H-Arg-Gly-Asp-OH (BioDeep_00000843534)
代谢物信息卡片
Arginyl-glycyl-aspartic acid
化学式: C12H22N6O6 (346.1600752)
中文名称: L-精氨酰甘氨酰-L-天冬氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(C(=O)NCC(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N
InChI: InChI=1S/C12H22N6O6/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16)/t6-,7-/m0/s1
描述信息
D000970 - Antineoplastic Agents
RGD is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
同义名列表
3 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:158966
- PubChem: 104802
- ChEMBL: CHEMBL313763
- CAS: 124123-27-9
- CAS: 119865-10-0
- CAS: 99896-85-2
- medchemexpress: HY-P0278
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 8692 - Bitis arietans: 10.1006/BBRC.1996.1345
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fatemeh Khosravani, Fatemeh Amiri, Rouzbeh Mahmoudi, Dina Morshedi, Farzad Kobarfard, Mohsen Alipour, Ebrahim Hosseini, Hassan Bardania. RGD-decorated nanoliposomes for combined delivery of arsenic trioxide and curcumin to prostate cancer cells.
Naunyn-Schmiedeberg's archives of pharmacology.
2023 Oct; ?(?):. doi:
10.1007/s00210-023-02752-7. [PMID: 37831114] - Jieke Yan, Jing Guo, Yuzhen Wang, Xiaowei Xing, Xuguang Zhang, Guanghao Zhang, Zhaoqiang Dong. Acute myocardial infarction therapy using calycosin and tanshinone co-loaded; mitochondrion-targeted tetrapeptide and cyclic arginyl-glycyl-aspartic acid peptide co-modified lipid-polymer hybrid nano-system: preparation, characterization, and anti myocardial infarction activity assessment.
Drug delivery.
2022 Dec; 29(1):2815-2823. doi:
10.1080/10717544.2022.2118401. [PMID: 36047255] - Kang Liang, Zhenyuan Tian, Xin Chen, Mengru Li, Xiaofen Zhang, Xiaoping Bian, Md Kaisar Ali, Qingke Kong. Attenuated Salmonella Typhimurium with truncated LPS and outer membrane-displayed RGD peptide for cancer therapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Nov; 155(?):113682. doi:
10.1016/j.biopha.2022.113682. [PMID: 36095964] - Naoya Kato, Takumi Sato, Yuki Fuchigami, Tadaharu Suga, Longjian Geng, Masako Tsurumaru, Masayori Hagimori, Hidefumi Mukai, Shigeru Kawakami. Synthesis and evaluation of a novel adapter lipid derivative for preparation of cyclic peptide-modified PEGylated liposomes: Application of cyclic RGD peptide.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2022 Sep; 176(?):106239. doi:
10.1016/j.ejps.2022.106239. [PMID: 35714942] - Ehsan Khabazian, Faezeh Vakhshiteh, Parisa Norouzi, Yousef Fatahi, Rassoul Dinarvand, Fatemeh Atyabi. Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells.
Journal of drug targeting.
2022 06; 30(5):522-533. doi:
10.1080/1061186x.2021.1973481. [PMID: 34482780] - Juan Pablo Robles, Magdalena Zamora, Elva Adan-Castro, Lourdes Siqueiros-Marquez, Gonzalo Martinez de la Escalera, Carmen Clapp. The spike protein of SARS-CoV-2 induces endothelial inflammation through integrin α5β1 and NF-κB signaling.
The Journal of biological chemistry.
2022 03; 298(3):101695. doi:
10.1016/j.jbc.2022.101695. [PMID: 35143839] - Chun-Yan Zheng, Xiao-Yang Chu, Chun-Yan Gao, Hua-Ying Hu, Xin He, Xu Chen, Kai Yang, Dong-Liang Zhang. TAT&RGD Peptide-Modified Naringin-Loaded Lipid Nanoparticles Promote the Osteogenic Differentiation of Human Dental Pulp Stem Cells.
International journal of nanomedicine.
2022; 17(?):3269-3286. doi:
10.2147/ijn.s371715. [PMID: 35924260] - Na Qi, Shangqian Zhang, Xiantai Zhou, Wenjuan Duan, Duan Gao, Jianfang Feng, Aimin Li. Combined integrin αvβ3 and lactoferrin receptor targeted docetaxel liposomes enhance the brain targeting effect and anti-glioma effect.
Journal of nanobiotechnology.
2021 Dec; 19(1):446. doi:
10.1186/s12951-021-01180-0. [PMID: 34949198] - Hamed Hajipour, Mohammad Nouri, Marjan Ghorbani, Ali Bahramifar, Reza Zolfaghari Emameh, Ramezan Ali Taheri. Targeted nanostructured lipid carrier containing galangin as a promising adjuvant for improving cytotoxic effects of chemotherapeutic agents.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 12; 394(12):2353-2362. doi:
10.1007/s00210-021-02152-9. [PMID: 34522984] - Shelly Roselyn Van Eyssen, Doga Kavaz. An evaluative in vitro investigation of the delivery of cytarabine with RGD decorated solid lipid nanoparticles.
Journal of microencapsulation.
2021 Nov; 38(7-8):546-558. doi:
10.1080/02652048.2021.1992028. [PMID: 34632926] - Hamed Hajipour, Roshanak Sambrani, Marjan Ghorbani, Zahra Mirzamohammadi, Mohammad Nouri. Sildenafil citrate-loaded targeted nanostructured lipid carrier enhances receptivity potential of endometrial cells via LIF and VEGF upregulation.
