7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol (BioDeep_00000842543)
代谢物信息卡片
7-Chloro-3-methyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepin-8-ol
化学式: C17H18ClNO (287.1076848)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC2=CC(=C(C=C2C(C1)C3=CC=CC=C3)O)Cl
InChI: InChI=1S/C17H18ClNO/c1-19-8-7-13-9-16(18)17(20)10-14(13)15(11-19)12-5-3-2-4-6-12/h2-6,9-10,15,20H,7-8,11H2,1H3
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rima Atria Japarin, Norsyifa Harun, Zurina Hassan, Christian P Müller. The dopamine D1 receptor antagonist SCH-23390 blocks the acquisition, but not expression of mitragynine-induced conditioned place preference in rats.
Behavioural brain research.
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Brain research bulletin.
2022 04; 181(?):121-128. doi:
10.1016/j.brainresbull.2022.01.012. [PMID: 35077843] - Yingliang Xie, Peizhen Wang, Xiaoyan Cui, Lei Liu, Pengcheng Wang, Shimei Jing, Qi Liu, Yuting Wang, Shiqiang Wang. Dopaminergic neurons project to the nucleus accumbens regulates anxiety-like behaviors through dopamine D1 signaling.
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10.1016/j.bbr.2021.113540. [PMID: 34419513] - Zhijun Diao, Li Yao, Qiangqiang Cheng, Meilin Wu, Yuanyuan Di, Zhaoqiang Qian, Chunling Wei, Yingxun Liu, Yingfang Tian, Wei Ren. Involvement of Midbrain Dopamine Neuron Activity in Negative Reinforcement Learning in Mice.
Molecular neurobiology.
2021 Nov; 58(11):5667-5681. doi:
10.1007/s12035-021-02515-6. [PMID: 34387814] - Riccardo Viaro, Francesco Longo, Fabrizio Vincenzi, Katia Varani, Michele Morari. l-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter.
Brain research.
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JCI insight.
2021 05; 6(10):. doi:
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Scientific reports.
2020 12; 10(1):22347. doi:
10.1038/s41598-020-79292-0. [PMID: 33339892] - Panpan Wang, Ting Cao, Jiaojiao Chen, Yiguo Jiang, Cheng Wang, John L Waddington, Xuechu Zhen. D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
Neuropharmacology.
2019 10; 157(?):107675. doi:
10.1016/j.neuropharm.2019.107675. [PMID: 31233824] - Anees A Banday, Andrea Diaz Diaz, Mustafa Lokhandwala. Kidney dopamine D1-like receptors and angiotensin 1-7 interaction inhibits renal Na+ transporters.
American journal of physiology. Renal physiology.
2019 10; 317(4):F949-F956. doi:
10.1152/ajprenal.00135.2019. [PMID: 31411069] - Emily S Rothwell, Sally P Mendoza, Benjamin J Ragen, Karen L Bales. Dopamine D1-like receptors regulate agonistic components of pair bond maintenance behaviors in male titi monkeys (Callicebus cupreus).
Psychoneuroendocrinology.
2019 08; 106(?):259-267. doi:
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Pain.
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PloS one.
2019; 14(1):e0211266. doi:
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Nature neuroscience.
2018 10; 21(10):1421-1430. doi:
10.1038/s41593-018-0222-1. [PMID: 30177795] - Chikako Shimizu, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima. Effects of Oral Calcium Dosage and Timing on Ethanol-Induced Sensitization of Locomotion in DBA/2 Mice.
Biological & pharmaceutical bulletin.
2018 Jul; 41(7):1049-1061. doi:
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2018 05; 133(?):171-180. doi:
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Toxicology and applied pharmacology.
2018 03; 343(?):29-39. doi:
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Brain : a journal of neurology.
2018 02; 141(2):505-520. doi:
10.1093/brain/awx351. [PMID: 29281030] - Morgane Milienne-Petiot, Lucianne Groenink, Arpi Minassian, Jared W Young. Blockade of dopamine D1-family receptors attenuates the mania-like hyperactive, risk-preferring, and high motivation behavioral profile of mice with low dopamine transporter levels.
