2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)- (BioDeep_00000842170)
代谢物信息卡片
2,4-Dioxaspiro[5.5]undec-8-ene, 3-(2-furanyl)-
化学式: C13H16O3 (220.1099)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CC2(CC=C1)COC(OC2)C3=CC=CO3
InChI: InChI=1S/C13H16O3/c1-2-6-13(7-3-1)9-15-12(16-10-13)11-5-4-8-14-11/h1-2,4-5,8,12H,3,6-7,9-10H2
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
|---|
文献列表
- Xiaopeng Peng, Haoyao Yuan, Guangtian Chen, Yuliang Guo, Qiuer Liang, Qiming Chen, Weidong Cao. Investigation on the effect of ulinastatin on the apoptosis of vascular smooth muscle cells in rats with aortic dissection based on the Sirt1/FoxO3a pathway.
Cellular and molecular biology (Noisy-le-Grand, France).
2023 Dec; 69(13):96-101. doi:
10.14715/cmb/2023.69.13.15. [PMID: 38158682] - Xiaosong Yang, Na Guo. Ulinastatin ameliorates podocyte ferroptosis via regulating miR-144-3p/SLC7A11 axis in acute kidney injury.
In vitro cellular & developmental biology. Animal.
2023 Oct; ?(?):. doi:
10.1007/s11626-023-00814-x. [PMID: 37819479] - Zhiguang Liu, Xiaochun Zhu, Chenglin Xu, Feng Min, Guofeng Yu, Chuhong Chen. Ulinastatin ameliorates the malignant progression of prostate cancer cells by blocking the RhoA/ROCK/NLRP3 pathway.
Drug development research.
2023 02; 84(1):36-44. doi:
10.1002/ddr.22010. [PMID: 36461611] - Guofu Zhong, Yue Han, Qinghua Zhu, Mujuan Xu, Xiao Chang, Mingtai Chen, Ling Men, Qiang Zhang, Ling Wang. The effects of Xuebijing injection combined with ulinastatin as adjunctive therapy on sepsis: An overview of systematic review and meta-analysis.
Medicine.
2022 Oct; 101(42):e31196. doi:
10.1097/md.0000000000031196. [PMID: 36281160] - Jin Li, Meijun Li, Liren Li, Lin Ma, Ailin Cao, Aiping Wen, Wenge Chen, Lingling Li, Yan Liang, Jianxiong Deng. Real-world safety of ulinastatin: a post-marketing surveillance of 11,252 patients in China.
BMC pharmacology & toxicology.
2022 07; 23(1):51. doi:
10.1186/s40360-022-00585-3. [PMID: 35842685] - Zhe Jin, Meng-Yun Li, Lijuan Tang, Yufeng Zou, Kai Chen. Protective effect of Ulinastatin on acute lung injury in diabetic sepsis rats.
International immunopharmacology.
2022 Jul; 108(?):108908. doi:
10.1016/j.intimp.2022.108908. [PMID: 35729837] - Poonam Sharma, Nikita Gaur, Shalini Jayant, B M Sharma, Bhagwat Singh, Harsha Kharkwal, Bhupesh Sharma. Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia.
Pharmacological reports : PR.
2022 Jun; 74(3):481-492. doi:
10.1007/s43440-022-00364-1. [PMID: 35396697] - Yanping He, Xuemei Chen, Guifang Zhang, Lijuan Guan, Xie Yu. Clinical efficacy and safety of norepinephrine combined with ulinastatin in the treatment of septic shock.
Pakistan journal of pharmaceutical sciences.
2022 Mar; 35(2(Special)):657-663. doi:
. [PMID: 35668567] - Xiong Zhang, Chenlin Su, Shuxin Zhao, Ji Li, Feng Yu. Combination therapy of Ulinastatin with Thrombomodulin alleviates endotoxin (LPS) - induced liver and kidney injury via inhibiting apoptosis, oxidative stress and HMGB1/TLR4/NF-κB pathway.
Bioengineered.
2022 02; 13(2):2951-2970. doi:
10.1080/21655979.2021.2024686. [PMID: 35148668] - Zexin An, Yong Yin, Lei Zhang, Bo Wang, Tao Cui, Meng Li, Jianwei Zhuo, Jing Zhang, Kai Wang, Wenwen Zhang, Meng Ji, Jilin Sun, Yinong Xu. Effect of Ulinastatin Combined with Xingnaojing Injection on Severe Traumatic Craniocerebral Injury and Its Influence on Oxidative Stress Response and Inflammatory Response.
BioMed research international.
2022; 2022(?):2621732. doi:
10.1155/2022/2621732. [PMID: 35047630] - Zhenying Zhang, Xiaojing Sun, Jiagui Ma, Qiaoyan Ma, Qian Cao, Liu Zhang, Lizhong Wang. Clinical Efficacy of Ulinastatin Combined with Meglumine Adenosine Cyclophosphate in the Treatment of Acute Myocardial Infarction.
