2-hydroxyethyl 12-hydroxyoctadecanoate (BioDeep_00000842973)
代谢物信息卡片
2-hydroxyethyl 12-hydroxyoctadecanoate
化学式: C20H40O4 (344.29264400000005)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCC(CCCCCCCCCCC(=O)OCCO)O
InChI: InChI=1S/C20H40O4/c1-2-3-4-11-14-19(22)15-12-9-7-5-6-8-10-13-16-20(23)24-18-17-21/h19,21-22H,2-18H2,1H3
描述信息
D013501 - Surface-Active Agents > D011092 - Polyethylene Glycols
D001697 - Biomedical and Dental Materials
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:177412
- ChEBI: CHEBI:9194
- PubChem: 124898
- CAS: 105109-85-1
- CAS: 61909-81-7
- CAS: 6284-41-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuna Zhang, Ying Wang, Jiaojiao Shan, Xueju Qi, Qun Liu. Improved Bioavailability and Hepatoprotective Activity of Baicalein Via a Self-assembled Solutol HS15 Micelles System.
Current drug delivery.
2023 Jun; ?(?):. doi:
10.2174/1567201820666230606163452. [PMID: 37282637] - Marina Raju, Shalvi Sinai Kunde, Sandip T Auti, Yogesh A Kulkarni, Sarika Wairkar. Berberine loaded nanostructured lipid carrier for Alzheimer's disease: Design, statistical optimization and enhanced in vivo performance.
Life sciences.
2021 Nov; 285(?):119990. doi:
10.1016/j.lfs.2021.119990. [PMID: 34592234] - Baoyu Liu, Wei Gao, Hui Wu, Hong Liu, Hongchun Pan. New PTX-HS15/T80 Mixed Micelles: Cytotoxicity, Pharmacokinetics and Tissue Distribution.
AAPS PharmSciTech.
2021 Jan; 22(2):56. doi:
10.1208/s12249-021-01929-8. [PMID: 33486601] - Maria Camilla Bergonzi, Marzia Vasarri, Giulia Marroncini, Emanuela Barletta, Donatella Degl'Innocenti. Thymoquinone-Loaded Soluplus®-Solutol® HS15 Mixed Micelles: Preparation, In Vitro Characterization, and Effect on the SH-SY5Y Cell Migration.
Molecules (Basel, Switzerland).
2020 Oct; 25(20):. doi:
10.3390/molecules25204707. [PMID: 33066549] - Yongshun Sun, Yiping Li, Ying Shen, Jian Wang, Jian Tang, Zhiying Zhao. Enhanced oral delivery and anti-gastroesophageal reflux activity of curcumin by binary mixed micelles.
Drug development and industrial pharmacy.
2019 Sep; 45(9):1444-1450. doi:
10.1080/03639045.2019.1628041. [PMID: 31170849] - Hongxue Shen, Yi Liu, Huanhuan Zhang, Pinggang Ding, Lan Zhang, Liefeng Zhang, Jianming Ju. Enhancing the oral bioavailability of baicalein via Solutol® HS15 and Poloxamer 188 mixed micelles system.
The Journal of pharmacy and pharmacology.
2019 May; 71(5):765-773. doi:
10.1111/jphp.13058. [PMID: 30549042] - Pinggang Ding, Yuxuan Chen, Guangshang Cao, Hongxue Shen, Jianming Ju, Weiguang Li. Solutol®HS15+pluronicF127 and Solutol®HS15+pluronicL61 mixed micelle systems for oral delivery of genistein.
Drug design, development and therapy.
2019; 13(?):1947-1956. doi:
10.2147/dddt.s201453. [PMID: 31239645] - Yawen Li, Angelina Angelova, Jianwen Liu, Vasil M Garamus, Na Li, Markus Drechsler, Yabin Gong, Aihua Zou. In situ phase transition of microemulsions for parenteral injection yielding lyotropic liquid crystalline carriers of the antitumor drug bufalin.