Journal of psychopharmacology (Oxford, England).
2017 10; 31(10):1334-1346. doi:
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2017 05; 124(5):655-667. doi:
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Stroke.
2017 04; 48(4):1044-1051. doi:
10.1161/strokeaha.116.014696. [PMID: 28289242] - Mariano E Ibarra, Maria F Albertoni Borghese, Mónica P Majowicz, María C Ortiz, Fabián Loidl, Manuel Rey-Funes, Luis A Di Ciano, Fernando R Ibarra. Concerted regulation of renal plasma flow and glomerular filtration rate by renal dopamine and NOS I in rats on high salt intake.
Physiological reports.
2017 Mar; 5(6):. doi:
10.14814/phy2.13202. [PMID: 28351967] - Panayotis K Thanos, Ronald Kim, Foteini Delis, Mark J Rocco, Jacob Cho, Nora D Volkow. Effects of chronic methamphetamine on psychomotor and cognitive functions and dopamine signaling in the brain.
Behavioural brain research.
2017 03; 320(?):282-290. doi:
10.1016/j.bbr.2016.12.010. [PMID: 27993694] - Megan L Fitzgerald, Suham A Kassir, Mark D Underwood, Mihran J Bakalian, J John Mann, Victoria Arango. Dysregulation of Striatal Dopamine Receptor Binding in Suicide.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2017 Mar; 42(4):974-982. doi:
10.1038/npp.2016.124. [PMID: 27402414] - Xiaoliang Jiang, Wei Chen, Xing Liu, Zihao Wang, Yunpeng Liu, Robin A Felder, John J Gildea, Pedro A Jose, Chuan Qin, Zhiwei Yang. The Synergistic Roles of Cholecystokinin B and Dopamine D5 Receptors on the Regulation of Renal Sodium Excretion.
PloS one.
2016; 11(1):e0146641. doi:
10.1371/journal.pone.0146641. [PMID: 26751218] - Laurie P Sutton, Marc G Caron. Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.
Neuropharmacology.
2015 Dec; 99(?):610-9. doi:
10.1016/j.neuropharm.2015.08.024. [PMID: 26314207] - Samuel J Rose, Xin Y Yu, Ann K Heinzer, Porter Harrast, Xueliang Fan, Robert S Raike, Valerie B Thompson, Jean-Francois Pare, David Weinshenker, Yoland Smith, Hyder A Jinnah, Ellen J Hess. A new knock-in mouse model of l-DOPA-responsive dystonia.
Brain : a journal of neurology.
2015 Oct; 138(Pt 10):2987-3002. doi:
10.1093/brain/awv212. [PMID: 26220941] - Ying-Shan Piao, Frank Scott Hall, Yuki Moriya, Miki Ito, Arihisa Ohara, Ruri Kikura-Hanajiri, Yukihiro Goda, Klaus-Peter Lesch, Dennis L Murphy, George R Uhl, Ichiro Sora. Methylone-induced hyperthermia and lethal toxicity: role of the dopamine and serotonin transporters.
Behavioural pharmacology.
2015 Jun; 26(4):345-52. doi:
10.1097/fbp.0000000000000135. [PMID: 25794333] - Grant L Lin, Candace B Borders, Leslie J Lundewall, Cara L Wellman. D1 receptors regulate dendritic morphology in normal and stressed prelimbic cortex.
Psychoneuroendocrinology.
2015 Jan; 51(?):101-11. doi:
10.1016/j.psyneuen.2014.09.020. [PMID: 25305546] - Julie A Marusich, Kateland R Antonazzo, Jenny L Wiley, Bruce E Blough, John S Partilla, Michael H Baumann. Pharmacology of novel synthetic stimulants structurally related to the 'bath salts' constituent 3,4-methylenedioxypyrovalerone (MDPV).
Neuropharmacology.