Computational and mathematical methods in medicine.
2022; 2022(?):2172412. doi:
10.1155/2022/2172412. [PMID: 35479188] - Tian Li, Xiaojun Ji, Jingfeng Liu, Xinjie Guo, Ran Pang, Haizhou Zhuang, Lei Dong, Meili Duan, Ang Li. Ulinastatin Improves Renal Microcirculation by Protecting Endothelial Cells and Inhibiting Autophagy in a Septic Rat Model.
Kidney & blood pressure research.
2022; 47(4):256-269. doi:
10.1159/000521648. [PMID: 35016182] - Chen Chen Hang, Yu Hong Guo, Chun Sheng Li, Shuo Wang. Ulinastatin Exerts the Protective Effects of Lung by Up-Regulating Aquaporins Expression in a Two-Hit Porcine Model of Acute Respiratory Distress Syndrome.
Biomedical and environmental sciences : BES.
2021 Dec; 34(12):1029-1032. doi:
10.3967/bes2021.140. [PMID: 34981729] - Feixiang Chen, Jiadong Zhu, Wei Wang. Ulinastatin Attenuates LPS-Induced Inflammation and Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis in Renal Tubular Epithelial Cells via Regulation of the TLR4/NF-κB and Nrf2/HO-1 Pathways.
Inflammation.
2021 Dec; 44(6):2323-2332. doi:
10.1007/s10753-021-01505-z. [PMID: 34585338] - Ren-Fei Shan, Yan-An Zhu, Jie Qin, Jian-Ping Chen. Traditional Chinese medicine for septic patients undergoing ulinastatin therapy: A meta-analysis.
Medicine.
2021 Sep; 100(38):e27151. doi:
10.1097/md.0000000000027151. [PMID: 34559104] - Xuejiao Wei, Xiaoyu Zhu, Lili Jiang, Mengtuan Long, Yujun Du. Recent research progress on the role of ulinastatin in chronic kidney disease.
Nephrology (Carlton, Vic.).
2021 Sep; 26(9):708-714. doi:
10.1111/nep.13906. [PMID: 34050574] - Xiang Li, Chunbo Yang, Tayier Gulifeire, Yi Wang, Xiangyou Yu. [Ulinastatin protects intestinal mucosal barrier by inhibiting the activation of intestinal NLRP3 inflammasomes in septic rats].
Zhonghua wei zhong bing ji jiu yi xue.
2021 Feb; 33(2):192-197. doi:
10.3760/cma.j.cn121430-20201208-00747. [PMID: 33729139] - Xi Luo, Le Huan, Feng Lin, Fanqi Kong, Xiaofei Sun, Fudong Li, Jian Zhu, Jingchuan Sun, Ximing Xu, Kaiqiang Sun, Liwei Duan, Jiangang Shi. Ulinastatin Ameliorates IL-1β-Induced Cell Dysfunction in Human Nucleus Pulposus Cells via Nrf2/NF-κB Pathway.
Oxidative medicine and cellular longevity.
2021; 2021(?):5558687. doi:
10.1155/2021/5558687. [PMID: 33968294] - D-M Zhang, S-L Chen. Cytokine storms caused by novel coronavirus 2019 and treatment for cardiac injury.
European review for medical and pharmacological sciences.
2020 12; 24(23):12527-12535. doi:
10.26355/eurrev_202012_24050. [PMID: 33336773] - Shahd Horie, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, Ger Curley, Danny McAuley, Cecilia O'Kane, Alistair Nichol, Claudia Dos Santos, Patricia R M Rocco, Giacomo Bellani, John G Laffey. Emerging pharmacological therapies for ARDS: COVID-19 and beyond.
Intensive care medicine.
2020 12; 46(12):2265-2283. doi:
10.1007/s00134-020-06141-z. [PMID: 32654006] - Haijin Lv, Xuxia Wei, Xiaomeng Yi, Jianrong Liu, Pinglan Lu, Mi Zhou, Yuling An, Huimin Yi. High-dose ulinastatin to prevent late-onset acute renal failure after orthotopic liver transplantation.
Renal failure.
2020 Nov; 42(1):137-145. doi:
10.1080/0886022x.2020.1717530. [PMID: 31984833] - Rehab E Abo El Gheit, Marwa Mohamed Atef, Ghada A Badawi, Walaa M Elwan, H A Alshenawy, Marwa Nagy Emam. Role of serine protease inhibitor, ulinastatin, in rat model of hepatic encephalopathy: aquaporin 4 molecular targeting and therapeutic implication.
Journal of physiology and biochemistry.
2020 Nov; 76(4):573-586. doi:
10.1007/s13105-020-00762-0. [PMID: 32794154] - J-G Zhu, K Jin, Y Ren. Ulinastatin reduces myocardial injury induced by doxorubicin in SD rats.
European review for medical and pharmacological sciences.
