10):613-9. doi: NULL. [PMID: 4955049]
  • F Pugliese, P P Campa, G Bellisario, G Migliau, A Parrinello, G Giuliano. [Place of the sympathetic and parasympathetic nervous systems in the origin of renal vasoconstriction induced by bloodletting]. Bollettino della Societa italiana di biologia sperimentale. 1964 Dec; 40(24):Suppl:2114-7. doi: NULL. [PMID: 4960993]
  • W G KUBICEK. Adrenolytic and sympatholytic action of certain dihydrogenated ergot alkaloids (hydergine) on dog kidney. Journal of applied physiology. 1960 Jan; 15(?):109-14. doi: 10.1152/jappl.1960.15.1.109. [PMID: 14412398]
  • B G BENFEY, G LEDOUX, M SEGAL. The action of antisympathomimetic drugs on the urinary excretion of adrenaline and noradrenaline. British journal of pharmacology and chemotherapy. 1959 Sep; 14(?):380-4. doi: 10.1111/j.1476-5381.1959.tb00262.x. [PMID: 13798857]
  • R BRIZZI, F FOSCHI. [Note and experience on the use of hydergine in cerebral pathology of vascular origin]. Il Policlinico. Sezione medica. 1959 May; 66(3):209-18. doi: NULL. [PMID: 13674926]
  • F MAGISTRIS, G BRENNER. [Effect of panthesin-hydergine (PH 203) on kidney shock]. Wiener medizinische Wochenschrift (1946). 1958 Apr; 108(15):332-4. doi: NULL. [PMID: 13558167]
  • F LASCH. [Hydergine treatment of acute kidney diseases]. Wiener klinische Wochenschrift. 1955 Feb; 67(6):108-10. doi: NULL. [PMID: 14359934]
  • E DEUTSCH, T MARKOFF. [On kidney clearance. VI. Effects of hydergine on kidney performance]. Klinische Medizin; osterreichische Zeitschrift fur wissenschaftliche und praktische Medizin. 1953 Mar; 8(3):105-15. doi: NULL. [PMID: 13070412]
  • F REUBI. [Renal functions in hypertensives during prolonged therapy with hydergine]. Helvetica medica acta. 1952 Mar; 19(1):29-41. doi: NULL. [PMID: 14945760]
  • P GOMORI, G GABOR, L URAI. [Cutaneous precapillaries in essential hypertension and in renal diseases and their modification following application of hydergine and thoracolumbar sympathectomy]. Magyar belorvosi archivum. 1950; 3(3):117-24. doi: NULL. [PMID: 13131961]