N(4)-Hydroxycytidine (BioDeep_00000843554)

   


代谢物信息卡片


N(4)-Hydroxycytidine

  化学式: C9H13N3O6 (259.0804)
中文名称:
  谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN(C(=O)N=C1NO)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H13N3O6/c13-3-4-6(14)7(15)8(18-4)12-2-1-5(11-17)10-9(12)16/h1-2,4,6-8,13-15,17H,3H2,(H,10,11,16)/t4-,6-,7-,8-/m1/s1


描述信息

A nucleoside analogue that is cytidine which carries a hydroxy group at the N(4)-positon. It has broad-spectrum antiviral activity against influenza, SARS-CoV , SARS-CoV-2 and MERS-CoV.
COVID info from DrugBank, Guide to PHARMACOLOGY
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

1 个代谢物同义名

N(4)-Hydroxycytidine



数据库引用编号

5 个数据库交叉引用编号

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相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

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INOH(0)

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0 个相关的物种来源信息

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表


文献列表

  • Zhao-Hui Wen, Meng-Meng Wang, Ling-Yun Li, Piet Herdewijn, Robert Snoeck, Graciela Andrei, Zhao-Peng Liu, Chao Liu. Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of β-D-N4-hydroxycytidine (NHC) and a 3'-fluoro-substituted analogue of NHC. Bioorganic chemistry. 2023 06; 135(?):106527. doi: 10.1016/j.bioorg.2023.106527. [PMID: 37031504]
  • Yuexiang Li, Miaomiao Liu, Yunzheng Yan, Zhuang Wang, Qingsong Dai, Xiaotong Yang, Xiaojia Guo, Wei Li, Xingjuan Chen, Ruiyuan Cao, Wu Zhong. Molnupiravir and Its Active Form, EIDD-1931, Show Potent Antiviral Activity against Enterovirus Infections In Vitro and In Vivo. Viruses. 2022 05; 14(6):. doi: 10.3390/v14061142. [PMID: 35746614]
  • Ronald Swanstrom, Raymond F Schinazi. Lethal mutagenesis as an antiviral strategy. Science (New York, N.Y.). 2022 Feb; 375(6580):497-498. doi: 10.1126/science.abn0048. [PMID: 35113690]
  • Laura Vangeel, Winston Chiu, Steven De Jonghe, Piet Maes, Bram Slechten, Joren Raymenants, Emmanuel André, Pieter Leyssen, Johan Neyts, Dirk Jochmans. Remdesivir, Molnupiravir and Nirmatrelvir remain active against SARS-CoV-2 Omicron and other variants of concern. Antiviral research. 2022 02; 198(?):105252. doi: 10.1016/j.antiviral.2022.105252. [PMID: 35085683]
  • Eric K Johnson. A Comment on 'Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites'. Molecular pharmacology. 2022 02; 101(2):120. doi: 10.1124/molpharm.121.000425. [PMID: 35105678]
  • Siennah R Miller, Meghan E McGrath, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington. Response to Comments on 'Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites'. Molecular pharmacology. 2022 02; 101(2):121-122. doi: 10.1124/molpharm.121.000448. [PMID: 35105679]
  • Michael D Waters, Stafford Warren, Claude Hughes, Philip Lewis, Fengyu Zhang. Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir. Environmental and molecular mutagenesis. 2022 01; 63(1):37-63. doi: 10.1002/em.22471. [PMID: 35023215]
  • Siennah R Miller, Meghan E McGrath, Kimberley M Zorn, Sean Ekins, Stephen H Wright, Nathan J Cherrington. Remdesivir and EIDD-1931 Interact with Human Equilibrative Nucleoside Transporters 1 and 2: Implications for Reaching SARS-CoV-2 Viral Sanctuary Sites. Molecular pharmacology. 2021 12; 100(6):548-557. doi: 10.1124/molpharm.121.000333. [PMID: 34503974]
  • Teresa L Parsons, Lindsay A Kryszak, Mark A Marzinke. Development and validation of assays for the quantification of β-D-N4-hydroxycytidine in human plasma and β-D-N4-hydroxycytidine-triphosphate in peripheral blood mononuclear cell lysates. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2021 Oct; 1182(?):122921. doi: 10.1016/j.jchromb.2021.122921. [PMID: 34555541]
  • Calvin J Gordon, Egor P Tchesnokov, Raymond F Schinazi, Matthias Götte. Molnupiravir promotes SARS-CoV-2 mutagenesis via the RNA template. The Journal of biological chemistry. 2021 07; 297(1):100770. doi: 10.1016/j.jbc.2021.100770. [PMID: 33989635]
  • Timothy P Sheahan, Amy C Sims, Shuntai Zhou, Rachel L Graham, Andrea J Pruijssers, Maria L Agostini, Sarah R Leist, Alexandra Schäfer, Kenneth H Dinnon, Laura J Stevens, James D Chappell, Xiaotao Lu, Tia M Hughes, Amelia S George, Collin S Hill, Stephanie A Montgomery, Ariane J Brown, Gregory R Bluemling, Michael G Natchus, Manohar Saindane, Alexander A Kolykhalov, George Painter, Jennifer Harcourt, Azaibi Tamin, Natalie J Thornburg, Ronald Swanstrom, Mark R Denison, Ralph S Baric. An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice. Science translational medicine. 2020 04; 12(541):. doi: 10.1126/scitranslmed.abb5883. [PMID: 32253226]
  • Nina Krompholz, Carmen Krischkowski, Debora Reichmann, Dieter Garbe-Schönberg, Ralf-R Mendel, Florian Bittner, Bernd Clement, Antje Havemeyer. The mitochondrial Amidoxime Reducing Component (mARC) is involved in detoxification of N-hydroxylated base analogues. Chemical research in toxicology. 2012 Nov; 25(11):2443-50. doi: 10.1021/tx300298m. [PMID: 22924387]
  • Brenda I Hernandez-Santiago, Thierry Beltran, Lieven Stuyver, Chung K Chu, Raymond F Schinazi. Metabolism of the anti-hepatitis C virus nucleoside beta-D-N4-hydroxycytidine in different liver cells. Antimicrobial agents and chemotherapy. 2004 Dec; 48(12):4636-42. doi: 10.1128/aac.48.12.4636-4642.2004. [PMID: 15561837]