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10.1016/j.neuropharm.2014.02.016. [PMID: 24594476] - Natsuka Tashiro, Kaneyasu Nishimura, Kanako Daido, Tomoe Oka, Mio Todo, Asami Toshikawa, Jun Tsushima, Kazuyuki Takata, Eishi Ashihara, Kanji Yoshimoto, Kiyokazu Agata, Yoshihisa Kitamura. Pharmacological assessment of methamphetamine-induced behavioral hyperactivity mediated by dopaminergic transmission in planarian Dugesia japonica.
Biochemical and biophysical research communications.
2014 Jul; 449(4):412-8. doi:
10.1016/j.bbrc.2014.05.059. [PMID: 24858686] - Michael L Granda, Frederick A Schroeder, Ronald H J Borra, Nathan Schauer, Ehimen Aisaborhale, Alexander R Guimaraes, Jacob M Hooker. First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring.
American journal of physiology. Renal physiology.
2014 Jul; 307(1):F116-21. doi:
10.1152/ajprenal.00111.2014. [PMID: 24808534] - Hiroshi Ikeda, Syuntaro Takasu, Kazuyuki Murase. Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice.
Molecular pain.
2014 Feb; 10(?):14. doi:
10.1186/1744-8069-10-14. [PMID: 24555533] - Andrew B Norman, Michael R Tabet, Mantana K Norman, Vladimir L Tsibulsky. Maintained cocaine self-administration is determined by quantal responses: implications for the measurement of antagonist potency.
The Journal of pharmacology and experimental therapeutics.
2014 Feb; 348(2):311-5. doi:
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Scientific reports.
2014 Jan; 4(?):3905. doi:
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Hypertension (Dallas, Tex. : 1979).
2013 Nov; 62(5):927-33. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2013 Oct; 38(11):2120-30. doi:
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Hypertension (Dallas, Tex. : 1979).
2013 Aug; 62(2):295-301. doi:
10.1161/hypertensionaha.113.01483. [PMID: 23753418] - Carl Björkholm, Kent Jardemark, Monica M Marcus, Anna Malmerfelt, Svante Nyberg, Björn Schilström, Torgny H Svensson. Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2013 Jul; 23(7):709-20. doi:
10.1016/j.euroneuro.2012.05.012. [PMID: 22732518] - X Yi, G Zhang, J Yuan. Renoprotective role of fenoldopam pretreatment through hypoxia-inducible factor-1alpha and heme oxygenase-1 expressions in rat kidney transplantation.
Transplantation proceedings.
2013 Mar; 45(2):517-22. doi:
10.1016/j.transproceed.2012.02.051. [PMID: 23498787] - Cátia Fernandes-Cerqueira, Benedita Sampaio-Maia, Janete Quelhas-Santos, Mónica Moreira-Rodrigues, Liliana Simões-Silva, Ana M Blazquez-Medela, C Martinez-Salgado, Jose M Lopez-Novoa, Manuel Pestana. Concerted action of ANP and dopamine D1-receptor to regulate sodium homeostasis in nephrotic syndrome.
BioMed research international.
2013; 2013(?):397391. doi:
10.1155/2013/397391. [PMID: 23956981] - Zhaopeng Du, Qingshang Yan, Laxiang Wan, Sheldon Weinbaum, Alan M Weinstein, Tong Wang. Regulation of glomerulotubular balance. I. Impact of dopamine on flow-dependent transport.
American journal of physiology. Renal physiology.
2012 Aug; 303(3):F386-95. doi:
10.1152/ajprenal.00531.2011. [PMID: 22552936] - Mattis B Wigestrand, Frode Fonnum, S Ivar Walaas. Subunit-specific modulation of [(3)H]MK-801 binding to NMDA receptors mediated by dopamine receptor ligands in rodent brain.
Neurochemistry international.
