4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)- (BioDeep_00000842367)
代谢物信息卡片
4-Thiazolidinecarboxylic acid, 2-(2-hydroxyphenyl)-3-(3-mercapto-1-oxopropyl)-
化学式: C13H15NO4S2 (313.0442)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(N(C(S1)C2=CC=CC=C2O)C(=O)CCS)C(=O)O
InChI: InChI=1S/C13H15NO4S2/c15-10-4-2-1-3-8(10)12-14(11(16)5-6-19)9(7-20-12)13(17)18/h1-4,9,12,15,19H,5-7H2,(H,17,18)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- K Takase, T Ikuse, H Aono, A Okahara. Toxicity study of the angiotensin converting enzyme inhibitor rentiapril in rats.
Arzneimittel-Forschung.
1995 Jan; 45(1):15-8. doi:
NULL. [PMID: 7893262] - K Nishimura, H Okunishi, M Miyazaki. Antihypertensive mechanism of an angiotensin converting enzyme inhibitor, SA446, in dogs.
Bulletin of the Osaka Medical College.
1989 Nov; 35(1-2):29-37. doi:
NULL. [PMID: 2486241] - M Ideishi, M Sasaguri, M Ikeda, K Arakawa. Effects of the angiotensin converting enzyme inhibitors captopril, rentiapril, and alacepril in patients with essential and renovascular hypertension.
Clinical therapeutics.
1989 Jul; 11(4):441-51. doi:
NULL. [PMID: 2550133] - K Mizuno, M Nakamaru, K Higashimori, T Inagami. Local generation and release of angiotensin II in peripheral vascular tissue.
Hypertension (Dallas, Tex. : 1979).
1988 Mar; 11(3):223-9. doi:
10.1161/01.hyp.11.3.223. [PMID: 3280482] - K Nishimura, M Miyazaki, H Okunishi, N Toda. Hypotensive effect of SA446, an angiotensin converting enzyme inhibitor, in 2-kidney, 1-clip renal hypertensive and normotensive dogs.
Japanese journal of pharmacology.
1987 Apr; 43(4):379-87. doi:
10.1254/jjp.43.379. [PMID: 3039218] - M Miyazaki, H Okunishi, T Okamura, N Toda. Elevated vascular angiotensin converting enzyme in chronic two-kidney, one clip hypertension in the dog.
Journal of hypertension.
1987 Apr; 5(2):155-60. doi:
10.1097/00004872-198704000-00005. [PMID: 3038993] - K Nakata, K Nishimura, T Takada, T Ikuse, H Yamauchi, T Iso. Effects of an angiotensin-converting enzyme (ACE) inhibitor, SA446, on tissue ACE activity in normotensive, spontaneously hypertensive, and renal hypertensive rats.
Journal of cardiovascular pharmacology.
1987 Mar; 9(3):305-10. doi:
10.1097/00005344-198703000-00007. [PMID: 2437397] - D D Cozens, S J Barton, R Clark, E W Hughes, J M Offer, Y Yamamoto. Reproductive toxicity studies of rentiapril.
Arzneimittel-Forschung.
1987 Feb; 37(2):164-9. doi:
NULL. [PMID: 3034299] - M Yasujima, K Abe, M Tanno, M Kohzuki, Y Kasai, M Kanazawa, K Omata, M Sato, K Takeuchi, K Yoshinaga. Effects of angiotensin converting enzyme inhibitors MK 421, SA 446 and captopril on renal prostaglandin E and kinins in conscious normotensive rats.
Clinical and experimental hypertension. Part A, Theory and practice.
1987; 9(2-3):401-4. doi:
10.3109/10641968709164205. [PMID: 3038402] - F Ikemoto, S Itoh, G Song, M Tanaka, T Takada, M Tominaga, M Hiruma, N Nakamura, K Yamamoto. Contribution of renal angiotensin converting enzyme (ACE) to blood pressure regulation: possible role of brush border ACE.
Clinical and experimental hypertension. Part A, Theory and practice.
