7-(2-Hydroxyethyl)guanine (BioDeep_00000842348)
代谢物信息卡片
化学式: C7H9N5O2 (195.07562140000002)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1CCO)C(=O)NC(=N2)N
InChI: InChI=1S/C7H9N5O2/c8-7-10-5-4(6(14)11-7)12(1-2-13)3-9-5/h3,13H,1-2H2,(H3,8,10,11,14)
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chih-Chun Jean Huang, Chia-Fang Wu, Wei-Chung Shih, Ming-Feng Chen, Chang-Yuh Chen, Yeh-Chung Chien, Saou-Hsing Liou, Su-Yin Chiang, Kuen-Yuh Wu. Comparative analysis of urinary N7-(2-hydroxyethyl)guanine for ethylene oxide- and non-exposed workers.
Toxicology letters.
2011 May; 202(3):237-43. doi:
10.1016/j.toxlet.2011.02.009. [PMID: 21354284] - Leslie A Bransfield, Alissa Rennie, Kala Visvanathan, Shelly-Ann Odwin, Thomas W Kensler, James D Yager, Marlin D Friesen, John D Groopman. Formation of two novel estrogen guanine adducts and HPLC/MS detection of 4-hydroxyestradiol-N7-guanine in human urine.
Chemical research in toxicology.
2008 Aug; 21(8):1622-30. doi:
10.1021/tx800145w. [PMID: 18582124] - Chih-Chun Jean Huang, Wei-Chung Shih, Chia-Fang Wu, Ming-Feng Chen, Yi-Lung Chen, Ying-Huei Lin, Kuen-Yuh Wu. Rapid and sensitive on-line liquid chromatographic/tandem mass spectrometric determination of an ethylene oxide-DNA adduct, N7-(2-hydroxyethyl)guanine, in urine of nonsmokers.
Rapid communications in mass spectrometry : RCM.
2008; 22(5):706-10. doi:
10.1002/rcm.3414. [PMID: 18257114] - Debbie A Marsden, Donald J L Jones, John H Lamb, Elaine M Tompkins, Peter B Farmer, Karen Brown. Determination of endogenous and exogenously derived N7-(2-hydroxyethyl)guanine adducts in ethylene oxide-treated rats.
Chemical research in toxicology.
2007 Feb; 20(2):290-9. doi:
10.1021/tx600264t. [PMID: 17263564] - Lia S Nakao, Elaine Fonseca, Ohara Augusto. Detection of C8-(1-hydroxyethyl)guanine in liver RNA and DNA from control and ethanol-treated rats.
Chemical research in toxicology.
2002 Oct; 15(10):1248-53. doi:
10.1021/tx0255166. [PMID: 12387621] - Chunyan Zhao, Kari Hemminki. The in vivo levels of DNA alkylation products in human lymphocytes are not age dependent: an assay of 7-methyl- and 7-(2-hydroxyethyl)-guanine DNA adducts.
Carcinogenesis.
2002 Feb; 23(2):307-10. doi:
10.1093/carcin/23.2.307. [PMID: 11872637] - I Eide, C Zhao, R Kumar, K Hemminki, K y Wu, J A Swenberg. Comparison of (32)P-postlabeling and high-resolution GC/MS in quantifying N7-(2-Hydroxyethyl)guanine adducts.
Chemical research in toxicology.
1999 Oct; 12(10):979-84. doi:
10.1021/tx990039l. [PMID: 10525275] - C Zhao, M Tyndyk, I Eide, K Hemminki. Endogenous and background DNA adducts by methylating and 2-hydroxyethylating agents.
Mutation research.
1999 Mar; 424(1-2):117-25. doi:
10.1016/s0027-5107(99)00013-5. [PMID: 10064855] - V E Walker, T R Fennell, P B Upton, J P MacNeela, J A Swenberg. Molecular dosimetry of DNA and hemoglobin adducts in mice and rats exposed to ethylene oxide.
Environmental health perspectives.
1993 Mar; 99(?):11-7. doi:
10.1289/ehp.939911. [PMID: 8319608] - V E Walker, T R Fennell, P B Upton, T R Skopek, V Prevost, D E Shuker, J A Swenberg. Molecular dosimetry of ethylene oxide: formation and persistence of 7-(2-hydroxyethyl)guanine in DNA following repeated exposures of rats and mice.
Cancer research.
1992 Aug; 52(16):4328-34. doi:
NULL. [PMID: 1643630] - P B Farmer. Tandem mass spectrometry study of urinary alkylated purines.
Biomedical & environmental mass spectrometry.
1988 Aug; 17(2):143-5. doi:
10.1002/bms.1200170213. [PMID: 3191254]