4-ethoxymethylene-2-phenyl-2-oxazolin-5-one (BioDeep_00000843575)
代谢物信息卡片
4-Ethoxymethylene-2-phenyl-2-oxazoline-5-one
化学式: C12H11NO3 (217.0738896)
中文名称: 4-乙氧基亚甲基-2-苯基恶唑啉-5-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC=C1C(=O)OC(=N1)C2=CC=CC=C2
InChI: InChI=1S/C12H11NO3/c1-2-15-8-10-12(14)16-11(13-10)9-6-4-3-5-7-9/h3-8H,2H2,1H3
描述信息
D007155 - Immunologic Factors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:53076
- PubChem: 1712093
- PubChem: 27435
- MeSH: Oxazolone
- CAS: 15646-46-5
- CAS: 57784-65-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yunji Bae, Taeyoung Kim, Nojune Park, Sangho Choi, Dongkeun Yi, Silvia Soto, Nelson Zamora, Sunam Kim, Minhye Yang. Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice.
Nutrients.
2022 Oct; 14(21):. doi:
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Marine drugs.
2022 Oct; 20(11):. doi:
10.3390/md20110669. [PMID: 36354992] - Hao Dong, Chenjie Feng, Xiyunyi Cai, Yuanyuan Hao, Xinyue Gu, Lei Cai, Shuting Wu, Jiamin Chen, Zhou Liu, Wen Xie, Xuanren Lu, Hongfa Qian, Yulin Liu, Yiming Cao, Junlin Zhu, Jiayi Xu, Yanjie Zhou, Shuangyu Ma, Sha Yang, Yufeng Shi, Haojiang Yu, Minjie Shi, Yurong Wang, Harvest F Gu, Lei Fan, Liang Wu. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production.
Scientific reports.
2022 05; 12(1):8760. doi:
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Molecules (Basel, Switzerland).
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Nutrients.
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Toxicology.
2011 Nov; 290(1):59-68. doi:
10.1016/j.tox.2011.08.017. [PMID: 21893156] - Laryssa K Rauh, Cíntia D S Horinouchi, Alliete M V Loddi, Evelise F Pietrovski, Rosalina Neris, Fernando Souza-Fonseca-Guimarães, Dorly F Buchi, Maique W Biavatti, Michel F Otuki, Daniela A Cabrini. Effectiveness of Vernonia scorpioides ethanolic extract against skin inflammatory processes.
Journal of ethnopharmacology.
2011 Nov; 138(2):390-7. doi:
10.1016/j.jep.2011.09.012. [PMID: 21959183] - Wenyan Man, Mona Man, Melanie Hupe, Gemma Martin-Ezquerra, Kenneth R Feingold, Peter M Elias, Mao-Qiang Man. Topical herbal extract (Huangdang mixture) exhibits both preventive and therapeutic effects in murine acute irritant contact dermatitis.
International journal of dermatology.
2011 Nov; 50(11):1421-1427. doi:
10.1111/j.1365-4632.2011.04970.x. [PMID: 22004502] - Pawel Olszowy, Malgorzata Szultka, Boguslaw Buszewski. Poly(3-alkylthiophenes): new sorption materials for solid phase microextraction of drugs isolated from human plasma.
Analytical and bioanalytical chemistry.
2011 Sep; 401(4):1377-84. doi:
10.1007/s00216-011-5159-0. [PMID: 21710286] - Young Bok Lee, Hyun Jung Park, Mi Jung Kwon, Se Kyoo Jeong, Sang Hyun Cho. Beneficial effects of pseudoceramide-containing physiologic lipid mixture as a vehicle for topical steroids.
European journal of dermatology : EJD.
2011 Sep; 21(5):710-6. doi:
10.1684/ejd.2011.1447. [PMID: 21708519] - Tamas Varga, Zsolt Czimmerer, Laszlo Nagy. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation.
Biochimica et biophysica acta.
2011 Aug; 1812(8):1007-22. doi:
10.1016/j.bbadis.2011.02.014. [PMID: 21382489] - Tor Regberg, Charlotta Lindquist, Ake Pilotti, Christel Ellström, Lars Fägerstam, Ann Eckersten, Yasuro Shinohara, Steven L Gallion, Joseph C Hogan. Novel affinity ligands for chromatography using combinatorial chemistry.
Combinatorial chemistry & high throughput screening.