2020 10; 24(20):10769-10778. doi:
10.26355/eurrev_202010_23437. [PMID: 33155237] - Hong-Yuan Lin. The severe COVID-19: A sepsis induced by viral infection? And its immunomodulatory therapy.
Chinese journal of traumatology = Zhonghua chuang shang za zhi.
2020 Aug; 23(4):190-195. doi:
10.1016/j.cjtee.2020.06.002. [PMID: 32690231] - Peng Zhang, Hong Lv, Xia Qi, Wenjing Xiao, Qinghua Xue, Lei Zhang, Lihuan Li, Jia Shi. Effect of ulinastatin on post-operative blood loss and allogeneic transfusion in patients receiving cardiac surgery with cardiopulmonary bypass: a prospective randomized controlled study with 10-year follow-up.
Journal of cardiothoracic surgery.
2020 May; 15(1):98. doi:
10.1186/s13019-020-01144-9. [PMID: 32410683] - Hong Gao, Yi Lyu, Yi Yang, Yingchuan Li, Honghua Cao. Perioperation ulinastatin intervention protects liver function in hepatectomy: a systematic review of randomized controlled trials and meta-analysis.
Annals of palliative medicine.
2020 May; 9(3):774-787. doi:
10.21037/apm.2020.04.28. [PMID: 32389014] - Lirong Hu, Bo Leng, Changxue Wu, Yuting Xue. A prospective observational study to explore the correlation of peripheral arterial pulse/resistance index, organ function, and inflammation in patients with septic shock.
Medicine.
2020 May; 99(20):e20235. doi:
10.1097/md.0000000000020235. [PMID: 32443357] - M-H Lun, X-Y Jin, M-Y Wang, Z Cai, W Du, Z-Q Huang. Ulinastatin improves myocardial ischemia-reperfusion injury in rats through endoplasmic reticulum stress-induced apoptosis pathway.
European review for medical and pharmacological sciences.
2020 05; 24(10):5742-5749. doi:
10.26355/eurrev_202005_21366. [PMID: 32495910] - Xin-Yue Yang, Jie Song, Shi-Ke Hou, Hao-Jun Fan, Qi Lv, Zi-Quan Liu, Hui Ding, Yong-Zhong Zhang, Jin-Yang Liu, Wen-Long Dong, Xue Wang. Ulinastatin ameliorates acute kidney injury induced by crush syndrome inflammation by modulating Th17/Treg cells.
International immunopharmacology.
2020 Apr; 81(?):106265. doi:
10.1016/j.intimp.2020.106265. [PMID: 32044661] - Fulei Meng, Chongbo Du, Yuxiao Zhang, Shunyao Wang, Qingming Zhou, Liping Wu, Yanli Wang, Xiufen Yang. Protective effect of rhubarb combined with ulinastatin for patients with sepsis.
Medicine.
2020 Feb; 99(7):e18895. doi:
10.1097/md.0000000000018895. [PMID: 32049789] - Yun-Tai Yao, Neng-Xin Fang, Ding-Hua Liu, Li-Huan Li. Ulinastatin reduces postoperative bleeding and red blood cell transfusion in patients undergoing cardiac surgery: A PRISMA-compliant systematic review and meta-analysis.
Medicine.
2020 Feb; 99(7):e19184. doi:
10.1097/md.0000000000019184. [PMID: 32049853] - Jia-Wan Wang, An-Shi Wu, Yun Yue, Yan Wu. Perioperative Ulinastatin helps preserve endothelial glycocalyx layer in periampullary carcinoma patients undergoing Traditional Whipple Procedure.
Clinical hemorheology and microcirculation.
2020; 75(2):135-142. doi:
10.3233/ch-190688. [PMID: 31903986] - Shuxia Liang, Panjian Lai, Xiaobing Li, Jie Xu, Yunguang Bao, Yuanshu Fang, Mingxing Ding. Ulinastatin Reduces the Severity of Intestinal Damage in the Neonatal Rat Model of Necrotizing Enterocolitis.
Medical science monitor : international medical journal of experimental and clinical research.
2019 Dec; 25(?):9123-9130. doi:
10.12659/msm.919413. [PMID: 31786582] - Xiangyun Zhang, Zhaozhong Zhu, Weijie Jiao, Wei Liu, Fang Liu, Xi Zhu. Ulinastatin treatment for acute respiratory distress syndrome in China: a meta-analysis of randomized controlled trials.
BMC pulmonary medicine.
2019 Nov; 19(1):196. doi:
10.1186/s12890-019-0968-6. [PMID: 31684936] - Z-H Yang, Y-J Lu, K-P Gu, Z-Y Xiang, H-M Huang. Effect of ulinastatin on myocardial ischemia-reperfusion injury through JNK and P38 MAPK signaling pathways.
European review for medical and pharmacological sciences.