Naunyn-Schmiedeberg's archives of pharmacology.
2021 11; 394(11):2323-2331. doi:
10.1007/s00210-021-02153-8. [PMID: 34515834] - Cui Li, Fujiao Nie, Xiaoyan Liu, Meng Chen, David Chi, Shuai Li, Iraklis I Pipinos, Xiaowei Li. Antioxidative and Angiogenic Hyaluronic Acid-Based Hydrogel for the Treatment of Peripheral Artery Disease.
ACS applied materials & interfaces.
2021 Sep; 13(38):45224-45235. doi:
10.1021/acsami.1c11349. [PMID: 34519480] - Krishan Kumar, Karen Woolum. A Novel Reagent for Radioiodine Labeling of New Chemical Entities (NCEs) and Biomolecules.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144344. [PMID: 34299619] - Xinqi Deng, Ke Hou, Lei Yang, Zhengju Zhang, Wen Gu, Xiangwei Bu, Hui Liu, Weiguo Ma, Kang Wang, Hua Bai, Honghong Zhang, Dali Wang, Chunguo Wang, Huiyuan Zhang, Fengxian Meng. A folate/RGD-dual-functionalized mesoporous silica nanoparticles targeting GABA-p38 MAPK-MRTFs/SRF signaling pathway in rheumatoid arthritis.
Clinical and translational medicine.
2021 05; 11(5):e408. doi:
10.1002/ctm2.408. [PMID: 34047483] - Xiaoyan Wu, Yingying Hua, Tiantian Wei, Chenjun Ma, Zhongjie Wang, Liefeng Zhang, Jing Wang. Effect and mechanism of actionin vitroof cyclodextrin derivative nanoparticles loaded with tyroserleutide on hepatoma.
Nanotechnology.
2021 Apr; 32(28):. doi:
10.1088/1361-6528/abf3f2. [PMID: 33789260] - Caifeng Deng, Quan Zhang, Penghui He, Bin Zhou, Ke He, Xun Sun, Guanghua Lei, Tao Gong, Zhirong Zhang. Targeted apoptosis of macrophages and osteoclasts in arthritic joints is effective against advanced inflammatory arthritis.
Nature communications.
2021 04; 12(1):2174. doi:
10.1038/s41467-021-22454-z. [PMID: 33846342] - Eun Jeong Park, Phyoe Kyawe Myint, Michael Gyasi Appiah, Samuel Darkwah, Siqingaowa Caidengbate, Atsushi Ito, Eri Matsuo, Eiji Kawamoto, Arong Gaowa, Motomu Shimaoka. The Spike Glycoprotein of SARS-CoV-2 Binds to β1 Integrins Expressed on the Surface of Lung Epithelial Cells.
Viruses.
2021 04; 13(4):. doi:
10.3390/v13040645. [PMID: 33918599] - Mingfang Wu, Chen Zhong, Qian Zhang, Lu Wang, Lingling Wang, Yanjie Liu, Xiaoxue Zhang, Xiuhua Zhao. pH-responsive delivery vehicle based on RGD-modified polydopamine-paclitaxel-loaded poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles for targeted therapy in hepatocellular carcinoma.
Journal of nanobiotechnology.
2021 Feb; 19(1):39. doi:
10.1186/s12951-021-00783-x. [PMID: 33549107] - Reza Mahmoudi, Seyedeh Ashraf Mirahmadi-Babaheidri, Hamdollah Delaviz, Mohamad Hassan Fouani, Mohsen Alipour, Mehrzad Jafari Barmak, Gunna Christiansen, Hassan Bardania. RGD peptide-mediated liposomal curcumin targeted delivery to breast cancer cells.
Journal of biomaterials applications.
2021 02; 35(7):743-753. doi:
10.1177/0885328220949367. [PMID: 32807016] - Nidhi Raval, Hardi Jogi, Piyush Gondaliya, Kiran Kalia, Rakesh K Tekade. Cyclo-RGD Truncated Polymeric Nanoconstruct with Dendrimeric Templates for Targeted HDAC4 Gene Silencing in a Diabetic Nephropathy Mouse Model.
Molecular pharmaceutics.
2021 02; 18(2):641-666. doi:
10.1021/acs.molpharmaceut.0c00094. [PMID: 32453574] - Lee Makowski, William Olson-Sidford, John W-Weisel. Biological and Clinical Consequences of Integrin Binding via a Rogue RGD Motif in the SARS CoV-2 Spike Protein.
Viruses.
2021 Jan; 13(2):. doi:
10.3390/v13020146. [PMID: 33498225] - Bálint Mészáros, Hugo Sámano-Sánchez, Jesús Alvarado-Valverde, Jelena Čalyševa, Elizabeth Martínez-Pérez, Renato Alves, Denis C Shields, Manjeet Kumar, Friedrich Rippmann, Lucía B Chemes, Toby J Gibson. Short linear motif candidates in the cell entry system used by SARS-CoV-2 and their potential therapeutic implications.
Science signaling.
2021 01; 14(665):. doi:
10.1126/scisignal.abd0334. [PMID: 33436497] - Van Phuc Nguyen, Wei Qian, Yanxiu Li, Bing Liu, Michael Aaberg, Jessica Henry, Wei Zhang, Xueding Wang, Yannis M Paulus. Chain-like gold nanoparticle clusters for multimodal photoacoustic microscopy and optical coherence tomography enhanced molecular imaging.
