2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo(2.2.2)octan-3-amine (BioDeep_00000843559)

   


代谢物信息卡片


2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo(2.2.2)octan-3-amine

化学式: C28H32N2O (412.25145019999997)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=CC=C1CNC2C3CCN(C2C(C4=CC=CC=C4)C5=CC=CC=C5)CC3
InChI: InChI=1S/C28H32N2O/c1-31-25-15-9-8-14-24(25)20-29-27-23-16-18-30(19-17-23)28(27)26(21-10-4-2-5-11-21)22-12-6-3-7-13-22/h2-15,23,26-29H,16-20H2,1H3/t27-,28-/m0/s1

描述信息

D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D018501 - Antirheumatic Agents

同义名列表

1 个代谢物同义名

2-(Diphenylmethyl)-N-((2-methoxyphenyl)methyl)-1-azabicyclo(2.2.2)octan-3-amine



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Yoki Nakamura, Norimitsu Morioka, Fang Fang Zhang, Kazue Hisaoka-Nakashima, Yoshihiro Nakata. Downregulation of connexin36 in mouse spinal dorsal horn neurons leads to mechanical allodynia. Journal of neuroscience research. 2015 Apr; 93(4):584-91. doi: 10.1002/jnr.23515. [PMID: 25400139]
  • Ping-Chia Li, Wen-Chung Chen, Li-Ching Chang, Shao-Chieh Lin. Substance P acts via the neurokinin receptor 1 to elicit bronchoconstriction, oxidative stress, and upregulated ICAM-1 expression after oil smoke exposure. American journal of physiology. Lung cellular and molecular physiology. 2008 May; 294(5):L912-20. doi: 10.1152/ajplung.00443.2007. [PMID: 18326823]
  • A M Landau, K Yashpal, C M Cahill, M St Louis, A Ribeiro-da-Silva, J L Henry. Sensory neuron and substance P involvement in symptoms of a zymosan-induced rat model of acute bowel inflammation. Neuroscience. 2007 Mar; 145(2):699-707. doi: 10.1016/j.neuroscience.2006.11.066. [PMID: 17257769]
  • Hon Yen Lau, Fei Ling Wong, Madhav Bhatia. A key role of neurokinin 1 receptors in acute pancreatitis and associated lung injury. Biochemical and biophysical research communications. 2005 Feb; 327(2):509-15. doi: 10.1016/j.bbrc.2004.12.030. [PMID: 15629143]
  • Zhi-Jun He, John H Winston, Tony E Yusuf, Maria-Adelaide Micci, Asem Elfert, Shu-Yuan Xiao, Pankaj J Pasricha. Intraductal administration of an NK1 receptor antagonist attenuates the inflammatory response to retrograde infusion of radiological contrast in rats: implications for the pathogenesis and prevention of ERCP-induced pancreatitis. Pancreas. 2003 Jul; 27(1):e13-7. doi: 10.1097/00006676-200307000-00018. [PMID: 12826913]
  • Renate Bang, Gabriele Sass, Alexandra K Kiemer, Angelika M Vollmar, Winfried L Neuhuber, Gisa Tiegs. Neurokinin-1 receptor antagonists CP-96,345 and L-733,060 protect mice from cytokine-mediated liver injury. The Journal of pharmacology and experimental therapeutics. 2003 Apr; 305(1):31-9. doi: 10.1124/jpet.102.043539. [PMID: 12649350]
  • A F Stucchi, S Shofer, S Leeman, O Materne, E Beer, J McClung, K Shebani, F Moore, M O'Brien, J M Becker. NK-1 antagonist reduces colonic inflammation and oxidative stress in dextran sulfate-induced colitis in rats. American journal of physiology. Gastrointestinal and liver physiology. 2000 Dec; 279(6):G1298-306. doi: 10.1152/ajpgi.2000.279.6.g1298. [PMID: 11093954]
  • J L Turvill, P Connor, M J Farthing. Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Gastroenterology. 2000 Oct; 119(4):1037-44. doi: 10.1053/gast.2000.18147. [PMID: 11040190]
  • J Maa, E F Grady, E H Kim, S K Yoshimi, M M Hutter, N W Bunnett, K S Kirkwood. NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation. American journal of physiology. Gastrointestinal and liver physiology. 2000 Oct; 279(4):G726-32. doi: 10.1152/ajpgi.2000.279.4.g726. [PMID: 11005759]
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  • H Tsushima, M Mori. Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release. Japanese journal of pharmacology. 1999 Feb; 79(2):237-41. doi: 10.1254/jjp.79.237. [PMID: 10202860]