2019 Oct; 23(19):8658-8664. doi:
10.26355/eurrev_201910_19183. [PMID: 31646600] - Yunpeng Wang, Cheng Peng, Zheng Zhang, Jing Shi, Yingli Lin, Liangyou Gu, Xin Ma, Hongzhao Li. Intravenous infusion of ulinastatin attenuates acute kidney injury after cold ischemia/reperfusion.
International urology and nephrology.
2019 Oct; 51(10):1873-1881. doi:
10.1007/s11255-019-02204-3. [PMID: 31332701] - H Che, Y-F Lv, Y-G Liu, Y-X Hou, L-Y Zhao. Effect of ulinastatin on myocardial ischemia reperfusion injury through ERK signaling pathway.
European review for medical and pharmacological sciences.
2019 May; 23(10):4458-4464. doi:
10.26355/eurrev_201905_17957. [PMID: 31173321] - Shi Huanling, Lv Rongju, Ji Min. Effect and analysis of ulinastatin combined with thymosin on cardiopulmonary function and delirium in sepsis patients.
Pakistan journal of pharmaceutical sciences.
2019 May; 32(3 Special):1281-1284. doi:
NULL. [PMID: 31551204] - Linhui Shi, Longqiang Ye, Panpan Liu, Danqin Liu, Gongjie Ye, Jiahong Chen, Zhouzhou Dong. Ulinastatin inhibits apoptosis induced by serum deprivation in mesenchymal stem cells.
Molecular medicine reports.
2019 03; 19(3):2397-2406. doi:
10.3892/mmr.2019.9847. [PMID: 30664153] - Shiyan Li, Weixi Yang, Liangliang Zhou, Dekang Nie, Haizhou Yu. Vascular permeability and hemodynamic effects of ulinastatin on organs affected by shock during early burn injury.
The American journal of emergency medicine.
2019 02; 37(2):249-253. doi:
10.1016/j.ajem.2018.05.038. [PMID: 30150106] - Luyang Meng, Ziheng Wu, Hongkun Zhang. Effect of Ulinastatin Combined with Octreotide on Serum Endothelin, Endotoxin Levels and Immune Function in Acute Pancreatitis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2019 Jan; 29(1):90-92. doi:
10.29271/jcpsp.2019.01.90. [PMID: 30630581] - Zhiqiang Yu, Jianbo Wang, Peijun Zhang, Wei Ding. Ulinastatin attenuates vascular endothelial cell damage in pregnant women with severe pre-eclampsia.
Anais da Academia Brasileira de Ciencias.
2019; 91(3):e20180746. doi:
10.1590/0001-3765201920180746. [PMID: 31576915] - S Wang, Z-Y Cheng, X-J Chen, H-Z Xue. Ulinastatin protects rats with myocardial infarction by activating Nrf2/NOS pathway.
European review for medical and pharmacological sciences.
2018 12; 22(24):8990-8998. doi:
10.26355/eurrev_201812_16670. [PMID: 30575944] - Xue-Lian Liao, Qu-Zhen Danzeng, Wei Zhang, Chen-Shu Hou, Bin-Bin Xu, Jie Yang, Yan Kang. Role of using two-route ulinastatin injection to alleviate intestinal injury in septic rats.
Chinese journal of traumatology = Zhonghua chuang shang za zhi.
2018 Dec; 21(6):323-328. doi:
10.1016/j.cjtee.2018.05.002. [PMID: 30591258] - Zhiwu Ji, Hao Tian, Jincai Shang, Wensi Liu, Min Zhong, Zhendong Chen. Effect of different doses of ulinastatin on cellular immunity and hepatorenal functions in patients undergoing laparoscopic colorectalcarcinoma surgery.
Pakistan journal of pharmaceutical sciences.
2018 Sep; 31(5(Special)):2311-2314. doi:
NULL. [PMID: 30463832] - G Wang, J-Y Li, Y-Q Weng, M Ding, H-L Yu, Q Wang, H-C Ren, R-B Xu, W-L Yu. Protective effect of ulinastatin combined with dexmedetomidine on lung injury after cold ischemia-reperfusion in rats.
European review for medical and pharmacological sciences.
2018 09; 22(17):5712-5718. doi:
10.26355/eurrev_201809_15839. [PMID: 30229849] - Si-Tong Li, Qi Dai, Shu-Xian Zhang, Ya-Jun Liu, Qiu-Qiong Yu, Fei Tan, Shu-Hong Lu, Quan Wang, Jian-Wen Chen, He-Qing Huang, Pei-Qing Liu, Min Li. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway.
Acta pharmacologica Sinica.
2018 Aug; 39(8):1294-1304. doi:
10.1038/aps.2017.143. [PMID: 29323338] - Z Q Z Dan, X L Liao, C S Hou, B B Xu, J Yang, Y Kang. [The expression of trypsin in serum and vital organs of septic rats].
Zhonghua nei ke za zhi.
