4(1H)-Pteridinone, 2-amino-7-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro- (BioDeep_00000842828)
代谢物信息卡片
4(1H)-Pteridinone, 2-amino-7-(1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-
化学式: C9H15N5O3 (241.1175)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C1CNC2=C(N1)N=C(NC2=O)N)O)O
InChI: InChI=1S/C9H15N5O3/c1-3(15)6(16)4-2-11-5-7(12-4)13-9(10)14-8(5)17/h3-4,6,11,15-16H,2H2,1H3,(H4,10,12,13,14,17)
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Youguo Dai, Jin Cui, Yingli Cun, Anhua Shi. Tetrahydrobiopterin ameliorates hepatic ischemia-reperfusion Injury by coupling with eNOS in mice.
The Journal of surgical research.
2012 Aug; 176(2):e65-71. doi:
10.1016/j.jss.2011.12.034. [PMID: 22475351] - Luz Graciela Cervantes-Pérez, María de la Luz Ibarra-Lara, Bruno Escalante, Leonardo Del Valle-Mondragón, Hilda Vargas-Robles, Francisca Pérez-Severiano, Gustavo Pastelín, María Alicia Sánchez-Mendoza. Endothelial nitric oxide synthase impairment is restored by clofibrate treatment in an animal model of hypertension.
European journal of pharmacology.
2012 Jun; 685(1-3):108-15. doi:
10.1016/j.ejphar.2012.04.006. [PMID: 22542661] - Yi-Chen Liao, Ying-Ho Lee, Lea-Yea Chuang, Jinn-Yuh Guh, Ming-Der Shi, Jau-Shyang Huang. Advanced glycation end products-mediated hypertrophy is negatively regulated by tetrahydrobiopterin in renal tubular cells.
Molecular and cellular endocrinology.
2012 May; 355(1):71-7. doi:
10.1016/j.mce.2012.01.018. [PMID: 22326994] - Francesco Porta, Alessandro Mussa, Daniela Concolino, Marco Spada, Alberto Ponzone. Dopamine agonists in dihydropteridine reductase deficiency.
Molecular genetics and metabolism.
2012 Apr; 105(4):582-4. doi:
10.1016/j.ymgme.2012.01.013. [PMID: 22325981] - Akiko Ohashi, Yasuko Suetake, Yusuke Saeki, Tomonori Harada, Shin Aizawa, Hiroyuki Hasegawa. Rapid clearance of supplemented tetrahydrobiopterin is driven by high-capacity transporters in the kidney.
Molecular genetics and metabolism.
2012 Apr; 105(4):575-81. doi:
10.1016/j.ymgme.2012.01.009. [PMID: 22318121] - Caroline Heintz, Heinz Troxler, Aurora Martinez, Beat Thöny, Nenad Blau. Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.
Molecular genetics and metabolism.
2012 Apr; 105(4):559-65. doi:
10.1016/j.ymgme.2011.12.025. [PMID: 22300847] - Colin Cunnington, Tim Van Assche, Cheerag Shirodaria, Ilias Kylintireas, Alistair C Lindsay, Justin M Lee, Charalambos Antoniades, Marios Margaritis, Regent Lee, Ruha Cerrato, Mark J Crabtree, Jane M Francis, Rana Sayeed, Chandi Ratnatunga, Ravi Pillai, Robin P Choudhury, Stefan Neubauer, Keith M Channon. Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease.
Circulation.
2012 Mar; 125(11):1356-66. doi:
10.1161/circulationaha.111.038919. [PMID: 22315282] - Zheng Zhang, Mi Wang, Sheng-Jiang Xue, Dong-Hong Liu, Yong-Bo Tang. Simvastatin ameliorates angiotensin II-induced endothelial dysfunction through restoration of Rho-BH4-eNOS-NO pathway.
Cardiovascular drugs and therapy.
2012 Feb; 26(1):31-40. doi:
10.1007/s10557-011-6351-3. [PMID: 22083280] - Rani H Singh, Meghan E Quirk. Using change in plasma phenylalanine concentrations and ability to liberalize diet to classify responsiveness to tetrahydrobiopterin therapy in patients with phenylketonuria.
Molecular genetics and metabolism.
2011 Dec; 104(4):485-91. doi:
10.1016/j.ymgme.2011.09.009. [PMID: 21986447] - Hongchao Wang, Bo Yang, Guangfei Hao, Yun Feng, Haiqin Chen, Lu Feng, Jianxin Zhao, Hao Zhang, Yong Q Chen, Lei Wang, Wei Chen. Biochemical characterization of the tetrahydrobiopterin synthesis pathway in the oleaginous fungus Mortierella alpina.
Microbiology (Reading, England).
2011 Nov; 157(Pt 11):3059-3070. doi:
10.1099/mic.0.051847-0. [PMID: 21852350] - Charalambos Antoniades, Colin Cunnington, Alexis Antonopoulos, Matt Neville, Marios Margaritis, Michael Demosthenous, Jennifer Bendall, Ashley Hale, Ruha Cerrato, Dimitris Tousoulis, Constantinos Bakogiannis, Kyriakoula Marinou, Marina Toutouza, Charalambos Vlachopoulos, Paul Leeson, Christodoulos Stefanadis, Fredrik Karpe, Keith M Channon. Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
Circulation.
