2-Tert-Butyl-5-phenyl 4-[(4-piperidin-1-ylphenyl)amino]isothiazol-3(2H)-one 1,1-dioxide (BioDeep_00000842314)
代谢物信息卡片
化学式: C24H29N3O3S (439.1929524000001)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)N1C(=O)C(=C(S1(=O)=O)C2=CC=CC=C2)NC3=CC=C(C=C3)N4CCCCC4
InChI: InChI=1S/C24H29N3O3S/c1-24(2,3)27-23(28)21(22(31(27,29)30)18-10-6-4-7-11-18)25-19-12-14-20(15-13-19)26-16-8-5-9-17-26/h4,6-7,10-15,25H,5,8-9,16-17H2,1-3H3
描述信息
AZ876 is a potent and high-affinity LXR agonist. AZ876 displays 25-fold and 2.5-fold more potent than GW3965 (HY-10627) on human (h)LXRα and hLXRβ respectively[1][2].
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代谢反应
0 个相关的代谢反应过程信息。
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Daniel Ritter, Madeleine Goeritzer, Arne Thiele, Annelie Blumrich, Niklas Beyhoff, Katja Luettges, Elia Smeir, Juliane Kasch, Jana Grune, Oliver J Müller, Robert Klopfleisch, Carsten Jaeger, Anna Foryst-Ludwig, Ulrich Kintscher. Liver X Receptor Agonist AZ876 Induces Beneficial Endogenous Cardiac Lipid Reprogramming and Protects Against Isoproterenol-Induced Cardiac Damage.
Journal of the American Heart Association.
2021 07; 10(14):e019473. doi:
10.1161/jaha.120.019473
. [PMID: 34227403] - Jeroen Bogie, Cindy Hoeks, Melissa Schepers, Assia Tiane, Ann Cuypers, Frank Leijten, Yupyn Chintapakorn, Thiti Suttiyut, Surachai Pornpakakul, Dicky Struik, Anja Kerksiek, Hong-Bing Liu, Niels Hellings, Pilar Martinez-Martinez, Johan W Jonker, Ilse Dewachter, Eric Sijbrands, Jochen Walter, Jerome Hendriks, Albert Groen, Bart Staels, Dieter Lütjohann, Tim Vanmierlo, Monique Mulder. Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
Scientific reports.
2019 03; 9(1):4908. doi:
10.1038/s41598-019-41399-4
. [PMID: 30894635] - Megan V Cannon, Hongjuan Yu, Wellington M Candido, Martin M Dokter, Eva-Lotte Lindstedt, Herman H W Silljé, Wiek H van Gilst, Rudolf A de Boer. The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects.
European journal of heart failure.
2015 Mar; 17(3):273-82. doi:
10.1002/ejhf.243
. [PMID: 25684370] - Jwa van der Hoorn, D Lindén, U Lindahl, Mea Bekkers, M Voskuilen, R Nilsson, J Oscarsson, El Lindstedt, Hmg Princen. Low dose of the liver X receptor agonist, AZ876, reduces atherosclerosis in APOE*3Leiden mice without affecting liver or plasma triglyceride levels.
British journal of pharmacology.
2011 Apr; 162(7):1553-63. doi:
10.1111/j.1476-5381.2010.01168.x
. [PMID: 21175581]