Pivaloyl carnitine (BioDeep_00000843085)
代谢物信息卡片
Pivaloyl carnitine
化学式: C12H24NO4+ (246.17052439999998)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)C(=O)OC(CC(=O)O)C[N+](C)(C)C
InChI: InChI=1S/C12H23NO4/c1-12(2,3)11(16)17-9(7-10(14)15)8-13(4,5)6/h9H,7-8H2,1-6H3/p+1
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sabrina Forni, Xiaowei Fu, Susan E Palmer, Lawrence Sweetman. Rapid determination of C4-acylcarnitine and C5-acylcarnitine isomers in plasma and dried blood spots by UPLC-MS/MS as a second tier test following flow-injection MS/MS acylcarnitine profile analysis.
Molecular genetics and metabolism.
2010 Sep; 101(1):25-32. doi:
10.1016/j.ymgme.2010.05.012. [PMID: 20591710] - Yoko Nakajima, Tetsuya Ito, Yasuhiro Maeda, Sayaka Ichiki, Naruji Sugiyama, Mihoko Mizuno, Yasuko Makino, Tokio Sugiura, Yukihisa Kurono, Hajime Togari. Detection of pivaloylcarnitine in pediatric patients with hypocarnitinemia after long-term administration of pivalate-containing antibiotics.
The Tohoku journal of experimental medicine.
2010 Aug; 221(4):309-13. doi:
10.1620/tjem.221.309. [PMID: 20651467] - Liliane Todesco, Michael Bodmer, Karin Vonwil, Daniel Häussinger, Stephan Krähenbühl. Interaction between pivaloylcarnitine and L-carnitine transport into L6 cells overexpressing hOCTN2.
Chemico-biological interactions.
2009 Aug; 180(3):472-7. doi:
10.1016/j.cbi.2009.02.014. [PMID: 19539806] - Shuichi Ohnishi, Noboru Okamura, Shingo Sakamoto, Hiroshi Hasegawa, Ryo Norikura, Eri Kanaoka, Kouji Takahashi, Kazutoshi Horie, Kiyoshi Sakamoto, Takahiko Baba. Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment.
Drug metabolism and pharmacokinetics.
2008; 23(4):293-303. doi:
10.2133/dmpk.23.293. [PMID: 18762717] - Noboru Okamura, Shuichi Ohnishi, Hiroyuki Shimaoka, Ryo Norikura, Hiroshi Hasegawa. Involvement of recognition and interaction of carnitine transporter in the decrease of L-carnitine concentration induced by pivalic acid and valproic acid.
Pharmaceutical research.
2006 Aug; 23(8):1729-35. doi:
10.1007/s11095-006-9002-9. [PMID: 16826461] - Toshiro Yamaguchi, Yoshitsugu Nakajima, Yutaka Nakamura. Possible mechanism for species difference on the toxicity of pivalic acid between dogs and rats.
Toxicology and applied pharmacology.
2006 Jul; 214(1):61-8. doi:
10.1016/j.taap.2005.11.013. [PMID: 16430936] - Tom L Broderick. Hypocarnitinaemia induced by sodium pivalate in the rat is associated with left ventricular dysfunction and impaired energy metabolism.
Drugs in R&D.
2006; 7(3):153-61. doi:
10.2165/00126839-200607030-00002. [PMID: 16752941] - Charles A Stanley. Carnitine deficiency disorders in children.
Annals of the New York Academy of Sciences.
2004 Nov; 1033(?):42-51. doi:
10.1196/annals.1320.004. [PMID: 15591002] - Eric P Brass, Michael D Mayer, Darcy J Mulford, Therese K Stickler, Charles L Hoppel. Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil.
Clinical pharmacology and therapeutics.
2003 Apr; 73(4):338-47. doi:
10.1016/s0009-9236(02)17636-3. [PMID: 12709724] - Eric P Brass. Pivalate-generating prodrugs and carnitine homeostasis in man.
Pharmacological reviews.
2002 Dec; 54(4):589-98. doi:
10.1124/pr.54.4.589. [PMID: 12429869] - K Totsuka, K Shimizu, N Mori, T Sugihara, A Sakai, S Yamaji, Y Michisuji, Y Shinohara, A Kubo, H Tokuoka. Effect of antacid pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic--comparison with cefteram-pivoxil.
International journal of antimicrobial agents.
2001 Nov; 18(5):477-82. doi:
10.1016/s0924-8579(01)00445-9. [PMID: 11711264] - A Yanagawa, J Shimada, N Mori, T Sugihara, A Sakai, S Yamaji, K Yano, T Kitamura, T Kano. Effects of gastrointestinal stimulant and suppressant pretreatment on the pharmacokinetics of AS-924, a novel ester-type cephem antibiotic.
International journal of antimicrobial agents.
2001 Nov; 18(5):483-7. doi:
10.1016/s0924-8579(01)00442-3. [PMID: 11711265] - N Okudaira, M Fujigaki, T Nakayoshi, I Komiya, Y Sugiyama. Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid.
Pharmaceutical research.
2001 Apr; 18(4):439-45. doi:
10.1023/a:1011042008169. [PMID: 11451029]