1-Cycloheptyl-1-[[3-[[cycloheptyl-[[4-(dimethylamino)phenyl]carbamoyl]amino]methyl]phenyl]methyl]-3-[4-(dimethylamino)phenyl]urea (BioDeep_00000842965)
代谢物信息卡片
化学式: C40H56N6O2 (652.4464516)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C)C1=CC=C(C=C1)NC(=O)N(CC2=CC(=CC=C2)CN(C3CCCCCC3)C(=O)NC4=CC=C(C=C4)N(C)C)C5CCCCCC5
InChI: InChI=1S/C40H56N6O2/c1-43(2)35-24-20-33(21-25-35)41-39(47)45(37-16-9-5-6-10-17-37)29-31-14-13-15-32(28-31)30-46(38-18-11-7-8-12-19-38)40(48)42-34-22-26-36(27-23-34)44(3)4/h13-15,20-28,37-38H,5-12,16-19,29-30H2,1-4H3,(H,41,47)(H,42,48)
描述信息
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC50 of 44 nM in rabbit liver microsomes in vitro.
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- A Brown, D Wiggins, G F Gibbons. Manipulation of cholesterol and cholesteryl ester synthesis has multiple effects on the metabolism of apolipoprotein B and the secretion of very-low-density lipoprotein by primary hepatocyte cultures.
Biochimica et biophysica acta.
1999 Sep; 1440(2-3):253-65. doi:
10.1016/s1388-1981(99)00133-x. [PMID: 10521709] - T Uchida, K Aoyama, T Watanabe, S Higuchi. Relationship between bioavailability and hypocholesterolemic activity of YM17E, an inhibitor of ACAT, in cholesterol-fed rats.
Atherosclerosis.
1998 Mar; 137(1):97-106. doi:
10.1016/s0021-9150(97)00259-1. [PMID: 9568741] - T Uchida, T Usui, T Watanabe, S Higuchi, M Nakata, K Maezawa, Y Kikawa, M Tsunoo, N Nakaya, Y Goto. Pharmacokinetic properties of YM17E, an inhibitor of acyl coenzyme A: cholesterol acyl transferase, and serum cholesterol levels in healthy volunteers.
European journal of clinical pharmacology.
1997; 51(5):399-406. doi:
10.1007/s002280050221. [PMID: 9049582] - M Kashiwa, Y Masuyama, H Miyauchi, T Uchida, S Naganuma, H Kakuta, M Terada, T Kiriyama, K Matsuda, N Ito, Y Iizumi, T Takenaka. Pharmacological properties of YM17E, an acyl-CoA:cholesterol acyltransferase inhibitor, and diarrheal effect in beagle dogs.
Japanese journal of pharmacology.
1997 Jan; 73(1):41-50. doi:
10.1254/jjp.73.41. [PMID: 9032133] - T Uchida, T Watanabe, E J Van Hoogdalem, S Higuchi. In-vitro metabolism of YM17E, an inhibitor of acyl coenzyme A:cholesterol acyltransferase, by liver microsomes in man.
The Journal of pharmacy and pharmacology.
1996 Oct; 48(10):1049-56. doi:
10.1111/j.2042-7158.1996.tb05898.x. [PMID: 8953507] - R A Harte, S J Yeaman, B Jackson, K E Suckling. Effect of membrane environment on inhibition of acyl-CoA:cholesterol acyltransferase by a range of synthetic inhibitors.
Biochimica et biophysica acta.
1995 Oct; 1258(3):241-50. doi:
10.1016/0005-2760(95)00113-q. [PMID: 7548193] - T Uchida, E Nakamura, T Usui, H Imasaki, R Kawakami, T Watanabe, S Higuchi. Disposition and metabolism of a novel diurea inhibitor of acyl CoA: cholesterol acyltransferase (YM17E) in the rat and dog.
Xenobiotica; the fate of foreign compounds in biological systems.
1994 Dec; 24(12):1223-36. doi:
10.3109/00498259409038678. [PMID: 7771109] - T Uchida, T Usui, T Watanabe, S Higuchi. Simultaneous determination of a new inhibitor of acyl CoA:cholesterol acyltransferase, YM17E, and five metabolites using high-performance liquid chromatography with electrochemical detection.
Journal of chromatography.
1993 Mar; 613(1):179-83. doi:
10.1016/0378-4347(93)80214-o. [PMID: 8458898]