17-(1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthrene-3,5,6-triol (BioDeep_00000842262)
代谢物信息卡片
17-(1,5-Dimethylhexyl)-10,13-dimethylhexadecahydrocyclopenta[a]phenanthrene-3,5,6-triol
化学式: C27H48O3 (420.36032579999994)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCC3C2CC(C4(C3(CCC(C4)O)C)O)O)C
InChI: InChI=1S/C27H48O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-24,28-30H,6-16H2,1-5H3
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代谢反应
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ahmet Yalcinkaya, Afshin Samadi, Incilay Lay, Selma Unal, Suna Sabuncuoglu, Yesim Oztas. Oxysterol concentrations are associated with cholesterol concentrations and anemia in pediatric patients with sickle cell disease.
Scandinavian journal of clinical and laboratory investigation.
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Biochemical and biophysical research communications.
2018 01; 496(1):95-100. doi:
10.1016/j.bbrc.2018.01.004. [PMID: 29307820] - Sara Boenzi, Federica Deodato, Roberta Taurisano, Bianca Maria Goffredo, Cristiano Rizzo, Carlo Dionisi-Vici. Evaluation of plasma cholestane-3β,5α,6β-triol and 7-ketocholesterol in inherited disorders related to cholesterol metabolism.
Journal of lipid research.
2016 Mar; 57(3):361-7. doi:
10.1194/jlr.m061978. [PMID: 26733147] - Janine Reunert, Manfred Fobker, Frank Kannenberg, Ingrid Du Chesne, Maria Plate, Judith Wellhausen, Stephan Rust, Thorsten Marquardt. Rapid Diagnosis of 83 Patients with Niemann Pick Type C Disease and Related Cholesterol Transport Disorders by Cholestantriol Screening.
EBioMedicine.
2016 Feb; 4(?):170-5. doi:
10.1016/j.ebiom.2015.12.018. [PMID: 26981555] - Sonia Pajares, Angela Arias, Judit García-Villoria, Judit Macías-Vidal, Emilio Ros, Javier de las Heras, Marisa Girós, Maria J Coll, Antonia Ribes. Cholestane-3β,5α,6β-triol: high levels in Niemann-Pick type C, cerebrotendinous xanthomatosis, and lysosomal acid lipase deficiency.
Journal of lipid research.
2015 Oct; 56(10):1926-35. doi:
10.1194/jlr.m060343. [PMID: 26239048] - Xuntian Jiang, Rohini Sidhu, Forbes D Porter, Nicole M Yanjanin, Anneliese O Speak, Danielle Taylor te Vruchte, Frances M Platt, Hideji Fujiwara, David E Scherrer, Jessie Zhang, Dennis J Dietzen, Jean E Schaffer, Daniel S Ory. A sensitive and specific LC-MS/MS method for rapid diagnosis of Niemann-Pick C1 disease from human plasma.
Journal of lipid research.
2011 07; 52(7):1435-45. doi:
10.1194/jlr.d015735. [PMID: 21518695] - Hongmei Liu, Tiebing Wang, Kaixun Huang. Cholestane-3beta,5alpha,6beta-triol-induced reactive oxygen species production promotes mitochondrial dysfunction in isolated mice liver mitochondria.
Chemico-biological interactions.
2009 May; 179(2-3):81-7. doi:
10.1016/j.cbi.2008.12.003. [PMID: 19121293] - S Ferderbar, E C Pereira, E Apolinário, M C Bertolami, A Faludi, O Monte, L E Calliari, J E Sales, A R Gagliardi, H T Xavier, D S P Abdalla. Cholesterol oxides as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus.
Diabetes/metabolism research and reviews.
2007 Jan; 23(1):35-42. doi:
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Atherosclerosis.
2002 May; 162(1):137-44. doi:
10.1016/s0021-9150(01)00707-9. [PMID: 11947907] - H Cantwell, R Devery. The response of the antioxidant defense system in rat hepatocytes challenged with oxysterols is modified by Covi-ox.
Cell biology and toxicology.
