2-Methyl-1,1,4-trioxo-N-(2-pyridinyl)-3H-1$l^{6},2-benzothiazine-3-carboxamide (BioDeep_00000842908)
代谢物信息卡片
2-Methyl-1,1,4-trioxo-N-(2-pyridinyl)-3H-1$l^{6},2-benzothiazine-3-carboxamide
化学式: C15H13N3O4S (331.0626738)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C(C(=O)C2=CC=CC=C2S1(=O)=O)C(=O)NC3=CC=CC=N3
InChI: InChI=1S/C15H13N3O4S/c1-18-13(15(20)17-12-8-4-5-9-16-12)14(19)10-6-2-3-7-11(10)23(18,21)22/h2-9,13H,1H3,(H,16,17,20)
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
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Nutrition journal.
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Pakistan journal of pharmaceutical sciences.
2012 Apr; 25(2):429-33. doi:
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2012 Apr; 92(?):277-85. doi:
10.1016/j.colsurfb.2011.11.050. [PMID: 22196462] - Zhen Liu, Zhiwei Xu, Hanyu Zhou, Gang Cao, Xiao-Dong Cong, Yun Zhang, Bao-Chang Cai. Simultaneous determination of four bioactive compounds in Verbena officinalis L. by using high-performance liquid chromatography.
Pharmacognosy magazine.
2012 Apr; 8(30):162-5. doi:
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Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
2012 Mar; 18(2):99-101. doi:
10.1097/rhu.0b013e31824a47b5. [PMID: 22334264] - Ingo Beyer, Rose Njemini, Ivan Bautmans, Christian Demanet, Tony Mets. Immunomodulatory effect of NSAID in geriatric patients with acute infection: effects of piroxicam on chemokine/cytokine secretion patterns and levels of heat shock proteins. A double-blind randomized controlled trial. (ISRCTN58517443).
Cell stress & chaperones.
2012 Mar; 17(2):255-65. doi:
10.1007/s12192-011-0304-4. [PMID: 22057579] - Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids.
Lipids in health and disease.
2012 Jan; 11(?):3. doi:
10.1186/1476-511x-11-3. [PMID: 22221489] - Iti Som, Kashish Bhatia, Mohd Yasir. Status of surfactants as penetration enhancers in transdermal drug delivery.
Journal of pharmacy & bioallied sciences.
2012 Jan; 4(1):2-9. doi:
10.4103/0975-7406.92724. [PMID: 22368393] - Jean-Pascal Fournier, Maryse Lapeyre-Mestre, Agnès Sommet, Julie Dupouy, Jean-Christophe Poutrain, Jean-Louis Montastruc. Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.
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The journal of physical chemistry. B.
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Schweizer Archiv fur Tierheilkunde.
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BMC complementary and alternative medicine.
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Clinics (Sao Paulo, Brazil).
2011; 66(10):1787-92. doi:
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Journal of drug delivery.
2011; 2011(?):841054. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):. doi:
10.1155/2011/546560. [PMID: 20953434] - Salawu Oluwakanyinsola Adeola, Tijani Adeniyi Yahaya, Babayi Hafsatu, Nwaeze Angela Chinwe, Ezeonu Chidimma Maryjane, Igwe Sunday, Ndukuba Mary Adanna. Gastro-protective effect of Crossopteryx febrifuga in Wistar rats.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2011; 8(3):300-6. doi:
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International journal of nanomedicine.
2011; 6(?):2499-512. doi:
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International journal of molecular sciences.
2011; 12(4):2692-749. doi:
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Evidence-based complementary and alternative medicine : eCAM.
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2011; 12(9):6194-225. doi:
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Journal of lipids.
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Acta pharmaceutica Hungarica.
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PloS one.
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Cancer chemotherapy and pharmacology.
2010 Feb; 65(3):549-56. doi:
10.1007/s00280-009-1061-2. [PMID: 19629487] - Young-Chang Ah, Jin-Kyu Choi, Yang-Kyu Choi, Han-Moi Ki, Joon-Ho Bae. A novel transdermal patch incorporating meloxicam: in vitro and in vivo characterization.
International journal of pharmaceutics.
2010 Jan; 385(1-2):12-9. doi:
10.1016/j.ijpharm.2009.10.013. [PMID: 19833177] - Marcelo Soares Privado, Adriana Machado Issy, Vera Lucia Lanchote, João Batista Santos Garcia, Rioko Kimiko Sakata. Epidural versus intravenous fentanyl for postoperative analgesia following orthopedic surgery: randomized controlled trial.
Sao Paulo medical journal = Revista paulista de medicina.
