9-Carboxymethoxymethylguanine (BioDeep_00000842296)
代谢物信息卡片
9-Carboxymethoxymethylguanine
化学式: C8H9N5O4 (239.0655)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=NC2=C(N1COCC(=O)O)N=C(NC2=O)N
InChI: InChI=1S/C8H9N5O4/c9-8-11-6-5(7(16)12-8)10-2-13(6)3-17-1-4(14)15/h2H,1,3H2,(H,14,15)(H3,9,11,12,16)
描述信息
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Andreas Ärlemalm, Anders Helldén, Louise Karlsson, Björn Carlsson. Rapid determination of acyclovir, its main metabolite 9-carboxymethoxymethylguanine, ganciclovir, and penciclovir in human serum using LC-MS/MS.
Biomedical chromatography : BMC.
2022 Apr; 36(4):e5315. doi:
10.1002/bmc.5315. [PMID: 34981553] - Romana Urinovska, Ivana Kacirova, Jiri Sagan. Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanide in human serum by ultra-high-performance liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2021 Aug; 44(16):3080-3088. doi:
10.1002/jssc.202100241. [PMID: 34165890] - Tsuneaki Kenzaka, Kazuma Sugimoto, Ken Goda, Hozuka Akita. Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function: A case report and literature review.
Medicine.
2021 May; 100(21):e26147. doi:
10.1097/md.0000000000026147. [PMID: 34032768] - Johan Lindström, Anders Helldén, Jan Lycke, Anna Grahn, Marie Studahl. An unexpectedly high occurrence of aciclovir-induced neuropsychiatric symptoms in patients treated for herpesvirus CNS infection: a prospective observational study.
The Journal of antimicrobial chemotherapy.
2019 12; 74(12):3565-3572. doi:
10.1093/jac/dkz357. [PMID: 31504577] - L Berry, P Venkatesan. Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2014 Dec; 61(4):608-10. doi:
10.1016/j.jcv.2014.09.001. [PMID: 25440915] - Patrina Gunness, Katarina Aleksa, John Bend, Gideon Koren. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite.
Translational research : the journal of laboratory and clinical medicine.
2011 Nov; 158(5):290-301. doi:
10.1016/j.trsl.2011.07.002. [PMID: 22005269] - James P Smith, Stephen Weller, Benjamin Johnson, Janet Nicotera, James M Luther, David W Haas. Pharmacokinetics of acyclovir and its metabolites in cerebrospinal fluid and systemic circulation after administration of high-dose valacyclovir in subjects with normal and impaired renal function.
Antimicrobial agents and chemotherapy.
2010 Mar; 54(3):1146-51. doi:
10.1128/aac.00729-09. [PMID: 20038622] - Raymond Fleischer, Michael Johnson. Acyclovir nephrotoxicity: a case report highlighting the importance of prevention, detection, and treatment of acyclovir-induced nephropathy.
Case reports in medicine.
2010; 2010(?):. doi:
10.1155/2010/602783. [PMID: 20862348] - Katsutoshi Hara, Kazuaki Suyama, Hiroshi Itoh, Satoru Nagashima. Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients.
Drug metabolism and pharmacokinetics.
2008; 23(5):306-12. doi:
10.2133/dmpk.23.306. [PMID: 18974607] - Hung-Hsu Yang, Yu-Ping Hsiao, Hung-Chun Shih, Jen-Hung Yang. Acyclovir-induced neuropsychosis successfully recovered after immediate hemodialysis in an end-stage renal disease patient.
International journal of dermatology.
2007 Aug; 46(8):883-4. doi:
10.1111/j.1365-4632.2007.03269.x. [PMID: 17651180] - J M Darville, A M Lovering, A P MacGowan. Development, evaluation and application of an isocratic high-performance liquid chromatography (HPLC) assay for the simultaneous determination of aciclovir and its metabolite 9-carboxymethoxymethylguanine in human serum and cerebrospinal fluid.
International journal of antimicrobial agents.
2007 Jul; 30(1):30-3. doi:
10.1016/j.ijantimicag.2007.02.005. [PMID: 17428641] - Anders Helldén, Ulf Bergman, Richard Dwyer, Charlotte Medin, Hadi Molanaei, Lars Ståhle, Pia Thylén, Ingegerd Odar-Cederlöf. [Risk of CNS adverse effects of aciclovir and valaciclovir. Watch the renal function in treatment of herpes simplex and herpes zoster].
Lakartidningen.
2007 Jun; 104(24-25):1916-20. doi:
NULL. [PMID: 17674672] - Anders Helldén, Jan Lycke, Tatiana Vander, Jan-Olof Svensson, Ingegerd Odar-Cederlöf, Lars Ståhle. The aciclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment.
The Journal of antimicrobial chemotherapy.
2006 May; 57(5):945-9. doi:
10.1093/jac/dkl067. [PMID: 16540518] - Anders Helldén, Ingegerd Odar-Cederlöf, Per Diener, Lisbeth Barkholt, Charlotte Medin, Jan-Olof Svensson, Juliette Säwe, Lars Ståhle. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2003 Jun; 18(6):1135-41. doi:
10.1093/ndt/gfg119. [PMID: 12748346] - J O Svensson, L Barkholt, J Säwe. Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 690(1-2):363-6. doi:
10.1016/s0378-4347(96)00424-0. [PMID: 9106067] - S S Good, P de Miranda. Metabolic disposition of acyclovir in the guinea pig, rabbit, and monkey.
The American journal of medicine.
1982 Jul; 73(1A):91-5. doi:
10.1016/0002-9343(82)90071-7. [PMID: 7102713]