1998 Dec; 14(6):401-9. doi:
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Comparative biochemistry and physiology. Part C, Pharmacology, toxicology & endocrinology.
1998 Aug; 120(2):269-82. doi:
10.1016/s0742-8413(98)10005-1. [PMID: 9827041] - Y V Yuan, D D Kitts, D V Godin. Interactive effects of increased intake of saturated fat and cholesterol on atherosclerosis in the Japanese quail (Coturnix japonica).
The British journal of nutrition.
1998 Jul; 80(1):89-100. doi:
10.1017/s0007114598001810. [PMID: 9797648] - M M Mahfouz, F A Kummerow. Oxysterols and TBARS are among the LDL oxidation products which enhance thromboxane A2 synthesis by platelets.
Prostaglandins & other lipid mediators.
1998 Jul; 56(4):197-217. doi:
10.1016/s0090-6980(98)00056-2. [PMID: 9777653] - A M Wilson, R M Sisk, N M O'Brien. Modulation of cholestane-3 beta,5 alpha,6 beta-triol toxicity by butylated hydroxytoluene, alpha-tocopherol and beta-carotene in newborn rat kidney cells in vitro.
The British journal of nutrition.
1997 Sep; 78(3):479-92. doi:
10.1079/bjn19970165. [PMID: 9306888] - O Breuer, S Dzeletovic, E Lund, U Diczfalusy. The oxysterols cholest-5-ene-3 beta,4 alpha-diol, cholest-5-ene-3 beta,4 beta-diol and cholestane-3 beta,5 alpha,6 alpha-triol are formed during in vitro oxidation of low density lipoprotein, and are present in human atherosclerotic plaques.
Biochimica et biophysica acta.
1996 Jul; 1302(2):145-52. doi:
10.1016/0005-2760(96)00052-5. [PMID: 8695664] - M M Mahfouz, T L Smith, Q Zhou, F A Kummerow. Cholestane-3 beta, 5 alpha, 6 beta-triol stimulates phospholipid synthesis and CTP-phosphocholine cytidyltransferase in cultured LLC-PK cells.
The international journal of biochemistry & cell biology.
1996 Jul; 28(7):739-50. doi:
10.1016/1357-2725(96)00025-8. [PMID: 8925405] - S Ramasamy, D W Lipke, G A Boissonneault, H Guo, B Hennig. Oxidized lipid-mediated alterations in proteoglycan metabolism in cultured pulmonary endothelial cells.
Atherosclerosis.
1996 Feb; 120(1-2):199-208. doi:
10.1016/0021-9150(95)05702-1. [PMID: 8645361] - B A Cunningham, L Midmore, O Kucuk, L J Lis, M P Westerman, W Bras, D H Wolfe, P J Quinn, S B Qadri. Sterols stabilize the ripple phase structure in dihexadecylphosphatidylcholine.
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1991 Jan; 32(1):147-55. doi:
10.1016/s0022-2275(20)42253-9. [PMID: 2010686] - C Seillan. Oxysterol mediated changes in fatty acid distribution and lipid synthesis in cultured bovine aortic smooth muscle cells.
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1990 Mar; 25(3):172-6. doi:
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1989 Mar; 24(3):217-20. doi:
10.1007/bf02535237. [PMID: 2761354] - I Björkhem, O Breuer, B Angelin, S A Wikström. Assay of unesterified cholesterol-5,6-epoxide in human serum by isotope dilution mass spectrometry. Levels in the healthy state and in hyperlipoproteinemia.
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1988 Aug; 29(8):1031-8. doi:
. [PMID: 3183516] - D Matthias, C H Becker, W Gödicke, R Schmidt, K Ponsold. Action of cholestane-3 beta,5 alpha,6 beta-triol on rats with particular reference to the aorta.
Atherosclerosis.
1987 Feb; 63(2-3):115-24. doi:
10.1016/0021-9150(87)90111-0. [PMID: 3827976] - B H Cho, P O Egwim, G C Fahey. Effects of pure and auto-oxidized forms of cholesterol on plasma, liver lipids and hepatic lipogenesis in chicks.
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