Fluorofenidone (BioDeep_00000842291)
代谢物信息卡片
Fluorofenidone
化学式: C12H10FNO (203.0746)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN(C(=O)C=C1)C2=CC(=CC=C2)F
InChI: InChI=1S/C12H10FNO/c1-9-5-6-12(15)14(8-9)11-4-2-3-10(13)7-11/h2-8H,1H3
描述信息
Fluorofenidone (AKF-PD), an analogue of AMR69, shows equivalent antifibrotic activity, lower toxicity and longer half-life. Fluorofenidone (AKF-PD) attenuates the progression of renal interstitial fibrosis partly by suppressing NADPH oxidase and extracellular matrix (ECM) deposition via the PI3K/Akt signalling pathway[1][2].
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代谢反应
0 个相关的代谢反应过程信息。
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INOH(0)
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COVID-19 Disease Map(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
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文献列表
- Wei Wu, Ze-Neng Cheng. Metabolism and Mass Balance in Rats Following Oral Administration of the Novel Antifibrotic Drug Fluorofenidone.
Drug design, development and therapy.
2022; 16(?):973-979. doi:
10.2147/dddt.s346661. [PMID: 35386852] - Xiaohua Liao, Xin Lv, Yan Zhang, Yuanyuan Han, Jiajia Li, Jianhua Zeng, Damu Tang, Jie Meng, Xiangning Yuan, Zhangzhe Peng, Lijian Tao, Yanyun Xie. Fluorofenidone Inhibits UUO/IRI-Induced Renal Fibrosis by Reducing Mitochondrial Damage.
Oxidative medicine and cellular longevity.
2022; 2022(?):2453617. doi:
10.1155/2022/2453617. [PMID: 35355864] - Sha Tu, Yanzhi Jiang, Haihua Cheng, Xiangning Yuan, Ying He, Yu Peng, Xiongqun Peng, Zhangzhe Peng, Lijian Tao, Huixiang Yang. Fluorofenidone protects liver against inflammation and fibrosis by blocking the activation of NF-κB pathway.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 07; 35(7):e21497. doi:
10.1096/fj.202002402r. [PMID: 34152015] - Linling Li, Xi Luo, Zeneng Cheng. In vitro inhibition and induction of human liver cytochrome P450 enzymes by a novel anti-fibrotic drug fluorofenidone.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Jul; 51(7):745-751. doi:
10.1080/00498254.2020.1820626. [PMID: 32897767] - Xiaohua Liao, Yupeng Jiang, Qin Dai, Yue Yu, Yan Zhang, Gaoyun Hu, Jie Meng, Yanyun Xie, Zhangzhe Peng, Lijian Tao. Fluorofenidone attenuates renal fibrosis by inhibiting the mtROS-NLRP3 pathway in a murine model of folic acid nephropathy.
Biochemical and biophysical research communications.
2021 01; 534(?):694-701. doi:
10.1016/j.bbrc.2020.11.017. [PMID: 33220928] - YuPeng Jiang, Jiao Quan, Yang Chen, Xiaohua Liao, Qin Dai, Rong Lu, Yue Yu, Gaoyun Hu, Qianbin Li, Jie Meng, Yanyun Xie, Zhangzhe Peng, Lijian Tao. Fluorofenidone protects against acute kidney injury.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 12; 33(12):14325-14336. doi:
10.1096/fj.201901468rr. [PMID: 31661638] - Haihua Chen, Qixin Gan, Congying Yang, Xiongqun Peng, Jiao Qin, Sisi Qiu, Yanzhi Jiang, Sha Tu, Ying He, Shenglan Li, Huixiang Yang, Lijian Tao, Yu Peng. A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis.
Journal of translational medicine.
2019 08; 17(1):280. doi:
10.1186/s12967-019-2027-8. [PMID: 31443720] - Jiao Qin, Zhangzhe Peng, QiongJing Yuan, Qian Li, Yu Peng, Rui Wen, Zhaolan Hu, Jun Liu, Xiongfang Xia, Hong Deng, Xuan Xiong, Jinyue Hu, Lijian Tao. AKF-PD alleviates diabetic nephropathy via blocking the RAGE/AGEs/NOX and PKC/NOX Pathways.
Scientific reports.