2011 Oct; 124(17):1860-70. doi:
10.1161/circulationaha.111.029272. [PMID: 21969008] - Ruslan Rafikov, Fabio V Fonseca, Sanjiv Kumar, Daniel Pardo, Charles Darragh, Shawn Elms, David Fulton, Stephen M Black. eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity.
The Journal of endocrinology.
2011 Sep; 210(3):271-84. doi:
10.1530/joe-11-0083. [PMID: 21642378] - Hiromi Jo, Hajime Otani, Fusakazu Jo, Takayuki Shimazu, Toru Okazaki, Kei Yoshioka, Masanori Fujita, Atsushi Kosaki, Toshiji Iwasaka. Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice.
Clinical and experimental pharmacology & physiology.
2011 Aug; 38(8):485-93. doi:
10.1111/j.1440-1681.2011.05535.x. [PMID: 21554376] - Matthieu Legrand, Asli Kandil, Didier Payen, Can Ince. Effects of sepiapterin infusion on renal oxygenation and early acute renal injury after suprarenal aortic clamping in rats.
Journal of cardiovascular pharmacology.
2011 Aug; 58(2):192-8. doi:
10.1097/fjc.0b013e31821f8ec3. [PMID: 21562427] - Thomas Opladen, Bettina Abu Seda, Anahita Rassi, Beat Thöny, Georg F Hoffmann, Nenad Blau. Diagnosis of tetrahydrobiopterin deficiency using filter paper blood spots: further development of the method and 5 years experience.
Journal of inherited metabolic disease.
2011 Jun; 34(3):819-26. doi:
10.1007/s10545-011-9300-1. [PMID: 21416196] - Amy L Sindler, Bradley S Fleenor, John W Calvert, Kurt D Marshall, Melanie L Zigler, David J Lefer, Douglas R Seals. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging.
Aging cell.
2011 Jun; 10(3):429-37. doi:
10.1111/j.1474-9726.2011.00679.x. [PMID: 21276184] - Luciana Giugliani, Angela Sitta, Carmen R Vargas, Luiz C Santana-da-Silva, Tatiéle Nalin, Maria Luiza Saraiva-Pereira, Roberto Giugliani, Ida Vanessa D Schwartz. Tetrahydrobiopterin responsiveness of patients with phenylalanine hydroxylase deficiency.
Jornal de pediatria.
2011 May; 87(3):245-51. doi:
10.2223/jped.2090. [PMID: 21660367] - Emma J Footitt, Simon J Heales, Philippa B Mills, George F G Allen, Marcus Oppenheim, Peter T Clayton. Pyridoxal 5'-phosphate in cerebrospinal fluid; factors affecting concentration.
Journal of inherited metabolic disease.
2011 Apr; 34(2):529-38. doi:
10.1007/s10545-011-9279-7. [PMID: 21305354] - Ivan M Robbins, Anna R Hemnes, J Simon Gibbs, Brian W Christman, Luke Howard, Sharon Meehan, Ines Cabrita, Rochelle Gonzalez, Tracy Oyler, Lan Zhao, Rui-Hong Du, Lisa A Mendes, Martin R Wilkins. Safety of sapropterin dihydrochloride (6r-bh4) in patients with pulmonary hypertension.
Experimental lung research.
2011 Feb; 37(1):26-34. doi:
10.3109/01902148.2010.512972. [PMID: 21077779] - Olav A Christophersen, Anna Haug. Animal products, diseases and drugs: a plea for better integration between agricultural sciences, human nutrition and human pharmacology.
Lipids in health and disease.
2011 Jan; 10(?):16. doi:
10.1186/1476-511x-10-16. [PMID: 21247506] - Akiko Ohashi, Yuko Sugawara, Kaori Mamada, Yoshinori Harada, Tomomi Sumi, Naohiko Anzai, Shin Aizawa, Hiroyuki Hasegawa. Membrane transport of sepiapterin and dihydrobiopterin by equilibrative nucleoside transporters: a plausible gateway for the salvage pathway of tetrahydrobiopterin biosynthesis.
Molecular genetics and metabolism.
2011 Jan; 102(1):18-28. doi:
10.1016/j.ymgme.2010.09.005. [PMID: 20956085] - Tatiéle Nalin, Ingrid Dalira Schweigert Perry, Angela Sitta, Carmen Regla Vargas, Maria Luiza Saraiva-Pereira, Roberto Giugliani, Nenad Blau, Ida Vanessa Doederlein Schwartz. Optimized loading test to evaluate responsiveness to tetrahydrobiopterin (BH4) in Brazilian patients with phenylalanine hydroxylase deficiency.
Molecular genetics and metabolism.
2011; 104 Suppl(?):S80-5. doi:
10.1016/j.ymgme.2011.09.019. [PMID: 22014474] - Zoltán Kukor, Sándor Valent. [Nitric oxide and preeclampsia].
Orvosi hetilap.
