Benzonitrile, 3-fluoro-5-(2-(2-(fluoromethyl)-4-thiazolyl)ethynyl)- (BioDeep_00000842684)
代谢物信息卡片
化学式: C13H6F2N2S (260.021974)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C=C1C#N)F)C#CC2=CSC(=N2)CF
InChI: InChI=1S/C13H6F2N2S/c14-6-13-17-12(8-18-13)2-1-9-3-10(7-16)5-11(15)4-9/h3-5,8H,6H2
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- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
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文献列表
- Yasuyuki Kimura, Fabrice G Siméon, Sami S Zoghbi, Yi Zhang, Jun Hatazawa, Victor W Pike, Robert B Innis, Masahiro Fujita. Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using 18F-SP203.
NeuroImage.
2012 Feb; 59(3):2124-30. doi:
10.1016/j.neuroimage.2011.10.028. [PMID: 22032949] - Yasuyuki Kimura, Fabrice G Siméon, Jun Hatazawa, P David Mozley, Victor W Pike, Robert B Innis, Masahiro Fujita. Biodistribution and radiation dosimetry of a positron emission tomographic ligand, 18F-SP203, to image metabotropic glutamate subtype 5 receptors in humans.
European journal of nuclear medicine and molecular imaging.
2010 Oct; 37(10):1943-9. doi:
10.1007/s00259-010-1447-8. [PMID: 20585776] - H Umesha Shetty, Sami S Zoghbi, Fabrice G Siméon, Jeih-San Liow, Amira K Brown, Pavitra Kannan, Robert B Innis, Victor W Pike. Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain.
The Journal of pharmacology and experimental therapeutics.
2008 Dec; 327(3):727-35. doi:
10.1124/jpet.108.143347. [PMID: 18806125] - Amira K Brown, Yasuyuki Kimura, Sami S Zoghbi, Fabrice G Siméon, Jeih-San Liow, William C Kreisl, Andrew Taku, Masahiro Fujita, Victor W Pike, Robert B Innis. Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
2008 Dec; 49(12):2042-8. doi:
10.2967/jnumed.108.056291. [PMID: 19038998] - Fabrice G Siméon, Amira K Brown, Sami S Zoghbi, Velvet M Patterson, Robert B Innis, Victor W Pike. Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.
Journal of medicinal chemistry.
2007 Jul; 50(14):3256-66. doi:
10.1021/jm0701268. [PMID: 17571866]