3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one (BioDeep_00000842336)

   


代谢物信息卡片


3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one

  化学式: C28H26O9 (506.1577)
中文名称:
  谱图信息: 最多检出来源 () %

分子结构信息

SMILES: COC1=CC=C(C=C1)C2(C(=C(C(=O)O2)C3=CC4=C(C=C3)OCO4)CC5=CC(=C(C(=C5)OC)OC)OC)O
InChI: InChI=1S/C28H26O9/c1-31-19-8-6-18(7-9-19)28(30)20(11-16-12-23(32-2)26(34-4)24(13-16)33-3)25(27(29)37-28)17-5-10-21-22(14-17)36-15-35-21/h5-10,12-14,30H,11,15H2,1-4H3


描述信息

同义名列表

1 个代谢物同义名

3-Benzo[1,3]dioxol-5-yl-5-hydroxy-5-(4-methoxy-phenyl)-4-(3,4,5-trimethoxy-benzyl)-5H-furan-2-one



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yoshinari Yokoyama, Ayaka Osano, Hideki Hayashi, Kunihiko Itoh, Takashi Okura, Yoshiharu Deguchi, Yoshihiko Ito, Shizuo Yamada. Endothelin-1 receptors in rat tissues: characterization by bosentan, ambrisentan and CI-1020. Biological & pharmaceutical bulletin. 2014; 37(3):461-5. doi: 10.1248/bpb.b13-00881. [PMID: 24583865]
  • Kristin Michel, Katrin Büther, Marilyn P Law, Stefan Wagner, Otmar Schober, Sven Hermann, Michael Schäfers, Burkhard Riemann, Carsten Höltke, Klaus Kopka. Development and evaluation of endothelin-A receptor (radio)ligands for positron emission tomography. Journal of medicinal chemistry. 2011 Feb; 54(4):939-48. doi: 10.1021/jm101110w. [PMID: 21275367]
  • Susan K Fellner, William J Arendshorst. Endothelin A and B receptors of preglomerular vascular smooth muscle cells. Kidney international. 2004 May; 65(5):1810-7. doi: 10.1111/j.1523-1755.2004.00579.x. [PMID: 15086921]
  • Boaz Ovadia, Janine M Bekker, Robert K Fitzgerald, Alexander Kon, Stephan Thelitz, Michael J Johengen, Karen Hendricks-Munoz, Rene Gerrets, Stephen M Black, Jeffrey R Fineman. Nitric oxide-endothelin-1 interactions after acute ductal constriction in fetal lambs. American journal of physiology. Heart and circulatory physiology. 2002 Mar; 282(3):H862-71. doi: 10.1152/ajpheart.00417.2001. [PMID: 11834480]
  • S Wedgwood, R W Dettman, S M Black. ET-1 stimulates pulmonary arterial smooth muscle cell proliferation via induction of reactive oxygen species. American journal of physiology. Lung cellular and molecular physiology. 2001 Nov; 281(5):L1058-67. doi: 10.1152/ajplung.2001.281.5.l1058. [PMID: 11597896]
  • S Wedgwood, D M McMullan, J M Bekker, J R Fineman, S M Black. Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circulation research. 2001 Aug; 89(4):357-64. doi: 10.1161/hh1601.094983. [PMID: 11509453]
  • M A Albassam, A L Metz, R E Potoczak, K P Gallagher, S Haleen, H Hallak, E J McGuire. Studies on coronary arteriopathy in dogs following administration of CI-1020, an endothelin A receptor antagonist. Toxicologic pathology. 2001 May; 29(3):277-84. doi: 10.1080/019262301316905228. [PMID: 11442013]
  • D M McMullan, J M Bekker, M J Johengen, K Hendricks-Munoz, R Gerrets, S M Black, J R Fineman. Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. American journal of physiology. Heart and circulatory physiology. 2001 Feb; 280(2):H777-85. doi: 10.1152/ajpheart.2001.280.2.h777. [PMID: 11158977]
  • M Stephan-Gueldner, A Inomata. Coronary arterial lesions induced by endothelin antagonists. Toxicology letters. 2000 Mar; 112-113(?):531-5. doi: 10.1016/s0378-4274(99)00218-0. [PMID: 10720776]
  • P I McConnell, C E Olson, K P Patel, D U Blank, M T Olivari, K P Gallagher, E Quenby-Brown, I H Zucker. Chronic endothelin blockade in dogs with pacing-induced heart failure: possible modulation of sympathoexcitation. Journal of cardiac failure. 2000 Mar; 6(1):56-65. doi: 10.1016/s1071-9164(00)00012-9. [PMID: 10746820]
  • M A Albassam, A L Metz, N J Gragtmans, L M King, G E Macallum, H Hallak, E J McGuire. Coronary arteriopathy in monkeys following administration of CI-1020, an endothelin A receptor antagonist. Toxicologic pathology. 1999 Mar; 27(2):156-64. doi: 10.1177/019262339902700202. [PMID: 10207979]