2010 Dec; 151(52):2125-35. doi:
10.1556/oh.2010.29012. [PMID: 21147698] - Lila Mayahi, Lydia Mason, Katherine Bleasdale-Barr, Ann Donald, Iris Trender-Gerhard, Mary G Sweeney, Mary B Davis, Nicholas Wood, Christopher J Mathias, Laura Watson, Denis Pellerin, Simon Heales, John E Deanfield, Kailash Bhatia, Judith Murray-Rust, Aroon D Hingorani. Endothelial, sympathetic, and cardiac function in inherited (6R)-L-erythro-5,6,7,8-tetrahydro-L-biopterin deficiency.
Circulation. Cardiovascular genetics.
2010 Dec; 3(6):513-22. doi:
10.1161/circgenetics.110.957605. [PMID: 20937667] - Liyun He, Hui Zeng, Fuwang Li, Jieli Feng, Shan Liu, Jinbo Liu, Jie Yu, Jieming Mao, Tianpei Hong, Alex F Chen, Xian Wang, Guang Wang. Homocysteine impairs coronary artery endothelial function by inhibiting tetrahydrobiopterin in patients with hyperhomocysteinemia.
American journal of physiology. Endocrinology and metabolism.
2010 Dec; 299(6):E1061-5. doi:
10.1152/ajpendo.00367.2010. [PMID: 20858749] - Jean-Louis Dhondt. Lessons from 30 years of selective screening for tetrahydrobiopterin deficiency.
Journal of inherited metabolic disease.
2010 Oct; 33(Suppl 2):S219-23. doi:
10.1007/s10545-010-9091-9. [PMID: 20458544] - Richard E Frye, Lynne C Huffman, Glen R Elliott. Tetrahydrobiopterin as a novel therapeutic intervention for autism.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2010 Jul; 7(3):241-9. doi:
10.1016/j.nurt.2010.05.004. [PMID: 20643376] - H J Vernon, C B Koerner, M R Johnson, A Bergner, A Hamosh. Introduction of sapropterin dihydrochloride as standard of care in patients with phenylketonuria.
Molecular genetics and metabolism.
2010 Jul; 100(3):229-33. doi:
10.1016/j.ymgme.2010.03.022. [PMID: 20418136] - Lars Hagberg, Paola Cinque, Magnus Gisslen, Bruce J Brew, Serena Spudich, Arabella Bestetti, Richard W Price, Dietmar Fuchs. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection.
AIDS research and therapy.
2010 Jun; 7(?):15. doi:
10.1186/1742-6405-7-15. [PMID: 20525234] - Tim S Schmidt, Eileen McNeill, Gillian Douglas, Mark J Crabtree, Ashley B Hale, Jeffrey Khoo, Charles A O'Neill, Alphonsus Cheng, Keith M Channon, Nicholas J Alp. Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
Clinical science (London, England : 1979).
2010 May; 119(3):131-42. doi:
10.1042/cs20090559. [PMID: 20337596] - Dae Won Jun, Jin Hee Park, Yoo Sin Park, Ju-Seop Kang, Eun Kyung Kim, Kyung Tae Kim, Byoung Kwan Son, Seong Hwan Kim, Yun Ju Jo, Young Sook Park. The role of nitric oxide in the expression of renal aquaporin 2 in a cirrhotic rat model: does an AVP-independent mechanism exist for the regulation of AQP2 expression?.
Digestive diseases and sciences.
2010 May; 55(5):1296-304. doi:
10.1007/s10620-009-0852-y. [PMID: 19517235] - Alberto Ponzone, Francesco Porta, Alessandro Mussa, Alessandra Alluto, Silvio Ferraris, Marco Spada. Unresponsiveness to tetrahydrobiopterin of phenylalanine hydroxylase deficiency.
Metabolism: clinical and experimental.
2010 May; 59(5):645-52. doi:
10.1016/j.metabol.2009.09.008. [PMID: 19913839] - Israel Coronel, Monica G Arellano-Mendoza, Leonardo del Valle-Mondragon, Hilda Vargas-Robles, Fabiola Castorena-Torres, Eunice Romo, Amelia Rios, Bruno Escalante. L-arginine and antioxidant diet supplementation partially restores nitric oxide-dependent regulation of phenylephrine renal vasoconstriction in diabetics rats.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2010 May; 20(3):158-68. doi:
10.1053/j.jrn.2009.10.008. [PMID: 20097580] - Pratibha Mehta Luthra, Satendra Singh. Identification and optimization of tyrosine hydroxylase activity in Mucuna pruriens DC. var. utilis.
Planta.
2010 May; 231(6):1361-9. doi:
10.1007/s00425-010-1140-y. [PMID: 20300771] - Katsuhiko Noguchi, Naobumi Hamadate, Toshihiro Matsuzaki, Mayuko Sakanashi, Junko Nakasone, Makiko Sakanashi, Masato Tsutsui, Matao Sakanashi. Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats.
European journal of pharmacology.
2010 Apr; 631(1-3):28-35. doi:
10.1016/j.ejphar.2010.01.003. [PMID: 20096684] - Maria A Vilaseca, Nilo Lambruschini, Lilianne Gómez-López, Alejandra Gutiérrez, Juan Moreno, Mireia Tondo, Rafael Artuch, Jaume Campistol. Long-chain polyunsaturated fatty acid status in phenylketonuric patients treated with tetrahydrobiopterin.
