Panduratin A (BioDeep_00000843540)
代谢物信息卡片
Panduratin A
化学式: C26H30O4 (406.214398)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CCC(C(C1CC=C(C)C)C(=O)C2=C(C=C(C=C2O)OC)O)C3=CC=CC=C3
InChI: InChI=1S/C26H30O4/c1-16(2)10-12-20-17(3)11-13-21(18-8-6-5-7-9-18)24(20)26(29)25-22(27)14-19(30-4)15-23(25)28/h5-11,14-15,20-21,24,27-28H,12-13H2,1-4H3/t20-,21+,24-/m1/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:66725
- PubChem: 6483648
- ChEMBL: CHEMBL379110
- CAS: 89837-52-5
- MetaboLights: MTBLC66725
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nalumon Thadtapong, Soraya Chaturongakul, Chanita Napaswad, Padungsri Dubbs, Sunhapas Soodvilai. Enhancing effect of natural adjuvant, panduratin A, on antibacterial activity of colistin against multidrug-resistant Acinetobacter baumannii.
Scientific reports.
2024 04; 14(1):9863. doi:
10.1038/s41598-024-60627-0. [PMID: 38684853] - Aung Khine Linn, Suwimon Manopwisedjaroen, Phongthon Kanjanasirirat, Suparerk Borwornpinyo, Suradej Hongeng, Phetcharat Phanthong, Arunee Thitithanyanont. Unveiling the Antiviral Properties of Panduratin A through SARS-CoV-2 Infection Modeling in Cardiomyocytes.
International journal of molecular sciences.
2024 Jan; 25(3):. doi:
10.3390/ijms25031427. [PMID: 38338708] - Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Apisada Jiso, Pinnakarn Techapichetvanich, Nitra Nuengchamnong, Kittitach Supannapan, Anusak Kijtawornrat, Phisit Khemawoot. Absolute oral bioavailability and possible metabolic pathway of panduratin A from Boesenbergia rotunda extract in beagle dogs.
Pharmaceutical biology.
2023 Dec; 61(1):590-597. doi:
10.1080/13880209.2023.2190777. [PMID: 36994846] - Christian Bailly. Toward the use of Boesenbergia rotunda extracts and the chalcone panduratin A to treat periodontitis.
Journal of oral biosciences.
2022 06; 64(2):183-192. doi:
10.1016/j.job.2022.03.002. [PMID: 35306173] - Kanlayanee Tonum, Nipitpon Srimai, Napason Chabang, Somsak Fongsupa, Patoomratana Tuchinda, Jacob A Torres, Thomas Weimbs, Sunhapas Soodvilai. Pharmacological Effects of Panduratin A on Renal Cyst Development in In Vitro and In Vivo Models of Polycystic Kidney Disease.
International journal of molecular sciences.
2022 Apr; 23(8):. doi:
10.3390/ijms23084328. [PMID: 35457146] - Nichakorn Worakajit, Natechanok Thipboonchoo, Soraya Chaturongakul, Promsuk Jutabha, Virawudh Soontornniyomkij, Patoomratana Tuchinda, Sunhapas Soodvilai. Nephroprotective potential of Panduratin A against colistin-induced renal injury via attenuating mitochondrial dysfunction and cell apoptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Apr; 148(?):112732. doi:
10.1016/j.biopha.2022.112732. [PMID: 35217281] - Jihyun Won, Keumhan Noh, Jae-Kwan Hwang, Beom Soo Shin, Wonku Kang. Pharmacokinetics of panduratin A following oral administration of a Boesenbergia pandurata extract to rats.
Journal of food and drug analysis.
2021 12; 29(4):676-683. doi:
10.38212/2224-6614.3382. [PMID: 35649144] - Penjai Thongnuanjan, Sirima Soodvilai, Somsak Fongsupa, Natechanok Thipboonchoo, Napason Chabang, Bamroong Munyoo, Patoomratana Tuchinda, Sunhapas Soodvilai. Panduratin A Derivative Protects against Cisplatin-Induced Apoptosis of Renal Proximal Tubular Cells and Kidney Injury in Mice.
