2-Amino-3-phenylmethoxybutanedioic acid (BioDeep_00000842856)
代谢物信息卡片
2-Amino-3-phenylmethoxybutanedioic acid
化学式: C11H13NO5 (239.0794)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)COC(C(C(=O)O)N)C(=O)O
InChI: InChI=1S/C11H13NO5/c12-8(10(13)14)9(11(15)16)17-6-7-4-2-1-3-5-7/h1-5,8-9H,6,12H2,(H,13,14)(H,15,16)
描述信息
D018377 - Neurotransmitter Agents > D018846 - Excitatory Amino Acids
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
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Human molecular genetics.
2012 Jul; 21(13):2923-35. doi:
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Hippocampus.
2012 Jul; 22(7):1622-34. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Apr; 32(17):6000-13. doi:
10.1523/jneurosci.5347-11.2012. [PMID: 22539860] - Yi Chang, Yu-Wan Lin, Su-Jane Wang. Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A.
Naunyn-Schmiedeberg's archives of pharmacology.
2011 Jul; 384(1):59-70. doi:
10.1007/s00210-011-0630-1. [PMID: 21541760] - Shan Jiang, Hua Yuan, Li Duan, Rong Cao, Bei Gao, Ying-Fei Xiong, Zhi-Ren Rao. Glutamate release through connexin 43 by cultured astrocytes in a stimulated hypertonicity model.
Brain research.
2011 May; 1392(?):8-15. doi:
10.1016/j.brainres.2011.03.056. [PMID: 21458428] - Hui Nie, Han-Rong Weng. Glutamate transporters prevent excessive activation of NMDA receptors and extrasynaptic glutamate spillover in the spinal dorsal horn.
Journal of neurophysiology.
2009 Apr; 101(4):2041-51. doi:
10.1152/jn.91138.2008. [PMID: 19211657] - Emanuelle Sagot, Anders A Jensen, Darryl S Pickering, Xiaosui Pu, Michelle Umberti, Tine B Stensbøl, Birgitte Nielsen, Zeinab Assaf, Bétina Aboab, Jean Bolte, Thierry Gefflaut, Lennart Bunch. Chemo-enzymatic synthesis of (2S,4R)-2-amino-4-(3-(2,2-diphenylethylamino)-3-oxopropyl)pentanedioic acid: a novel selective inhibitor of human excitatory amino acid transporter subtype 2.
Journal of medicinal chemistry.
2008 Jul; 51(14):4085-92. doi:
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Neuroscience.
2008 Feb; 151(4):1042-52. doi:
10.1016/j.neuroscience.2007.11.055. [PMID: 18207650] - Keiko Shimamoto. Glutamate transporter blockers for elucidation of the function of excitatory neurotransmission systems.
Chemical record (New York, N.Y.).
2008; 8(3):182-99. doi:
10.1002/tcr.20145. [PMID: 18563834] - Luca Raiteri, Simona Zappettini, Marco Milanese, Ernesto Fedele, Maurizio Raiteri, Giambattista Bonanno. Mechanisms of glutamate release elicited in rat cerebrocortical nerve endings by 'pathologically' elevated extraterminal K+ concentrations.
Journal of neurochemistry.
2007 Nov; 103(3):952-61. doi:
10.1111/j.1471-4159.2007.04784.x. [PMID: 17662048] - Olga Boudker, Renae M Ryan, Dinesh Yernool, Keiko Shimamoto, Eric Gouaux. Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature.
2007 Jan; 445(7126):387-93. doi:
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Molecular pharmacology.
2007 Jan; 71(1):294-302. doi:
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Neuron.
2006 Apr; 50(1):63-74. doi:
10.1016/j.neuron.2006.02.022. [PMID: 16600856] - John Dunlop. Glutamate-based therapeutic approaches: targeting the glutamate transport system.
Current opinion in pharmacology.
2006 Feb; 6(1):103-7. doi:
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The European journal of neuroscience.
2005 Apr; 21(8):2291-6. doi:
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2004 Apr; 65(4):1008-15. doi:
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Journal of neurochemistry.
2003 Mar; 84(6):1332-9. doi:
10.1046/j.1471-4159.2003.01630.x. [PMID: 12614333] - Y Shigeri, K Shimamoto, Y Yasuda-Kamatani, R P Seal, N Yumoto, T Nakajima, S G Amara. Effects of threo-beta-hydroxyaspartate derivatives on excitatory amino acid transporters (EAAT4 and EAAT5).
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2001 Oct; 79(2):297-302. doi:
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