2018 Jul; 57(7):505-510. doi:
10.3760/cma.j.issn.0578-1426.2018.07.007. [PMID: 29996269] - Shi-Hui Xiao, Liang Luo, Xiang-Hong Liu, Yu-Ming Zhou, Hong-Ming Liu, Zhen-Fei Huang. Curative efficacy and safety of traditional Chinese medicine xuebijing injections combined with ulinastatin for treating sepsis in the Chinese population: A meta-analysis.
Medicine.
2018 Jun; 97(23):e10971. doi:
10.1097/md.0000000000010971. [PMID: 29879049] - Wei Jiang, Xiangyou Yu, Tongwen Sun, Yanfen Chai, Ping Chang, Zhongqing Chen, Jingye Pan, Zhiyong Peng, Ruilan Wang, Xiaozhi Wang, Yuan Xu, Li Yu, Qingshan Zheng, Bin Du. ADJunctive Ulinastatin in Sepsis Treatment in China (ADJUST study): study protocol for a randomized controlled trial.
Trials.
2018 Feb; 19(1):133. doi:
10.1186/s13063-018-2513-y. [PMID: 29467017] - K-W Ren, N Shen, J-L Tang, L-M Nong, Y-Q Gu. Effects of ulinastatin on inflammatory response and cognitive function after hip arthroplasty for the elderly patients with femoral neck fracture.
European review for medical and pharmacological sciences.
2018 02; 22(4):1126-1132. doi:
10.26355/eurrev_201802_14401. [PMID: 29509266] - W Liu, J K Chai. [Influences of ulinastatin on acute lung injury and time phase changes of coagulation parameters in rats with burn-blast combined injuries].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2018 Jan; 34(1):32-39. doi:
10.3760/cma.j.issn.1009-2587.2018.01.007. [PMID: 29374925] - Jingjing Ji, Zhengtao Gu, Hui Li, Lei Su, Zhifeng Liu. Cryptdin-2 predicts intestinal injury during heatstroke in mice.
International journal of molecular medicine.
2018 Jan; 41(1):137-146. doi:
10.3892/ijmm.2017.3229. [PMID: 29115396] - Shaoyun Liu, Jiefeng Xu, Yuzhi Gao, Peng Shen, Senlin Xia, Zilong Li, Mao Zhang. Multi-organ protection of ulinastatin in traumatic cardiac arrest model.
World journal of emergency surgery : WJES.
2018; 13(?):51. doi:
10.1186/s13017-018-0212-3. [PMID: 30459824] - Antonio Junior Lepedda, Gabriele Nieddu, Silvia Rocchiccioli, Nadia Ucciferri, Michela Idini, Pierina De Muro, Marilena Formato. Levels of Urinary Trypsin Inhibitor and Structure of Its Chondroitin Sulphate Moiety in Type 1 and Type 2 Diabetes.
Journal of diabetes research.
2018; 2018(?):9378515. doi:
10.1155/2018/9378515. [PMID: 29541644] - Q F Zhang, Y Li, J K Feng, Y F Xu, L L Tu. [Changes of platelet rheological behavior and the interventional effects of ulinastatin in rats with high-voltage electrical burns].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2017 Dec; 33(12):744-749. doi:
10.3760/cma.j.issn.1009-2587.2017.12.005. [PMID: 29275615] - Qing-Fang Zhang. Ulinastatin inhibits renal tubular epithelial apoptosis and interstitial fibrosis in rats with unilateral ureteral obstruction.
Molecular medicine reports.
2017 Dec; 16(6):8916-8922. doi:
10.3892/mmr.2017.7692. [PMID: 28990075] - Siyi Liu, Fu Wei, Li Luo, Shan Xu, Shuke Liu, Dan Zhang. [Ulinastatin attenuates hyper-permeability of vascular endothelialium cells induced by serum from patients with sepsis].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2017 Dec; 33(12):1600-1604. doi:
NULL. [PMID: 29382417] - Xiao-Dan Zhao, Hao Liu, Tao Li, Quan Gong, Wen-Li Zhang. [Protective Effect and Its Possible Mechanism of Ulinastatin on Lung Injury Induced by Hip Fracture].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2017 Nov; 48(6):869-872. doi:
NULL. [PMID: 29260522] - Bora Lee, Sook Young Lee, Na Young Kim, Koon Ho Rha, Young Deuk Choi, Sujung Park, So Yeon Kim. Effect of ulinastatin on postoperative renal function in patients undergoing robot-assisted laparoscopic partial nephrectomy: a randomized trial.
Surgical endoscopy.
2017 09; 31(9):3728-3736. doi:
10.1007/s00464-017-5608-8. [PMID: 28593413] - Guo-Dong Zhen, Lian-Bin Zhao, Shan-Shan Wu, Ming-Yu Chen, Zhen-He Li, Sheng-Zhi Zhou, Zhen-Fu Li. Associations of MMP-2 and MMP-9 gene polymorphism with ulinastatin efficacy in patients with severe acute pancreatitis.
Bioscience reports.