2012 Jul; 61(2):266-76. doi:
10.1016/j.neuint.2012.04.017. [PMID: 22561101] - Benjamin R Chemel, Lisa A Bonner, Val J Watts, David E Nichols. Ligand-specific roles for transmembrane 5 serine residues in the binding and efficacy of dopamine D(1) receptor catechol agonists.
Molecular pharmacology.
2012 May; 81(5):729-38. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):4319-29. doi:
10.1523/jneurosci.5952-11.2012. [PMID: 22442093] - Ana C Stein, Alice F Viana, Liz G Müller, Jéssica M Nunes, Eveline D Stolz, Jean-Claude Do Rego, Jean Costentin, Gilsane L von Poser, Stela M K Rates. Uliginosin B, a phloroglucinol derivative from Hypericum polyanthemum: a promising new molecular pattern for the development of antidepressant drugs.
Behavioural brain research.
2012 Mar; 228(1):66-73. doi:
10.1016/j.bbr.2011.11.031. [PMID: 22155486] - Dong Li, Lena Scott, Susanne Crambert, Sergey Zelenin, Ann-Christine Eklöf, Luis Di Ciano, Fernando Ibarra, Anita Aperia. Binding of losartan to angiotensin AT1 receptors increases dopamine D1 receptor activation.
Journal of the American Society of Nephrology : JASN.
2012 Mar; 23(3):421-8. doi:
10.1681/asn.2011040344. [PMID: 22193384] - Richard J A Goodwin, C Logan Mackay, Anna Nilsson, David J Harrison, Lars Farde, Per E Andren, Suzanne L Iverson. Qualitative and quantitative MALDI imaging of the positron emission tomography ligands raclopride (a D2 dopamine antagonist) and SCH 23390 (a D1 dopamine antagonist) in rat brain tissue sections using a solvent-free dry matrix application method.
Analytical chemistry.
2011 Dec; 83(24):9694-701. doi:
10.1021/ac202630t. [PMID: 22077717] - Hiroki Nakashioya, Kazuhisa Nakano, Naoko Watanabe, Nobuyuki Miyasaka, Sho Matsushita, Hitoshi Kohsaka. Therapeutic effect of D1-like dopamine receptor antagonist on collagen-induced arthritis of mice.
Modern rheumatology.
2011 Jun; 21(3):260-6. doi:
10.1007/s10165-010-0387-2. [PMID: 21188452] - Andrew B Norman, Mantana K Norman, Michael R Tabet, Vladimir L Tsibulsky, Amadeo J Pesce. Competitive dopamine receptor antagonists increase the equiactive cocaine concentration during self-administration.
Synapse (New York, N.Y.).
2011 May; 65(5):404-11. doi:
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Journal of neuroendocrinology.
2011 Apr; 23(4):302-9. doi:
10.1111/j.1365-2826.2011.02114.x. [PMID: 21276102] - Chiara Fiorentini, Cinzia Mattanza, Ginetta Collo, Paola Savoia, Pierfranco Spano, Cristina Missale. The tyrosine phosphatase Shp-2 interacts with the dopamine D(1) receptor and triggers D(1) -mediated Erk signaling in striatal neurons.
Journal of neurochemistry.
2011 Apr; 117(2):253-63. doi:
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European journal of pharmacology.
2010 May; 634(1-3):77-83. doi:
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American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Dec; 297(6):R1660-9. doi:
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Hypertension (Dallas, Tex. : 1979).
2009 Nov; 54(5):1077-83. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2009 Jun; 33(4):642-50. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Jun; 329(3):1040-7. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Apr; 329(1):169-74. doi:
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Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Apr; 34(5):1162-71. doi:
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American journal of nephrology.
2009; 30(3):274-9. doi:
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Toxicology and applied pharmacology.
2008 Mar; 227(2):239-47. doi:
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Apoptosis : an international journal on programmed cell death.
2007 Jan; 12(1):167-79. doi:
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Synapse (New York, N.Y.).
2005 Nov; 58(2):110-21. doi:
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Molecular pharmacology.
2005 Oct; 68(4):1039-48. doi:
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