Colloids and surfaces. B, Biointerfaces.
2019 Jan; 173(?):217-225. doi:
10.1016/j.colsurfb.2018.09.023. [PMID: 30296646] - Qingqing Zhai, Hailong Li, Yanlin Song, Ruijiao Wu, Chuanfang Tang, Xiaodong Ma, Zhihao Liu, Jinyong Peng, Jianbin Zhang, Zeyao Tang. Preparation and Optimization Lipid Nanocapsules to Enhance the Antitumor Efficacy of Cisplatin in Hepatocellular Carcinoma HepG2 Cells.
AAPS PharmSciTech.
2018 Jul; 19(5):2048-2057. doi:
10.1208/s12249-018-1011-6. [PMID: 29679292] - Rania A H Ishak, Nada M Mostafa, Amany O Kamel. Stealth lipid polymer hybrid nanoparticles loaded with rutin for effective brain delivery - comparative study with the gold standard (Tween 80): optimization, characterization and biodistribution.
Drug delivery.
2017 Nov; 24(1):1874-1890. doi:
10.1080/10717544.2017.1410263. [PMID: 29191047] - Gaël Le Roux, Hélène Moche, Alejandro Nieto, Jean-Pierre Benoit, Fabrice Nesslany, Frédéric Lagarce. Cytotoxicity and genotoxicity of lipid nanocapsules.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Jun; 41(?):189-199. doi:
10.1016/j.tiv.2017.03.007. [PMID: 28323104] - Hong-Mei Yan, Jie Song, Zhen-Hai Zhang, Xiao-Bin Jia. Optimization and anticancer activity in vitro and in vivo of baohuoside I incorporated into mixed micelles based on lecithin and Solutol HS 15.
Drug delivery.
2016 Oct; 23(8):2911-2918. doi:
10.3109/10717544.2015.1120365. [PMID: 26644047] - José Carlos Rittes, Guilherme Cagno, Marcelo Vaz Perez, Ligia Andrade da Silva Telles Mathias. Comparative evaluation of propofol in nanoemulsion with solutol and soy lecithin for general anesthesia.
Brazilian journal of anesthesiology (Elsevier).
2016 May; 66(3):225-30. doi:
10.1016/j.bjane.2013.03.026. [PMID: 27108816] - Gabriela Hädrich, Samantha Oliveira Monteiro, Marisa Raquel Rodrigues, Vânia Rodrigues de Lima, Jean-Luc Putaux, Juliana Bidone, Helder Ferreira Teixeira, Ana Luiza Muccillo-Baisch, Cristiana Lima Dora. Lipid-based nanocarrier for quercetin delivery: system characterization and molecular interactions studies.
Drug development and industrial pharmacy.
2016; 42(7):1165-73. doi:
10.3109/03639045.2015.1118491. [PMID: 26571009] - Sylvain Chauvet, Alexandre Barras, Rabah Boukherroub, Alexandre Bouron. Lipid nanocapsules containing the non-ionic surfactant Solutol HS15 inhibit the transport of calcium through hyperforin-activated channels in neuronal cells.
Neuropharmacology.
2015 Dec; 99(?):726-34. doi:
10.1016/j.neuropharm.2015.08.043. [PMID: 26341818] - Anita Umerska, Celia R A Mouzouvi, André Bigot, Patrick Saulnier. Formulation and nebulization of fluticasone propionate-loaded lipid nanocarriers.
International journal of pharmaceutics.
2015 Sep; 493(1-2):224-32. doi:
10.1016/j.ijpharm.2015.07.008. [PMID: 26183331] - Wei Meng Lim, Paruvathanahalli Siddalingam Rajinikanth, Chitneni Mallikarjun, Yew Beng Kang. Formulation and delivery of itraconazole to the brain using a nanolipid carrier system.
International journal of nanomedicine.