2017 Aug; 37(4):. doi:
10.1042/bsr20160612. [PMID: 28779012] - Fu Wei, Siyi Liu, Li Luo, Nina Gu, Yan Zeng, Xiaoying Chen, Shan Xu, Dan Zhang. Anti-inflammatory mechanism of ulinastatin: Inhibiting the hyperpermeability of vascular endothelial cells induced by TNF-α via the RhoA/ROCK signal pathway.
International immunopharmacology.
2017 May; 46(?):220-227. doi:
10.1016/j.intimp.2017.03.007. [PMID: 28329735] - J Wang, J Jin, J Huang, D R Li, Y Hao, J D Kong, Z Y Chu, J H Fu, F Huang. [Clinical value of the early use of ulinastatin in patients with moderately severe or severe acute pancreatitis].
Zhonghua yi xue za zhi.
2017 Apr; 97(16):1252-1255. doi:
10.3760/cma.j.issn.0376-2491.2017.16.015. [PMID: 28441856] - Kai-Yuan Wang, Quan-Yong Yang, Peng Tang, Hui-Xia Li, Hong-Wei Zhao, Xiu-Bao Ren. Effects of ulinastatin on early postoperative cognitive function after one-lung ventilation surgery in elderly patients receiving neoadjuvant chemotherapy.
Metabolic brain disease.
2017 04; 32(2):427-435. doi:
10.1007/s11011-016-9926-7. [PMID: 27830357] - Yun Liu, Xing-Heng Wu. [Effect of ulinastatin on serum levels of tumor necrosis factor-α, P-selectin, and thrombin-antithrombin complex in young rats with sepsis].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2017 Feb; 19(2):237-241. doi:
NULL. [PMID: 28202126] - JiaWan Wang, AnShi Wu, Yan Wu. Endothelial Glycocalyx Layer: A Possible Therapeutic Target for Acute Lung Injury during Lung Resection.
BioMed research international.
2017; 2017(?):5969657. doi:
10.1155/2017/5969657. [PMID: 29423410] - Qian Chen, Chaoying Hu, Ye Liu, Yun Liu, Wei Wang, Hongchao Zheng, Lianchen Rong, Jingying Jia, Shixuan Sun, Chen Yu, Yan Mei Liu. Safety and tolerability of high-dose ulinastatin after 2-hour intravenous infusion in adult healthy Chinese volunteers: A randomized, double-blind, placebo-controlled, ascending-dose study.
PloS one.
2017; 12(5):e0177425. doi:
10.1371/journal.pone.0177425. [PMID: 28493932] - L P Zhang, J G Li. [Glabridin reduces lipopolysaccharide-induced lung injury in rats by inhibiting p38 mitogen activated protein kinase/extracellular regulated protein kinases signaling pathway].
Zhonghua yi xue za zhi.
2016 Dec; 96(48):3893-3897. doi:
10.3760/cma.j.issn.0376-2491.2016.48.009. [PMID: 28057160] - Ling-Zhang Wang, Ming-Yu Luo, Jin-Shan Zhang, Fu-Gui Ge, Jian-Ling Chen, Chang-Qing Zheng. Effect of ulinastatin on serum inflammatory factors in Asian patients with acute pancreatitis before and after treatment: a meta-analysis
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International journal of clinical pharmacology and therapeutics.
2016 Nov; 54(11):890-898. doi:
10.5414/cp202454. [PMID: 27569736] - Yu Sun, Yu-Jun Du, Hui Zhao, Guo-Xing Zhang, Ni Sun, Xiu-Jiang Li. Protective effects of ulinastatin and methylprednisolone against radiation-induced lung injury in mice.
Journal of radiation research.
2016 Sep; 57(5):505-511. doi:
10.1093/jrr/rrw036. [PMID: 27342837] - Leng Zhou, Haidan Lan, Qinghua Zhou, Xiao Jun Tang, Daxing Zhu, Jianming Yue, Bin Liu. Continuous infusion of high-dose ulinastatin during surgery does not improve early postoperative clinical outcomes in patients undergoing radical lung cancer surgery: A pilot study.
Thoracic cancer.
2016 Sep; 7(5):581-587. doi:
10.1111/1759-7714.12371. [PMID: 27766771] - Xian-Yue Wang, Wen-Peng Dong, Guang Tong, Sheng-Hui Bi, Ben Zhang, Hua Lu, Xiao-Wu Wang, Wei-da Zhang. [Protective effects of high-dose ulinastatin on vital organs in patients receiving total arch replacement for type A aortic dissection].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2016 Aug; 36(8):1085-9. doi:
NULL. [PMID: 27578577] - Linlin Ma, Chunsheng Li, Shuo Wang, Junyu Wang, Rui Shao, Chenchen Hang, Tao Wang. Ulinastatin ameliorates gastrointestinal injury sustained in a 2-hit porcine model of septic shock.
The American journal of emergency medicine.