Nature communications.
2021 01; 12(1):34. doi:
10.1038/s41467-020-20276-z. [PMID: 33397947] - Xiang Li, Zhen Wang, Mian Ma, Zhouqing Chen, Xiang-Long Tang, Zhong Wang. Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy.
Journal of immunology research.
2021; 2021(?):9958239. doi:
10.1155/2021/9958239. [PMID: 33880384] - Tikam Chand Dakal. SARS-CoV-2 attachment to host cells is possibly mediated via RGD-integrin interaction in a calcium-dependent manner and suggests pulmonary EDTA chelation therapy as a novel treatment for COVID 19.
Immunobiology.
2021 01; 226(1):152021. doi:
10.1016/j.imbio.2020.152021. [PMID: 33232865] - Chuyue Zhang, Yuna Shang, Xiaoniao Chen, Adam C Midgley, Zhongyan Wang, Dashuai Zhu, Jie Wu, Pu Chen, Lingling Wu, Xu Wang, Kaiyue Zhang, Hongfeng Wang, Deling Kong, Zhimou Yang, Zongjin Li, Xiangmei Chen. Supramolecular Nanofibers Containing Arginine-Glycine-Aspartate (RGD) Peptides Boost Therapeutic Efficacy of Extracellular Vesicles in Kidney Repair.
ACS nano.
2020 09; 14(9):12133-12147. doi:
10.1021/acsnano.0c05681. [PMID: 32790341] - Radoslava Sivkova, Johanka Táborská, Alain Reparaz, Andres de Los Santos Pereira, Ilya Kotelnikov, Vladimir Proks, Jan Kučka, Jan Svoboda, Tomáš Riedel, Ognen Pop-Georgievski. Surface Design of Antifouling Vascular Constructs Bearing Biofunctional Peptides for Tissue Regeneration Applications.
International journal of molecular sciences.
2020 Sep; 21(18):. doi:
10.3390/ijms21186800. [PMID: 32947982] - Xiangfeng Lv, Chun Zhang, Qingyun Shuaizhen, Rong Yu, Yongxiang Zheng. Design of integrin αvβ3 targeting self-assembled protein nanoparticles with RGD peptide.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Aug; 128(?):110236. doi:
10.1016/j.biopha.2020.110236. [PMID: 32447209] - Paul J Davis, Hung-Yun Lin, Aleck Hercbergs, Kelly A Keating, Shaker A Mousa. Coronaviruses and Integrin αvβ3: Does Thyroid Hormone Modify the Relationship?.
Endocrine research.
2020 Aug; 45(3):210-215. doi:
10.1080/07435800.2020.1767127. [PMID: 32628899] - Di Wu, Zheng Zhao, Nan Wang, Xinrui Zhang, Honghong Yan, Xiaoqi Chen, Yunyun Fan, Weiwei Liu, Xuekui Liu. Fluorescence imaging-guided multifunctional liposomes for tumor-specific phototherapy for laryngeal carcinoma.
Biomaterials science.
2020 Jun; 8(12):3443-3453. doi:
10.1039/d0bm00249f. [PMID: 32412569] - Lucia Ferrazzano, Dario Corbisiero, Eleonora Potenza, Monica Baiula, Samantha Deianira Dattoli, Santi Spampinato, Laura Belvisi, Monica Civera, Alessandra Tolomelli. Side chain effect in the modulation of αvβ3/α5β1 integrin activity via clickable isoxazoline-RGD-mimetics: development of molecular delivery systems.
Scientific reports.
2020 05; 10(1):7410. doi:
10.1038/s41598-020-64396-4. [PMID: 32366988] - Sanjai Karanth, Mihaela Delcea. Nitrosative stress affects the interaction of integrin alphaIIbbeta3 with its ligands.
Biochimica et biophysica acta. Biomembranes.
2020 05; 1862(5):183198. doi:
10.1016/j.bbamem.2020.183198. [PMID: 31958436] - Jeannine Basta, Lynn Robbins, Lisa Stout, Michael J Prinsen, David W Griggs, Michael Rauchman. Pharmacologic inhibition of RGD-binding integrins ameliorates fibrosis and improves function following kidney injury.
Physiological reports.
2020 04; 8(7):e14329. doi:
10.14814/phy2.14329. [PMID: 32281744] - Johanna F M Verstappen, Jianfeng Jin, Gülistan Koçer, Mohammad Haroon, Pascal Jonkheijm, Astrid D Bakker, Jenneke Klein-Nulend, Richard T Jaspers. RGD-functionalized supported lipid bilayers modulate pre-osteoblast adherence and promote osteogenic differentiation.
Journal of biomedical materials research. Part A.
2020 04; 108(4):923-937. doi:
10.1002/jbm.a.36870. [PMID: 31895490] - Mahmoud Dabbah, Osnat Jarchowsky-Dolberg, Oshrat Attar-Schneider, Shelly Tartakover Matalon, Metsada Pasmanik-Chor, Liat Drucker, Michael Lishner. Multiple myeloma BM-MSCs increase the tumorigenicity of MM cells via transfer of VLA4-enriched microvesicles.
Carcinogenesis.
2020 03; 41(1):100-110. doi:
10.1093/carcin/bgz169. [PMID: 31586190] - Fakun Cao, Yuhuan Zhou, Xiaoting Liu, Cheng-Han Yu. Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane.
Communications biology.
