2-[(2-Amino-2-oxoethyl)-[2-[(2-amino-2-oxoethyl)-(carboxymethyl)amino]propyl]amino]acetic acid (BioDeep_00000843198)

   


代谢物信息卡片


2-[(2-Amino-2-oxoethyl)-[2-[(2-amino-2-oxoethyl)-(carboxymethyl)amino]propyl]amino]acetic acid

化学式: C11H20N4O6 (304.138278)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CN(CC(=O)N)CC(=O)O)N(CC(=O)N)CC(=O)O
InChI: InChI=1S/C11H20N4O6/c1-7(15(4-9(13)17)6-11(20)21)2-14(3-8(12)16)5-10(18)19/h7H,2-6H2,1H3,(H2,12,16)(H2,13,17)(H,18,19)(H,20,21)

描述信息

同义名列表

1 个代谢物同义名

2-[(2-Amino-2-oxoethyl)-[2-[(2-amino-2-oxoethyl)-(carboxymethyl)amino]propyl]amino]acetic acid



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代谢反应

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Eduard Jirkovský, Anna Jirkovská, Jan Bureš, Jaroslav Chládek, Olga Lenčová, Ján Stariat, Zuzana Pokorná, Galina Karabanovich, Jaroslav Roh, Petra Brázdová, Tomáš Šimůnek, Petra Kovaříková, Martin Štěrba. Pharmacokinetics of the Cardioprotective Drug Dexrazoxane and Its Active Metabolite ADR-925 with Focus on Cardiomyocytes and the Heart. The Journal of pharmacology and experimental therapeutics. 2018 03; 364(3):433-446. doi: 10.1124/jpet.117.244848. [PMID: 29273587]
  • Anna Tycova, Marek Vido, Petra Kovarikova, Frantisek Foret. Interface-free capillary electrophoresis-mass spectrometry system with nanospray ionization-Analysis of dexrazoxane in blood plasma. Journal of chromatography. A. 2016 Sep; 1466(?):173-9. doi: 10.1016/j.chroma.2016.08.042. [PMID: 27613146]
  • Petra Kovarikova, Ivana Pasakova-Vrbatova, Anna Vavrova, Jan Stariat, Jiri Klimes, Tomas Simunek. Development of LC-MS/MS method for the simultaneous analysis of the cardioprotective drug dexrazoxane and its metabolite ADR-925 in isolated cardiomyocytes and cell culture medium. Journal of pharmaceutical and biomedical analysis. 2013 Mar; 76(?):243-51. doi: 10.1016/j.jpba.2012.12.024. [PMID: 23339990]
  • Patricia E Schroeder, Brian B Hasinoff. Metabolism of the one-ring open metabolites of the cardioprotective drug dexrazoxane to its active metal-chelating form in the rat. Drug metabolism and disposition: the biological fate of chemicals. 2005 Sep; 33(9):1367-72. doi: 10.1124/dmd.105.005546. [PMID: 15980099]
  • Patricia E Schroeder, Peter Buhl Jensen, Maxwell Sehested, Kenneth Francis Hofland, Seppo W Langer, Brian B Hasinoff. Metabolism of dexrazoxane (ICRF-187) used as a rescue agent in cancer patients treated with high-dose etoposide. Cancer chemotherapy and pharmacology. 2003 Aug; 52(2):167-74. doi: 10.1007/s00280-003-0619-7. [PMID: 12750840]
  • Patricia E Schroeder, Brian B Hasinoff. The doxorubicin-cardioprotective drug dexrazoxane undergoes metabolism in the rat to its metal ion-chelating form ADR-925. Cancer chemotherapy and pharmacology. 2002 Dec; 50(6):509-13. doi: 10.1007/s00280-002-0538-z. [PMID: 12451479]
  • J Cole, D Ertoy, H Lin, R L Sutliff, E Ezan, T T Guyene, M Capecchi, P Corvol, K E Bernstein. Lack of angiotensin II-facilitated erythropoiesis causes anemia in angiotensin-converting enzyme-deficient mice. The Journal of clinical investigation. 2000 Dec; 106(11):1391-8. doi: 10.1172/jci10557. [PMID: 11104792]
  • S Vaidyanathan, M Boroujerdi. Interaction of dexrazoxane with red blood cells and hemoglobin alters pharmacokinetics of doxorubicin. Cancer chemotherapy and pharmacology. 2000; 46(2):93-100. doi: 10.1007/s002800000122. [PMID: 10972478]
  • B B Hasinoff. Quantitation of the dexrazoxane hydrolysis product ADR-925 by fluorescence detection of its terbium(III) complex after high-performance liquid chromatographic separation. Journal of chromatography. B, Biomedical applications. 1994 Jun; 656(2):451-5. doi: 10.1016/s0378-4347(94)80108-8. [PMID: 7987502]
  • C Thomas, G F Vile, C C Winterbourn. The hydrolysis product of ICRF-187 promotes iron-catalysed hydroxyl radical production via the Fenton reaction. Biochemical pharmacology. 1993 May; 45(10):1967-72. doi: 10.1016/0006-2952(93)90005-h. [PMID: 8390256]
  • T P Ryan, V M Samokyszyn, S Dellis, S D Aust. Effects of (+)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (ADR-529) on iron-catalyzed lipid peroxidation. Chemical research in toxicology. 1990 Jul; 3(4):384-90. doi: 10.1021/tx00016a018. [PMID: 1966787]
  • G F Vile, C C Winterbourn. dl-N,N'-dicarboxamidomethyl-N,N'-dicarboxymethyl-1,2-diaminopropane (ICRF-198) and d-1,2-bis(3,5-dioxopiperazine-1-yl)propane (ICRF-187) inhibition of Fe3+ reduction, lipid peroxidation, and CaATPase inactivation in heart microsomes exposed to adriamycin. Cancer research. 1990 Apr; 50(8):2307-10. doi: ". [PMID: 2156615]