6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (BioDeep_00000842289)

   


Metabolite Card


6-(4-(Trifluoromethoxy)phenyl)-3-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine

Formula: C14H7F6N3O (347.0493)
Chinese Names:
Spectrum Hits: Top Source () 0%

Molecular Structure

SMILES: C1=CC(=CC=C1C2=CN3C(=NN=C3C(F)(F)F)C=C2)OC(F)(F)F
InChI: InChI=1S/C14H7F6N3O/c15-13(16,17)12-22-21-11-6-3-9(7-23(11)12)8-1-4-10(5-2-8)24-14(18,19)20/h1-7H



Cross Reference

3 cross reference id

Classification Terms

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0 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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Literature Reference

  • Emily R Mason, Theodore R Cummins. Differential Inhibition of Human Nav1.2 Resurgent and Persistent Sodium Currents by Cannabidiol and GS967. International journal of molecular sciences. 2020 Apr; 21(7):. doi: 10.3390/ijms21072454. [PMID: 32244818]
  • Dmitry O Koltun, Eric Q Parkhill, Elfatih Elzein, Tetsuya Kobayashi, Robert H Jiang, Xiaofen Li, Thao D Perry, Belem Avila, Wei-Qun Wang, Ryoko Hirakawa, Catherine Smith-Maxwell, Lin Wu, Arvinder K Dhalla, Sridharan Rajamani, Nevena Mollova, Brian Stafford, Jennifer Tang, Luiz Belardinelli, Jeff A Zablocki. Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine. Bioorganic & medicinal chemistry letters. 2016 07; 26(13):3207-3211. doi: 10.1016/j.bmcl.2016.03.096. [PMID: 27038498]
  • Juliana Saran Carneiro, Afonso S Alves Bento, Danilo Bacic, Bruce D Nearing, Sridharan Rajamani, Luiz Belardinelli, Richard L Verrier. The Selective Cardiac Late Sodium Current Inhibitor GS-458967 Suppresses Autonomically Triggered Atrial Fibrillation in an Intact Porcine Model. Journal of cardiovascular electrophysiology. 2015 Dec; 26(12):1364-9. doi: 10.1111/jce.12824. [PMID: 26331943]
  • Sarah Fernandes, Kirsten Hoyer, Gongxin Liu, Wei-Qun Wang, Arvinder K Dhalla, Luiz Belardinelli, Sridharan Rajamani. Selective inhibition of the late sodium current has no adverse effect on electrophysiological or contractile function of the normal heart. Journal of cardiovascular pharmacology. 2014 Jun; 63(6):512-9. doi: 10.1097/fjc.0000000000000075. [PMID: 24406487]