  • X P Gao. Grain sorghum dust increases macromolecular efflux from the in situ nasal mucosa. Journal of applied physiology (Bethesda, Md. : 1985). 1998 Apr; 84(4):1431-6. doi: 10.1152/jappl.1998.84.4.1431. [PMID: 9516214]
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  • X P Gao. Tannic acid elicits neurogenic plasma exudation from the in situ hamster cheek pouch. The American journal of physiology. 1998 01; 274(1):R237-42. doi: 10.1152/ajpregu.1998.274.1.r237. [PMID: 9458923]
  • U C Kopp, D M Farley, L A Smith. Bradykinin-mediated activation of renal sensory neurons due to prostaglandin-dependent release of substance P. The American journal of physiology. 1997 Jun; 272(6 Pt 2):R2009-16. doi: 10.1152/ajpregu.1997.272.6.r2009. [PMID: 9227622]
  • O Kohlmann, M L Cesaretti, M Ginoza, A Tavares, M T Zanella, A B Ribeiro, O L Ramos, S E Leeman, I Gavras, H Gavras. Role of substance P in blood pressure regulation in salt-dependent experimental hypertension. Hypertension (Dallas, Tex. : 1979). 1997 Jan; 29(1 Pt 2):506-9. doi: 10.1161/01.hyp.29.1.506. [PMID: 9039150]
  • J Luber-Narod, T Austin-Ritchie, C Hollins, M Menon, R K Malhotra, S Baker, R E Carraway. Role of substance P in several models of bladder inflammation. Urological research. 1997; 25(6):395-9. doi: 10.1007/bf01268854. [PMID: 9443648]
  • A Parenti, S Amerini, F Ledda, C A Maggi, M Ziche. The tachykinin NK1 receptor mediates the migration-promoting effect of substance P on human skin fibroblasts in culture. Naunyn-Schmiedeberg's archives of pharmacology. 1996 Apr; 353(5):475-81. doi: 10.1007/bf00169165. [PMID: 8740139]
  • F W Bach, T L Yaksh. Release of beta-endorphin immunoreactivity into ventriculo-cisternal perfusate by lumbar intrathecal capsaicin in the rat. Brain research. 1995 Dec; 701(1-2):192-200. doi: 10.1016/0006-8993(95)01003-1. [PMID: 8925284]
  • G C Gao, E T Wei. Inhibition of substance P-induced vascular leakage in rat by N-acetyl-neurotensin-(8-13). Regulatory peptides. 1995 Aug; 58(3):117-21. doi: 10.1016/0167-0115(95)00070-r. [PMID: 8577923]
  • P Baluk, C Bertrand, P Geppetti, D M McDonald, J A Nadel. NK1 receptors mediate leukocyte adhesion in neurogenic inflammation in the rat trachea. The American journal of physiology. 1995 Feb; 268(2 Pt 1):L263-9. doi: 10.1152/ajplung.1995.268.2.l263. [PMID: 7864147]
  • F Berti, G Rossoni, D Della Bella, F Trento, M Bernareggi, M Robuschi. Influence of acetaldehyde on airway resistance and plasma exudation in the guinea-pig. Arzneimittel-Forschung. 1994 Dec; 44(12):1342-6. doi: NULL. [PMID: 7531441]
  • A M Garland, E F Grady, D G Payan, S R Vigna, N W Bunnett. Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells. The Biochemical journal. 1994 Oct; 303 ( Pt 1)(?):177-86. doi: 10.1042/bj3030177. [PMID: 7524481]
  • N P Kerezoudis, L Olgart, L Edwall. Involvement of substance P but not nitric oxide or calcitonin gene-related peptide in neurogenic plasma extravasation in rat incisor pulp and lip. Archives of oral biology. 1994 Sep; 39(9):769-74. doi: 10.1016/0003-9969(94)90006-x. [PMID: 7528497]
  • F L Ricciardolo, J A Nadel, C Bertrand, I Yamawaki, B Chan, P Geppetti. Tachykinins and kinins in antigen-evoked plasma extravasation in guinea-pig nasal mucosa. European journal of pharmacology. 1994 Aug; 261(1-2):127-32. doi: 10.1016/0014-2999(94)90310-7. [PMID: 7528144]
  • F J Legat, T Griesbacher, F Lembeck. Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum. British journal of pharmacology. 1994 Jun; 112(2):453-60. doi: 10.1111/j.1476-5381.1994.tb13094.x. [PMID: 7915609]
  • W B Weglicki, I T Mak, T M Phillips. Blockade of cardiac inflammation in Mg2+ deficiency by substance P receptor inhibition. Circulation research. 1994 May; 74(5):1009-13. doi: 10.1161/01.res.74.5.1009. [PMID: 7512452]