2011 May; 14(4):267-78. doi:
10.2174/138620711795222482. [PMID: 21143179] - Jun-Won Yun, Jung A Seo, Yeon Su Jeong, Il-Hong Bae, Won-Hee Jang, Jihae Lee, Sun-Young Kim, Song-Seok Shin, Byoung-Young Woo, Ki-Wha Lee, Kyung-Min Lim, Young-Ho Park. TRPV1 antagonist can suppress the atopic dermatitis-like symptoms by accelerating skin barrier recovery.
Journal of dermatological science.
2011 Apr; 62(1):8-15. doi:
10.1016/j.jdermsci.2010.10.014. [PMID: 21345654] - Allisson Freire Bento, Rodrigo Marcon, Rafael Cypriano Dutra, Rafaela Franco Claudino, Maíra Cola, Daniela Ferraz Pereira Leite, João B Calixto. β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway.
The American journal of pathology.
2011 Mar; 178(3):1153-66. doi:
10.1016/j.ajpath.2010.11.052. [PMID: 21356367] - Fatemeh Sabermahani, Mohammad Ali Taher, Habibe Bahrami, Samieh Fozooni. Alumina coated with oxazolone derivative for extraction of trace amounts of cadmium and copper from water and plant samples.
Journal of hazardous materials.
2011 Jan; 185(2-3):945-50. doi:
10.1016/j.jhazmat.2010.09.111. [PMID: 21074321] - Chan Hum Park, Noriko Yamabe, Takuya Okamoto, Kazuo Toriizuka, Takako Yokozawa. Chinese prescription kangen-karyu ameliorates the development of diabetic hepatic damages via regulating oxidative stress and inflammation in the liver of db/db mice.
Biological & pharmaceutical bulletin.
2011; 34(3):383-8. doi:
10.1248/bpb.34.383. [PMID: 21372389] - Zenro Ikezawa, Junko Komori, Yuko Ikezawa, Yusuke Inoue, Mio Kirino, Masako Katsuyama, Michiko Aihara. A Role of Staphyococcus aureus, Interleukin-18, Nerve Growth Factor and Semaphorin 3A, an Axon Guidance Molecule, in Pathogenesis and Treatment of Atopic Dermatitis.
Allergy, asthma & immunology research.
2010 Oct; 2(4):235-46. doi:
10.4168/aair.2010.2.4.235. [PMID: 20885908] - Kyoji Yoshino, Katsuko Yamazaki, Mitsuaki Sano. Preventive effects of black tea theaflavins against mouse type IV allergy.
Journal of the science of food and agriculture.
2010 Sep; 90(12):1983-7. doi:
10.1002/jsfa.4035. [PMID: 20597096] - V J Galani, B G Patel, N B Patel. Argyreia speciosa (Linn. f.) sweet: A comprehensive review.
Pharmacognosy reviews.
2010 Jul; 4(8):172-8. doi:
10.4103/0973-7847.70913. [PMID: 22228958] - Yan Pan, Qin Ouyang. [Effects of Bawei Xilei San on mice with oxazolone-induced colitis and the mechanisms].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2010 Jun; 8(6):568-74. doi:
10.3736/jcim20100610. [PMID: 20550880] - Soon-Hee Lee, Yong Heo, Young-Chul Kim. Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.
Journal of veterinary science.
2010 Mar; 11(1):35-41. doi:
10.4142/jvs.2010.11.1.35. [PMID: 20195063] - Nicole Wittenbrink, Tom S Weber, Anke Klein, Armin A Weiser, Werner Zuschratter, Michael Sibila, Johannes Schuchhardt, Michal Or-Guil. Broad volume distributions indicate nonsynchronized growth and suggest sudden collapses of germinal center B cell populations.
Journal of immunology (Baltimore, Md. : 1950).
2010 Feb; 184(3):1339-47. doi:
10.4049/jimmunol.0901040. [PMID: 20053939] - Yutaka Hatano, Mao-Qiang Man, Yoshikazu Uchida, Debra Crumrine, Theodora M Mauro, Kenneth R Feingold, Peter M Elias, Walter M Holleran. Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators.
The Journal of allergy and clinical immunology.
2010 Jan; 125(1):160-9.e1. doi:
10.1016/j.jaci.2009.06.049. [PMID: 19818482] - Yi Zhou, He Wang, Yue-Shan Li, Yi-Wen Tao, Jian-Ye Zhang, Zhi-Qiang Zhang. [Paeoniflorin increases beta-defensin expression and attenuates lesion in the colonic mucosa from mice with oxazolone-induced colitis].
Yao xue xue bao = Acta pharmaceutica Sinica.