2020 03; 3(1):117. doi:
10.1038/s42003-020-0843-2. [PMID: 32170110] - Kai Xu, Zhenghuan Zhao, Junfeng Zhang, Wei Xue, Haipeng Tong, Heng Liu, Weiguo Zhang. Albumin-stabilized manganese-based nanocomposites with sensitive tumor microenvironment responsivity and their application for efficient SiRNA delivery in brain tumors.
Journal of materials chemistry. B.
2020 02; 8(7):1507-1515. doi:
10.1039/c9tb02341k. [PMID: 32003397] - Lyudmila V Parfenova, Elena S Lukina, Zulfia R Galimshina, Guzel U Gil'fanova, Veta R Mukaeva, Ruzil G Farrakhov, Ksenia V Danilko, Grigory S Dyakonov, Evgeny V Parfenov. Biocompatible Organic Coatings Based on Bisphosphonic Acid RGD-Derivatives for PEO-Modified Titanium Implants.
Molecules (Basel, Switzerland).
2020 Jan; 25(1):. doi:
10.3390/molecules25010229. [PMID: 31935900] - Qifang Long, Weipei Zhu, Liangsheng Guo, Li Pu. RGD-Conjugated Resveratrol HSA Nanoparticles as a Novel Delivery System in Ovarian Cancer Therapy.
Drug design, development and therapy.
2020; 14(?):5747-5756. doi:
10.2147/dddt.s248950. [PMID: 33408463] - Xiang-Zhi Zhao, Wei Zhang, Yang Cao, Shuai-Shuai Huang, Yi-Zhen Li, Dan Guo, Xing-Yue Wang, Hai-Tao Ran. A Cleverly Designed Novel Lipid Nanosystem: Targeted Retention, Controlled Visual Drug Release, and Cascade Amplification Therapy for Mammary Carcinoma in vitro.
International journal of nanomedicine.
2020; 15(?):3953-3964. doi:
10.2147/ijn.s244743. [PMID: 32581539] - Arezou M Farahani, Fariba Maleki, Nourollah Sadeghzadeh. The Influence of Different Spacers on Biological Profile of Peptide Radiopharmaceuticals for Diagnosis and Therapy of Human Cancers.
Anti-cancer agents in medicinal chemistry.
2020; 20(4):402-416. doi:
10.2174/1871520620666191231161227. [PMID: 31889492] - He Bao, Nanbo Zheng, Zhuanting Li, Yuan Zhi. Synergistic Effect of Tangeretin and Atorvastatin for Colon Cancer Combination Therapy: Targeted Delivery of These Dual Drugs Using RGD Peptide Decorated Nanocarriers.
Drug design, development and therapy.
2020; 14(?):3057-3068. doi:
10.2147/dddt.s256636. [PMID: 32801644] - Yupeng Liu, Suhuan Dai, Lijuan Wen, Yun Zhu, Yanan Tan, Guoxi Qiu, Tingting Meng, Fangying Yu, Hong Yuan, Fuqiang Hu. Enhancing Drug Delivery for Overcoming Angiogenesis and Improving the Phototherapy Efficacy of Glioblastoma by ICG-Loaded Glycolipid-Like Micelles.
International journal of nanomedicine.
2020; 15(?):2717-2732. doi:
10.2147/ijn.s234240. [PMID: 32368051] - Yanchi Pu, Hao Zhang, Yao Peng, Qiuyi Fu, Qiming Yue, Yi Zhao, Li Guo, Yong Wu. Dual-targeting liposomes with active recognition of GLUT5 and αvβ3 for triple-negative breast cancer.
European journal of medicinal chemistry.
2019 Dec; 183(?):111720. doi:
10.1016/j.ejmech.2019.111720. [PMID: 31553933] - Lei Zhang, Xue Shan, Xia Meng, Tingting Gu, Qiangbing Lu, Jikang Zhang, Jiao Chen, Qing Jiang, Xinghai Ning. The first integrins β3-mediated cellular and nuclear targeting therapeutics for prostate cancer.
Biomaterials.
2019 12; 223(?):119471. doi:
10.1016/j.biomaterials.2019.119471. [PMID: 31525693] - Ricardo Cruz-Acuña, Adriana Mulero-Russe, Amy Y Clark, Roy Zent, Andrés J García. Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels.
Journal of cell science.
2019 10; 132(20):. doi:
10.1242/jcs.226639. [PMID: 31558679] - Zhanxia Zhang, Changsheng Dong, Guanzhen Yu, Wei Cheng, Yupei Liang, Yongfu Pan, Hegen Li, Hongbin Ji. Smart and dual-targeted BSA nanomedicine with controllable release by high autolysosome levels.
Colloids and surfaces. B, Biointerfaces.
2019 Oct; 182(?):110325. doi:
10.1016/j.colsurfb.2019.06.055. [PMID: 31301582] - Sry D Hujaya, Aki Manninen, Kirsten Kling, Jakob B Wagner, Seppo J Vainio, Henrikki Liimatainen. Self-assembled nanofibrils from RGD-functionalized cellulose nanocrystals to improve the performance of PEI/DNA polyplexes.
Journal of colloid and interface science.
2019 Oct; 553(?):71-82. doi:
10.1016/j.jcis.2019.06.001. [PMID: 31200231] - Jing Wang, Duanwei Liang, Jie Feng, Xinjing Tang. Multicolor Cocktail for Breast Cancer Multiplex Phenotype Targeting and Diagnosis Using Bioorthogonal Surface-Enhanced Raman Scattering Nanoprobes.
Analytical chemistry.