  • E Petrossian, A J Parry, V M Reddy, G P Akkersdijk, D M McMullan, L Thompson, K D Hendricks-Munoz, H Hallak, F L Hanley, J R Fineman. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow. The Journal of thoracic and cardiovascular surgery. 1999 Feb; 117(2):314-23. doi: 10.1016/s0022-5223(99)70429-0. [PMID: 9918974]
  • J J Maguire, A P Davenport. Endothelin receptor expression and pharmacology in human saphenous vein graft. British journal of pharmacology. 1999 Jan; 126(2):443-50. doi: 10.1038/sj.bjp.0702326. [PMID: 10077237]
  • J M Forbes, B Leaker, T D Hewitson, G J Becker, C L Jones. Macrophage and myofibroblast involvement in ischemic acute renal failure is attenuated by endothelin receptor antagonists. Kidney international. 1999 Jan; 55(1):198-208. doi: 10.1046/j.1523-1755.1999.00253.x. [PMID: 9893128]
  • J R Wu-Wong, D B Dixon, T J Opgenorth. Effects of human plasma proteins on endothelin binding and function. Journal of cardiovascular pharmacology. 1998; 31 Suppl 1(?):S164-8. doi: 10.1097/00005344-199800001-00047. [PMID: 9595428]
  • S Haleen, R Schroeder, D Walker, E Quenby-Brown, K Welch, H Hallak, A Uprichard, J Keiser. Efficacy of CI-1020, an endothelin-A receptor antagonist, in hypoxic pulmonary hypertension. Journal of cardiovascular pharmacology. 1998; 31 Suppl 1(?):S331-5. doi: 10.1097/00005344-199800001-00092. [PMID: 9595473]
  • R L Macdonald, L Johns, G Lin, L S Marton, H Hallak, F Marcoux, A Kowalczuk. Prevention of vasospasm after subarachnoid hemorrhage in dogs by continuous intravenous infusion of PD156707. Neurologia medico-chirurgica. 1998; 38 Suppl(?):138-45. doi: 10.2176/nmc.38.suppl_138. [PMID: 10234996]
  • J R Wu-Wong, D B Dixon, W J Chiou, T J Opgenorth. Endothelin receptor antagonists: effect of serum albumin on potency and comparison of pharmacological characteristics. The Journal of pharmacology and experimental therapeutics. 1997 May; 281(2):791-8. doi: NULL. [PMID: 9152387]
  • F G Spinale, J D Walker, R Mukherjee, J P Iannini, A T Keever, K P Gallagher. Concomitant endothelin receptor subtype-A blockade during the progression of pacing-induced congestive heart failure in rabbits. Beneficial effects on left ventricular and myocyte function. Circulation. 1997 Apr; 95(7):1918-29. doi: 10.1161/01.cir.95.7.1918. [PMID: 9107181]
  • J J Maguire, R E Kuc, A P Davenport. Affinity and selectivity of PD156707, a novel nonpeptide endothelin antagonist, for human ET(A) and ET(B) receptors. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):1102-8. doi: NULL. [PMID: 9023329]
  • P I McConnell, W Wang, I H Zucker. Effects of an orally effective endothelin-A receptor antagonist in dogs with pacing-induced heart failure. The Nebraska medical journal. 1996 Nov; 81(11):349-55. doi: NULL. [PMID: 8979712]
  • T E Mertz, T B McClanahan, M A Flynn, P Juneau, E E Reynolds, H Hallak, L Bradford, K P Gallagher. Endothelin A receptor antagonism by PD 156707 does not reduce infarct size after coronary artery occlusion/reperfusion in pigs. The Journal of pharmacology and experimental therapeutics. 1996 Jul; 278(1):42-9. doi: NULL. [PMID: 8764334]
  • D T Rossi, H Hallak, L Bradford. Liquid chromatographic assay for a butenolide endothelin antagonist (PD 156707) in plasma. Journal of chromatography. B, Biomedical applications. 1996 Mar; 677(2):299-304. doi: 10.1016/0378-4347(95)00456-4. [PMID: 8704933]
  • J R Wu-Wong, W J Chiou, D J Hoffman, M Winn, T W von Geldern, T J Opgenorth. Endothelins and endothelin receptor antagonists: binding to plasma proteins. Life sciences. 1996; 58(21):1839-47. doi: 10.1016/0024-3205(96)00168-3. [PMID: 8637410]
  • A M Doherty, W C Patt, J Repine, J J Edmunds, K A Berryman, B R Reisdorph, D M Walker, S J Haleen, J A Keiser, M A Flynn. Structure-activity relationships of a novel series of orally active nonpeptide ETA and ETA/B endothelin receptor-selective antagonists. Journal of cardiovascular pharmacology. 1995; 26 Suppl 3(?):S358-61. doi: . [PMID: 8587414]