3-Octadecyloxy-2-methoxypropylphosphonocholine (BioDeep_00000842212)
代谢物信息卡片
3-Octadecyloxy-2-methoxypropylphosphonocholine
化学式: C27H59NO6P+ (524.408)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCOCC(COP(=O)(O)OCC[N+](C)(C)C)OC
InChI: InChI=1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3/p+1
描述信息
D013501 - Surface-Active Agents > D054709 - Lecithins
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Chu-Wen Yang, Chi-Lun Chang, Hsin-Chen Lee, Chin-Wen Chi, Jia-Ping Pan, Wen-Chin Yang. Curcumin induces the apoptosis of human monocytic leukemia THP-1 cells via the activation of JNK/ERK pathways.
BMC complementary and alternative medicine.
2012 Mar; 12(?):22. doi:
10.1186/1472-6882-12-22. [PMID: 22443687] - Lars Kuerschner, Doris Richter, Hans Kristian Hannibal-Bach, Anne Gaebler, Andrej Shevchenko, Christer S Ejsing, Christoph Thiele. Exogenous ether lipids predominantly target mitochondria.
PloS one.
2012; 7(2):e31342. doi:
10.1371/journal.pone.0031342. [PMID: 22348073] - Geo Semini, Andreas Klein, Kerstin Danker. Impact of alkylphospholipids on the gene expression profile of HaCaT cells.
Pharmacogenetics and genomics.
2011 Jul; 21(7):375-87. doi:
10.1097/fpc.0b013e32834549b9. [PMID: 21681147] - Somayeh Rajaie, Ahmad Esmaillzadeh. Dietary choline and betaine intakes and risk of cardiovascular diseases: review of epidemiological evidence.
ARYA atherosclerosis.
2011; 7(2):78-86. doi:
NULL. [PMID: 22577451] - Chang-Hee Kim, Hye-Young Kim, Ho Sun Lee, Sun O Chang, Seung-Ha Oh, Jun Ho Lee. P2Y4-mediated regulation of Na+ absorption in the Reissner's membrane of the cochlea.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Mar; 30(10):3762-9. doi:
10.1523/jneurosci.3300-09.2010. [PMID: 20220010] - Faustino Mollinedo, Consuelo Gajate, Ana I Morales, Esther del Canto-Jañez, Nicole Justies, Francisco Collía, Juan V Rivas, Manuel Modolell, Antonio Iglesias. Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.
The Journal of pharmacology and experimental therapeutics.
2009 May; 329(2):439-49. doi:
10.1124/jpet.108.148254. [PMID: 19244550] - Jon V Busto, Esther Del Canto-Jañez, Félix M Goñi, Faustino Mollinedo, Alicia Alonso. Combination of the anti-tumour cell ether lipid edelfosine with sterols abolishes haemolytic side effects of the drug.
Journal of chemical biology.
2008 Nov; 1(1-4):89-94. doi:
10.1007/s12154-008-0009-z. [PMID: 19568801] - Ander Estella-Hermoso de Mendoza, Marta Rayo, Faustino Mollinedo, María J Blanco-Prieto. Lipid nanoparticles for alkyl lysophospholipid edelfosine encapsulation: development and in vitro characterization.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2008 Feb; 68(2):207-13. doi:
10.1016/j.ejpb.2007.06.015. [PMID: 17707618] - Jon V Busto, Jesús Sot, Félix M Goñi, Faustino Mollinedo, Alicia Alonso. Surface-active properties of the antitumour ether lipid 1-O-octadecyl-2-O-methyl-rac-glycero-3-phosphocholine (edelfosine).
Biochimica et biophysica acta.
2007 Jul; 1768(7):1855-60. doi:
10.1016/j.bbamem.2007.04.025. [PMID: 17543274] - Faustino Mollinedo, Consuelo Gajate, Sonsoles Martín-Santamaría, Federico Gago. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.
Current medicinal chemistry.
2004 Dec; 11(24):3163-84. doi:
10.2174/0929867043363703. [PMID: 15579006] - V Jendrossek, R Handrick. Membrane targeted anticancer drugs: potent inducers of apoptosis and putative radiosensitisers.
Current medicinal chemistry. Anti-cancer agents.
2003 Sep; 3(5):343-53. doi:
10.2174/1568011033482341. [PMID: 12871080] - Arnold H van der Luit, Marianne Budde, Paula Ruurs, Marcel Verheij, Wim J van Blitterswijk. Alkyl-lysophospholipid accumulates in lipid rafts and induces apoptosis via raft-dependent endocytosis and inhibition of phosphatidylcholine synthesis.
The Journal of biological chemistry.
2002 Oct; 277(42):39541-7. doi:
10.1074/jbc.m203176200. [PMID: 12183451] - G A Ruiter, M Verheij, S F Zerp, W J van Blitterswijk. Alkyl-lysophospholipids as anticancer agents and enhancers of radiation-induced apoptosis.
International journal of radiation oncology, biology, physics.
2001 Feb; 49(2):415-9. doi:
10.1016/s0360-3016(00)01476-0. [PMID: 11173135] - H Salari, S Howard, R Bittman. Synthesis and antineoplastic properties of an ether glycerophosphonocholine, and analog of ET-18-OCH3-GPC.
Biochemical and biophysical research communications.
1992 Sep; 187(2):603-8. doi:
10.1016/0006-291x(92)91237-k. [PMID: 1530618]
