Terodiline hydrochloride (BioDeep_00000843600)
代谢物信息卡片
Terodiline hydrochloride
化学式: C20H28ClN (317.19101580000006)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CC(C1=CC=CC=C1)C2=CC=CC=C2)NC(C)(C)C.Cl
InChI: 1H
描述信息
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
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WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Ruth L Martin, Zhi Su, James T Limberis, Jason D Palmatier, Marlon D Cowart, Bryan F Cox, Gary A Gintant. In vitro preclinical cardiac assessment of tolterodine and terodiline: multiple factors predict the clinical experience.
Journal of cardiovascular pharmacology.
2006 Nov; 48(5):199-206. doi:
10.1097/01.fjc.0000246853.15926.d4. [PMID: 17110801] - Maya K Leabman, Kathleen M Giacomini. Estimating the contribution of genes and environment to variation in renal drug clearance.
Pharmacogenetics.
2003 Sep; 13(9):581-4. doi:
10.1097/00008571-200309000-00007. [PMID: 12972957] - Premala Sureshkumar, Wendy Bower, Jonathan C Craig, John F Knight. Treatment of daytime urinary incontinence in children: a systematic review of randomized controlled trials.
The Journal of urology.
2003 Jul; 170(1):196-200; discussion 200. doi:
10.1097/01.ju.0000072341.34333.43. [PMID: 12796688] - Anthony A Fossa, Michael J DePasquale, David L Raunig, Michael J Avery, Derek J Leishman. The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.
The Journal of pharmacology and experimental therapeutics.
2002 Aug; 302(2):828-33. doi:
10.1124/jpet.102.035220. [PMID: 12130750] - R Webster, G Allan, K Anto-Awuakye, A Harrison, T Kidd, D Leishman, J Phipps, D Walker. Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog.
Xenobiotica; the fate of foreign compounds in biological systems.
2001 Aug; 31(8-9):633-50. doi:
10.1080/00498250110054632. [PMID: 11569530] - K Hartigan-Go, D N Bateman, A K Daly, S H Thomas. Stereoselective cardiotoxic effects of terodiline.
Clinical pharmacology and therapeutics.
1996 Jul; 60(1):89-98. doi:
10.1016/s0009-9236(96)90171-x. [PMID: 8689817] - S H Thomas, P D Higham, K Hartigan-Go, F Kamali, P Wood, R W Campbell, G A Ford. Concentration dependent cardiotoxicity of terodiline in patients treated for urinary incontinence.
British heart journal.
1995 Jul; 74(1):53-6. doi:
10.1136/hrt.74.1.53. [PMID: 7662454] - B Hallén, J Gabrielsson, S Nyambati, A Johansson, E Larsson, O Guilbaud. Concomitant single-dose and multiple-dose pharmacokinetics of terodiline in man, with a note on its enantiomers and major metabolites.
Pharmacology & toxicology.
1995 Mar; 76(3):171-7. doi:
10.1111/j.1600-0773.1995.tb00125.x. [PMID: 7617541] - B Hallén, M O Karlsson, S Stromberg, B Norén. Bioavailability and disposition of terodiline in man.
Journal of pharmaceutical sciences.
1994 Sep; 83(9):1241-6. doi:
10.1002/jps.2600830911. [PMID: 7830238] - B Ekström, B Larsson, K E Andersson, A Mattiasson. Intravesical instillation of terodiline--an in vivo study of drug absorption in rabbit and man.
The Journal of urology.
1993 Dec; 150(6):1926-31. doi:
10.1016/s0022-5347(17)35940-2. [PMID: 8230539] - B Hallén, J Gabrielsson, L Palmér, B Ekström. Pharmacokinetics of R(+)-terodiline given intravenously and orally to healthy volunteers.
Pharmacology & toxicology.
1993 Sep; 73(3):153-8. doi:
10.1111/j.1600-0773.1993.tb01555.x. [PMID: 8265519] - P Botstein. Is QT interval prolongation harmful? A regulatory perspective.
The American journal of cardiology.
1993 Aug; 72(6):50B-52B. doi:
10.1016/0002-9149(93)90041-a. [PMID: 8256756] - H Yoshihara, R Yasumoto, T Kishimoto, M Maekawa, A Horii, T Nishijima, T Sugimoto, N Kashiwara, M Tsujita, M Senjyu. [Clinical study of terodiline hydrochloride for the treatment of urinary frequency and urinary incontinence, and its cardiovascular adverse effects].
Hinyokika kiyo. Acta urologica Japonica.
1992 Aug; 38(8):967-72. doi:
NULL. [PMID: 1414748] - B Ekström. Intravesical instillation of drugs in patients with detrusor hyperactivity.
Scandinavian journal of urology and nephrology. Supplementum.