2014; 9(?):2117-26. doi:
10.2147/ijn.s57565. [PMID: 24833900] - Christoph Luschmann, Joerg Tessmar, Simon Schoeberl, Olaf Strauss, Carsten Framme, Karl Luschmann, Achim Goepferich. Developing an in situ nanosuspension: a novel approach towards the efficient administration of poorly soluble drugs at the anterior eye.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2013 Nov; 50(3-4):385-92. doi:
10.1016/j.ejps.2013.07.002. [PMID: 23880334] - Deiry Marín-Quintero, Francisco Fernández-Campos, Ana C Calpena-Campmany, María J Montes-López, Beatriz Clares-Naveros, Alfonso Del Pozo-Carrascosa. Formulation design and optimization for the improvement of nystatin-loaded lipid intravenous emulsion.
Journal of pharmaceutical sciences.
2013 Nov; 102(11):4015-23. doi:
10.1002/jps.23711. [PMID: 23970386] - Nasim Heshmati, Xinlai Cheng, Gerhard Eisenbrand, Gert Fricker. Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats.
Journal of pharmaceutical sciences.
2013 Oct; 102(10):3792-9. doi:
10.1002/jps.23696. [PMID: 23934779] - A Griveau, J Bejaud, S Anthiya, S Avril, D Autret, E Garcion. Silencing of miR-21 by locked nucleic acid-lipid nanocapsule complexes sensitize human glioblastoma cells to radiation-induced cell death.
International journal of pharmaceutics.
2013 Oct; 454(2):765-74. doi:
10.1016/j.ijpharm.2013.05.049. [PMID: 23732394] - Wenji Zhang, Xuedong Li, Tiantian Ye, Fen Chen, Xiao Sun, Jun Kong, Xinggang Yang, Weisan Pan, Sanming Li. Design, characterization, and in vitro cellular inhibition and uptake of optimized genistein-loaded NLC for the prevention of posterior capsular opacification using response surface methodology.
International journal of pharmaceutics.
2013 Sep; 454(1):354-66. doi:
10.1016/j.ijpharm.2013.07.032. [PMID: 23876384] - Zhiwen Zhang, Fang Gao, Shijun Jiang, Lingli Chen, Zeying Liu, Haijun Yu, Yaping Li. Bile salts enhance the intestinal absorption of lipophilic drug loaded lipid nanocarriers: mechanism and effect in rats.
International journal of pharmaceutics.
2013 Aug; 452(1-2):374-81. doi:
10.1016/j.ijpharm.2013.05.021. [PMID: 23694804] - Marietta von Suesskind-Schwendi, Michael Gruber, Didier Touraud, Werner Kunz, Christof Schmid, Stephan W Hirt, Karla Lehle. Pharmacokinetics of a self-microemulsifying drug delivery system of tacrolimus.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2013 Jul; 67(6):469-73. doi:
10.1016/j.biopha.2013.04.001. [PMID: 23669280] - Alan H Stokes, Daniel C Kemp, Brenda Faiola, Holly L Jordan, Christine L Merrill, James R Hailey, Randy E Brown, David W Bailey. Effects of Solutol (Kolliphor) and cremophor in polyethylene glycol 400 vehicle formulations in Sprague-Dawley rats and beagle dogs.
International journal of toxicology.
2013 May; 32(3):189-97. doi:
10.1177/1091581813485452. [PMID: 23616145] - Anett Engel, Stefan Oswald, Werner Siegmund, Markus Keiser. Pharmaceutical excipients influence the function of human uptake transporting proteins.
Molecular pharmaceutics.
2012 Sep; 9(9):2577-81. doi:
10.1021/mp3001815. [PMID: 22808947] - Yuan Gao, Li Li, Jianjun Zhang, Feng Su, Zhenhua Gong, Yisheng Lai, Yihua Zhang. Physicochemical characterization and an injection formulation study of water insoluble ZCVI₄-2, a novel NO-donor anticancer compound.
