4-Hydroxy Nimesulide (BioDeep_00000842947)
代谢物信息卡片
化学式: C13H12N2O6S (324.0416)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NC1=C(C=C(C=C1)[N+](=O)[O-])OC2=CC=C(C=C2)O
InChI: InChI=1S/C13H12N2O6S/c1-22(19,20)14-12-7-2-9(15(17)18)8-13(12)21-11-5-3-10(16)4-6-11/h2-8,14,16H,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Dhiman Halder, Shubhasis Dan, Pradipta Sarkar, Dibya Das, Umesh Chandra Halder, Tapan Kumar Pal. LC-MS/MS determination of 4-hydroxynimesulide, an active metabolite of nimesulide and application to bioequivalence study in Indian subjects.
European journal of mass spectrometry (Chichester, England).
2019 Oct; 25(5):399-411. doi:
10.1177/1469066718822621
. [PMID: 30696255] - Lei Zhou, Xiaoyan Pang, Jingfang Jiang, Dafang Zhong, Xiaoyan Chen. Nimesulide and 4'-Hydroxynimesulide as Bile Acid Transporters Inhibitors Are Contributory Factors for Drug-Induced Cholestasis.
Drug metabolism and disposition: the biological fate of chemicals.
2017 05; 45(5):441-448. doi:
10.1124/dmd.116.074104
. [PMID: 28202577] - M Bianchi, P Ferrario, P Balzarini, M Broggini. Plasma and synovial fluid concentrations of nimesulide and its main metabolite after a single or repeated oral administration in patients with knee osteoarthritis.
The Journal of international medical research.
2006 Jul; 34(4):348-54. doi:
10.1177/147323000603400402
. [PMID: 16989489] - Paolo Ferrario, Mauro Bianchi. Simultaneous determination of nimesulide and hydroxynimesulide in rat plasma, cerebrospinal fluid and brain by liquid chromatography using solid-phase extraction.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2003 Mar; 785(2):227-36. doi:
10.1016/s1570-0232(02)00857-7
. [PMID: 12554135] - A M Mouithys-Mickalad, S X Zheng, G P Deby-Dupont, C M Deby, M M Lamy, J Y Reginster, Y E Henrotin. In vitro study of the antioxidant properties of non steroidal anti-inflammatory drugs by chemiluminescence and electron spin resonance (ESR).
Free radical research.
2000 Nov; 33(5):607-21. doi:
10.1080/10715760000301131
. [PMID: 11200092] - C Giachetti, A Tenconi. Determination of nimesulide and hydroxynimesulide in human plasma by high performance liquid chromatography.
Biomedical chromatography : BMC.
1998 Mar; 12(2):50-6. doi:
10.1002/(sici)1099-0801(199803/04)12:2<50::aid-bmc719>3.0.co;2-b
. [PMID: 9568269] - S K Gupta, T Velpandian, P Mathur, S Sengupta. Comparative analgesic activity of nimesulide and diclofenac by intramuscular route: correlation with pharmacokinetic profile of nimesulide.
Pharmacology.
1998 Mar; 56(3):137-43. doi:
10.1159/000028191
. [PMID: 9532613] - R Maffei Facino, M Carini, G Aldini, M T Calloni. Hydroxynimesulide, the main metabolite of nimesulide, prevents hydroperoxide/hemoglobin-induced hemolysis of rat erythrocytes.
Drugs under experimental and clinical research.
1997; 23(5-6):157-65. doi:
"
. [PMID: 9515225] - R Maffei Facino, M Carini, G Aldini, L Saibene, R Morelli. Differential inhibition of superoxide, hydroxyl and peroxyl radicals by nimesulide and its main metabolite 4-hydroxynimesulide.
Arzneimittel-Forschung.
1995 Oct; 45(10):1102-9. doi:
"
. [PMID: 8595069] - D Canale, I Scaricabarozzi, P Giorgi, P Turchi, M Ducci, G F Menchini-Fabris. Use of a novel non-steroidal anti-inflammatory drug, nimesulide, in the treatment of abacterial prostatovesiculitis.
Andrologia.
1993 May; 25(3):163-6. doi:
10.1111/j.1439-0272.1993.tb02701.x
. [PMID: 8517557] - R Gandini, C Montalto, D Castoldi, V Monzani, M L Nava, I Scaricabarozzi, G Vargiu, I Bartosek. First dose and steady state pharmacokinetics of nimesulide and its 4-hydroxy metabolite in healthy volunteers.
Farmaco (Societa chimica italiana : 1989).
1991 Sep; 46(9):1071-9. doi:
NULL
. [PMID: 1807292] - D Castoldi, V Monzani, O Tofanetti. Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography.
1988 Mar; 425(2):413-8. doi:
10.1016/0378-4347(88)80048-3
. [PMID: 3372653]