2019 03; 9(1):4407. doi:
10.1038/s41598-018-36344-w. [PMID: 30867431] - Hui Yang, Weiru Zhang, Tingting Xie, Xuan Wang, Wangbin Ning. Fluorofenidone inhibits apoptosis of renal tubular epithelial cells in rats with renal interstitial fibrosis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2019; 52(11):e8772. doi:
10.1590/1414-431x20198772. [PMID: 31664306] - Yang Chen, Nasui Wang, Qiongjing Yuan, Jiao Qin, Gaoyun Hu, Qianbin Li, Lijian Tao, Yanyun Xie, Zhangzhe Peng. The Protective Effect of Fluorofenidone against Cyclosporine A-Induced Nephrotoxicity.
Kidney & blood pressure research.
2019; 44(4):656-668. doi:
10.1159/000500924. [PMID: 31387101] - Linfeng Zheng, Jin Zhang, Xiangning Yuan, Juan Tang, Sisi Qiu, Zhangzhe Peng, Qiongjing Yuan, Yanyun Xie, Wenjuan Mei, Yiting Tang, Jie Meng, Gaoyun Hu, Lijian Tao. Fluorofenidone attenuates interleukin-1β production by interacting with NLRP3 inflammasome in unilateral ureteral obstruction.
Nephrology (Carlton, Vic.).
2018 Jun; 23(6):573-584. doi:
10.1111/nep.13062. [PMID: 28437591] - Wenqing Tan, Wei Wang, Xuan Zheng, Jiying Chen, Xiangning Yuan, Fangfang Zhang, Shuting Wang, Lijian Tao. [Effect of fluorofenidone on renal interstitial fibrosis in rats with unilateral ureteral obstruction].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2018 May; 43(5):511-519. doi:
10.11817/j.issn.1672-7347.2018.05.009. [PMID: 29886467] - Wenjuan Mei, Zhangzhe Peng, Miaomiao Lu, Chunyan Liu, Zhenghao Deng, Yun Xiao, Jishi Liu, Ying He, Qiongjing Yuan, Xiangning Yuan, Damu Tang, Huixiang Yang, Lijian Tao. Peroxiredoxin 1 inhibits the oxidative stress induced apoptosis in renal tubulointerstitial fibrosis.
Nephrology (Carlton, Vic.).
2015 Nov; 20(11):832-42. doi:
10.1111/nep.12515. [PMID: 25989822] - Yiting Tang, Fangfang Zhang, Ling Huang, Qiongjing Yuan, Jiao Qin, Bingxin Li, Nasui Wang, Yanyun Xie, Linghao Wang, Wei Wang, Kevin Kwan, Zhangzhe Peng, Gaoyun Hu, Jing Li, Lijian Tao. The Protective Mechanism of Fluorofenidone in Renal Interstitial Inflammation and Fibrosis.
The American journal of the medical sciences.
2015 Sep; 350(3):195-203. doi:
10.1097/maj.0000000000000501. [PMID: 26035627] - Juan Tang, Chun-yan Liu, Miao-miao Lu, Jing Zhang, Wen-juan Mei, Wen-jun Yang, Yan-yun Xie, Ling Huang, Zhang-zhe Peng, Qiong-jing Yuan, Ji-shi Liu, Gao-yun Hu, Li-jian Tao. Fluorofenidone protects against renal fibrosis by inhibiting STAT3 tyrosine phosphorylation.
Molecular and cellular biochemistry.
2015 Sep; 407(1-2):77-87. doi:
10.1007/s11010-015-2456-5. [PMID: 26033204] - Hong Ma, Zhangzhe Peng, Gaoyun Hu, Lijian Tao. [Effect and mechanism of fluorofenidone on organ fibrosis].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2015 Feb; 40(2):208-13. doi:
10.11817/j.issn.1672-7347.2015.02.016. [PMID: 25769329] - Jiao Qin, Wen-Juan Mei, Yan-Yun Xie, Ling Huang, Qiong-Jing Yuan, Gao-Yun Hu, Li-Jian Tao, Zhang-Zhe Peng. Fluorofenidone attenuates oxidative stress and renal fibrosis in obstructive nephropathy via blocking NOX2 (gp91phox) expression and inhibiting ERK/MAPK signaling pathway.
Kidney & blood pressure research.
2015; 40(1):89-99. doi:
10.1159/000368485. [PMID: 26029782] - Xuan Xiong, Wenjuan Mei, Yanyun Xie, Jishi Liu, Miaomiao Lu, Xiongqun Peng, Congyin Yang, Xin Zhang, Mingyan Xie, Renna Luo, Xiangning Yuan, Ling Huang, Lin Wu, Jiao Qin, Yu Peng, Xiujie Jia, Gaoyun Hu, Damu Tang, Lijian Tao. Fluorofenidone offers improved renoprotection at early interventions during the course of diabetic nephropathy in db/db mice via multiple pathways.