Molecules (Basel, Switzerland).
2021 Nov; 26(21):. doi:
10.3390/molecules26216642. [PMID: 34771049] - Penjai Thongnuanjan, Sirima Soodvilai, Somsak Fongsupa, Napason Chabang, Pornpun Vivithanaporn, Patoomratana Tuchinda, Sunhapas Soodvilai. Protective Effect of Panduratin A on Cisplatin-Induced Apoptosis of Human Renal Proximal Tubular Cells and Acute Kidney Injury in Mice.
Biological & pharmaceutical bulletin.
2021; 44(6):830-837. doi:
10.1248/bpb.b21-00036. [PMID: 34078815] - Phongthon Kanjanasirirat, Ampa Suksatu, Suwimon Manopwisedjaroen, Bamroong Munyoo, Patoomratana Tuchinda, Kedchin Jearawuttanakul, Sawinee Seemakhan, Sitthivut Charoensutthivarakul, Patompon Wongtrakoongate, Noppawan Rangkasenee, Supaporn Pitiporn, Neti Waranuch, Napason Chabang, Phisit Khemawoot, Khanit Sa-Ngiamsuntorn, Yongyut Pewkliang, Piyanoot Thongsri, Somchai Chutipongtanate, Suradej Hongeng, Suparerk Borwornpinyo, Arunee Thitithanyanont. High-content screening of Thai medicinal plants reveals Boesenbergia rotunda extract and its component Panduratin A as anti-SARS-CoV-2 agents.
Scientific reports.
2020 11; 10(1):19963. doi:
10.1038/s41598-020-77003-3. [PMID: 33203926] - Seungmok Choi, Changhee Kim, Heebin Son, Jae-Kwan Hwang, Wonku Kang. Estimation of an Appropriate Human Dose of Boesenbergia pandurata Extracts Based on Allometric Scaling Data of Panduratin A in Mice, Rats, and Dogs.
Journal of medicinal food.
2020 Apr; 23(4):453-458. doi:
10.1089/jmf.2019.4564. [PMID: 32176564] - Haebom Kim, Changhee Kim, Kyo Eun Kook, Yanti, Seungmok Choi, Wonku Kang, Jae-Kwan Hwang. Inhibitory Effects of Standardized Boesenbergia pandurata Extract and Its Active Compound Panduratin A on Lipopolysaccharide-Induced Periodontal Inflammation and Alveolar Bone Loss in Rats.
Journal of medicinal food.
2018 Oct; 21(10):961-970. doi:
10.1089/jmf.2017.4155. [PMID: 30088980] - Suzy M Salama, Ibrahim Abdel Aziz Ibrahim, Naiyer Shahzad, Saeed Al-Ghamdi, Nahla Ayoub, Ahmed Salim AlRashdi, Mahmood Ameen Abdulla, Nur'Ain Salehen, Mehmet Bilgen. Hepatoprotectivity of Panduratin A against liver damage: In vivo demonstration with a rat model of cirrhosis induced by thioacetamide.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica.
2018 Sep; 126(9):710-721. doi:
10.1111/apm.12878. [PMID: 30058214] - Siew-Li Lai, Mohd Rais Mustafa, Pooi-Fong Wong. Panduratin A induces protective autophagy in melanoma via the AMPK and mTOR pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2018 Mar; 42(?):144-151. doi:
10.1016/j.phymed.2018.03.027. [PMID: 29655680] - Haebom Kim, Mi-Bo Kim, Changhee Kim, Jae-Kwan Hwang. Inhibitory Effects of Panduratin A on Periodontitis-Induced Inflammation and Osteoclastogenesis through Inhibition of MAPK Pathways In Vitro.
Journal of microbiology and biotechnology.
2018 Feb; 28(2):190-198. doi:
10.4014/jmb.1707.07042. [PMID: 29061028] - Do Un Kim, Hee Chul Chung, Changhee Kim, Jae-Kwan Hwang. Oral intake of Boesenbergia pandurata extract improves skin hydration, gloss, and wrinkling: A randomized, double-blind, and placebo-controlled study.
