Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)- (BioDeep_00000842668)
代谢物信息卡片
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(4-azido-3-iodobenzoyl)-
化学式: C21H21IN8O3 (560.0781)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4=CC(=C(C=C4)N=[N+]=[N-])I)N)OC
InChI: InChI=1S/C21H21IN8O3/c1-32-17-10-13-16(11-18(17)33-2)25-21(26-19(13)23)30-7-5-29(6-8-30)20(31)12-3-4-15(27-28-24)14(22)9-12/h3-4,9-11H,5-8H2,1-2H3,(H2,23,25,26)
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Biebele Abel, Dilip K Tosh, Stewart R Durell, Megumi Murakami, Shahrooz Vahedi, Kenneth A Jacobson, Suresh V Ambudkar. Evidence for the Interaction of A3 Adenosine Receptor Agonists at the Drug-Binding Site(s) of Human P-glycoprotein (ABCB1).
Molecular pharmacology.
2019 08; 96(2):180-192. doi:
10.1124/mol.118.115295. [PMID: 31127007] - Pornsiri Pitchakarn, Shinobu Ohnuma, Komsak Pintha, Wilart Pompimon, Suresh V Ambudkar, Pornngarm Limtrakul. Kuguacin J isolated from Momordica charantia leaves inhibits P-glycoprotein (ABCB1)-mediated multidrug resistance.
The Journal of nutritional biochemistry.
2012 Jan; 23(1):76-84. doi:
10.1016/j.jnutbio.2010.11.005. [PMID: 21414769] - Wisinee Chanmahasathien, Shinobu Ohnuma, Suresh V Ambudkar, Pornngarm Limtrakul. Biochemical mechanism of modulation of human P-glycoprotein by stemofoline.
Planta medica.
2011 Dec; 77(18):1990-5. doi:
10.1055/s-0031-1280054. [PMID: 21786221] - Robert W Robey, Suneet Shukla, Elizabeth M Finley, Robert K Oldham, Daryl Barnett, Suresh V Ambudkar, Tito Fojo, Susan E Bates. Inhibition of P-glycoprotein (ABCB1)- and multidrug resistance-associated protein 1 (ABCC1)-mediated transport by the orally administered inhibitor, CBT-1((R)).
Biochemical pharmacology.
2008 Mar; 75(6):1302-12. doi:
10.1016/j.bcp.2007.12.001. [PMID: 18234154] - Nazli Maki, Saibal Dey. Biochemical and pharmacological properties of an allosteric modulator site of the human P-glycoprotein (ABCB1).
Biochemical pharmacology.
2006 Jul; 72(2):145-55. doi:
10.1016/j.bcp.2006.04.008. [PMID: 16729976] - Leanne Hanson, Leopold May, Pamela Tuma, James Keeven, Patrick Mehl, Michelle Ferenz, Suresh V Ambudkar, John Golin. The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.
Biochemistry.
2005 Jul; 44(28):9703-13. doi:
10.1021/bi0502994. [PMID: 16008355] - W Chearwae, S Anuchapreeda, K Nandigama, S V Ambudkar, P Limtrakul. Biochemical mechanism of modulation of human P-glycoprotein (ABCB1) by curcumin I, II, and III purified from Turmeric powder.
Biochemical pharmacology.
2004 Nov; 68(10):2043-52. doi:
10.1016/j.bcp.2004.07.009. [PMID: 15476675] - B Isenberg, H Thole, B Tümmler, A Demmer. Identification and localization of three photobinding sites of iodoarylazidoprazosin in hamster P-glycoprotein.
European journal of biochemistry.
2001 May; 268(9):2629-34. doi:
10.1046/j.1432-1327.2001.02155.x. [PMID: 11322883] - Z E Sauna, S V Ambudkar. Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein. The two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect different functional outcomes.
The Journal of biological chemistry.
2001 Apr; 276(15):11653-61. doi:
10.1074/jbc.m011294200. [PMID: 11154703] - L Beaudet, I L Urbatsch, P Gros. Mutations in the nucleotide-binding sites of P-glycoprotein that affect substrate specificity modulate substrate-induced adenosine triphosphatase activity.
Biochemistry.
1998 Jun; 37(25):9073-82. doi:
10.1021/bi972656j. [PMID: 9636053] - L Jetté, G F Murphy, R Béliveau. Drug binding to P-glycoprotein is inhibited in normal tissues following SDZ-PSC 833 treatment.
International journal of cancer.
1998 May; 76(5):729-37. doi:
10.1002/(sici)1097-0215(19980529)76:5<729::aid-ijc19>3.0.co;2-z. [PMID: 9610733] - E Beaulieu, M Demeule, L Ghitescu, R Béliveau. P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain.
The Biochemical journal.
1997 Sep; 326 ( Pt 2)(?):539-44. doi:
10.1042/bj3260539. [PMID: 9291129] - Y Wang, E Georges. N-ethylmaleimide increases P-glycoprotein photoaffinity labeling with iodoaryl-azidoprazosin in multidrug resistant cells.
Anticancer research.
1997 Jan; 17(1A):357-64. doi:
. [PMID: 9066677] - L Jetté, E Beaulieu, J M Leclerc, R Béliveau. Cyclosporin A treatment induces overexpression of P-glycoprotein in the kidney and other tissues.
The American journal of physiology.
1996 May; 270(5 Pt 2):F756-65. doi:
10.1152/ajprenal.1996.270.5.f756. [PMID: 8928836] - L M Canessa, M M Piccio, P Vachvanichsanong, A Sidhu, C C Porter, J E Robillard, R A Felder, P A Jose. Alpha 1B-adrenergic receptors in rat renal microvessels.
Kidney international.
1995 Nov; 48(5):1412-9. doi:
10.1038/ki.1995.430. [PMID: 8544397] - D Piwnica-Worms, V V Rao, J F Kronauge, J M Croop. Characterization of multidrug resistance P-glycoprotein transport function with an organotechnetium cation.
Biochemistry.
1995 Sep; 34(38):12210-20. doi:
10.1021/bi00038a015. [PMID: 7547962] - T L Hwang, Y T Lau, M F Chen, C Tang, M S Liu. Biphasic intracellular redistribution of alpha 1-adrenergic receptors in rat liver during sepsis.
The American journal of physiology.
1993 Aug; 265(2 Pt 2):R385-91. doi:
10.1152/ajpregu.1993.265.2.r385. [PMID: 8396354] - H T Cohen, F Takemoto, T Satoh, A I Katz. Renal adrenergic receptors: localization of [125I]prazosin binding sites along the microdissected rat nephron.
Canadian journal of physiology and pharmacology.
1992 Jul; 70(7):1016-20. doi:
10.1139/y92-140. [PMID: 1451023] - C E Seidman, H J Hess, C J Homcy, R M Graham. Synthesis and characterization of a radioiodinated photoaffinity probe for the alpha 1-adrenergic receptor.
Hypertension (Dallas, Tex. : 1979).
1984 Mar; 6(2 Pt 2):I7-11. doi:
10.1161/01.hyp.6.2_pt_2.i7. [PMID: 6327524]