PloS one.
2014; 9(10):e111242. doi:
10.1371/journal.pone.0111242. [PMID: 25347392] - Jiao Qin, Yan-Yun Xie, Ling Huang, Qiong-Jing Yuan, Wen-Juan Mei, Xiang-Ning Yuan, Gao-Yun Hu, Guang-Jie Cheng, Li-Jian Tao, Zhang-Zhe Peng. Fluorofenidone inhibits nicotinamide adeninedinucleotide phosphate oxidase via PI3K/Akt pathway in the pathogenesis of renal interstitial fibrosis.
Nephrology (Carlton, Vic.).
2013 Oct; 18(10):690-9. doi:
10.1111/nep.12128. [PMID: 23841831] - Qiongjing Yuan, Linghao Wang, Fangfang Zhang, Rui Wang, Xiao Fu, Zhangzhe Peng, Wangbin Ning, Gaoyun Hu, Zhaohe Wang, Lijian Tao. Fluorofenidone suppresses epithelial-mesenchymal transition and the expression of connective tissue growth factor via inhibiting TGF-beta/Smads signaling in human proximal tubular epithelial cells.
Die Pharmazie.
2011 Dec; 66(12):961-7. doi:
NULL. [PMID: 22312703] - Wang-bin Ning, Gao-yun Hu, Zhang-zhe Peng, Ling Wang, Wei Wang, Ji-ying Chen, Xuan Zheng, Jing Li, Li-jian Tao. Fluorofenidone inhibits Ang II-induced apoptosis of renal tubular cells through blockage of the Fas/FasL pathway.
International immunopharmacology.
2011 Sep; 11(9):1327-32. doi:
10.1016/j.intimp.2011.04.016. [PMID: 21586345] - Bing-Xin Li, Yi-Ting Tang, Wei Wang, Yan-Yun Xie, Na-Sui Wang, Qiong-Jing Yuan, Fang-Fang Zhang, Zhang-Zhe Peng, Gao-Yun Hu, Li-Jian Tao. Fluorofenidone attenuates renal interstitial fibrosis in the rat model of obstructive nephropathy.
Molecular and cellular biochemistry.
2011 Aug; 354(1-2):263-73. doi:
10.1007/s11010-011-0826-1. [PMID: 21594754] - Ling Hao Wang, Ji Shi Liu, Wang Bin Ning, Qiong Jing Yuan, Fang Fang Zhang, Zhang Zhe Peng, Miao Miao Lu, Ren Na Luo, Xiao Fu, Gao Yun Hu, Zhao He Wang, Li Jian Tao. Fluorofenidone attenuates diabetic nephropathy and kidney fibrosis in db/db mice.
Pharmacology.
2011; 88(1-2):88-99. doi:
10.1159/000329419. [PMID: 21847000] - Qiongjing Yuan, Rui Wang, Yu Peng, Xiao Fu, Wei Wang, Linghao Wang, Fangfang Zhang, Zhangzhe Peng, Wangbin Ning, Gaoyun Hu, Zhaohe Wang, Lijian Tao. Fluorofenidone attenuates tubulointerstitial fibrosis by inhibiting TGF-β(1)-induced fibroblast activation.
American journal of nephrology.
2011; 34(2):181-94. doi:
10.1159/000329080. [PMID: 21791914] - Zhang-Zhe Peng, Gao-Yun Hu, Hong Shen, Ling Wang, Wang-Bin Ning, Yan-Yun Xie, Na-Sui Wang, Bing-Xin Li, Yi-Ting Tang, Li-Jian Tao. Fluorofenidone attenuates collagen I and transforming growth factor-beta1 expression through a nicotinamide adenine dinucleotide phosphate oxidase-dependent way in NRK-52E cells.
Nephrology (Carlton, Vic.).
2009 Sep; 14(6):565-72. doi:
10.1111/j.1440-1797.2009.01129.x. [PMID: 19712256] - Li-Jian Tao, Jun Zhang, Gao-Yun Hu. [Effects of 1-(3-fluorophenyl)-5-methyl-2-(1H)-pyridone on renal fibroblast in rats].
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences.
2004 Apr; 29(2):139-41. doi:
NULL. [PMID: 16145895]
