3-[3-[(4-Fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid (BioDeep_00000842473)
代谢物信息卡片
3-[3-[(4-Fluorophenyl)sulfonylamino]-1,2,3,4-tetrahydrocarbazol-9-yl]propanoic acid
化学式: C21H21FN2O4S (416.1206)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2=C(CC1NS(=O)(=O)C3=CC=C(C=C3)F)C4=CC=CC=C4N2CCC(=O)O
InChI: InChI=1S/C21H21FN2O4S/c22-14-5-8-16(9-6-14)29(27,28)23-15-7-10-20-18(13-15)17-3-1-2-4-19(17)24(20)12-11-21(25)26/h1-6,8-9,15,23H,7,10-13H2,(H,25,26)
描述信息
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Ralf Schröder, Luzheng Xue, Viktoria Konya, Lene Martini, Nora Kampitsch, Jennifer L Whistler, Trond Ulven, Akos Heinemann, Roy Pettipher, Evi Kostenis. PGH1, the precursor for the anti-inflammatory prostaglandins of the 1-series, is a potent activator of the pro-inflammatory receptor CRTH2/DP2.
PloS one.
2012; 7(3):e33329. doi:
10.1371/journal.pone.0033329. [PMID: 22442685] - T Ulrych, A Böhm, A Polzin, G Daum, R M Nüsing, G Geisslinger, T Hohlfeld, K Schrör, B H Rauch. Release of sphingosine-1-phosphate from human platelets is dependent on thromboxane formation.
Journal of thrombosis and haemostasis : JTH.
2011 Apr; 9(4):790-8. doi:
10.1111/j.1538-7836.2011.04194.x. [PMID: 21251196] - Naoko Kanda, Takeko Ishikawa, Shinichi Watanabe. Prostaglandin D2 induces the production of human beta-defensin-3 in human keratinocytes.
Biochemical pharmacology.
2010 Apr; 79(7):982-9. doi:
10.1016/j.bcp.2009.11.012. [PMID: 19925780] - Hong-qiang Lou, Yan-feng Ying, Ye Hu. [CRTH2 antagonist ameliorates airway inflammation in rats with asthma].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2010 01; 39(1):64-70. doi:
10.3785/j.issn.1008-9292.2010.01.011. [PMID: 20175238] - Kosuke Akiyama, Masayuki Karaki, Ryuichi Kobayshi, Hiroaki Dobashi, Toshihiko Ishida, Nozomu Mori. IL-16 variability and modulation by antiallergic drugs in a murine experimental allergic rhinitis model.
International archives of allergy and immunology.
2009; 149(4):315-22. doi:
10.1159/000205577. [PMID: 19295235] - Rie Nomiya, Mitsuhiro Okano, Tazuko Fujiwara, Megumi Maeda, Yoshinobu Kimura, Kosuke Kino, Minehiko Yokoyama, Hiroyuki Hirai, Kinya Nagata, Toshifumi Hara, Kazunori Nishizaki, Masataka Nakamura. CRTH2 plays an essential role in the pathophysiology of Cry j 1-induced pollinosis in mice.
Journal of immunology (Baltimore, Md. : 1950).
2008 Apr; 180(8):5680-8. doi:
10.4049/jimmunol.180.8.5680. [PMID: 18390753] - Petra Schratl, Eva M Sturm, Julia F Royer, Gunter J Sturm, Irmgard T Lippe, Bernhard A Peskar, Akos Heinemann. Hierarchy of eosinophil chemoattractants: role of p38 mitogen-activated protein kinase.
European journal of immunology.
2006 Sep; 36(9):2401-9. doi:
10.1002/eji.200535672. [PMID: 16906532] - Jesper Mosolff Mathiesen, Arthur Christopoulos, Trond Ulven, Julia F Royer, Mercedes Campillo, Akos Heinemann, Leonardo Pardo, Evi Kostenis. On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2.
Molecular pharmacology.
2006 Apr; 69(4):1441-53. doi:
10.1124/mol.105.017681. [PMID: 16418339] - Frédéric Michel, Jean-Sébastien Silvestre, Ludovic Waeckel, Stefano Corda, Tony Verbeuren, Jean Paul Vilaine, Michel Clergue, Micheline Duriez, Bernard I Levy. Thromboxane A2/prostaglandin H2 receptor activation mediates angiotensin II-induced postischemic neovascularization.
Arteriosclerosis, thrombosis, and vascular biology.
2006 Mar; 26(3):488-93. doi:
10.1161/01.atv.0000201969.93348.74. [PMID: 16385086] - Lucien Gazi, Shân Gyles, Jennifer Rose, Sally Lees, Chris Allan, Luzheng Xue, Ramesh Jassal, Graham Speight, Vicki Gamble, Roy Pettipher. Delta12-prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes.
Prostaglandins & other lipid mediators.
2005 Jan; 75(1-4):153-67. doi:
10.1016/j.prostaglandins.2004.11.003. [PMID: 15789622] - Hiroko Kariyazono, Kazuo Nakamura, Junko Arima, Osamu Ayukawa, Shunji Onimaru, Hiroshi Masuda, Yoshifumi Iguro, Hideyuki J Majima, Ryuzo Sakata, Katsushi Yamada. Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole blood.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2004 Mar; 15(2):157-67. doi:
10.1097/00001721-200403000-00007. [PMID: 15091003] - Toshiaki Ishizuka, Takemi Matsui, Akira Kurita. Ramatroban, a TP receptor antagonist, improves vascular responses to acetylcholine in hypercholesterolemic rabbits in vivo.
European journal of pharmacology.
2003 May; 468(1):27-35. doi:
10.1016/s0014-2999(03)01626-1. [PMID: 12729840]