1992; 149(?):1-67. doi:
NULL. [PMID: 1290084] - T Sugiyama, H Kiwamoto, A Uchida, N Nagai, Y C Park, T Kurita, M Ikegami, A Nakanishi, M Kawamura, T Umekawa. [Clinical effect of terodiline hydrochloride on pollakisuria and urinary incontinence].
Hinyokika kiyo. Acta urologica Japonica.
1990 Nov; 36(11):1371-7. doi:
NULL. [PMID: 2288317] - H Kontani, M Nakagawa, S Takeno, T Sakai. Evaluation of drugs for treatment of urinary bladder dysfunction in conscious rats with intact pelvic nerve and after resection of the left pelvic nerve.
Japanese journal of pharmacology.
1990 Aug; 53(4):427-33. doi:
10.1254/jjp.53.427. [PMID: 2214368] - B Hallén, M Grälls, H Brötell, S Strömberg. Pharmacokinetics of terodiline and a major metabolite in dogs with a correlation to a pharmacodynamic effect.
Pharmacology & toxicology.
1990 May; 66(5):373-81. doi:
10.1111/j.1600-0773.1990.tb00765.x. [PMID: 2371244] - P Höglund, O Paulsen, S Bogentoft. No effect of terodiline on anticoagulation effect of warfarin and steady-state plasma levels of warfarin enantiomers in healthy volunteers.
Therapeutic drug monitoring.
1989 Nov; 11(6):667-73. doi:
10.1097/00007691-198911000-00010. [PMID: 2595747] - D Jensen. Terodiline treatment of detrusor hyperreflexia in sclerosis multiplex.
Journal of the Oslo city hospitals.
1989 Jun; 39(6-7):67-73. doi:
NULL. [PMID: 2674379] - R A Cattini, H L Makin, D J Trafford, P Vanezis. An apparent fatal overdose of terodiline.
Journal of analytical toxicology.
1989 Mar; 13(2):110-2. doi:
10.1093/jat/13.2.110. [PMID: 2733388] - B Hallén, S Bogentoft, S Sandquist, S Strömberg, G Setterberg, E Ryd-Kjellén. Tolerability and steady-state pharmacokinetics of terodiline and its main metabolites in elderly patients with urinary incontinence.
European journal of clinical pharmacology.
1989; 36(5):487-93. doi:
10.1007/bf00558074. [PMID: 2753067] - K E Andersson, B Ekström, A Mattiasson. Actions of terodiline, its isomers and main metabolite on isolated detrusor muscle from rabbit and man.
Pharmacology & toxicology.
1988 Nov; 63(5):390-5. doi:
10.1111/j.1600-0773.1988.tb00974.x. [PMID: 3237596] - B Hallén, O Guilbaud, S Strömberg, B Lindeke. Single-dose pharmacokinetics of terodiline, including a stable isotope technique for improvement of statistical evaluations.
Biopharmaceutics & drug disposition.
1988 May; 9(3):229-50. doi:
10.1002/bod.2510090302. [PMID: 3395665] - T Ishido, K Miyazaki. [Clinical evaluation of long-term administration with terodiline hydrochloride for the treatment of patients with neurogenic bladder].
Hinyokika kiyo. Acta urologica Japonica.
1988 Apr; 34(4):754-8. doi:
NULL. [PMID: 3400554] - A Ogawa, J Shimazaki, H Mitsuya, S Miyazaki, T Kurita. [Clinical effects of terodiline hydrochloride on urinary frequency and sense of residual urine--a double blind clinical trial using flavoxate hydrochloride as a control].
Hinyokika kiyo. Acta urologica Japonica.
1988 Apr; 34(4):739-53. doi:
NULL. [PMID: 3041785] - J R Andersen, G Lose, M Nørgaard, H Stimpel, J T Andersen. Terodiline, emepronium bromide or placebo for treatment of female detrusor overactivity? A randomised, double-blind, cross-over study.
British journal of urology.
1988 Apr; 61(4):310-3. doi:
10.1111/j.1464-410x.1988.tb13964.x. [PMID: 3289675] - E Fujiwara, H Nakano, H Nihira, T Kitano, R Ukai, C Masu, Y Onishi, M Kodama, K Hatachi, A Matsuki. [Clinical effects of terodiline hydrochloride for urinary frequency and sense of residual urine].
Hinyokika kiyo. Acta urologica Japonica.
1988 Apr; 34(4):733-8. doi:
NULL. [PMID: 3400553] - B Hallén, A Magnusson, S Bogentoft, P Ekelund. Single- and multiple-dose pharmacokinetics of terodiline in geriatric patients.
European journal of clinical pharmacology.