1987; 9(2-3):441-7. doi:
10.3109/10641968709164211. [PMID: 3038408] - Y Suzuki, M Ito, N Saito. Studies on mechanisms of antinephritic action of SA-446 an angiotensin I converting enzyme inhibitor (1). A comparison with actions of spironolactone, kallidinogenase and saralasin.
Japanese journal of pharmacology.
1986 Dec; 42(4):465-75. doi:
10.1254/jjp.42.465. [PMID: 3027437] - M Horiuchi, H Takashina, K Fujimura, T Iso. [High-performance liquid chromatography of organosulfur compounds using the postcolumn ligand exchange reaction with iodoplatinate. Application to the simultaneous determination of (2R,4R)-2-(o-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidine carboxylic acid (SA446), an angiotensin converting enzyme inhibitor and its urinary metabolites].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
1986 Nov; 106(11):1028-33. doi:
10.1248/yakushi1947.106.11_1028. [PMID: 3031265] - K Nakata, T Iwatani, M Horiuchi, H Kito, H Yamauchi, T Iso. Species difference of (2R,4R)-2-(o-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinec arb oxylic acid (SA446) in inhibition of angiotensin converting enzyme.
Japanese journal of pharmacology.
1986 Mar; 40(3):367-72. doi:
10.1254/jjp.40.367. [PMID: 3012163] - T Takada, K Nakata, H Yamauchi, T Iso. [Combined effect of (2R, 4R)-2-(o-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarbo xyl ic acid (SA446) with hydrochlorothiazide or propranolol on development of hypertension in spontaneously hypertensive rats (SHR) by long-term administration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1986 Mar; 87(3):331-7. doi:
10.1254/fpj.87.331. [PMID: 3710315] - K Nakata, T Takada, H Yamauchi, T Iso. Effects of sodium loading on antihypertensive responses to an angiotensin-converting enzyme inhibitor in spontaneously hypertensive and renal hypertensive rats.
European journal of pharmacology.
1986 Feb; 121(2):293-5. doi:
10.1016/0014-2999(86)90504-2. [PMID: 3009208] - K Nakata, K Nishimura, T Takada, H Yamauchi, T Iso. [Antihypertensive effects of SA446, hydralazine and the combination on renal hypertensive rats and spontaneously hypertensive rats by long-term treatment].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1986 Feb; 87(2):113-21. doi:
10.1254/fpj.87.113. [PMID: 3699625] - K Abe, J Tajima, K Omata, M Tanno, K Tsunoda, K Kudo, Y Onoda, M Kohzuki, S Sasaki, K Takeuchi. Effects of three different kininase II inhibitors on blood pressure and renal vasoactive substances in essential hypertensives.
Advances in experimental medicine and biology.
1986; 198 Pt B(?):269-77. doi:
10.1007/978-1-4757-0154-8_33. [PMID: 3028076] - T Takada, K Yamamoto, S Fujioka, T Tamaki, K Fukui, Y Abe. Effects of angiotensin I-converting enzyme inhibitor (SA-446) on renal function in dogs.
Japanese journal of pharmacology.
1985 Jun; 38(2):227-30. doi:
10.1254/jjp.38.227. [PMID: 2993720] - K Miura, T Yukimura, M Imanishi, T Okahara, Y Abe, K Yamamoto. Effect of SA-446, an angiotensin-converting enzyme inhibitor, on renal function in anesthetized dogs: special reference to arachidonic acid metabolites.
Journal of cardiovascular pharmacology.
1985 Jan; 7(1):102-7. doi:
10.1097/00005344-198501000-00017. [PMID: 2580127] - J Tajima, K Abe, M Yasujima, M Tanno, K Yoshinaga. [Effects of 3 different angiotensin converting enzyme inhibitors, MK 421, SQ 14225 and SA 446 on renal function and blood pressure in patients with essential hypertension].
Nihon Jinzo Gakkai shi.
1984 Jun; 26(6):779-89. doi:
NULL. [PMID: 6096607] - V N Orekhovich, Iu E Eliseeva, L V Pavlikhina, N A Krit, M P Filatova. [Peptides--inhibitors of carboxycathepsin (peptidyl-dipeptidase A) and their role in clinical medicine].