Clinical biochemistry.
2010 Mar; 43(4-5):411-5. doi:
10.1016/j.clinbiochem.2009.11.013. [PMID: 19948162] - Hye-Lim Kim, Do Hyung Kim, Yeol Kun Lee, Sun Ok Park, Yong-Woo Lee, O-Seob Kwon, Young Shik Park. An enzymatic method to distinguish tetrahydrobiopterin from oxidized biopterins using UDP-glucose:tetrahydrobiopterin glucosyltransferase.
Analytical biochemistry.
2010 Feb; 397(1):79-83. doi:
10.1016/j.ab.2009.10.007. [PMID: 19819217] - Donald G Musson, William G Kramer, Erik D Foehr, Frederick A Bieberdorf, Carl S Hornfeldt, Sun Sook Kim, Alex Dorenbaum. Relative bioavailability of sapropterin from intact and dissolved sapropterin dihydrochloride tablets and the effects of food: a randomized, open-label, crossover study in healthy adults.
Clinical therapeutics.
2010 Feb; 32(2):338-46. doi:
10.1016/j.clinthera.2010.02.012. [PMID: 20206791] - Minoru Satoh, Yoshisuke Haruna, Sohachi Fujimoto, Tamaki Sasaki, Naoki Kashihara. Telmisartan improves endothelial dysfunction and renal autoregulation in Dahl salt-sensitive rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2010 Feb; 33(2):135-42. doi:
10.1038/hr.2009.190. [PMID: 19927153] - Jytte Bieber Nielsen, Karin E Nielsen, Flemming Güttler. Tetrahydrobiopterin responsiveness after extended loading test of 12 Danish PKU patients with the Y414C mutation.
Journal of inherited metabolic disease.
2010 Feb; 33(1):9-16. doi:
10.1007/s10545-009-9002-0. [PMID: 20063067] - Sowndramalingam Sankaralingam, Han Xu, Sandra T Davidge. Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia.
Cardiovascular research.
2010 Jan; 85(1):194-203. doi:
10.1093/cvr/cvp277. [PMID: 19684035] - Yvette C Luiking, Mariëlle P K J Engelen, Nicolaas E P Deutz. Regulation of nitric oxide production in health and disease.
Current opinion in clinical nutrition and metabolic care.
2010 Jan; 13(1):97-104. doi:
10.1097/mco.0b013e328332f99d. [PMID: 19841582] - Richard E Frye. Central tetrahydrobiopterin concentration in neurodevelopmental disorders.
Frontiers in neuroscience.
2010; 4(?):52. doi:
10.3389/fnins.2010.00052. [PMID: 20661295] - Yukinori Tamura, Aki Naemura, Ayumi Inoue, Yoshinobu Ijiri, Junji Seki, Toyotaka Yada, Masami Goto, Masakazu Shinohara, Seinosuke Kawashima, John C Giddings, Junichiro Yamamoto. Impaired endothelial function may be due to decreased aortic tetrahydrobiopterin, assessed by a new flow-mediated vasodilation in vivo in hypercholesterolemic/atherogenic mice.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2009 Dec; 20(8):699-705. doi:
10.1097/mbc.0b013e328331fd18. [PMID: 19741507] - Florentina Cañada-Cañada, Anunciación Espinosa-Mansilla, Arsenio Muñoz de la Peña, Alicia Mancha de Llanos. Determination of marker pteridins and biopterin reduced forms, tetrahydrobiopterin and dihydrobiopterin, in human urine, using a post-column photoinduced fluorescence liquid chromatographic derivatization method.
Analytica chimica acta.
2009 Aug; 648(1):113-22. doi:
10.1016/j.aca.2009.06.045. [PMID: 19616696] - Xiang-Qun Yang, Alex F Chen. High-cholesterol diet augments endothelial dysfunction via elevated oxidative stress and reduced tetrahydrobiopterin in Ins2(Akita) mice, an autosomal dominant mutant type 1 diabetic model.
Clinical and experimental pharmacology & physiology.
2009 Aug; 36(8):764-9. doi:
10.1111/j.1440-1681.2009.05145.x. [PMID: 19207718] - Yuwen Zhao, Jerry Cao, Yuan-Shek Chen, Yongdong Zhu, Colin Patrick, Benjamin Chien, Alphonsus Cheng, Erik D Foehr. Detection of tetrahydrobiopterin by LC-MS/MS in plasma from multiple species.
Bioanalysis.
2009 Aug; 1(5):895-903. doi:
10.4155/bio.09.77. [PMID: 21083061] - Sanjiv Kumar, Xutong Sun, Shruti Sharma, Saurabh Aggarwal, Kandasamy Ravi, Jeffery R Fineman, Stephen M Black. GTP cyclohydrolase I expression is regulated by nitric oxide: role of cyclic AMP.
American journal of physiology. Lung cellular and molecular physiology.
2009 Aug; 297(2):L309-17. doi:
10.1152/ajplung.90538.2008. [PMID: 19447893] - Haruka Hirakawa, Hiroshi Sawada, Yumi Yamahama, Shin-Ichiro Takikawa, Haruo Shintaku, Akira Hara, Keisuke Mase, Tomoyoshi Kondo, Teruhiko Iino. Expression analysis of the aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues.