Archives of pharmacal research.
2012 Jul; 35(7):1177-86. doi:
10.1007/s12272-012-0708-4. [PMID: 22864740] - Thiago Alves Rodrigues, Ricardo Andrade Alexandrino, Marcelo Epstein Kanczuk, Judymara Lauzi Gozzani, Ligia Andrade da Silva Telles Mathias. A comparative study of non-lipid nanoemulsion of propofol with solutol and propofol emulsion with lecithin.
Revista brasileira de anestesiologia.
2012 May; 62(3):325-34. doi:
10.1016/s0034-7094(12)70133-2. [PMID: 22656678] - Ngoc Trinh Huynh, Catherine Passirani, Emilie Allard-Vannier, Laurent Lemaire, Jerome Roux, Emmanuel Garcion, Anne Vessieres, Jean-Pierre Benoit. Administration-dependent efficacy of ferrociphenol lipid nanocapsules for the treatment of intracranial 9L rat gliosarcoma.
International journal of pharmaceutics.
2012 Feb; 423(1):55-62. doi:
10.1016/j.ijpharm.2011.04.037. [PMID: 21536115] - Mathilde Roger, Anne Clavreul, Ngoc Trinh Huynh, Catherine Passirani, Paul Schiller, Anne Vessières, Claudia Montero-Menei, Philippe Menei. Ferrociphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy.
International journal of pharmaceutics.
2012 Feb; 423(1):63-8. doi:
10.1016/j.ijpharm.2011.04.058. [PMID: 21554935] - Stephanie David, Nathalie Carmoy, Pauline Resnier, Caroline Denis, Laurent Misery, Bruno Pitard, Jean-Pierre Benoit, Catherine Passirani, Tristan Montier. In vivo imaging of DNA lipid nanocapsules after systemic administration in a melanoma mouse model.
International journal of pharmaceutics.
2012 Feb; 423(1):108-15. doi:
10.1016/j.ijpharm.2011.06.031. [PMID: 21726617] - E Bourseau-Guilmain, J Béjaud, A Griveau, N Lautram, F Hindré, M Weyland, J P Benoit, E Garcion. Development and characterization of immuno-nanocarriers targeting the cancer stem cell marker AC133.
International journal of pharmaceutics.
2012 Feb; 423(1):93-101. doi:
10.1016/j.ijpharm.2011.06.001. [PMID: 21683129] - Mona M A Abdel-Mottaleb, Dirk Neumann, Alf Lamprecht. Lipid nanocapsules for dermal application: a comparative study of lipid-based versus polymer-based nanocarriers.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2011 Sep; 79(1):36-42. doi:
10.1016/j.ejpb.2011.04.009. [PMID: 21558002] - Ya Zhang, Weikai Zhang, Marian Löbler, Klaus-Peter Schmitz, Patrick Saulnier, Thomas Perrier, Ilmari Pyykkö, Jing Zou. Inner ear biocompatibility of lipid nanocapsules after round window membrane application.
International journal of pharmaceutics.
2011 Feb; 404(1-2):211-9. doi:
10.1016/j.ijpharm.2010.11.006. [PMID: 21075187] - Rui Liu, Zhidong Liu, Lexin Shu, Chengui Zhang, Boli Zhang. [Effect of three penetration enhancers on corneal permeability of mangiferin in vitro].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Dec; 35(23):3131-5. doi:
10.4268/cjcmm20102308. [PMID: 21355232] - Thomas Perrier, Patrick Saulnier, Florian Fouchet, Nolwenn Lautram, Jean-Pierre Benoît. Post-insertion into Lipid NanoCapsules (LNCs): From experimental aspects to mechanisms.
International journal of pharmaceutics.
2010 Aug; 396(1-2):204-9. doi:
10.1016/j.ijpharm.2010.06.019. [PMID: 20600733] - Arnaud Vonarbourg, Catherine Passirani, Léa Desigaux, Emilie Allard, Patrick Saulnier, Olivier Lambert, Jean-Pierre Benoit, Bruno Pitard. The encapsulation of DNA molecules within biomimetic lipid nanocapsules.