2010 Jan; 128(1):5-9. doi:
10.1590/s1516-31802010000100002. [PMID: 20512273] - S O Mashayekhi, M Ghandforoush-Sattari, D C Buss, P A Routledge, R Dw Hain. Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2010; 18(2):107-13. doi:
. [PMID: 22615603] - Sheng Qi, Delphine Marchaud, Duncan Q M Craig. An investigation into the mechanism of dissolution rate enhancement of poorly water-soluble drugs from spray chilled gelucire 50/13 microspheres.
Journal of pharmaceutical sciences.
2010 Jan; 99(1):262-74. doi:
10.1002/jps.21832. [PMID: 19653284] - Sutapa Mondal, Munna Sarkar. Non-steroidal anti-inflammatory drug induced membrane fusion: concentration and temperature effects.
The journal of physical chemistry. B.
2009 Dec; 113(51):16323-31. doi:
10.1021/jp9069527. [PMID: 19954169] - Hena Jiao, Fei Ren. Pretreatment with lornoxicam, a cyclooxygenase inhibitor, relieves postoperative immuno-suppression after total abdominal hysterectomy.
The Tohoku journal of experimental medicine.
2009 Dec; 219(4):289-94. doi:
10.1620/tjem.219.289. [PMID: 19966527] - Sandra Simões, Cláudia Marques, Maria Eugénia Cruz, Maria Bárbara Figueira Martins. Anti-inflammatory effects of locally applied enzyme-loaded ultradeformable vesicles on an acute cutaneous model.
Journal of microencapsulation.
2009 Nov; 26(7):649-58. doi:
10.3109/02652040802630403. [PMID: 19839801] - Jean-Philippe Lafrance, Donald R Miller. Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury.
Pharmacoepidemiology and drug safety.
2009 Oct; 18(10):923-31. doi:
10.1002/pds.1798. [PMID: 19585463] - Martina Tvrdonova, Jana Chrenova, Zuzana Rausova, Daniela Miklovicova, Maria Durisova, Constantin Mircioiu, Ladislav Dedik. Novel approach to bioequivalence assessment based on physiologically motivated model.
International journal of pharmaceutics.
2009 Oct; 380(1-2):89-95. doi:
10.1016/j.ijpharm.2009.07.004. [PMID: 19596057] - Sylvie Fernandez, Stéphanie Chevrier, Nicolas Ritter, Bruno Mahler, Frédéric Demarne, Frédéric Carrière, Vincent Jannin. In vitro gastrointestinal lipolysis of four formulations of piroxicam and cinnarizine with the self emulsifying excipients Labrasol and Gelucire 44/14.
Pharmaceutical research.
2009 Aug; 26(8):1901-10. doi:
10.1007/s11095-009-9906-2. [PMID: 19452130] - Akash A Savaliya, Bhagwat Prasad, Dhara K Raijada, Saranjit Singh. Detection and characterization of synthetic steroidal and non-steroidal anti-inflammatory drugs in Indian ayurvedic/herbal products using LC-MS/TOF.
Drug testing and analysis.
2009 Aug; 1(8):372-81. doi:
10.1002/dta.75. [PMID: 20355217] - Deniz Ekinci, Sükrü Beydemir. Effect of some analgesics on paraoxonase-1 purified from human serum.
Journal of enzyme inhibition and medicinal chemistry.
2009 Aug; 24(4):1034-9. doi:
10.1080/14756360802608351. [PMID: 19548782] - B Rezaei, S Mallakpour, N Majidi. Solid-phase molecularly imprinted pre-concentration and spectrophotometric determination of isoxicam in pharmaceuticals and human serum.
Talanta.
2009 Apr; 78(2):418-23. doi:
10.1016/j.talanta.2008.11.042. [PMID: 19203603] - Sarathi Kundu, Hirak Chakraborty, Munna Sarkar, Alokmay Datta. Interaction of Oxicam NSAIDs with lipid monolayer: anomalous dependence on drug concentration.
Colloids and surfaces. B, Biointerfaces.
2009 Apr; 70(1):157-61. doi:
10.1016/j.colsurfb.2008.12.017. [PMID: 19157803] - Hye Won Lee, Hye Young Ji, Hoi Yun Kim, Kang Choon Lee, Hye Suk Lee. Liquid chromatography-tandem mass spectrometry method for the determination of meloxicam and its metabolite 5-carboxymeloxicam in human plasma.
Bioanalysis.
2009 Apr; 1(1):63-70. doi:
10.4155/bio.09.10. [PMID: 21083189] - Patrick Wortman, Yuko Miyazaki, Nishan S Kalupahana, Suyeon Kim, Melissa Hansen-Petrik, Arnold M Saxton, Kate J Claycombe, Brynn H Voy, Jay Whelan, Naima Moustaid-Moussa. n3 and n6 polyunsaturated fatty acids differentially modulate prostaglandin E secretion but not markers of lipogenesis in adipocytes.