2016 Aug; 34(8):1497-504. doi:
10.1016/j.ajem.2016.05.011. [PMID: 27233693] - Juncong Li, Chao Hu, Hongming Yang, Yongming Yao. [Effects of ulinastatin on immune function of patients with severe burn injury].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2016 Jun; 32(6):345-50. doi:
10.3760/cma.j.issn.1009-2587.2016.06.009. [PMID: 27321488] - X Gao, B Y Zhu, W Z Wang, J Q He, D L Han, Y J Liu, H Meng, Q M Xiao, X T Liu, Y Y Han. [Clinical value of serum presepsin (SCD14-ST) concentration measurement in patients with pesticide poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 May; 34(5):333-6. doi:
10.3760/cma.j.issn.1001-9391.2016.05.004. [PMID: 27514411] - Juncong Li, Chao Hu, Yongming Yao, Hongming Yang. [Effects of ulinastatin on immune function of spleen in severely burned rats and its mechanism].
Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns.
2016 May; 32(5):266-71. doi:
10.3760/cma.j.issn.1009-2587.2016.05.003. [PMID: 27188484] - Chunze Zhang, Yijia Wang, Wenzheng Fu, Weihua Zhang, Tao Wang, Hai Qin. A Meta-analysis on the Effect of Ulinastatin on Serum Levels of C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor Alpha in Asian Patients with Acute Pancreatitis.
Genetic testing and molecular biomarkers.
2016 Mar; 20(3):118-24. doi:
10.1089/gtmb.2015.0192. [PMID: 26780230] - Xin Wan, Xiangcheng Xie, Yasser Gendoo, Xin Chen, Xiaobing Ji, Changchun Cao. Ulinastatin administration is associated with a lower incidence of acute kidney injury after cardiac surgery: a propensity score matched study.
Critical care (London, England).
2016 Feb; 20(?):42. doi:
10.1186/s13054-016-1207-7. [PMID: 26884251] - Bo Zhao, Lanju Yang, Lei Xiao, Baoquan Sun, Xianbao Zou, Dongmei Gao, Xiandong Jian. [The influence of sodium bicarbonate combined with ulinastatin on cholinesterase activity for patients with acute phoxim pesticide poisoning].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 Jan; 34(1):53-5. doi:
10.3760/cma.j.issn.1001-9391.2016.01.015. [PMID: 27014821] - Yan Qiu, Jing Lin, Yang Yang, Jing Zhou, Li-Na Gong, Zhen Qin, Lei Du. Lack of Efficacy of Ulinastatin Therapy During Cardiopulmonary Bypass Surgery.
Chinese medical journal.
2015 Dec; 128(23):3138-42. doi:
10.4103/0366-6999.170364. [PMID: 26612285] - Ying Deng, Junying Kong. Urinary Trypsin Inhibitor Reduced Inflammation Response Induced by Hyperlipidemia.
Journal of cardiovascular pharmacology and therapeutics.
2015 Nov; 20(6):572-8. doi:
10.1177/1074248415578907. [PMID: 25896908] - Ikuko Kakizaki, Ryoki Takahashi, Miho Yanagisawa, Futaba Yoshida, Keiichi Takagaki. Enzymatic synthesis of hyaluronan hybrid urinary trypsin inhibitor.
Carbohydrate research.
2015 Sep; 413(?):129-34. doi:
10.1016/j.carres.2015.05.009. [PMID: 26142361] - Ya-li Ge, Hong-wei Shi, Wen-fei Zhu, Zheng-Liang Ma, Hai-yan Wei, Xiao-ping Gu, Hong-guang Bao. [Effects of ulinastatin on cognitive function in patients with coronary artery bypass grafting].
Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences.
2015 09; 44(5):532-8. doi:
10.3785/j.issn.1008-9292.2015.09.10. [PMID: 26713528] - Xiaohua Guo, Zhenglian Wang, Yanan Liu, Qiulin Xu, Lei Su, Fan Wu. [Mechanism of continuous venovenous hemofiltration combined with ulinastatin for the treatment of septic shock].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2015 Aug; 35(8):1189-92, 1196. doi:
. [PMID: 26277520] - Young-Sam Cho, Mal-Soon Shin, Il-Gyu Ko, Sung-Eun Kim, Chang-Ju Kim, Yun-Hee Sung, Hye-Sun Yoon, Bong-Jae Lee. Ulinastatin inhibits cerebral ischemia-induced apoptosis in the hippocampus of gerbils.
Molecular medicine reports.
2015 Aug; 12(2):1796-802. doi:
10.3892/mmr.2015.3612. [PMID: 25891426] - Chun-Yan Xie, Jin-Fang Xiao, Zhen-Long Zhao. [Protective Effect of Ulinastatin against Activation of Tourniquet-Induced Platelet Mitochondria Apoptotic Signaling].
Zhongguo shi yan xue ye xue za zhi.