Journal of biochemistry.
2009 Jul; 146(1):51-60. doi:
10.1093/jb/mvp042. [PMID: 19273550] - Nicola Longo. Disorders of biopterin metabolism.
Journal of inherited metabolic disease.
2009 Jun; 32(3):333-42. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Jun; 329(3):890-9. doi:
10.1124/jpet.108.148569. [PMID: 19307452] - Asli F Ceylan-Isik, Kelly K Guo, Edward C Carlson, Jamie R Privratsky, Song-Jie Liao, Lu Cai, Alex F Chen, Jun Ren. Metallothionein abrogates GTP cyclohydrolase I inhibition-induced cardiac contractile and morphological defects: role of mitochondrial biogenesis.
Hypertension (Dallas, Tex. : 1979).
2009 Jun; 53(6):1023-31. doi:
10.1161/hypertensionaha.108.123422. [PMID: 19398661] - Steven F Dobrowolski, K Borski, C C Ellingson, R Koch, H L Levy, E W Naylor. A limited spectrum of phenylalanine hydroxylase mutations is observed in phenylketonuria patients in western Poland and implications for treatment with 6R tetrahydrobiopterin.
Journal of human genetics.
2009 Jun; 54(6):335-9. doi:
10.1038/jhg.2009.37. [PMID: 19444284] - Masafumi Takeda, Tomoya Yamashita, Masakazu Shinohara, Naoto Sasaki, Tomofumi Takaya, Kenji Nakajima, Nobutaka Inoue, Tomoya Masano, Hideto Tawa, Seimi Satomi-Kobayashi, Ryuji Toh, Daisuke Sugiyama, Kunihiro Nishimura, Mitsuhiro Yokoyama, Ken-ichi Hirata, Seinosuke Kawashima. Plasma tetrahydrobiopterin/dihydrobiopterin ratio: a possible marker of endothelial dysfunction.
Circulation journal : official journal of the Japanese Circulation Society.
2009 May; 73(5):955-62. doi:
10.1253/circj.cj-08-0850. [PMID: 19293532] - Mark Sanford, Gillian M Keating. Sapropterin: a review of its use in the treatment of primary hyperphenylalaninaemia.
Drugs.
2009; 69(4):461-76. doi:
10.2165/00003495-200969040-00006. [PMID: 19323589] - Katrin Watschinger, Markus A Keller, Albin Hermetter, Georg Golderer, Gabriele Werner-Felmayer, Ernst R Werner. Glyceryl ether monooxygenase resembles aromatic amino acid hydroxylases in metal ion and tetrahydrobiopterin dependence.
Biological chemistry.
2009 Jan; 390(1):3-10. doi:
10.1515/bc.2009.010. [PMID: 19007315] - Haruo Shintaku, Misao Ohwada, Kikumaro Aoki, Teruo Kitagawa, Tsunekazu Yamano. Diagnosis of tetrahydrobiopterin (BH4) responsive mild phenylketonuria in Japan over the past 10 years.
Annals of the Academy of Medicine, Singapore.
2008 Dec; 37(12 Suppl):77-2. doi:
NULL. [PMID: 19904458] - Minoru Satoh, Sohachi Fujimoto, Sayaka Arakawa, Toyotaka Yada, Tamehachi Namikoshi, Yoshisuke Haruna, Hideyuki Horike, Tamaki Sasaki, Naoki Kashihara. Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2008 Dec; 23(12):3806-13. doi:
10.1093/ndt/gfn357. [PMID: 18596126] - Phillip Lee, Eileen P Treacy, Eric Crombez, Melissa Wasserstein, Lewis Waber, Jon Wolff, Udo Wendel, Alex Dorenbaum, Judith Bebchuk, Heidi Christ-Schmidt, Margretta Seashore, Marcello Giovannini, Barbara K Burton, Andrew A Morris. Safety and efficacy of 22 weeks of treatment with sapropterin dihydrochloride in patients with phenylketonuria.
American journal of medical genetics. Part A.
2008 Nov; 146A(22):2851-9. doi:
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Journal of nephrology.
2008 Nov; 21(6):850-60. doi:
. [PMID: 19034869] - Gyeong In Mun, Sang Mi An, Heonyong Park, Hanjoong Jo, Yong Chool Boo. Laminar shear stress inhibits lipid peroxidation induced by high glucose plus arachidonic acid in endothelial cells.
American journal of physiology. Heart and circulatory physiology.
2008 Nov; 295(5):H1966-73. doi:
10.1152/ajpheart.00727.2008. [PMID: 18790833] - Ziad A Ali, Christina A Bursill, Gillian Douglas, Eileen McNeill, Marianna Papaspyridonos, Amy L Tatham, Jennifer K Bendall, Asim M Akhtar, Nicholas J Alp, David R Greaves, Keith M Channon. CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
Circulation.