  • F Montier, A Carruette, S Moussaoui, D Boccio, C Garret. Antagonism of substance P and related peptides by RP 67580 and CP-96,345, at tachykinin NK1 receptor sites, in the rat urinary bladder. European journal of pharmacology. 1994 Jan; 251(1):9-14. doi: 10.1016/0014-2999(94)90436-7. [PMID: 7511108]
  • C Bertrand, J A Nadel, I Yamawaki, P Geppetti. Role of kinins in the vascular extravasation evoked by antigen and mediated by tachykinins in guinea pig trachea. Journal of immunology (Baltimore, Md. : 1950). 1993 Nov; 151(9):4902-7. doi: . [PMID: 7691957]
  • S Giuliani, P Santicioli, I T Lippe, A Lecci, C A Maggi. Effect of bradykinin and tachykinin receptor antagonist on xylene-induced cystitis in rats. The Journal of urology. 1993 Sep; 150(3):1014-7. doi: 10.1016/s0022-5347(17)35677-x. [PMID: 7688430]
  • X P Gao, R A Robbins, R M Snider, J Lowe, S I Rennard, P Anding, I Rubinstein. NK1 receptors mediate tachykinin-induced increase in microvascular clearance in hamster cheek pouch. The American journal of physiology. 1993 Aug; 265(2 Pt 2):H593-8. doi: 10.1152/ajpheart.1993.265.2.h593. [PMID: 7690191]
  • C Bertrand, P Geppetti, J Baker, I Yamawaki, J A Nadel. Tachykinins, via NK1 receptor activation, play a relevant role in plasma protein extravasation evoked by allergen challenge in the airways of sensitized guinea-pigs. Regulatory peptides. 1993 Jul; 46(1-2):214-6. doi: 10.1016/0167-0115(93)90037-9. [PMID: 7692494]
  • C J Fowler, T Martinsson, G Brännström. 'Specific' binding of [3H]-[Sar9,Met(O2)11]-substance P to tissue culture plates is found when substance P is used to define non-specific binding. Methods and findings in experimental and clinical pharmacology. 1993 Jul; 15(6):337-43. doi: NULL. [PMID: 7694018]
  • E W Greeno, P Mantyh, G M Vercellotti, C F Moldow. Functional neurokinin 1 receptors for substance P are expressed by human vascular endothelium. The Journal of experimental medicine. 1993 May; 177(5):1269-76. doi: 10.1084/jem.177.5.1269. [PMID: 7683033]
  • P Dagenais, E Escher. Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model. Regulatory peptides. 1993 Mar; 44(2):239-47. doi: 10.1016/0167-0115(93)90248-7. [PMID: 8385792]
  • Y Qian, X Emonds-Alt, C Advenier. Effects of capsaicin, (+/-)-CP-96,345 and SR 48968 on the bradykinin-induced airways microvascular leakage in guinea-pigs. Pulmonary pharmacology. 1993 Mar; 6(1):63-7. doi: 10.1006/pulp.1993.1009. [PMID: 7682876]
  • M Nicolau, M G Sirois, M Bui, G E Plante, P Sirois, D Regoli. Plasma extravasation induced by neurokinins in conscious rats: receptor characterization with agonists and antagonists. Canadian journal of physiology and pharmacology. 1993 Mar; 71(3-4):217-21. doi: 10.1139/y93-034. [PMID: 7691388]
  • U C Kopp, L A Smith. Effects of the substance P receptor antagonist CP-96,345 on renal sensory receptor activation. The American journal of physiology. 1993 Mar; 264(3 Pt 2):R647-53. doi: 10.1152/ajpregu.1993.264.3.r647. [PMID: 8384427]
  • C Bertrand, P Geppetti, J Baker, I Yamawaki, J A Nadel. Role of neurogenic inflammation in antigen-induced vascular extravasation in guinea pig trachea. Journal of immunology (Baltimore, Md. : 1950). 1993 Feb; 150(4):1479-85. doi: NULL. [PMID: 8381836]
  • P Delay-Goyet, A Franco-Cereceda, S F Gonsalves, C A Clingan, J A Lowe, J M Lundberg. CP-96,345 antagonism of NK1 receptors and smoke-induced protein extravasation in relation to its cardiovascular effects. European journal of pharmacology. 1992 Nov; 222(2-3):213-8. doi: 10.1016/0014-2999(92)90857-z. [PMID: 1280591]
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  • A Eglezos, S Giuliani, G Viti, C A Maggi. Direct evidence that capsaicin-induced plasma protein extravasation is mediated through tachykinin NK1 receptors. European journal of pharmacology. 1991 Dec; 209(3):277-9. doi: 10.1016/0014-2999(91)90183-q. [PMID: 1665800]