2019 09; 91(17):11045-11054. doi:
10.1021/acs.analchem.9b01382. [PMID: 31361124] - Tian Zhang, Hoyin Lip, Chunsheng He, Ping Cai, Zhigao Wang, Jeffrey T Henderson, Andrew M Rauth, Xiao Yu Wu. Multitargeted Nanoparticles Deliver Synergistic Drugs across the Blood-Brain Barrier to Brain Metastases of Triple Negative Breast Cancer Cells and Tumor-Associated Macrophages.
Advanced healthcare materials.
2019 09; 8(18):e1900543. doi:
10.1002/adhm.201900543. [PMID: 31348614] - Sheng Wang, Baolin Zhang, Lichao Su, Wan Nie, Dong Han, Guihua Han, Hao Zhang, Chuangang Chong, Jie Tan. Subcellular distributions of iron oxide nanoparticles in rat brains affected by different surface modifications.
Journal of biomedical materials research. Part A.
2019 09; 107(9):1988-1998. doi:
10.1002/jbm.a.36711. [PMID: 31067350] - Isabell Kemker, Christian Schnepel, David C Schröder, Antoine Marion, Norbert Sewald. Cyclization of RGD Peptides by Suzuki-Miyaura Cross-Coupling.
Journal of medicinal chemistry.
2019 08; 62(16):7417-7430. doi:
10.1021/acs.jmedchem.9b00360. [PMID: 31306009] - Zhengfei Huang, Zhifeng Wang, Chuanhua Li, Ning Zhou, Fei Liu, Jing Lan. The osteoinduction of RGD and Mg ion functionalized bioactive zirconia coating.
Journal of materials science. Materials in medicine.
2019 Aug; 30(8):95. doi:
10.1007/s10856-019-6298-7. [PMID: 31414276] - Yuchen Zhu, Zhe Cao, Ying Peng, Liqiu Hu, Tankut Guney, Bin Tang. Facile Surface Modification Method for Synergistically Enhancing the Biocompatibility and Bioactivity of Poly(ether ether ketone) That Induced Osteodifferentiation.
ACS applied materials & interfaces.
2019 Aug; 11(31):27503-27511. doi:
10.1021/acsami.9b03030. [PMID: 31291088] - Kyeong-Min Lee, Jung-Hee Kim, Eun-Sook Choi, Eunjoo Kim, Seong-Kyoon Choi, Won Bae Jeon. RGD-containing elastin-like polypeptide improves islet transplantation outcomes in diabetic mice.
Acta biomaterialia.
2019 08; 94(?):351-360. doi:
10.1016/j.actbio.2019.06.011. [PMID: 31200117] - Yu Sheng, Zhen Wang, Gella Maelys Ngandeu Neubi, Hao Cheng, Chenshuang Zhang, Huaqing Zhang, Ruoning Wang, Jianping Zhou, Yang Ding. Lipoprotein-inspired penetrating nanoparticles for deep tumor-targeted shuttling of indocyanine green and enhanced photo-theranostics.
Biomaterials science.
2019 Aug; 7(8):3425-3437. doi:
10.1039/c9bm00588a. [PMID: 31268061] - Gang Zheng, Meizhu Zheng, Ben Yang, Hui Fu, Yongqing Li. Improving breast cancer therapy using doxorubicin loaded solid lipid nanoparticles: Synthesis of a novel arginine-glycine-aspartic tripeptide conjugated, pH sensitive lipid and evaluation of the nanomedicine in vitro and in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Aug; 116(?):109006. doi:
10.1016/j.biopha.2019.109006. [PMID: 31152925] - Zbynek Novy, Jana Stepankova, Michaela Hola, Dominika Flasarova, Miroslav Popper, Milos Petrik. Preclinical Evaluation of Radiolabeled Peptides for PET Imaging of Glioblastoma Multiforme.
Molecules (Basel, Switzerland).
2019 Jul; 24(13):. doi:
10.3390/molecules24132496. [PMID: 31288488] - Rungnapa Malasao, Pattara Khamrin, Kattareeya Kumthip, Hiroshi Ushijima, Niwat Maneekarn. Molecular epidemiology and genetic diversity of human parechoviruses in children hospitalized with acute diarrhea in Thailand during 2011-2016.
Archives of virology.
2019 Jul; 164(7):1743-1752. doi:
10.1007/s00705-019-04249-2. [PMID: 30972593] - Bhargab Kalita, Sumita Dutta, Ashis K Mukherjee. RGD-independent binding of Russell's Viper venom Kunitz-type protease inhibitors to platelet GPIIb/IIIa receptor.
Scientific reports.
2019 06; 9(1):8316. doi:
10.1038/s41598-019-44767-2. [PMID: 31165757] - Avraham Dayan, Gideon Fleminger, Osnat Ashur-Fabian. Targeting the Achilles' heel of cancer cells via integrin-mediated delivery of ROS-generating dihydrolipoamide dehydrogenase.
Oncogene.
2019 06; 38(25):5050-5061. doi:
10.1038/s41388-019-0775-9. [PMID: 30872792] - Jian Qing Peng, Shintaro Fumoto, Tadaharu Suga, Hirotaka Miyamoto, Naotaka Kuroda, Shigeru Kawakami, Koyo Nishida. Targeted co-delivery of protein and drug to a tumor in vivo by sophisticated RGD-modified lipid-calcium carbonate nanoparticles.
Journal of controlled release : official journal of the Controlled Release Society.