2008 Sep; 118(14 Suppl):S71-7. doi:
10.1161/circulationaha.107.753558. [PMID: 18824773] - Toshio Imanishi, Hiroto Tsujioka, Hideyuki Ikejima, Akio Kuroi, Shigeho Takarada, Hironori Kitabata, Takashi Tanimoto, Yasuteru Muragaki, Seiichi Mochizuki, Masami Goto, Kiyoshi Yoshida, Takashi Akasaka. Renin inhibitor aliskiren improves impaired nitric oxide bioavailability and protects against atherosclerotic changes.
Hypertension (Dallas, Tex. : 1979).
2008 Sep; 52(3):563-72. doi:
10.1161/hypertensionaha.108.111120. [PMID: 18645051] - François Feillet, Céline Chery, Fares Namour, Antoine Kimmoun, Elisabeth Favre, Elisabeth Lorentz, Shyue-Fang Battaglia-Hsu, Jean-Louis Guéant. Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia.
Early human development.
2008 Sep; 84(9):561-7. doi:
10.1016/j.earlhumdev.2008.01.003. [PMID: 18321666] - M Ploder, G Neurauter, A Spittler, K Schroecksnadel, E Roth, D Fuchs. Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations.
Amino acids.
2008 Aug; 35(2):303-7. doi:
10.1007/s00726-007-0625-x. [PMID: 18163176] - Karel Tyml, Fuyan Li, John X Wilson. Septic impairment of capillary blood flow requires nicotinamide adenine dinucleotide phosphate oxidase but not nitric oxide synthase and is rapidly reversed by ascorbate through an endothelial nitric oxide synthase-dependent mechanism.
Critical care medicine.
2008 Aug; 36(8):2355-62. doi:
10.1097/ccm.0b013e31818024f6. [PMID: 18596627] - Charalambos Antoniades, Cheerag Shirodaria, Tim Van Assche, Colin Cunnington, Irmgard Tegeder, Jörn Lötsch, Tomasz J Guzik, Paul Leeson, Jonathan Diesch, Dimitris Tousoulis, Christodoulos Stefanadis, Michael Costigan, Clifford J Woolf, Nicholas J Alp, Keith M Channon. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function.
Journal of the American College of Cardiology.
2008 Jul; 52(2):158-65. doi:
10.1016/j.jacc.2007.12.062. [PMID: 18598896] - Naoto Sasaki, Tomoya Yamashita, Tomofumi Takaya, Masakazu Shinohara, Rio Shiraki, Masafumi Takeda, Noriaki Emoto, Akiko Fukatsu, Toshio Hayashi, Kazuhisa Ikemoto, Takahide Nomura, Mitsuhiro Yokoyama, Ken-Ichi Hirata, Seinosuke Kawashima. Augmentation of vascular remodeling by uncoupled endothelial nitric oxide synthase in a mouse model of diabetes mellitus.
Arteriosclerosis, thrombosis, and vascular biology.
2008 Jun; 28(6):1068-76. doi:
10.1161/atvbaha.107.160754. [PMID: 18403727] - Hideyuki Ikejima, Toshio Imanishi, Hiroto Tsujioka, Akio Kuroi, Yasuteru Muragaki, Seiichi Mochizuki, Masami Goto, Kiyoshi Yoshida, Takashi Akasaka. Effect of pioglitazone on nitroglycerin-induced impairment of nitric oxide bioavailability by a catheter-type nitric oxide sensor.
Circulation journal : official journal of the Japanese Circulation Society.
2008 Jun; 72(6):998-1002. doi:
10.1253/circj.72.998. [PMID: 18503229] - Erik R Kline, Dean J Kleinhenz, Bill Liang, Sergey Dikalov, David M Guidot, C Michael Hart, Dean P Jones, Roy L Sutliff. Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration.
American journal of physiology. Heart and circulatory physiology.
2008 Jun; 294(6):H2792-804. doi:
10.1152/ajpheart.91447.2007. [PMID: 18456725] - Naobumi Hamadate, Katsuhiko Noguchi, Mayuko Sakanashi, Toshihiro Matsuzaki, Junko Nakasone, Matao Sakanashi. Effect of decreased levels of intrinsic tetrahydrobiopterin on endothelial function in anesthetized rats.
Journal of pharmacological sciences.
2008 May; 107(1):49-56. doi:
10.1254/jphs.fp0071967. [PMID: 18446004] - F Cosentino, D Hürlimann, C Delli Gatti, R Chenevard, N Blau, N J Alp, K M Channon, M Eto, P Lerch, F Enseleit, F Ruschitzka, M Volpe, T F Lüscher, G Noll. Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
Heart (British Cardiac Society).
2008 Apr; 94(4):487-92. doi:
10.1136/hrt.2007.122184. [PMID: 17916662] - Wei Wang, Einath Zolty, Sandor Falk, Sandra Summer, Zhu Zhou, Patricia Gengaro, Sarah Faubel, Nicholas Alp, Keith Channon, Robert Schrier. Endotoxemia-related acute kidney injury in transgenic mice with endothelial overexpression of GTP cyclohydrolase-1.
American journal of physiology. Renal physiology.
2008 Mar; 294(3):F571-6. doi:
10.1152/ajprenal.00538.2007. [PMID: 18171994] - Yan-Hua Du, Yong-Yuan Guan, Nicholas J Alp, Keith M Channon, Alex F Chen. Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension.