Journal of cosmetic dermatology.
2017 Dec; 16(4):512-519. doi:
10.1111/jocd.12343. [PMID: 28421656] - Bo-Kyung Sa, Changhee Kim, Mi-Bo Kim, Jae-Kwan Hwang. Panduratin A Prevents Tumor Necrosis Factor-Alpha-Induced Muscle Atrophy in L6 Rat Skeletal Muscle Cells.
Journal of medicinal food.
2017 Nov; 20(11):1047-1054. doi:
10.1089/jmf.2017.3970. [PMID: 28933980] - Minsoo Kim, Seungmok Choi, Keumhan Noh, Changhee Kim, Eunyoung Kim, Jae-Kwan Hwang, Wonku Kang. Determination of panduratin A in rat plasma by HPLC-MS/MS and its application to a pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2017 Apr; 137(?):151-154. doi:
10.1016/j.jpba.2017.01.027. [PMID: 28119213] - Nhan Trung Nguyen, Mai Thanh Thi Nguyen, Hai Xuan Nguyen, Phu Hoang Dang, Dya Fita Dibwe, Hiroyasu Esumi, Suresh Awale. Constituents of the Rhizomes of Boesenbergia pandurata and Their Antiausterity Activities against the PANC-1 Human Pancreatic Cancer Line.
Journal of natural products.
2017 01; 80(1):141-148. doi:
10.1021/acs.jnatprod.6b00784. [PMID: 28099006] - Namrita Lall, Elizabeth Mogapi, Marco Nuno de Canha, Bridget Crampton, Mabatho Nqephe, Ahmed A Hussein, Vivek Kumar. Insights into tyrosinase inhibition by compounds isolated from Greyia radlkoferi Szyszyl using biological activity, molecular docking and gene expression analysis.
Bioorganic & medicinal chemistry.
2016 11; 24(22):5953-5959. doi:
10.1016/j.bmc.2016.09.054. [PMID: 27720556] - Noor Diyana Md-Mustafa, Norzulaani Khalid, Huan Gao, Zhiyu Peng, Mohd Firdaus Alimin, Noraini Bujang, Wong Sher Ming, Yusmin Mohd-Yusuf, Jennifer A Harikrishna, Rofina Yasmin Othman. Transcriptome profiling shows gene regulation patterns in a flavonoid pathway in response to exogenous phenylalanine in Boesenbergia rotunda cell culture.
BMC genomics.
2014 Nov; 15(?):984. doi:
10.1186/1471-2164-15-984. [PMID: 25407215] - Suzy M Salama, Ahmed S AlRashdi, Mahmood A Abdulla, Pouya Hassandarvish, Mehmet Bilgen. Protective activity of Panduratin A against thioacetamide-induced oxidative damage: demonstration with in vitro experiments using WRL-68 liver cell line.
BMC complementary and alternative medicine.
2013 Oct; 13(?):279. doi:
10.1186/1472-6882-13-279. [PMID: 24156366] - Yuri Choi, Myung Suk Kim, Jae-Kwan Hwang. Inhibitory effects of panduratin A on allergy-related mediator production in rat basophilic leukemia mast cells.
Inflammation.
2012 Dec; 35(6):1904-15. doi:
10.1007/s10753-012-9513-y. [PMID: 22864999] - T P Tim Cushnie, Andrew J Lamb. Recent advances in understanding the antibacterial properties of flavonoids.
International journal of antimicrobial agents.
2011 Aug; 38(2):99-107. doi:
10.1016/j.ijantimicag.2011.02.014. [PMID: 21514796] - D Kim, M-S Lee, K Jo, K-E Lee, J-K Hwang. Therapeutic potential of panduratin A, LKB1-dependent AMP-activated protein kinase stimulator, with activation of PPARα/δ for the treatment of obesity.
Diabetes, obesity & metabolism.
