Desbutyllumefantrine (BioDeep_00000842626)
代谢物信息卡片
化学式: C26H24Cl3NO (471.0923384)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCNCC(C1=CC(=CC2=C1C3=C(C2=CC4=CC=C(C=C4)Cl)C=C(C=C3)Cl)Cl)O
InChI: InChI=1S/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11+
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Sa'ad T Abdullahi, Julius O Soyinka, Adeniyi Olagunju, Rahman A Bolarinwa, Olusola J Olarewaju, Moji T Bakare-Odunola, Markus Winterberg, Joel Tarning, Andrew Owen, Saye Khoo. CYP2B6*6 Genotype Specific Differences in Artemether-Lumefantrine Disposition in Healthy Volunteers.
Journal of clinical pharmacology.
2020 03; 60(3):351-360. doi:
10.1002/jcph.1527. [PMID: 31549442] - Frank Kloprogge, Lesley Workman, Steffen Borrmann, Mamadou Tékété, Gilbert Lefèvre, Kamal Hamed, Patrice Piola, Johan Ursing, Poul Erik Kofoed, Andreas Mårtensson, Billy Ngasala, Anders Björkman, Michael Ashton, Sofia Friberg Hietala, Francesca Aweeka, Sunil Parikh, Leah Mwai, Timothy M E Davis, Harin Karunajeewa, Sam Salman, Francesco Checchi, Carole Fogg, Paul N Newton, Mayfong Mayxay, Philippe Deloron, Jean François Faucher, François Nosten, Elizabeth A Ashley, Rose McGready, Michele van Vugt, Stephane Proux, Ric N Price, Juntra Karbwang, Farkad Ezzet, Rajesh Bakshi, Kasia Stepniewska, Nicholas J White, Philippe J Guerin, Karen I Barnes, Joel Tarning. Artemether-lumefantrine dosing for malaria treatment in young children and pregnant women: A pharmacokinetic-pharmacodynamic meta-analysis.
PLoS medicine.
2018 06; 15(6):e1002579. doi:
10.1371/journal.pmed.1002579. [PMID: 29894518] - A V Silva, N Mwebaza, M Ntale, L L Gustafsson, A Pohanka. A fast and sensitive method for quantifying lumefantrine and desbutyl-lumefantrine using LC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Nov; 1004(?):60-6. doi:
10.1016/j.jchromb.2015.09.027. [PMID: 26447936] - Frank Kloprogge, Rose McGready, Warunee Hanpithakpong, Daniel Blessborn, Nicholas P J Day, Nicholas J White, François Nosten, Joel Tarning. Lumefantrine and Desbutyl-Lumefantrine Population Pharmacokinetic-Pharmacodynamic Relationships in Pregnant Women with Uncomplicated Plasmodium falciparum Malaria on the Thailand-Myanmar Border.
Antimicrobial agents and chemotherapy.
2015 Oct; 59(10):6375-84. doi:
10.1128/aac.00267-15. [PMID: 26239986] - Fazli Khuda, Zafar Iqbal, Yasar Shah, Lateef Ahmmad, Fazli Nasir, Amir Zada Khan, Amanullah, Naila Shahbaz. Method development and validation for simultaneous determination of lumefantrine and its major metabolite, desbutyl lumefantrine in human plasma using RP-HPLC/UV detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jan; 944(?):114-22. doi:
10.1016/j.jchromb.2013.10.037. [PMID: 24316521] - Rina P M Wong, Sam Salman, Kenneth F Ilett, Peter M Siba, Ivo Mueller, Timothy M E Davis. Desbutyl-lumefantrine is a metabolite of lumefantrine with potent in vitro antimalarial activity that may influence artemether-lumefantrine treatment outcome.
Antimicrobial agents and chemotherapy.
2011 Mar; 55(3):1194-8. doi:
10.1128/aac.01312-10. [PMID: 21199927]