Circulation.
2008 Feb; 117(8):1045-54. doi:
10.1161/circulationaha.107.748236. [PMID: 18268143] - Atsushi Ogawa, Masaki Kanazawa, Masaki Takayanagi, Yutaka Kitani, Haruo Shintaku, Yoichi Kohno. A case of 6-pyruvoyl-tetrahydropterin synthase deficiency demonstrates a more significant correlation of L-Dopa dosage with serum prolactin levels than CSF homovanillic acid levels.
Brain & development.
2008 Jan; 30(1):82-5. doi:
10.1016/j.braindev.2007.05.011. [PMID: 17590551] - Toshio Imanishi, Akio Kuroi, Hideyuki Ikejima, Katsunobu Kobayashi, Seiichi Mochizuki, Masami Goto, Kiyoshi Yoshida, Takashi Akasaka. Effects of pioglitazone on nitric oxide bioavailability measured using a catheter-type nitric oxide sensor in angiotensin II-infusion rabbit.
Hypertension research : official journal of the Japanese Society of Hypertension.
2008 Jan; 31(1):117-25. doi:
10.1291/hypres.31.117. [PMID: 18360026] - François Feillet, Lorne Clarke, Concetta Meli, Mark Lipson, Andrew A Morris, Paul Harmatz, Diane R Mould, Bruce Green, Alex Dorenbaum, Marcello Giovannini, Erik Foehr. Pharmacokinetics of sapropterin in patients with phenylketonuria.
Clinical pharmacokinetics.
2008; 47(12):817-25. doi:
10.2165/0003088-200847120-00006. [PMID: 19026037] - Giovana Seno Di Marco, Juliana Almada Colucci, Fernanda Barrinha Fernandes, Carlos Pablo Vio, Nestor Schor, Dulce Elena Casarini. Diabetes induces changes of catecholamines in primary mesangial cells.
The international journal of biochemistry & cell biology.
2008; 40(4):747-54. doi:
10.1016/j.biocel.2007.10.016. [PMID: 18037336] - Aida A Korish, Maha M Arafah. The potential anti-inflammatory effect of tetrahydrobiopterin administration in renal mass reduction-induced chronic renal failure in rats.
Saudi medical journal.
2007 Dec; 28(12):1803-9. doi:
. [PMID: 18060206] - Jennifer Whitsett, Matthew J Picklo, Jeannette Vasquez-Vivar. 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation.
Arteriosclerosis, thrombosis, and vascular biology.
2007 Nov; 27(11):2340-7. doi:
10.1161/atvbaha.107.153742. [PMID: 17872449] - M D Bóveda, M L Couce, D E Castiñeiras, J A Cocho, B Pérez, M Ugarte, J M Fraga. The tetrahydrobiopterin loading test in 36 patients with hyperphenylalaninaemia: evaluation of response and subsequent treatment.
Journal of inherited metabolic disease.
2007 Oct; 30(5):812. doi:
10.1007/s10545-007-0567-1. [PMID: 17603758] - B K Burton, D K Grange, A Milanowski, G Vockley, F Feillet, E A Crombez, V Abadie, C O Harding, S Cederbaum, D Dobbelaere, A Smith, A Dorenbaum. The response of patients with phenylketonuria and elevated serum phenylalanine to treatment with oral sapropterin dihydrochloride (6R-tetrahydrobiopterin): a phase II, multicentre, open-label, screening study.
Journal of inherited metabolic disease.
2007 Oct; 30(5):700-7. doi:
10.1007/s10545-007-0605-z. [PMID: 17846916] - Eduardo Podjarny, Joelle Bernheim, Galit Hasdan, Dorit Karsh, Gloria Rashid, Janice Green, Bernardo Katz, Jacques Bernheim. Additive renoprotective effect of candesartan and tetrahydrobiopterin in rats after 5/6 nephrectomy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Jul; 22(7):1864-72. doi:
10.1093/ndt/gfm129. [PMID: 17442743] - Yoshisuke Haruna, Yoshitaka Morita, Toyotaka Yada, Minoru Satoh, David A Fox, Naoki Kashihara. Fluvastatin reverses endothelial dysfunction and increased vascular oxidative stress in rat adjuvant-induced arthritis.
Arthritis and rheumatism.
2007 Jun; 56(6):1827-35. doi:
10.1002/art.22632. [PMID: 17530711] - Ling Yang, Zhi-xin Zhang, Jun Ye, Zhong-shu Zhou, Ming Shen, Lian-shu Han, Wenjuan Qiu, Wei-min Yu, Xue-fan Gu. [Clinical study of tetrahydrobiopterin responsive phenylalanine hydroxylase deficiency in southern and northern Chinese patients].
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.
2007 Jun; 24(3):310-3. doi:
NULL. [PMID: 17557244] - Lila Mayahi, Simon Heales, David Owen, Juan P Casas, Joanne Harris, Raymond J MacAllister, Aroon D Hingorani. (6R)-5,6,7,8-tetrahydro-L-biopterin and its stereoisomer prevent ischemia reperfusion injury in human forearm.
Arteriosclerosis, thrombosis, and vascular biology.
