Tretoquinol (BioDeep_00000842151)
代谢物信息卡片
化学式: C19H23NO5 (345.15761480000003)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC(=CC(=C1OC)OC)CC2C3=CC(=C(C=C3CCN2)O)O
InChI: InChI=1S/C19H23NO5/c1-23-17-7-11(8-18(24-2)19(17)25-3)6-14-13-10-16(22)15(21)9-12(13)4-5-20-14/h7-10,14,20-22H,4-6H2,1-3H3
描述信息
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03C - Adrenergics for systemic use > R03CC - Selective beta-2-adrenoreceptor agonists
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03A - Adrenergics, inhalants > R03AC - Selective beta-2-adrenoreceptor agonists
D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D001993 - Bronchodilator Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
同义名列表
1 个代谢物同义名
相关代谢途径
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Masato Okano, Asami Miyamoto, Mitsuhiko Sato, Shinji Kageyama. Analysis of tretoquinol and its metabolites in human urine by liquid chromatography-tandem mass spectrometry.
Drug testing and analysis.
2019 Nov; 11(11-12):1724-1730. doi:
10.1002/dta.2714. [PMID: 31664780] - Hideaki Oka, Taro Kamimura, Yuki Hiramatsu, Kento Fukumitsu, Rei Iwata, Mika Kondo, Yutaro Hirashima, Seishi Aihara, Atsumi Harada, Kazuhiko Tsuruya. Cholesterol Crystal Embolism Induced by Direct Factor Xa Inhibitor: A First Case Report.
Internal medicine (Tokyo, Japan).
2018 Jan; 57(1):71-74. doi:
10.2169/internalmedicine.8660-16. [PMID: 28943551] - F C Camargo, N E Robinson, L Dirikolu, C Berney, S Eberhart, F J Derksen, A F Lehner, J May, C Hughes, T Tobin. Plasma and urinary concentrations of trimetoquinol by LC-MS-MS following intravenous and intra-tracheal administration to horses with heaves.
Journal of veterinary pharmacology and therapeutics.
2008 Dec; 31(6):501-10. doi:
10.1111/j.1365-2885.2008.00984.x. [PMID: 19000271] - H Kawai, Y Makino, M Hirobe, S Ohta. Novel endogenous 1,2,3,4-tetrahydroisoquinoline derivatives: uptake by dopamine transporter and activity to induce parkinsonism.
Journal of neurochemistry.
1998 Feb; 70(2):745-51. doi:
10.1046/j.1471-4159.1998.70020745.x. [PMID: 9453570] - K J Romstedt, Y Shin, G Shams, K Doyle, V Tantishaiyakul, M T Clark, A Adejare, A Hamada, D D Miller, D R Feller. Halogen-substituted trimetoquinol analogs as thromboxane A2 receptor antagonists in platelets and aorta.
Biochemical pharmacology.
1993 Dec; 46(11):2051-9. doi:
10.1016/0006-2952(93)90647-f. [PMID: 8267653] - M F Bureau, F De Clerck, J Lefort, C D Arreto, B B Vargaftig. Thromboxane A2 accounts for bronchoconstriction but not for platelet sequestration and microvascular albumin exchanges induced by fMLP in the guinea pig lung.
The Journal of pharmacology and experimental therapeutics.
1992 Feb; 260(2):832-40. doi:
NULL. [PMID: 1738127] - Y Shin, K J Romstedt, K Doyle, M W Harrold, M A Gerhardt, D D Miller, P N Patil, D R Feller. Pharmacologic antagonism of thromboxane A2 receptors by trimetoquinol analogs in vitro and in vivo.
Chirality.
1991; 3(2):112-7. doi:
10.1002/chir.530030206. [PMID: 1830752] - J Sugihara, S Furuuchi, K Nakano, S Harigaya. Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs.
Journal of pharmacobio-dynamics.
1988 May; 11(5):369-76. doi:
10.1248/bpb1978.11.369. [PMID: 3171878] - M W Harrold, M A Gerhardt, K Romstedt, D R Feller, D D Miller. Synthesis and platelet antiaggregatory activity of trimetoquinol analogs as endoperoxide/thromboxane A2 antagonists.
Drug design and delivery.
1987 Feb; 1(3):193-207. doi:
". [PMID: 3509333] - E Brode, R Binder, W Breckwoldt. [Determination of trimethoquinol in plasma by electrochemical detection after HPLC separation].
Arzneimittel-Forschung.
1986 Mar; 36(3):437-42. doi:
NULL. [PMID: 3707662] - T Suzuki, K Tsuzurahara, T Murata, S Takeyama. Quantitative determination of trimetoquinol in plasma as its mixed pentafluoropropionyl-trimethylsilyl derivative by gas chromatography mass spectrometry.
Biomedical mass spectrometry.
1982 Mar; 9(3):94-8. doi:
10.1002/bms.1200090303. [PMID: 7066482] - D D Miller, J F Bossart, J R Mayo, D R Feller. Synthesis, beta-adrenergic activity, and platelet antiaggregatory activity of a positional isomer of trimetoquinol: 1-(2',4',5'-trimethoxybenzyl)-6,7-dihydroxy-1,2,3,4,-tetrahydroisoquinoline.
Journal of medicinal chemistry.
1980 Mar; 23(3):331-3. doi:
10.1021/jm00177a027. [PMID: 6102607] - M T Piascik, P Osei-Gyimah, D D Miller, D R Feller. beta-Adrenoceptor blocking activity of 1-substituted trimetoquinol analogs.
Biochemical pharmacology.
1979 Jun; 28(11):1807-10. doi:
10.1016/0006-2952(79)90546-x. [PMID: 38798] - P Osei-Gyimah, M T Piascik, J W Fowble, D R Feller, D D Miller. Synthesis and beta-adrenoceptor activity of the erythro and threo isomers of substituted alpha-hydroxytrimetoquinol.
Journal of medicinal chemistry.
1978 Nov; 21(11):1173-8. doi:
10.1021/jm00209a019. [PMID: 31479] - D Castello, T Bignante, F De Candussio, D Franchi, A Martini. [Comparative studies of the metabolic and cardiovascular effects of 3 current bronchodilator agents (trimethoquinol, terbutaline and Th 1165a)].
Minerva pediatrica.
1977 Dec; 29(38):2293-309. doi:
". [PMID: 342900] - D D Miller, P Osei-Gyimah, R V Raman, D R Feller. Synthesis of 1-substituted analogues of trimetoquinol possessing differential and selective beta-adrenergic properties.
Journal of medicinal chemistry.
1977 Nov; 20(11):1502-4. doi:
10.1021/jm00221a029. [PMID: 21293] - M T Piascik, D D Miller, D R Feller. Phosphodiesterase inhibition and lipolytic action of the stereoisomers of trimetoquinol.
Research communications in chemical pathology and pharmacology.
1976 Feb; 13(2):203-15. doi:
". [PMID: 176706] - A Kaneto, E Miki, K Kosaka. Effect of beta and beta2 adrenoreceptor stimulants infused intrapancreatically on glucagon and insulin secretion.
Endocrinology.
1975 Nov; 97(5):1166-73. doi:
10.1210/endo-97-5-1166. [PMID: 241626] - D D Miller, P Osei-Gyimah, J Bardin, D R Feller. Synthesis and biological evaluation of fragmented derivatives of tetrahydroisoquinolines. 2. Trimetoquinol studies.
Journal of medicinal chemistry.
1975 May; 18(5):454-7. doi:
10.1021/jm00239a002. [PMID: 239233]