Methyl 2-(2-acetoxy-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-2-(2-chlorophenyl)acetate (BioDeep_00000842730)
代谢物信息卡片
化学式: C18H18ClNO4S (379.0645018000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OC1=CC2=C(S1)CCN(C2)C(C3=CC=CC=C3Cl)C(=O)OC
InChI: InChI=1S/C18H18ClNO4S/c1-11(21)24-16-9-12-10-20(8-7-15(12)25-16)17(18(22)23-2)13-5-3-4-6-14(13)19/h3-6,9,17H,7-8,10H2,1-2H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuan-Dong Zheng, Hua Zhang, Yan Zhan, Yi-Cong Bian, Sheng Ma, Hai-Xian Gan, Xiao-Juan Lai, Yong-Qiang Liu, Yan-Chun Gong, Xue-Fang Liu, Hong-Bin Sun, Yong-Guo Li, Da-Fang Zhong, Li-Yan Miao, Xing-Xing Diao. Pharmacokinetics, mass balance, and metabolism of [14C]vicagrel, a novel irreversible P2Y12 inhibitor in humans.
Acta pharmacologica Sinica.
2021 Sep; 42(9):1535-1546. doi:
10.1038/s41401-020-00547-7. [PMID: 33244163] - Ting Tai, Huan Zhou, Ting Zhu, Yu-Meng Jia, Jin-Zi Ji, Yi-Fei Li, Qiong-Yu Mi, Hong-Guang Xie. Development and validation of a UPLC-MS/MS method for simultaneous determination of vicagrel and its major metabolites in rat or human plasma: An optimized novel strategy for the stabilization of vicagrel.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 179(?):112955. doi:
10.1016/j.jpba.2019.112955. [PMID: 31866139] - Yu-Meng Jia, Peng-Xin Ge, Huan Zhou, Jin-Zi Ji, Ting Tai, Tong-Tong Gu, Ting Zhu, Yi-Fei Li, Qiong-Yu Mi, Bei-Bei Huang, Hong-Guang Xie. Vicagrel enhances aspirin-induced inhibition of both platelet aggregation and thrombus formation in rodents due to its decreased metabolic inactivation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108906. doi:
10.1016/j.biopha.2019.108906. [PMID: 31060007] - Yu-Meng Jia, Huan Zhou, Ting Tai, Tong-Tong Gu, Jin-Zi Ji, Qiong-Yu Mi, Bei-Bei Huang, Yi-Fei Li, Ting Zhu, Hong-Guang Xie. Enhanced responsiveness of platelets to vicagrel in IL-10-deficient mice through STAT3-dependent up-regulation of the hydrolase arylacetamide deacetylase in the intestine.
British journal of pharmacology.
2019 06; 176(11):1717-1727. doi:
10.1111/bph.14646. [PMID: 30825385] - Cai Liu, Yifan Zhang, Weili Chen, Youming Lu, Wei Li, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yongguo Li, Xiaoyan Chen, Xuening Li, Hongbin Sun, Jin Yang, Dafang Zhong. Pharmacokinetics and pharmacokinetic/pharmacodynamic relationship of vicagrel, a novel thienopyridine P2Y12 inhibitor, compared with clopidogrel in healthy Chinese subjects following single oral dosing.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Jan; 127(?):151-160. doi:
10.1016/j.ejps.2018.10.011. [PMID: 30326264] - Yu-Meng Jia, Tong-Tong Gu, Jin-Zi Ji, Ting Tai, Meng-Ran Zhang, Bei-Bei Huang, Huan Zhou, Qiong-Yu Mi, Hong-Guang Xie. Aspirin Attenuates the Bioactivation of and Platelet Response to Vicagrel in Mice.
Journal of cardiovascular pharmacology.
2018 11; 72(5):252-258. doi:
10.1097/fjc.0000000000000622. [PMID: 30358688] - Cai Liu, Youming Lu, Hongbin Sun, Jin Yang, Yongqiang Liu, Xiaojuan Lai, Yanchun Gong, Xuefang Liu, Yongguo Li, Yifan Zhang, Xiaoyan Chen, Dafang Zhong. Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma.
Journal of pharmaceutical and biomedical analysis.
2018 Feb; 149(?):394-402. doi:
10.1016/j.jpba.2017.11.019. [PMID: 29154109] - Zhixia Qiu, Ning Li, Ling Song, Yang Lu, Jing Jing, Harendra S Parekha, Wenchao Gao, Fengjie Tian, Xin Wang, Shuangxia Ren, Xijing Chen. Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel.
Pharmaceutical research.
2014 Jan; 31(1):238-51. doi:
10.1007/s11095-013-1158-5. [PMID: 24037619]