2007 Jun; 27(6):1334-9. doi:
10.1161/atvbaha.107.142257. [PMID: 17413035] - Javid Wani, Marina Carl, Anna Henger, Peter J Nelson, Harald Rupprecht. Nitric oxide modulates expression of extracellular matrix genes linked to fibrosis in kidney mesangial cells.
Biological chemistry.
2007 May; 388(5):497-506. doi:
10.1515/bc.2007.056. [PMID: 17516845] - Minchan Gil, Cushla McKinney, Mi Kyeong Lee, Jeffrey B Eells, Marcia A Phyillaier, Vera M Nikodem. Regulation of GTP cyclohydrolase I expression by orphan receptor Nurr1 in cell culture and in vivo.
Journal of neurochemistry.
2007 Apr; 101(1):142-50. doi:
10.1111/j.1471-4159.2006.04356.x. [PMID: 17394463] - A A J Lam, K Hyland, S J R Heales. Tetrahydrobiopterin availability, nitric oxide metabolism and glutathione status in the hph-1 mouse; implications for the pathogenesis and treatment of tetrahydrobiopterin deficiency states.
Journal of inherited metabolic disease.
2007 Apr; 30(2):256-62. doi:
10.1007/s10545-006-0502-x. [PMID: 17242981] - Kohei Yamamizu, Kazuya Shinozaki, Kazuhide Ayajiki, Munekazu Gemba, Tomio Okamura. Oral administration of both tetrahydrobiopterin and L-arginine prevents endothelial dysfunction in rats with chronic renal failure.
Journal of cardiovascular pharmacology.
2007 Mar; 49(3):131-9. doi:
10.1097/fjc.0b013e31802f9923. [PMID: 17414224] - Durk Fekkes, Ans Voskuilen-Kooijman. Quantitation of total biopterin and tetrahydrobiopterin in plasma.
Clinical biochemistry.
2007 Mar; 40(5-6):411-3. doi:
10.1016/j.clinbiochem.2006.12.001. [PMID: 17291474] - Yuchun Miao, Yi Zhang, Pek S Lim, Yada Kanjanapan, Trevor A Mori, Kevin D Croft, John Earl, Sze Y Lee, Katja U S McKenzie, Lexian Hu, Judith A Whitworth. Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat.
American journal of hypertension.
2007 Mar; 20(3):304-10. doi:
10.1016/j.amjhyper.2006.08.007. [PMID: 17324744] - Yasuyoshi Watanabe. [Molecular imaging for drug development].
Brain and nerve = Shinkei kenkyu no shinpo.
2007 Mar; 59(3):209-14. doi:
NULL. [PMID: 17370646] - Chigusa Iwata, Xi Wang, Kohsuke Uchida, Nobuo Nakanishi, Yoshiyuki Hattori. Buthionine sulfoximine causes endothelium dependent hyper-relaxation and hypoadiponectinemia.
Life sciences.
2007 Feb; 80(9):873-8. doi:
10.1016/j.lfs.2006.11.012. [PMID: 17137603] - Xi Wang, Yoshiyuki Hattori, Hiroko Satoh, Chigusa Iwata, Nobuyuki Banba, Tsuyoshi Monden, Kohsuke Uchida, Yuichiro Kamikawa, Kikuo Kasai. Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats.
European journal of pharmacology.
2007 Jan; 555(1):48-53. doi:
10.1016/j.ejphar.2006.10.017. [PMID: 17098227] - Mary Ann Richardson, Laura L Read, Margaret A Reilly, James D Clelland, Catherine L Taylor Clelland. Analysis of plasma biopterin levels in psychiatric disorders suggests a common BH4 deficit in schizophrenia and schizoaffective disorder.
Neurochemical research.
2007 Jan; 32(1):107-13. doi:
10.1007/s11064-006-9233-5. [PMID: 17160504] - Toyotaka Yada, Shuichiro Kaji, Takashi Akasaka, Seiichi Mochizuki, Yasuo Ogasawara, Kazuo Tanemoto, Kiyoshi Yoshida, Fumihiko Kajiya. Changes of asymmetric dimethylarginine, nitric oxide, tetrahydrobiopterin, and oxidative stress in patients with acute myocardial infarction by medical treatments.
Clinical hemorheology and microcirculation.
2007; 37(3):269-76. doi:
NULL. [PMID: 17726257] - Henning Tiemeier, Durk Fekkes, Albert Hofman, H Ruud van Tuijl, Amanda J Kiliaan, Monique M B Breteler. Plasma pterins and folate in late life depression: the Rotterdam Study.
Psychiatry research.
2006 Dec; 145(2-3):199-206. doi:
10.1016/j.psychres.2005.07.035. [PMID: 17070603] - Angel L Pey, Aurora Martinez, Ramamurthy Charubala, Derek J Maitland, Knut Teigen, Ana Calvo, Wolfgang Pfleiderer, John M Wood, Karin U Schallreuter. Specific interaction of the diastereomers 7(R)- and 7(S)-tetrahydrobiopterin with phenylalanine hydroxylase: implications for understanding primapterinuria and vitiligo.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2006 Oct; 20(12):2130-2. doi:
10.1096/fj.06-5835fje. [PMID: 16935936]