Biomaterials.
2009 Jun; 30(18):3197-204. doi:
10.1016/j.biomaterials.2009.03.009. [PMID: 19329183] - Nicolas Anton, Pascal Gayet, Jean-Pierre Benoit, Patrick Saulnier. Nano-emulsions and nanocapsules by the PIT method: an investigation on the role of the temperature cycling on the emulsion phase inversion.
International journal of pharmaceutics.
2007 Nov; 344(1-2):44-52. doi:
10.1016/j.ijpharm.2007.04.027. [PMID: 17592746] - Ahmed Abdalla, Karsten Mäder. Preparation and characterization of a self-emulsifying pellet formulation.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2007 May; 66(2):220-6. doi:
10.1016/j.ejpb.2006.11.015. [PMID: 17196807] - A Malzert-Fréon, S Vrignaud, P Saulnier, V Lisowski, J P Benoît, S Rault. Formulation of sustained release nanoparticles loaded with a tripentone, a new anticancer agent.
International journal of pharmaceutics.
2006 Aug; 320(1-2):157-64. doi:
10.1016/j.ijpharm.2006.04.007. [PMID: 16723200] - Martin Alexander Schubert, Meike Harms, Christel Charlotte Müller-Goymann. Structural investigations on lipid nanoparticles containing high amounts of lecithin.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2006 Feb; 27(2-3):226-36. doi:
10.1016/j.ejps.2005.10.004. [PMID: 16298113] - Beate Bittner, Roberto Carlos Bravo González, Hughes Isel, Christophe Flament. Impact of Solutol HS 15 on the pharmacokinetic behavior of midazolam upon intravenous administration to male Wistar rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2003 Jul; 56(1):143-6. doi:
10.1016/s0939-6411(03)00041-9. [PMID: 12837492] - Beate Bittner, Roberto Carlos Bravo González, Isabelle Walter, Martin Kapps, Jörg Huwyler. Impact of Solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats.
Biopharmaceutics & drug disposition.
2003 May; 24(4):173-81. doi:
10.1002/bdd.353. [PMID: 12698501] - Béatrice Heurtault, Patrick Saulnier, Brigitte Pech, Marie-Claire Venier-Julienne, Jacques-Emile Proust, Roger Phan-Tan-Luu, Jean-Pierre Benoît. The influence of lipid nanocapsule composition on their size distribution.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2003 Jan; 18(1):55-61. doi:
10.1016/s0928-0987(02)00241-5. [PMID: 12554073] - Roberto Carlos Bravo González, Jörg Huwyler, Isabelle Walter, Richard Mountfield, Beate Bittner. Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension.
International journal of pharmaceutics.
2002 Oct; 245(1-2):143-51. doi:
10.1016/s0378-5173(02)00339-3. [PMID: 12270251] - K Buszello, S Harnisch, R H Müller, B W Müller. The influence of alkali fatty acids on the properties and the stability of parenteral O/W emulsions modified with solutol HS 15.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2000 Mar; 49(2):143-9. doi:
10.1016/s0939-6411(99)00081-8. [PMID: 10704897] - K Woodburn, E Sykes, D Kessel. Interactions of Solutol HS 15 and Cremophor EL with plasma lipoproteins.
The international journal of biochemistry & cell biology.
1995 Jul; 27(7):693-9. doi:
10.1016/1357-2725(95)00030-s. [PMID: 7648425] - P K Dudeja, K M Anderson, J S Harris, L Buckingham, J S Coon. Reversal of multidrug resistance phenotype by surfactants: relationship to membrane lipid fluidity.
Archives of biochemistry and biophysics.
1995 May; 319(1):309-15. doi:
10.1006/abbi.1995.1298. [PMID: 7771801]