1988; 34(3):291-7. doi:
10.1007/bf00540958. [PMID: 3396620] - B Norén, S Strömberg, O Ericsson, B Lindeke. Biotransformation of terodiline. IV. Identification of unconjugated and conjugated metabolites in dog and human urine.
Acta pharmaceutica Suecica.
1988; 25(6):281-92. doi:
NULL. [PMID: 3245454] - M Nakano, A Tajima, Y Aso, K Suzuki, M Hata, T Tsukada, H Masuda, J Hirose, M Kitagawa, M Nakahara. [Clinical effect of terodiline hydrochloride (TD-758) in patients with urinary disturbances].
Hinyokika kiyo. Acta urologica Japonica.
1988 Jan; 34(1):196-200. doi:
NULL. [PMID: 3376801] - T Petersen, J Jakobsen. A calcium blocking and anticholinergic agent (terodiline) in the treatment of detrusor hyperreflexia: a placebo-controlled, cross-over trial.
Journal of neurology, neurosurgery, and psychiatry.
1987 Oct; 50(10):1331-6. doi:
10.1136/jnnp.50.10.1331. [PMID: 3681312] - T Yoneyama, A Ogawa, J Fukui, M Wajiki, Y Tomita, Y Igawa, A Yanagisawa, S Uchiyama, K Watanabe, Y Aida. [Clinical effect of terodiline hydrochloride on nervous pollakisuria or irritative bladder].
Hinyokika kiyo. Acta urologica Japonica.
1987 Feb; 33(2):319-26. doi:
NULL. [PMID: 3591595] - O Lukkarinen, P Gröhn, G Wilén-Rosenqvist, H Juusela, M Sotarauta, T Lehtonen. A controlled, double-blind, cross-over study of terodiline in motor urge incontinence.
Annales chirurgiae et gynaecologiae.
1987; 76(2):128-32. doi:
NULL. [PMID: 3304118] - T C Gerstenberg, P Klarskov, D Ramirez, T Hald. Terodiline in the treatment of women with urgency and motor urge incontinence. A clinical and urodynamic double-blind cross-over study.
British journal of urology.
1986 Apr; 58(2):129-33. doi:
10.1111/j.1464-410x.1986.tb09011.x. [PMID: 3516296] - P Klarskov, T C Gerstenberg, T Hald. Bladder training and terodiline in females with idiopathic urge incontinence and stable detrusor function.
Scandinavian journal of urology and nephrology.
1986; 20(1):41-6. doi:
10.3109/00365598609024478. [PMID: 3704568] - B Norén, S Stromberg, O Ericsson, L I Olsson, P Moses. Biotransformation of terodiline I. Identification of metabolites in dog urine by mass spectrometry.
Biomedical mass spectrometry.
1985 Aug; 12(8):367-79. doi:
10.1002/bms.1200120804. [PMID: 2931126] - B Norén, S Strömberg, O Ericsson, B Vangbo, M Grälls, L Widlund, B Lindeke. Biotransformation of terodiline. II. Disposition in the male rat. Identification of metabolites in rat urine and rat liver microsomes by mass spectrometry.
Acta pharmaceutica Suecica.
1985; 22(3):131-46. doi:
NULL. [PMID: 4036638] - K E Andersson. Clinical pharmacology of terodiline.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 87(?):13-20. doi:
NULL. [PMID: 6599419] - W Fischer-Rasmussen. Evaluation of long-term safety and clinical benefit of terodiline in women with urgency/urge incontinence. A multicentre study.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 87(?):35-47. doi:
NULL. [PMID: 6443541] - D Peters. Terodiline in the treatment of urinary frequency and motor urge incontinence. A controlled multicentre trial.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 87(?):21-33. doi:
NULL. [PMID: 6399953] - M Elmér. Terodiline in children with diurnal enuresis.
Scandinavian journal of urology and nephrology. Supplementum.
1984; 87(?):59-61. doi:
NULL. [PMID: 6599420] - B Karlén, K E Andersson, G Ekman, S Strömberg, U Ulmsten. Pharmacokinetics of terodiline in human volunteers.
European journal of clinical pharmacology.
1982; 23(3):267-70. doi:
10.1007/bf00547566. [PMID: 7173296] - G Ekman, K E Andersson, T Rud, U Ulmsten. A double-blind, cross-over study of the effects of terodiline in women with unstable bladder.
Acta pharmacologica et toxicologica.
1980; 46 Suppl 1(?):39-43. doi:
10.1111/j.1600-0773.1980.tb03246.x. [PMID: 6966882] - T Rud, K E Andersson, N Boye, U Ulmsten. Terodiline inhibition of human bladder contraction. Effects in vitro and in women with unstable bladder.
Acta pharmacologica et toxicologica.
1980; 46 Suppl 1(?):31-8. doi:
10.1111/j.1600-0773.1980.tb03245.x. [PMID: 7386219]