p-Hydroxy-p-methylphenytoin (BioDeep_00000843046)
代谢物信息卡片
化学式: C15H12N2O3 (268.0847882)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)C2(C(=O)N(C(=O)N2)O)C3=CC=CC=C3
InChI: InChI=1S/C15H12N2O3/c18-13-15(16-14(19)17(13)20,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10,20H,(H,16,19)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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BioCyc(0)
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Plant Reactome(0)
INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Tobias Klaassen, Alexander Jetter, Dorota Tomalik-Scharte, Dirk Kasel, Julia Kirchheiner, Ulrich Jaehde, Uwe Fuhr. Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity.
European journal of clinical pharmacology.
2008 Apr; 64(4):387-98. doi:
10.1007/s00228-007-0416-z
. [PMID: 18071681] - Upendra A Argikar, James C Cloyd, Angela K Birnbaum, Ilo E Leppik, Jeannine Conway, Smita Kshirsagar, William S Oetting, Erin C Klein, Rory P Remmel. Paradoxical urinary phenytoin metabolite (S)/(R) ratios in CYP2C19*1/*2 patients.
Epilepsy research.
2006 Sep; 71(1):54-63. doi:
10.1016/j.eplepsyres.2006.05.015
. [PMID: 16815679] - Aurel C Allabi, Jean-Luc Gala, Yves Horsmans. CYP2C9, CYP2C19, ABCB1 (MDR1) genetic polymorphisms and phenytoin metabolism in a Black Beninese population.
Pharmacogenetics and genomics.
2005 Nov; 15(11):779-86. doi:
10.1097/01.fpc.0000174787.92861.91
. [PMID: 16220110] - Hiroyuki Yamanaka, Miki Nakajima, Yusuke Hara, Miki Katoh, Osamu Tachibana, Junkoh Yamashita, Tsuyoshi Yokoi. Urinary excretion of phenytoin metabolites, 5-(4'-hydroxyphenyl)-5-phenylhydantoin and its O-glucuronide in humans and analysis of genetic polymorphisms of UDP-glucuronosyltransferases.
Drug metabolism and pharmacokinetics.
2005 Apr; 20(2):135-43. doi:
10.2133/dmpk.20.135
. [PMID: 15855726] - William L Roberts, Petrie M Rainey. Phenytoin overview--metabolite interference in some immunoassays could be clinically important.
Archives of pathology & laboratory medicine.
2004 Jul; 128(7):734; author reply 734-5. doi:
10.5858/2004-128-735-ir
. [PMID: 15229987] - Miki Nakajima, Nozomi Sakata, Noriko Ohashi, Toshiyuki Kume, Tsuyoshi Yokoi. Involvement of multiple UDP-glucuronosyltransferase 1A isoforms in glucuronidation of 5-(4'-hydroxyphenyl)-5-phenylhydantoin in human liver microsomes.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Nov; 30(11):1250-6. doi:
10.1124/dmd.30.11.1250
. [PMID: 12386132] - Cuyue Tang, Yuh Lin, A David Rodrigues, Jiunn H Lin. Effect of albumin on phenytoin and tolbutamide metabolism in human liver microsomes: an impact more than protein binding.
Drug metabolism and disposition: the biological fate of chemicals.
2002 Jun; 30(6):648-54. doi:
10.1124/dmd.30.6.648
. [PMID: 12019190] - Y Caraco, M Muszkat, A J Wood. Phenytoin metabolic ratio: a putative marker of CYP2C9 activity in vivo.
Pharmacogenetics.
2001 Oct; 11(7):587-96. doi:
10.1097/00008571-200110000-00005
. [PMID: 11668218]