9-(4-Hydroxy-2-(hydroxymethyl)butyl)guanine (BioDeep_00000842713)
代谢物信息卡片
化学式: C10H15N5O3 (253.11748400000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1CC(CCO)CO)N=C(NC2=O)N
InChI: InChI=1S/C10H15N5O3/c11-10-13-8-7(9(18)14-10)12-5-15(8)3-6(4-17)1-2-16/h5-6,16-17H,1-4H2,(H3,11,13,14,18)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Karen Yao, Christel Hoest, Farzin Rashti, Timm C Schott, Steven Jacobson. Effect of (r)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine (H2G) and AZT-lipid-PFA on human herpesvirus-6B infected cells.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2009 Sep; 46(1):10-4. doi:
10.1016/j.jcv.2009.05.014. [PMID: 19524486] - Dennis R Weller, Henry H Balfour, Heather E Vezina. Simultaneous determination of acyclovir, ganciclovir, and (R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine in human plasma using high-performance liquid chromatography.
Biomedical chromatography : BMC.
2009 Aug; 23(8):822-7. doi:
10.1002/bmc.1192. [PMID: 19358150] - M M Alauddin, A Shahinian, E M Gordon, J R Bading, P S Conti. Preclinical evaluation of the penciclovir analog 9-(4-[(18)F]fluoro-3-hydroxymethylbutyl)guanine for in vivo measurement of suicide gene expression with PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2001 Nov; 42(11):1682-90. doi:
. [PMID: 11696640] - J Neyts, G Andrei, E De Clercq. The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil.
Antimicrobial agents and chemotherapy.
1998 Dec; 42(12):3285-9. doi:
10.1128/aac.42.12.3285. [PMID: 9835529] - D M Lake-Bakaar, G Abele, B Lindborg, K F Soike, R Datema. Pharmacokinetics and antiviral activity in simian varicella virus-infected monkeys of (R,S)-9-[4-hydroxy-2-(hydroxymethyl) butyl]guanine, an anti-varicella-zoster virus drug.
Antimicrobial agents and chemotherapy.
1988 Dec; 32(12):1807-12. doi:
10.1128/aac.32.12.1807. [PMID: 2854453] - A Larsson, K Stenberg, A C Ericson, U Haglund, W A Yisak, N G Johansson, B Oberg, R Datema. Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.
Antimicrobial agents and chemotherapy.
1986 Oct; 30(4):598-605. doi:
10.1128/aac.30.4.598. [PMID: 3024562]