Ethyl 5-[[[4-(3-methylsulfonylphenyl)phenyl]methyl-(2,4,6-trimethylphenyl)sulfonylamino]methyl]furan-2-carboxylate (BioDeep_00000842319)
代谢物信息卡片
化学式: C31H33NO7S2 (595.1698348000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C1=CC=C(O1)CN(CC2=CC=C(C=C2)C3=CC(=CC=C3)S(=O)(=O)C)S(=O)(=O)C4=C(C=C(C=C4C)C)C
InChI: InChI=1S/C31H33NO7S2/c1-6-38-31(33)29-15-14-27(39-29)20-32(41(36,37)30-22(3)16-21(2)17-23(30)4)19-24-10-12-25(13-11-24)26-8-7-9-28(18-26)40(5,34)35/h7-18H,6,19-20H2,1-5H3
描述信息
SR9238 is a synthetic liver X receptor (LXR) inverse agonist with IC50s of 214 nM and 43 nM for LXRα and LXRβ, respectively.
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Bahaa Elgendy, Kristine Griffett, Lamees Hegazy, Paolo Di Fruscia, Kirby Sample, Emmalie Schoepke, Theodore M Kamenecka, Thomas P Burris. Synthesis and structure activity relationship of the first class of LXR inverse agonists.
Bioorganic chemistry.
2022 02; 119(?):105540. doi:
10.1016/j.bioorg.2021.105540. [PMID: 34902646] - Jing Zeng, Daitze Wu, Hui Hu, John A T Young, Zhipeng Yan, Lu Gao. Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes.
Hepatology (Baltimore, Md.).
2020 12; 72(6):1935-1948. doi:
10.1002/hep.31217. [PMID: 32145089] - Ziyang Chen, Hao Chen, Zizhen Zhang, Peng Ding, Xin Yan, Yanwen Li, Songxuan Zhang, Qiong Gu, Huihao Zhou, Jun Xu. Discovery of novel liver X receptor inverse agonists as lipogenesis inhibitors.
European journal of medicinal chemistry.
2020 Nov; 206(?):112793. doi:
10.1016/j.ejmech.2020.112793. [PMID: 32961480] - Yu Yang, Yu Zhao, Wenzhen Li, Yuyao Wu, Xin Wang, Yijie Wang, Tingmei Liu, Tinghong Ye, Yongmei Xie, Zhiqiang Cheng, Jun He, Peng Bai, Yiwen Zhang, Liang Ouyang. Emerging targets and potential therapeutic agents in non-alcoholic fatty liver disease treatment.
European journal of medicinal chemistry.
2020 Jul; 197(?):112311. doi:
10.1016/j.ejmech.2020.112311. [PMID: 32339855] - Zizhen Zhang, Hao Chen, Ziyang Chen, Peng Ding, Yingchen Ju, Qiong Gu, Jun Xu, Huihao Zhou. Identify liver X receptor β modulator building blocks by developing a fluorescence polarization-based competition assay.
European journal of medicinal chemistry.
2019 Sep; 178(?):458-467. doi:
10.1016/j.ejmech.2019.06.011. [PMID: 31202993] - Bahaa El-Dien M El-Gendy, Shaimaa S Goher, Lamees S Hegazy, Mohamed M H Arief, Thomas P Burris. Recent Advances in the Medicinal Chemistry of Liver X Receptors.
Journal of medicinal chemistry.
2018 12; 61(24):10935-10956. doi:
10.1021/acs.jmedchem.8b00045. [PMID: 30004226] - Kristine Griffett, Thomas P Burris. Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease.
Biochemical and biophysical research communications.
2016 Oct; 479(3):424-428. doi:
10.1016/j.bbrc.2016.09.036. [PMID: 27680310] - Kristine Griffett, Laura A Solt, Bahaa El-Dien M El-Gendy, Theodore M Kamenecka, Thomas P Burris. A liver-selective LXR inverse agonist that suppresses hepatic steatosis.
ACS chemical biology.
2013 Mar; 8(3):559-67. doi:
10.1021/cb300541g. [PMID: 23237488]