2019 05; 302(?):42-53. doi:
10.1016/j.jconrel.2019.03.021. [PMID: 30926479] - Rong Wu, Qianhao Min, Jingjing Guo, Tingting Zheng, Liping Jiang, Jun-Jie Zhu. Sequential Delivery and Cascade Targeting of Peptide Therapeutics for Triplexed Synergistic Therapy with Real-Time Monitoring Shuttled by Magnetic Gold Nanostars.
Analytical chemistry.
2019 04; 91(7):4608-4617. doi:
10.1021/acs.analchem.8b05877. [PMID: 30821439] - Abdulhalim Kilic, Fatma Nese Kok. Peptide-functionalized supported lipid bilayers to construct cell membrane mimicking interfaces.
Colloids and surfaces. B, Biointerfaces.
2019 Apr; 176(?):18-26. doi:
10.1016/j.colsurfb.2018.12.052. [PMID: 30590345] - Xue-Tao Li, Wei Tang, Hong-Jun Xie, Shuang Liu, Xiao-Li Song, Yao Xiao, Xin Wang, Lan Cheng, Gui-Rong Chen. The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma.
Journal of liposome research.
2019 Mar; 29(1):21-34. doi:
10.1080/08982104.2017.1408649. [PMID: 29166813] - Zhi-Gang Huang, Feng-Mei Lv, Jun Wang, Shui-Juan Cao, Zhe-Peng Liu, Yu Liu, Wei-Yue Lu. RGD-modified PEGylated paclitaxel nanocrystals with enhanced stability and tumor-targeting capability.
International journal of pharmaceutics.
2019 Feb; 556(?):217-225. doi:
10.1016/j.ijpharm.2018.12.023. [PMID: 30557679] - Dereje Kebebe, Yumei Wu, Bing Zhang, Jian Yang, Yuanyuan Liu, Xinyue Li, Zhe Ma, Peng Lu, Zhidong Liu, Jiawei Li. Dimeric c(RGD) peptide conjugated nanostructured lipid carriers for efficient delivery of Gambogic acid to breast cancer.
International journal of nanomedicine.
2019; 14(?):6179-6195. doi:
10.2147/ijn.s202424. [PMID: 31447559] - Yunfei Li, Yajuan Xiao, Hsuan-Pei Lin, Derek Reichel, Younsoo Bae, Eun Y Lee, Yiguo Jiang, Xuefei Huang, Chengfeng Yang, Zhishan Wang. In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis.
Biomaterials.
2019 01; 188(?):160-172. doi:
10.1016/j.biomaterials.2018.10.019. [PMID: 30352320] - Yunlong Wang, Zhongbing Liu, Ting Li, Lin Chen, Jiayao Lyu, Chunhong Li, Yan Lin, Na Hao, Meiling Zhou, Zhirong Zhong. Enhanced Therapeutic Effect of RGD-Modified Polymeric Micelles Loaded With Low-Dose Methotrexate and Nimesulide on Rheumatoid Arthritis.
Theranostics.
2019; 9(3):708-720. doi:
10.7150/thno.30418. [PMID: 30809303] - Jing Zhang, Peng Zhang, Qian Zou, Xiang Li, Jianjiang Fu, Ying Luo, Xinli Liang, Yi Jin. Co-Delivery of Gemcitabine and Paclitaxel in cRGD-Modified Long Circulating Nanoparticles with Asymmetric Lipid Layers for Breast Cancer Treatment.
Molecules (Basel, Switzerland).
2018 Nov; 23(11):. doi:
10.3390/molecules23112906. [PMID: 30405089] - Dongdong Bi, Lei Zhao, Runqi Yu, Haowen Li, Yifei Guo, Xiangtao Wang, Meihua Han. Surface modification of doxorubicin-loaded nanoparticles based on polydopamine with pH-sensitive property for tumor targeting therapy.
Drug delivery.
2018 Nov; 25(1):564-575. doi:
10.1080/10717544.2018.1440447. [PMID: 29457518] - Tadaharu Suga, Naoya Kato, Masayori Hagimori, Yuki Fuchigami, Naotaka Kuroda, Yukinobu Kodama, Hitoshi Sasaki, Shigeru Kawakami. Development of High-Functionality and -Quality Lipids with RGD Peptide Ligands: Application for PEGylated Liposomes and Analysis of Intratumoral Distribution in a Murine Colon Cancer Model.
Molecular pharmaceutics.
2018 10; 15(10):4481-4490. doi:
10.1021/acs.molpharmaceut.8b00476. [PMID: 30179010] - Guowen Wang, Zuyi Wang, Chuankui Li, Guixin Duan, Kangwu Wang, Qicai Li, Tao Tao. RGD peptide-modified, paclitaxel prodrug-based, dual-drugs loaded, and redox-sensitive lipid-polymer nanoparticles for the enhanced lung cancer therapy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):275-284. doi:
10.1016/j.biopha.2018.06.137. [PMID: 29966971] - Liyun Niu, Jian Li, Ruolan Gu, Zhuona Wu, Xiaoxia Zhu, Hui Gan, Baiping Ma, Bing Jia, Fan Wang, Zhiyun Meng, Xinyu Wang, Guifang Dou. An optimized LC-MS/MS method for determination of HYNIC-3PRGD2, a new promising imaging agent for tumor targeting, in rat plasma and its application.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Sep; 1095(?):142-148. doi:
10.1016/j.jchromb.2018.07.026. [PMID: 30077094] - Ming-Ming Li, Jia Cao, Jia-Chun Yang, Yu-Jie Shen, Xiao-Lei Cai, Yuan-Wen Chen, Chun-Ying Qu, Yi Zhang, Feng Shen, Min Zhou, Lei-Ming Xu. Biodistribution and toxicity assessment of intratumorally injected arginine-glycine-aspartic acid peptide conjugated to CdSe/ZnS quantum dots in mice bearing pancreatic neoplasm.