2011 Jul; 13(7):584-93. doi:
10.1111/j.1463-1326.2011.01379.x. [PMID: 21320266] - Neni Frimayanti, Chin Fei Chee, Sharifuddin M Zain, Noorsaadah Abd Rahman. Design of new competitive dengue NS2B/NS3 protease inhibitors-a computational approach.
International journal of molecular sciences.
2011 Feb; 12(2):1089-100. doi:
10.3390/ijms12021089. [PMID: 21541045] - Yanti, Myoungsu Lee, Daeyoung Kim, Jae-Kwan Hwang. Inhibitory effect of panduratin A on c-Jun N-terminal kinase and activator protein-1 signaling involved in Porphyromonas gingivalis supernatant-stimulated matrix metalloproteinase-9 expression in human oral epidermoid cells.
Biological & pharmaceutical bulletin.
2009 Oct; 32(10):1770-5. doi:
10.1248/bpb.32.1770. [PMID: 19801842] - Yanti, Yaya Rukayadi, Kwan-Hyoung Lee, Jae-Kwan Hwang. Activity of panduratin A isolated from Kaempferia pandurata Roxb. against multi-species oral biofilms in vitro.
Journal of oral science.
2009 Mar; 51(1):87-95. doi:
10.2334/josnusd.51.87. [PMID: 19325204] - Jung-Mi Yun, Mee-Hyang Kweon, Hoonjeong Kwon, Jae-Kwan Hwang, Hasan Mukhtar. Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145.
Carcinogenesis.
2006 Jul; 27(7):1454-64. doi:
10.1093/carcin/bgi348. [PMID: 16497706] - Tan Siew Kiat, Richard Pippen, Rohana Yusof, Halijah Ibrahim, Norzulaani Khalid, Noorsaadah Abd Rahman. Inhibitory activity of cyclohexenyl chalcone derivatives and flavonoids of fingerroot, Boesenbergia rotunda (L.), towards dengue-2 virus NS3 protease.
Bioorganic & medicinal chemistry letters.
2006 Jun; 16(12):3337-40. doi:
10.1016/j.bmcl.2005.12.075. [PMID: 16621533] - Sarot Cheenpracha, Chatchanok Karalai, Chanita Ponglimanont, Sanan Subhadhirasakul, Supinya Tewtrakul. Anti-HIV-1 protease activity of compounds from Boesenbergia pandurata.
Bioorganic & medicinal chemistry.
2006 Mar; 14(6):1710-4. doi:
10.1016/j.bmc.2005.10.019. [PMID: 16263298] - Jong Hee Sohn, Kyu-Lee Han, Sun-Hee Lee, Jae-Kwan Hwang. Protective effects of panduratin A against oxidative damage of tert-butylhydroperoxide in human HepG2 cells.
Biological & pharmaceutical bulletin.
2005 Jun; 28(6):1083-6. doi:
10.1248/bpb.28.1083. [PMID: 15930750] - Jung-Mi Yun, Hoonjeong Kwon, Hasan Mukhtar, Jae-Kwan Hwang. Induction of apoptosis by Panduratin A isolated from Kaempferia pandurata in human colon cancer HT-29 cells.
Planta medica.
2005 Jun; 71(6):501-7. doi:
10.1055/s-2005-864149. [PMID: 15971119] - Jung-Mi Yun, Hoonjeong Kwon, Jae-Kwan Hwang. In vitro anti-inflammatory activity of panduratin A isolated from Kaempferia pandurata in RAW264.7 cells.
Planta medica.
2003 Dec; 69(12):1102-8. doi:
10.1055/s-2003-45190. [PMID: 14750025] - Jian-Qiao Gu, Eun Jung Park, Jose Schunke Vigo, James G Graham, Harry H S Fong, John M Pezzuto, A Douglas Kinghorn. Activity-guided isolation of constituents of Renealmia nicolaioides with the potential to induce the phase II enzyme quinone reductase.
Journal of natural products.
2002 Nov; 65(11):1616-20. doi:
10.1021/np020249p. [PMID: 12444686]