2010 Jan; 45(1):37-42. doi:
". [PMID: 21351447] - Nerida Cole, Paul W Sou, Alanna Ngo, Karen H Tsang, Joseph A J Severino, Sondur J Arun, Colin C Duke, Vivienne E Reeve. Topical 'Sydney' propolis protects against UV-radiation-induced inflammation, lipid peroxidation and immune suppression in mouse skin.
International archives of allergy and immunology.
2010; 152(2):87-97. doi:
10.1159/000265530. [PMID: 20016191] - Toshiharu Hayashi. Therapeutic strategies for SLE involving cytokines: mechanism-oriented therapies especially IFN-gamma targeting gene therapy.
Journal of biomedicine & biotechnology.
2010; 2010(?):. doi:
10.1155/2010/461641. [PMID: 20827419] - Tetsuo Watanabe, Takeshi Yamamoto, Minako Yoshida, Kanae Fujiwara, Natsuko Kageyama-Yahara, Hirofumi Kuramoto, Yutaka Shimada, Makoto Kadowaki. The traditional herbal medicine saireito exerts its inhibitory effect on murine oxazolone-induced colitis via the induction of Th1-polarized immune responses in the mucosal immune system of the colon.
International archives of allergy and immunology.
2010; 151(2):98-106. doi:
10.1159/000235999. [PMID: 19752563] - Andrea Mencarelli, Barbara Renga, Giuseppe Palladino, Eleonora Distrutti, Stefano Fiorucci. The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease.
Biochemical pharmacology.
2009 Nov; 78(9):1214-23. doi:
10.1016/j.bcp.2009.06.026. [PMID: 19555671] - Ji Hae Lee, Kyoung-Mi Jung, Il-Hong Bae, SiYoung Cho, Dae-Bang Seo, Sang-Jun Lee, Young-Ho Park, Kyung-Min Lim. Anti-inflammatory and barrier protecting effect of Lithospermum erythrorhizon extracts in chronic oxazolone-induced murine atopic dermatitis.
Journal of dermatological science.
2009 Oct; 56(1):64-6. doi:
10.1016/j.jdermsci.2009.07.001. [PMID: 19651492] - Tiffany C Scharschmidt, Mao-Qiang Man, Yutaka Hatano, Debra Crumrine, Roshan Gunathilake, John P Sundberg, Kathleen A Silva, Theodora M Mauro, Melanie Hupe, Soyun Cho, Yan Wu, Anna Celli, Matthias Schmuth, Kenneth R Feingold, Peter M Elias. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens.
The Journal of allergy and clinical immunology.
2009 Sep; 124(3):496-506, 506.e1. doi:
10.1016/j.jaci.2009.06.046. [PMID: 19733297] - Yutaka Hatano, Mao-Qiang Man, Yoshikazu Uchida, Debra Crumrine, Tiffany C Scharschmidt, Esther G Kim, Theodora M Mauro, Kenneth R Feingold, Peter M Elias, Walter M Holleran. Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis.
The Journal of investigative dermatology.
2009 Jul; 129(7):1824-35. doi:
10.1038/jid.2008.444. [PMID: 19177139] - T Morioka, K Yamanaka, H Mori, Y Omoto, K Tokime, M Kakeda, I Kurokawa, E C Gabazza, A Tsubura, Y Yasutomi, H Mizutani. IL-4/IL-13 antagonist DNA vaccination successfully suppresses Th2 type chronic dermatitis.
The British journal of dermatology.
2009 Jun; 160(6):1172-9. doi:
10.1111/j.1365-2133.2009.09069.x. [PMID: 19416272] - Hai-Qiang Zhang, Tomas T Ding, Jun-Sheng Zhao, Xin Yang, Hai-Xia Zhang, Juan-Juan Zhang, Yun-Long Cui. Therapeutic effects of Clostridium butyricum on experimental colitis induced by oxazolone in rats.
World journal of gastroenterology.
2009 Apr; 15(15):1821-8. doi:
10.3748/wjg.15.1821. [PMID: 19370778] - Jos Oomens, Sarah Young, Sam Molesworth, Michael van Stipdonk. Spectroscopic evidence for an oxazolone structure of the b(2) fragment ion from protonated tri-alanine.
Journal of the American Society for Mass Spectrometry.
2009 Feb; 20(2):334-9. doi:
10.1016/j.jasms.2008.10.012. [PMID: 19013079] - J Faber, P Vos, D Kegler, K van Norren, J M Argilés, A Laviano, J Garssen, A van Helvoort. Beneficial immune modulatory effects of a specific nutritional combination in a murine model for cancer cachexia.
British journal of cancer.