Nutrition & metabolism.
2009 Jan; 6(?):5. doi:
10.1186/1743-7075-6-5. [PMID: 19159447] - Martina Tvrdonova, Ladislav Dedik, Constantin Mircioiu, Daniela Miklovicova, Maria Durisova. Physiologically motivated time-delay model to account for mechanisms underlying enterohepatic circulation of piroxicam in human beings.
Basic & clinical pharmacology & toxicology.
2009 Jan; 104(1):35-42. doi:
10.1111/j.1742-7843.2008.00304.x. [PMID: 18713233] - Erdal Yilmaz. Re: Takmaz SA, et al. Analgesic effect of 8- and 16-mg lornoxicam administered before shock wave lithotripsy: a randomized, double-blind, controlled study (Urology 2008;72:282-285).
Urology.
2009 Jan; 73(1):211-2. doi:
10.1016/j.urology.2008.09.034. [PMID: 19111738] - Fengshan Yu, Yangbin Zhang, Fang Chen, Lanhua Chen. Chemiluminescence method for the determination of piroxicam by the enhancement of the tris-(4,7-diphenyl-1,10-phenanthrolinedisulphonic acid) ruthenium(II) (RuBPS)-cerium(IV) system and its application.
Luminescence : the journal of biological and chemical luminescence.
2009 Jan; 24(1):50-4. doi:
10.1002/bio.1063. [PMID: 18780330] - Jennifer Frank, David Sommerfeld. Clinical approach in treatment of resistant hypertension.
Integrated blood pressure control.
2009; 2(?):9-23. doi:
10.2147/ibpc.s4315. [PMID: 21966229] - Saad A Hussain, Nizar A Jassim, Intesar T Numan, Ihab I Al-Khalifa, Talal A Abdullah. Anti-inflammatory activity of silymarin in patients with knee osteoarthritis. A comparative study with piroxicam and meloxicam.
Saudi medical journal.
2009 Jan; 30(1):98-103. doi:
. [PMID: 19139781] - S L Sigurdardottir, J Freysdottir, T Vikingsdottir, H Valdimarsson, A Vikingsson. Do non-steroidal anti-inflammatory drugs influence chronic inflammation? The effects of piroxicam on chronic antigen-induced arthritis in rats.
Scandinavian journal of rheumatology.
2008 Nov; 37(6):469-76. doi:
10.1080/03009740802225876. [PMID: 19005999] - P-S Hsieh, H-C Tsai, C-H Kuo, J Y-H Chan, J-F Shyu, W-T Cheng, T-T Liu. Selective COX2 inhibition improves whole body and muscular insulin resistance in fructose-fed rats.
European journal of clinical investigation.
2008 Nov; 38(11):812-9. doi:
10.1111/j.1365-2362.2008.02026.x. [PMID: 19021698] - Haixia Zhang, Hoo-Kyun Choi. Analysis of meloxicam by high-performance liquid chromatography with cloud-point extraction.
Analytical and bioanalytical chemistry.
2008 Nov; 392(5):947-53. doi:
10.1007/s00216-008-2333-0. [PMID: 18751683] - Hirak Chakraborty, Sutapa Mondal, Munna Sarkar. Membrane fusion: a new function of non steroidal anti-inflammatory drugs.
Biophysical chemistry.
2008 Sep; 137(1):28-34. doi:
10.1016/j.bpc.2008.06.007. [PMID: 18617319] - A Gadek-Michalska, A J Bugajski, J Bugajski. Prostaglandins and interleukin-1beta in the hypothalamic-pituitary-adrenal response to systemic phenylephrine under basal and stress conditions.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2008 Sep; 59(3):563-75. doi:
. [PMID: 18953098] - Mustafa Naziroğlu, Abdulhadi Cihangir Uğuz, Alpaslan Gokçimen, Metin Bülbül, Dilek Ulusoy Karatopuk, Yasin Türker, Celal Cerçi. Tenoxicam modulates antioxidant redox system and lipid peroxidation in rat brain.
Neurochemical research.
2008 Sep; 33(9):1832-7. doi:
10.1007/s11064-008-9643-7. [PMID: 18340531] - Barbara Shukitt-Hale, Francis C Lau, Amanda N Carey, Rachel L Galli, Edward L Spangler, Donald K Ingram, James A Joseph. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus.
Nutritional neuroscience.
2008 Aug; 11(4):172-82. doi:
10.1179/147683008x301487. [PMID: 18681986] - Jeffrey B Brown, Goo Lee, Gery R Grimm, Terrence A Barrett. Therapeutic benefit of pentostatin in severe IL-10-/- colitis.
Inflammatory bowel diseases.
2008 Jul; 14(7):880-7. doi:
10.1002/ibd.20410. [PMID: 18340641]