Chemico-biological interactions.
2018 Aug; 291(?):103-110. doi:
10.1016/j.cbi.2018.06.014. [PMID: 29908985] - Shimaa A Abdellatef, Jun Nakanishi. Photoactivatable substrates for systematic study of the impact of an extracellular matrix ligand on appearance of leader cells in collective cell migration.
Biomaterials.
2018 07; 169(?):72-84. doi:
10.1016/j.biomaterials.2018.03.045. [PMID: 29655082] - Tessa Buckle, Danny M van Willigen, Silvia J Spa, Albertus W Hensbergen, Steffen van der Wal, Clarize M de Korne, Mick M Welling, Henk G van der Poel, James C H Hardwick, Fijs W B van Leeuwen. Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2018 06; 59(6):986-992. doi:
10.2967/jnumed.117.205575. [PMID: 29449447] - Nathaniel J Hogrebe, James W Reinhardt, Nguyen K Tram, Anna C Debski, Gunjan Agarwal, Matthew A Reilly, Keith J Gooch. Independent control of matrix adhesiveness and stiffness within a 3D self-assembling peptide hydrogel.
Acta biomaterialia.
2018 04; 70(?):110-119. doi:
10.1016/j.actbio.2018.01.031. [PMID: 29410241] - Sheyla V Lucena, Gioconda E D D Moura, Tiago Rodrigues, Carolina M Watashi, Fabiana H Melo, Marcelo Y Icimoto, Gustavo M Viana, Helena B Nader, Hugo P Monteiro, Ivarne L S Tersariol, Fernando T Ogata. Heparan sulfate proteoglycan deficiency up-regulates the intracellular production of nitric oxide in Chinese hamster ovary cell lines.
Journal of cellular physiology.
2018 04; 233(4):3176-3194. doi:
10.1002/jcp.26160. [PMID: 28833096] - Wei Xiao, Jingyuan Xiong, Shuang Zhang, Yang Xiong, Huajin Zhang, Huile Gao. Influence of ligands property and particle size of gold nanoparticles on the protein adsorption and corresponding targeting ability.
International journal of pharmaceutics.
2018 Mar; 538(1-2):105-111. doi:
10.1016/j.ijpharm.2018.01.011. [PMID: 29341915] - Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez. Molecular clutch drives cell response to surface viscosity.
Proceedings of the National Academy of Sciences of the United States of America.
2018 02; 115(6):1192-1197. doi:
10.1073/pnas.1710653115. [PMID: 29358406] - Milad Enferadi, Sheng-Yung Fu, Ji-Hong Hong, Chuan-Jong Tung, Tsi-Chian Chao, Shiaw-Pyng Wey, Chun-Hui Chiu, Chun-Chieh Wang, Mahdi Sadeghi. Radiosensitization of ultrasmall GNP-PEG-cRGDfK in ALTS1C1 exposed to therapeutic protons and kilovoltage and megavoltage photons.
International journal of radiation biology.
2018 02; 94(2):124-136. doi:
10.1080/09553002.2018.1407462. [PMID: 29172866] - Tao Jia, Jungyoon Choi, Jéremy Ciccione, Maxime Henry, Ahmad Mehdi, Jean Martinez, Béatrice Eymin, Gilles Subra, Jean-Luc Coll. Heteromultivalent targeting of integrin αvβ3 and neuropilin 1 promotes cell survival via the activation of the IGF-1/insulin receptors.
Biomaterials.
2018 Feb; 155(?):64-79. doi:
10.1016/j.biomaterials.2017.10.042. [PMID: 29169039] - Shoshiro Yamamoto, Yu Sakurai, Hideyoshi Harashima. Failure of active targeting by a cholesterol-anchored ligand and improvement by altering the lipid composition to prevent ligand desorption.
International journal of pharmaceutics.
2018 Jan; 536(1):42-49. doi:
10.1016/j.ijpharm.2017.11.010. [PMID: 29126905] - Jicai Zhang, Xiang Xiao, Jianming Zhu, Ziyun Gao, Xianliang Lai, Xingen Zhu, Guohua Mao. Lactoferrin- and RGD-comodified, temozolomide and vincristine-coloaded nanostructured lipid carriers for gliomatosis cerebri combination therapy.
International journal of nanomedicine.
2018; 13(?):3039-3051. doi:
10.2147/ijn.s161163. [PMID: 29861635] - Yanping Lu, Shunping Han, Hongyue Zheng, Rui Ma, Yuting Ping, Jiafeng Zou, Hongxia Tang, Yongping Zhang, Xiuling Xu, Fanzhu Li. A novel RGDyC/PEG co-modified PAMAM dendrimer-loaded arsenic trioxide of glioma targeting delivery system.
International journal of nanomedicine.
2018; 13(?):5937-5952. doi:
10.2147/ijn.s175418. [PMID: 30323584] - Zeting Yuan, Yuxia Yuan, Lin Han, Yanyan Qiu, Xiaqin Huang, Feng Gao, Guohua Fan, Yixi Zhang, Xueyao Tang, Xue He, Ke Xu, Peihao Yin. Bufalin-loaded vitamin E succinate-grafted-chitosan oligosaccharide/RGD conjugated TPGS mixed micelles demonstrated improved antitumor activity against drug-resistant colon cancer.