2008 Dec; 99(12):2029-36. doi:
10.1038/sj.bjc.6604785. [PMID: 19018259] - Yu Jin, Venkata S Kotakadi, Lei Ying, Anne B Hofseth, Xiangli Cui, Patricia A Wood, Anthony Windust, Lydia E Matesic, Edsel A Pena, Codruta Chiuzan, Narendra P Singh, Mitzi Nagarkatti, Prakash S Nagarkatti, Michael J Wargovich, Lorne J Hofseth. American ginseng suppresses inflammation and DNA damage associated with mouse colitis.
Carcinogenesis.
2008 Dec; 29(12):2351-9. doi:
10.1093/carcin/bgn211. [PMID: 18802031] - Jonathan R Siscovick, Tamar Zapolanski, Cynthia Magro, Kristel Carrington, Shannon Prograis, Marnie Nussbaum, Salvador Gonzalez, Wanhong Ding, Richard D Granstein. Polypodium leucotomos inhibits ultraviolet B radiation-induced immunosuppression.
Photodermatology, photoimmunology & photomedicine.
2008 Jun; 24(3):134-41. doi:
10.1111/j.1600-0781.2008.00352.x. [PMID: 18477132] - Shinji Kagami, Hidehisa Saeki, Yuichiro Tsunemi, Koichiro Nakamura, Yoshihiro Kuwano, Mayumi Komine, Takashi Nakayama, Osamu Yoshie, Kunihiko Tamaki. CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli.
European journal of immunology.
2008 Mar; 38(3):647-57. doi:
10.1002/eji.200737685. [PMID: 18266301] - J M Prieto, M C Recio, R M Giner, G R Schinella, S Máñez, J L Ríos. In vitro and in vivo effects of Ranunculus peltatus subsp. baudotii methanol extract on models of eicosanoid production and contact dermatitis.
Phytotherapy research : PTR.
2008 Mar; 22(3):297-302. doi:
10.1002/ptr.2309. [PMID: 18058987] - Xun Sun, Shinichi Somada, Kensuke Shibata, Hiromi Muta, Hisakata Yamada, Hirofumi Yoshihara, Kuniomi Honda, Kazuhiko Nakamura, Ryhoichi Takayanagi, Kenzaburo Tani, Eckhard R Podack, Yasunobu Yoshikai. A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Gastroenterology.
2008 Feb; 134(2):447-58. doi:
10.1053/j.gastro.2007.11.004. [PMID: 18242212] - Mao-Qiang Man, Yutaka Hatano, Seung H Lee, Mona Man, Sandra Chang, Kenneth R Feingold, Donald Y M Leung, Walter Holleran, Yoshikazu Uchida, Peter M Elias. Characterization of a hapten-induced, murine model with multiple features of atopic dermatitis: structural, immunologic, and biochemical changes following single versus multiple oxazolone challenges.
The Journal of investigative dermatology.
2008 Jan; 128(1):79-86. doi:
10.1038/sj.jid.5701011. [PMID: 17671515] - A Olmos, R M Giner, M C Recio, J L Rios, J M Cerdá-Nicolás, S Máñez. Effects of plant alkylphenols on cytokine production, tyrosine nitration and inflammatory damage in the efferent phase of contact hypersensitivity.
British journal of pharmacology.
2007 Oct; 152(3):366-73. doi:
10.1038/sj.bjp.0707402. [PMID: 17660848] - Guangchen Sun, Yixiu Zhang, Daisuke Takuma, Masahide Onogawa, Junko Yokota, Atsuhide Hamada, Saburo Yoshioka, Masahiko Kusunose, Mitsuhiko Miyamura, Shojiro Kyotani, Yutaka Nishioka. Effect of orally administered Eriobotrya japonica seed extract on allergic contact dermatitis in rats.
The Journal of pharmacy and pharmacology.
2007 Oct; 59(10):1405-12. doi:
10.1211/jpp.59.10.0011. [PMID: 17910816] - Bo Pang, Xinfeng Zhou, Hongbin Yu, Min Dong, Koli Taghizadeh, John S Wishnok, Steven R Tannenbaum, Peter C Dedon. Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation.
Carcinogenesis.
2007 Aug; 28(8):1807-13. doi:
10.1093/carcin/bgm037. [PMID: 17347141] - Carolin Daniel, Nico A Sartory, Nadine Zahn, Ronald Schmidt, Gerd Geisslinger, Heinfried H Radeke, Jurgen M Stein. FTY720 ameliorates oxazolone colitis in mice by directly affecting T helper type 2 functions.
Molecular immunology.
2007 Jul; 44(13):3305-16. doi:
10.1016/j.molimm.2007.02.026. [PMID: 17475330]