2-[[2-[[4-Amino-2-[[2-[[2-[[2-[[2-(2-aminopropanoylamino)-3-hydroxypropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-hydroxybutanoic acid (BioDeep_00000843059)
代谢物信息卡片
化学式: C35H55N9O16 (857.3766589999999)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C(=O)NC(C(C)O)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CO)NC(=O)C(C)N)O
InChI: InChI=1S/C35H55N9O16/c1-13(36)28(52)40-22(12-45)31(55)41-25(15(3)47)33(57)43-26(16(4)48)34(58)42-24(14(2)46)32(56)39-21(11-23(37)51)29(53)38-20(10-18-6-8-19(50)9-7-18)30(54)44-27(17(5)49)35(59)60/h6-9,13-17,20-22,24-27,45-50H,10-12,36H2,1-5H3,(H2,37,51)(H,38,53)(H,39,56)(H,40,52)(H,41,55)(H,42,58)(H,43,57)(H,44,54)(H,59,60)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Angelina R Sekirnik, Jessica K Reynolds, Larissa See, Joseph P Bluck, Amy R Scorah, Cynthia Tallant, Bernadette Lee, Katarzyna B Leszczynska, Rachel L Grimley, R Ian Storer, Marta Malattia, Sara Crespillo, Sofia Caria, Stephanie Duclos, Ester M Hammond, Stefan Knapp, Garrett M Morris, Fernanda Duarte, Philip C Biggin, Stuart J Conway. Identification of Histone Peptide Binding Specificity and Small-Molecule Ligands for the TRIM33α and TRIM33β Bromodomains.
ACS chemical biology.
2022 10; 17(10):2753-2768. doi:
10.1021/acschembio.2c00266
. [PMID: 36098557] - Yongwei Gu, Xinmei Chen, Haiyan Zhang, Heyi Wang, Hang Chen, Sifan Huang, Youfa Xu, Yuansheng Zhang, Xin Wu, Jianming Chen. Study on the cellular internalization mechanisms and in vivo anti-bone metastasis prostate cancer efficiency of the peptide T7-modified polypeptide nanoparticles.
Drug delivery.
2020 Dec; 27(1):161-169. doi:
10.1080/10717544.2019.1709923
. [PMID: 31913730] - Karl Goodkin, Benedetto Vitiello, William D Lyman, Deshratn Asthana, J Hampton Atkinson, Peter N R Heseltine, Rebeca Molina, Wenli Zheng, Imad Khamis, Frances L Wilkie, Paul Shapshak. Cerebrospinal and peripheral human immunodeficiency virus type 1 load in a multisite, randomized, double-blind, placebo-controlled trial of D-Ala1-peptide T-amide for HIV-1-associated cognitive-motor impairment.
Journal of neurovirology.
2006 Jun; 12(3):178-89. doi:
10.1080/13550280600827344
. [PMID: 16877299] - Maria T Polianova, Francis W Ruscetti, Candace B Pert, Rochelle E Tractenberg, Gifford Leoung, Scott Strang, Michael R Ruff. Antiviral and immunological benefits in HIV patients receiving intranasal peptide T (DAPTA).
Peptides.
2003 Jul; 24(7):1093-8. doi:
10.1016/s0196-9781(03)00176-1
. [PMID: 14499289] - Michael R Ruff, Maria Polianova, Quan-en Yang, Gifford S Leoung, Francis W Ruscetti, Candace B Pert. Update on D-ala-peptide T-amide (DAPTA): a viral entry inhibitor that blocks CCR5 chemokine receptors.
Current HIV research.
2003 Jan; 1(1):51-67. doi:
10.2174/1570162033352066
. [PMID: 15043212] - M A Bagger, H W Nielsen, E Bechgaard. Nasal bioavailability of peptide T in rabbits: absorption enhancement by sodium glycocholate and glycofurol.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2001 Aug; 14(1):69-74. doi:
10.1016/s0928-0987(01)00146-4
. [PMID: 11457652] - S Manfredini, Marastoni-M, R Tomatis, E Durini, S Spisani, A Pani, T Marceddu, C Musiu, M E Marongiu, P La Colla. Peptide T-araC conjugates: solid-phase synthesis and biological activity of N4-(acylpeptidyl)-araC.
Bioorganic & medicinal chemistry.
2000 Mar; 8(3):539-47. doi:
10.1016/s0968-0896(99)00317-x
. [PMID: 10732970] - J Kim, M Ruff, E Karwatowska-Prokopczuk, L Hunt, H Ji, C B Pert, Z Zukowska-Grojec. HIV envelope protein gp120 induces neuropeptide Y receptor-mediated proliferation of vascular smooth muscle cells: relevance to AIDS cardiovascular pathogenesis.
Regulatory peptides.
1998 Sep; 75-76(?):201-5. doi:
10.1016/s0167-0115(98)00069-x
. [PMID: 9802410] - C Wen, D T Liu, M Li, J Michaelis, G W Grigg, J A Whitworth. Hypotensive effects of peptide T in conscious rats.