International journal of nanomedicine.
2018; 13(?):7533-7548. doi:
10.2147/ijn.s170692. [PMID: 30532537] - Hong Chen, Huizi Sha, Lianru Zhang, Hanqing Qian, Fangjun Chen, Naiqin Ding, Liulian Ji, Anqing Zhu, Qiuping Xu, Fanyan Meng, Lixia Yu, Yan Zhou, Baorui Liu. Lipid insertion enables targeted functionalization of paclitaxel-loaded erythrocyte membrane nanosystem by tumor-penetrating bispecific recombinant protein.
International journal of nanomedicine.
2018; 13(?):5347-5359. doi:
10.2147/ijn.s165109. [PMID: 30254439] - Hamed Hajipour, Hamed Hamishehkar, Saeed Nazari Soltan Ahmad, Siamak Barghi, Nazila Fathi Maroufi, Ramezan Ali Taheri. Improved anticancer effects of epigallocatechin gallate using RGD-containing nanostructured lipid carriers.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup1):283-292. doi:
10.1080/21691401.2017.1423493. [PMID: 29310467] - Tijia Chen, Ting Gong, Ting Zhao, Yao Fu, Zhirong Zhang, Tao Gong. A comparison study between lycobetaine-loaded nanoemulsion and liposome using nRGD as therapeutic adjuvant for lung cancer therapy.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2018 Jan; 111(?):293-302. doi:
10.1016/j.ejps.2017.09.041. [PMID: 28966099] - Jie Qiu, Guoqiang Cai, Xinmei Liu, Dongwen Ma. αvβ3 integrin receptor specific peptide modified, salvianolic acid B and panax notoginsenoside loaded nanomedicine for the combination therapy of acute myocardial ischemia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):1418-1426. doi:
10.1016/j.biopha.2017.10.086. [PMID: 29079344] - Yu-Chun Hung, Yu-Ju Kuo, Shiang-Suo Huang, Tur-Fu Huang. Trimucrin, an Arg-Gly-Asp containing disintegrin, attenuates myocardial ischemia-reperfusion injury in murine by inhibiting platelet function.
European journal of pharmacology.
2017 Oct; 813(?):24-32. doi:
10.1016/j.ejphar.2017.07.039. [PMID: 28739088] - Seoyoung Son, George J Moroney, Peter J Butler. β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent.
Biophysical journal.
2017 Sep; 113(5):1080-1092. doi:
10.1016/j.bpj.2017.07.010. [PMID: 28877491] - Nicholas Bodenberger, Dennis Kubiczek, Frank Rosenau. Easy Manipulation of Architectures in Protein-based Hydrogels for Cell Culture Applications.
Journal of visualized experiments : JoVE.
2017 08; ?(126):. doi:
10.3791/55813. [PMID: 28809838] - B Feldkoren, R Hutchinson, Y Rapoport, A Mahajan, V Margulis. Integrin signaling potentiates transforming growth factor-beta 1 (TGF-β1) dependent down-regulation of E-Cadherin expression - Important implications for epithelial to mesenchymal transition (EMT) in renal cell carcinoma.
Experimental cell research.
2017 06; 355(2):57-66. doi:
10.1016/j.yexcr.2017.03.051. [PMID: 28363829] - Jamila Hedhli, Andrzej Czerwinski, Matthew Schuelke, Agata Płoska, Paweł Sowinski, Lukas La Hood, Spencer B Mamer, John A Cole, Paulina Czaplewska, Maciej Banach, Iwona T Dobrucki, Leszek Kalinowski, Princess Imoukhuede, Lawrence W Dobrucki. Synthesis, Chemical Characterization and Multiscale Biological Evaluation of a Dimeric-cRGD Peptide for Targeted Imaging of α V β 3 Integrin Activity.
Scientific reports.
2017 06; 7(1):3185. doi:
10.1038/s41598-017-03224-8. [PMID: 28600529] - Tzu-Hung Lin, Rong-Sen Yang, Huang-Ju Tu, Houng-Chi Liou, Yen-Ming Lin, Woie-Jer Chuang, Wen-Mei Fu. Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants.
European journal of pharmacology.
2017 Jun; 804(?):94-101. doi:
10.1016/j.ejphar.2017.03.019. [PMID: 28315346] - Tian Zhang, Preethy Prasad, Ping Cai, Chunsheng He, Dan Shan, Andrew Michael Rauth, Xiao Yu Wu. Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice.
Acta pharmacologica Sinica.
2017 Jun; 38(6):835-847. doi:
10.1038/aps.2016.166. [PMID: 28216624] - Thomas Ebenhan, Isabel Schoeman, Daniel D Rossouw, Anne Grobler, Biljana Marjanovic-Painter, Judith Wagener, Hendrik G Kruger, Mike M Sathekge, Jan Rijn Zeevaart. Evaluation of a Flexible NOTA-RGD Kit Solution Using Gallium-68 from Different 68Ge/68Ga-Generators: Pharmacokinetics and Biodistribution in Nonhuman Primates and Demonstration of Solitary Pulmonary Nodule Imaging in Humans.
Molecular imaging and biology.
2017 06; 19(3):469-482. doi:
10.1007/s11307-016-1014-1. [PMID: 27743211]