2015 Aug; 23(4):1087-91. doi:
10.7534/j.issn.1009-2137.2015.04.035. [PMID: 26314451] - Xun Li, Jing Li, Yang-Jie Ou, Xiao-Xu Zhu, Xiao-Yu Yin, Yun-Xiao Zhu, Di Tang. Hepatoprotective effect of ulinastatin in a rat model of major hepatectomy after obstructive jaundice.
Digestive diseases and sciences.
2015 Jun; 60(6):1680-9. doi:
10.1007/s10620-015-3543-x. [PMID: 25647759] - Xin Shan, Xiuning Zhang, Xuejing Li, Guanjie Xu, Zhihua Li. [Effect of ulinastatin on postoperative cognitive function in the elderly with fracture].
Zhonghua yi xue za zhi.
2015 May; 95(20):1586-9. doi:
NULL. [PMID: 26463607] - Hua Guo, Jiong Chen, Dongwei Suo. [Clinical efficacy and safety of ulinastatin plus octreotide for patients with severe acute pancreatitis].
Zhonghua yi xue za zhi.
2015 May; 95(19):1471-4. doi:
NULL. [PMID: 26178495] - S Y Wang, Z J Li, X Wang, W F Li, Z F Lin. Effect of ulinastatin on HMGB1 expression in rats with acute lung injury induced by sepsis.
Genetics and molecular research : GMR.
2015 Apr; 14(2):4344-53. doi:
10.4238/2015.april.30.7. [PMID: 25966207] - Siyi He, Kailong Lin, Ruiyan Ma, Rufu Xu, Yingbin Xiao. Effect of the urinary tryptin inhibitor ulinastatin on cardiopulmonary bypass-related inflammatory response and clinical outcomes: a meta-analysis of randomized controlled trials.
Clinical therapeutics.
2015 Mar; 37(3):643-53. doi:
10.1016/j.clinthera.2014.12.015. [PMID: 25660078] - Xiaohong Wang, Xun Zhuang, Ronglong Wei, Chunrong Wang, Xianglong Xue, Ling Mao. Protective effects of Acanthopanax vs. Ulinastatin against severe acute pancreatitis-induced brain injury in rats.
International immunopharmacology.
2015 Feb; 24(2):285-298. doi:
10.1016/j.intimp.2014.12.020. [PMID: 25533505] - Yaqing Shu, Rui Li, Yu Yang, Yongqiang Dai, Wei Qiu, Ying Chen, Zhihua Zhao, Zhengqi Lu, Xueqiang Hu. Urinary trypsin inhibitor levels are reduced in cerebrospinal fluid of multiple sclerosis and neuromyelitis optica patients during relapse.
Neurochemistry international.
2015 Feb; 81(?):28-31. doi:
10.1016/j.neuint.2014.12.008. [PMID: 25555815] - Xiaocou Wang, Qinghua Xue, Fuxia Yan, Jinping Liu, Shoujun Li, Shengshou Hu. Ulinastatin Protects against Acute Kidney Injury in Infant Piglets Model Undergoing Surgery on Hypothermic Low-Flow Cardiopulmonary Bypass.
PloS one.
2015; 10(12):e0144516. doi:
10.1371/journal.pone.0144516. [PMID: 26656098] - Pengtao Bao, Weiguo Zhao, Yun Li, Yu Liu, Yi Zhou, Changting Liu. Protective effect of ulinastatin in patients with non-small cell lung cancer after radiation therapy: a randomized, placebo-controlled study.
Medical oncology (Northwood, London, England).
2015 Jan; 32(1):405. doi:
10.1007/s12032-014-0405-x. [PMID: 25502081] - Rongju Sun, Yana Li, Wei Chen, Fei Zhang, Tanshi Li. Total ginsenosides synergize with ulinastatin against septic acute lung injury and acute respiratory distress syndrome.
International journal of clinical and experimental pathology.
2015; 8(6):7385-90. doi:
". [PMID: 26261640] - Guodong Zhao, Yi Zhu, Dongnan Yu, Jue Ma. The effect of ulinastatin on hyperglycemia in patients undergoing hepatectomy.
The Journal of surgical research.
2015 Jan; 193(1):223-8. doi:
10.1016/j.jss.2014.08.027. [PMID: 25255724] - Yan-Hua Zhang, Xiu-Hai Guo, Qing-Ming Zhang, Guang-Tao Yan, Tian-Long Wang. Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients.
The International journal of neuroscience.
2015; 125(7):501-6. doi:
10.3109/00207454.2014.949341. [PMID: 25105909] - Bo Lin, Youtan Liu, Tao Li, Kai Zeng, Shumin Cai, Zhenhua Zeng, Caizhu Lin, Zhongqing Chen, Youguang Gao. Ulinastatin mediates protection against vascular hyperpermeability following hemorrhagic shock.
International journal of clinical and experimental pathology.
2015; 8(7):7685-93. doi:
NULL. [PMID: 26339335]