Voprosy meditsinskoi khimii.
1984 May; 30(3):51-6. doi:
NULL. [PMID: 6206649] - Y Abe, T Okahara, K Miura, T Yukimura, T Takada, T Iwatani, T Iso, K Yamamoto. Renal excretion of an angiotensin I converting enzyme inhibitor (SA-446) in dogs.
Naunyn-Schmiedeberg's archives of pharmacology.
1984 Apr; 325(4):356-9. doi:
10.1007/bf00504381. [PMID: 6328337] - M Yasujima, K Abe, M Tanno, K Omata, K Yoshinaga. Responses of the kallikrein-kinin system to angiotensin converting enzyme inhibitors in the rat.
Japanese circulation journal.
1984 Feb; 48(2):173-9. doi:
10.1253/jcj.48.173. [PMID: 6321815] - M Yasujima, K Abe, Y Kasai, M Tanno, J Tajima, M Seino, S Chiba, K Sato, T Goto, K Omata. Renal kallikrein-kinin system and the depressor effect of angiotensin converting enzyme inhibitors MK 421, SA 446, and captopril in rats.
Clinical and experimental hypertension. Part A, Theory and practice.
1984; 6(6):1207-25. doi:
10.3109/10641968409039592. [PMID: 6086184] - M Miyazaki, H Okunishi, K Nishimura, N Toda. Vascular angiotensin-converting enzyme activity in man and other species.
Clinical science (London, England : 1979).
1984 Jan; 66(1):39-45. doi:
10.1042/cs0660039. [PMID: 6317275] - T Ogihara, M Yoshizawa, T Yasui, H Nakane, Y Nakane, T Saruta. Effects of angiotensin I converting enzyme inhibitors on the renal excretory function, hemodynamics and renin release in isolated perfused rat kidney.
Japanese heart journal.
1983 Nov; 24(6):975-83. doi:
10.1536/ihj.24.975. [PMID: 6323782] - Y Suzuki, M Ito, T Komura. [Pharmacological studies on the diuretic action of azosemide [5-(4'-chloro-5'-sulfamoyl-2'-thenylamino)-phenyltetrazole], a new diuretic (3). Effect of azosemide following pretreatment with SA-446, an angiotensin I converting enzyme inhibitor, or propranolol, a beta-adrenergic blocker, in HgCl2-induced acute renal failure in rats].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1982 Nov; 80(5):395-404. doi:
NULL. [PMID: 6187650] - T Iwatani, M Naitoh, H Takashina, S Nagamori, Y Itoh, J Iwao. Determination of SA-446 in human whole blood and urine by electron capture-gas liquid chromatography.
Chemical & pharmaceutical bulletin.
1982 Jun; 30(6):2087-93. doi:
10.1248/cpb.30.2087. [PMID: 6290091] - R DiNicolantonio, R Dinicolantonio, J S Hutchinson, F A Mendelsohn, A E Doyle. In vivo comparison of three orally active inhibitors of angiotensin-converting enzyme.
The American journal of cardiology.
1982 Apr; 49(6):1502-4. doi:
10.1016/0002-9149(82)90368-x. [PMID: 6280478] - T Unger, T Yukimura, M Marin-Grez, R E Lang, W Rascher, D Ganten. SA446, a new orally active converting enzyme inhibitor: antihypertensive action and comparison with captopril in stroke-prone spontaneously hypersensitive rats.
European journal of pharmacology.
1982 Mar; 78(4):411-20. doi:
10.1016/0014-2999(82)90483-6. [PMID: 6281036] - T Iso, H Yamauchi, H Suda, K Nakata, K Nishimura, J Iwao. A new potent inhibitor of converting enzyme: (2R,4R)-2-(2-hydroxyphenyl)-3-(3-mercaptopropionyl)-4-thiazolidinecarboxylic acid(SA446).
Japanese journal of pharmacology.
1981 Dec; 31(6):875-82. doi:
10.1254/jjp.31.875. [PMID: 6174764]
