I-urobilin (BioDeep_00000842178)

   


代谢物信息卡片


3,18-diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropionic acid

化学式: C33H42N4O6 (590.3104)
中文名称: 尿膽素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=C(C(=O)NC1CC2=C(C(=C(N2)C=C3C(=C(C(=N3)CC4C(=C(C(=O)N4)CC)C)C)CCC(=O)O)CCC(=O)O)C)C
InChI: InChI=1S/C33H42N4O6/c1-7-20-19(6)32(42)37-27(20)14-25-18(5)23(10-12-31(40)41)29(35-25)15-28-22(9-11-30(38)39)17(4)24(34-28)13-26-16(3)21(8-2)33(43)36-26/h15,26-27,35H,7-14H2,1-6H3,(H,36,43)(H,37,42)(H,38,39)(H,40,41)/b28-15-

描述信息

Urobilin is one of the final by-products of hemoglobin breakdown. Urobilin is excreted in both the urine and feces from many mammals, particularly humans. The breakdown of hemoglobin to biliverdin is common to most animals, while the next step, the conversion of biliverdin to bilirubin, and subsequently to the urobilinogens (urobilin is one particular oxidized chemical form of urobilinogen) is unique to mammals. (PMID: 16604237) [HMDB]

同义名列表

3 个代谢物同义名

3,18-diethyl-1,4,5,15,16,19,22,24-octahydro-2,7,13,17-tetramethyl-1,19-dioxo-21H-biline-8,12-dipropionic acid; I-urobilin; Urobilin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(3)

  • Metabolism: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA
  • Porphyrin metabolism: Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN
  • Heme degradation: Oxygen + TPNH + heme ⟶ BV + CO + Fe2+ + H2O + TPN

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Evelyn A Bates, Zachary A Kipp, Genesee J Martinez, Olufunto O Badmus, Mangala M Soundarapandian, Donald Foster, Mei Xu, Justin F Creeden, Jennifer R Greer, Andrew J Morris, David E Stec, Terry D Hinds. Suppressing Hepatic UGT1A1 Increases Plasma Bilirubin, Lowers Plasma Urobilin, Reorganizes Kinase Signaling Pathways and Lipid Species and Improves Fatty Liver Disease. Biomolecules. 2023 Jan; 13(2):. doi: 10.3390/biom13020252. [PMID: 36830621]
  • Patrick B Kyle, Jaswinder Kaur. Evaluating Novel Markers for Specimen Validity Testing. Archives of pathology & laboratory medicine. 2020 02; 144(2):168-171. doi: 10.5858/arpa.2019-0197-oa. [PMID: 31755779]
  • Markus Stenemo, Andrea Ganna, Samira Salihovic, Christoph Nowak, Johan Sundström, Vilmantas Giedraitis, Corey D Broeckling, Jessica E Prenni, Per Svensson, Patrik K E Magnusson, Lars Lind, Erik Ingelsson, Johan Ärnlöv, Tove Fall. The metabolites urobilin and sphingomyelin (30:1) are associated with incident heart failure in the general population. ESC heart failure. 2019 08; 6(4):764-773. doi: 10.1002/ehf2.12453. [PMID: 31148414]
  • Charity G Owings, Christine Skaggs, Winyu Sheriff, Nicholas Manicke, Christine J Picard. Chemical Assay for the Detection of Vertebrate Fecal Metabolites in Adult Blow Flies (Diptera: Calliphoridae). Environmental entomology. 2018 06; 47(3):586-593. doi: 10.1093/ee/nvy027. [PMID: 29534166]
  • Aleikar Vásquez-Suárez, Francisco Lobos-González, Andrew Cronshaw, José Sepúlveda-Ugarte, Maximiliano Figueroa, Jorge Dagnino-Leone, Marta Bunster, José Martínez-Oyanedel. The γ33 subunit of R-phycoerythrin from Gracilaria chilensis has a typical double linked phycourobilin similar to β subunit. PloS one. 2018; 13(4):e0195656. doi: 10.1371/journal.pone.0195656. [PMID: 29634783]
  • Joel N Bixler, Michael T Cone, Brett H Hokr, John D Mason, Eleonora Figueroa, Edward S Fry, Vladislav V Yakovlev, Marlan O Scully. Ultrasensitive detection of waste products in water using fluorescence emission cavity-enhanced spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 2014 May; 111(20):7208-11. doi: 10.1073/pnas.1403175111. [PMID: 24799690]
  • D L Sampson, Y L Chng, Z Upton, C P Hurst, A W Parker, T J Parker. The highly abundant urinary metabolite urobilin interferes with the bicinchoninic acid assay. Analytical biochemistry. 2013 Nov; 442(1):110-7. doi: 10.1016/j.ab.2013.07.027. [PMID: 23911526]
  • Yu-Rong Chen, Yi-shin Su, Shih-Long Tu. Distinct phytochrome actions in nonvascular plants revealed by targeted inactivation of phytobilin biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. 2012 May; 109(21):8310-5. doi: 10.1073/pnas.1201744109. [PMID: 22566621]
  • Hailong Chen, Wei Dang, Jie Xie, Jingquan Zhao, Yuxiang Weng. Ultrafast energy transfer pathways in R-phycoerythrin from Polysiphonia urceolata. Photosynthesis research. 2012 Mar; 111(1-2):81-6. doi: 10.1007/s11120-011-9708-3. [PMID: 22083175]
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