Clinical and experimental pharmacology & physiology.
1997 Sep; 24(9-10):727-9. doi:
10.1111/j.1440-1681.1997.tb02120.x
. [PMID: 9315377] - E Bechgaard, M Bagger, R Larsen, H W Nielsen. High-performance liquid chromatographic analysis of Peptide T in rabbit plasma with on-line column enrichment.
Journal of chromatography. B, Biomedical sciences and applications.
1997 May; 693(1):237-40. doi:
10.1016/s0378-4347(96)00537-3
. [PMID: 9200542] - K V Prammer, L Otvos. Structural effects of glycosylation on the C-terminal pentapeptide of peptide T.
Biomedical peptides, proteins & nucleic acids : structure, synthesis & biological activity.
1995; 1(4):221-6. doi:
NULL
. [PMID: 9346835] - M Marastoni, S Salvadori, V Scaranari, S Spisani, E Reali, S Traniello, A Tomatis. Synthesis and activity of new linear and cyclic peptide T derivatives.
Arzneimittel-Forschung.
1994 Sep; 44(9):1073-6. doi:
NULL
. [PMID: 7986247] - M Marastoni, S Spisani, R Tomatis. Synthesis and biological activity of D-glucopyranosyl peptide T derivatives.
Arzneimittel-Forschung.
1994 Aug; 44(8):984-7. doi:
NULL
. [PMID: 7945547] - L A Ferreira, E W Alves, O B Henriques. Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom.
Toxicon : official journal of the International Society on Toxinology.
1993 Aug; 31(8):941-7. doi:
10.1016/0041-0101(93)90253-f
. [PMID: 8212046] - M Marastoni, S Salvadori, G Balboni, V Scaranari, S Spisani, E Reali, S Traniello, R Tomatis. Structure-activity relationships of cyclic and linear peptide T analogues.
International journal of peptide and protein research.
1993 May; 41(5):447-54. doi:
10.1111/j.1399-3011.1993.tb00464.x
. [PMID: 8320038] - J T Fisher, J W Anderson, M A Waldron. Nonadrenergic noncholinergic neurotransmitter of feline trachealis: VIP or nitric oxide?.
Journal of applied physiology (Bethesda, Md. : 1985).
1993 Jan; 74(1):31-9. doi:
10.1152/jappl.1993.74.1.31
. [PMID: 7680336] - L Bondesson, K Norolind, S Lidén, G Gafvelin, E Theodorsson, V Mutt. Dual effects of vasoactive intestinal peptide (VIP) on leucocyte migration.
Acta physiologica Scandinavica.
1991 Apr; 141(4):477-81. doi:
10.1111/j.1748-1716.1991.tb09108.x
. [PMID: 1877347] - M R Ruff, C Smith, T Kingan, H Jaffe, P Heseltine, M A Gill, K Mayer, C B Pert, T P Bridge. Pharmacokinetics of peptide T in patients with acquired immunodeficiency syndrome (AIDS).
Progress in neuro-psychopharmacology & biological psychiatry.
1991; 15(6):791-801. doi:
10.1016/0278-5846(91)90008-o
. [PMID: 1763193] - M Marastoni, S Salvadori, G Balboni, S Spisani, R Gavioli, S Traniello, R Tomatis. Synthesis, metabolic stability and chemotactic activity of peptide T and its analogues.
International journal of peptide and protein research.
1990 Feb; 35(2):81-8. doi:
10.1111/j.1399-3011.1990.tb00239.x
. [PMID: 2323889] - P A Baron, B Polsky, J W Gold, E E Zuckerman, W D Hardy, W Meyer-Glauner, D Armstrong. Peptide T does not inhibit HIV-1 infection in an in vitro serum-free system.
AIDS (London, England).
1988 Jun; 2(3):227-8. doi:
NULL
. [PMID: 3134920] - T D Nguyen. Peptide T from human immunodeficiency virus envelope does not interact with hepatic, intestinal and colonic vasoactive intestinal peptide (VIP) receptors.
Peptides.
1988 Mar; 9(2):425-8. doi:
10.1016/0196-9781(88)90279-3
. [PMID: 2836827] - C M Barrera, A J Kastin, W A Banks. D-[Ala1]-peptide T-amide is transported from blood to brain by a saturable system.
Brain research bulletin.
1987 Dec; 19(6):629-33. doi:
10.1016/0361-9230(87)90048-7
. [PMID: 3440215] - A Puigvert, D Ruano. [Etiopathogenesis of so-called congenital hydronephrosis].
Journal d'urologie et de nephrologie.
1979 Jan; 85(1-2):1-12. doi:
NULL
. [PMID: 439196] - D Trunkey, J Holcroft, M A Carpenter. Monitoring resuscitation of primates from hemorrhagic and septic shock.
JACEP.
1976 Apr; 5(4):249-52. doi:
10.1016/s0361-1124(76)80002-0
. [PMID: 6816]