2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran (BioDeep_00000842150)
代谢物信息卡片
2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran
化学式: C26H44O2 (388.3341124)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC1(CC2=C(O1)C=C(C(=C2C(C)(C)C)O)C(C)(C)C)CCCCC
InChI: InChI=1S/C26H44O2/c1-9-11-13-15-26(16-14-12-10-2)18-19-21(28-26)17-20(24(3,4)5)23(27)22(19)25(6,7)8/h17,27H,9-16,18H2,1-8H3
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代谢反应
0 个相关的代谢反应过程信息。
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Etsuo Niki. Do free radicals play causal role in atherosclerosis? Low density lipoprotein oxidation and vitamin E revisited.
Journal of clinical biochemistry and nutrition.
2011 Jan; 48(1):3-7. doi:
10.3164/jcbn.11-007fr. [PMID: 21297905] - Etsuo Niki, Akiko Fukuhara, Yo Omata, Yoshiro Saito, Yasukazu Yoshida. Antioxidant capacity of BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran, and uric acid as evaluated by ORAC method and inhibition of lipid peroxidation.
Bioorganic & medicinal chemistry letters.
2008 Apr; 18(7):2464-6. doi:
10.1016/j.bmcl.2008.02.038. [PMID: 18314329] - Yasukazu Yoshida, Mieko Hayakawa, Nanako Itoh, Yoko Habuchi, Ruriko Inoue, Zhi-Hua Chen, Jiaofei Cao, Osamu Cynshi, Kou-Ichi Jishage, Etsuo Niki. Antioxidant effects of 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran and alpha-tocopherol in hyperlipidemic mice as evaluated by hydroxyoctadecadienoic acid and 7-hydroxycholesterol.
Biochemical pharmacology.
2007 Oct; 74(7):1010-9. doi:
10.1016/j.bcp.2007.07.020. [PMID: 17706610] - Yasukazu Yoshida, Mieko Hayakawa, Yoko Habuchi, Nanako Itoh, Etsuo Niki. Evaluation of lipophilic antioxidant efficacy in vivo by the biomarkers hydroxyoctadecadienoic acid and isoprostane.
Lipids.
2007 May; 42(5):463-72. doi:
10.1007/s11745-007-3043-7. [PMID: 17476550] - Cacang Suarna, Ben J Wu, Katherine Choy, Trevor Mori, Kevin Croft, Osamu Cynshi, Roland Stocker. Protective effect of vitamin E supplements on experimental atherosclerosis is modest and depends on preexisting vitamin E deficiency.
Free radical biology & medicine.
2006 Sep; 41(5):722-30. doi:
10.1016/j.freeradbiomed.2006.05.013. [PMID: 16895792] - Yasukazu Yoshida, Nanako Itoh, Mieko Hayakawa, Yoko Habuchi, Ruriko Inoue, Zhi-Hua Chen, Jiaofei Cao, Osamu Cynshi, Etsuo Niki. Lipid peroxidation in mice fed a choline-deficient diet as evaluated by total hydroxyoctadecadienoic acid.
Nutrition (Burbank, Los Angeles County, Calif.).
2006 Mar; 22(3):303-11. doi:
10.1016/j.nut.2005.07.020. [PMID: 16500556] - Yasukazu Yoshida, Nanako Itoh, Mieko Hayakawa, Rosaria Piga, Osamu Cynshi, Kou-ichi Jishage, Etsuo Niki. Lipid peroxidation induced by carbon tetrachloride and its inhibition by antioxidant as evaluated by an oxidative stress marker, HODE.
Toxicology and applied pharmacology.
2005 Oct; 208(1):87-97. doi:
10.1016/j.taap.2005.01.015. [PMID: 16164964] - Hiroshi Araya, Shunsuke Nagao, Mikio Tomita, Masahiro Hayashi. The novel formulation design of self-emulsifying drug delivery systems (SEDDS) type O/W microemulsion I: enhancing effects on oral bioavailability of poorly water soluble compounds in rats and beagle dogs.
Drug metabolism and pharmacokinetics.
2005 Aug; 20(4):244-56. doi:
10.2133/dmpk.20.244. [PMID: 16141604] - Ryo Yamauchi, Peter Southwell-Keely, Cacang Suarna, Sangeeta Ray, Mark Raftery, Osamu Cynshi, Roland Stocker. Characterization of the oxidation products of BO-653 formed during peroxyl radical-mediated oxidation of human plasma.
Free radical biology & medicine.
2005 Jan; 38(1):32-40. doi:
10.1016/j.freeradbiomed.2004.09.018. [PMID: 15589369] - O Cynshi, R Stocker. Inhibition of lipoprotein lipid oxidation.
Handbook of experimental pharmacology.
2005; ?(170):563-90. doi:
10.1007/3-540-27661-0_21. [PMID: 16596815] - Nanako Itoh, Yasukazu Yoshida, Mieko Hayakawa, Noriko Noguchi, Tatsuhiko Kodama, Osamu Cynshi, Etsuo Niki. Inhibition of plasma lipid peroxidation by anti-atherogenic antioxidant BO-653, 2,3-dihydro-5-hydroxy-4,6-di-tert-butyl-2,2-dipentylbenzofuran.
Biochemical pharmacology.
2004 Sep; 68(5):813-8. doi:
10.1016/j.bcp.2004.05.045. [PMID: 15294444] - Kunio Tamura, Yoshiaki Kato, Akira Ishikawa, Yasuharu Kato, Motomu Himori, Mitsutaka Yoshida, Yoshiaki Takashima, Tsukasa Suzuki, Yoshiki Kawabe, Osamu Cynshi, Tatsuhiko Kodama, Etsuo Niki, Makoto Shimizu. Design and synthesis of 4,6-di-tert-butyl-2,3-dihydro-5-benzofuranols as a novel series of antiatherogenic antioxidants.
Journal of medicinal chemistry.
2003 Jul; 46(14):3083-93. doi:
10.1021/jm030062a. [PMID: 12825946] - Yasukazu Yoshida, Noriko Noguchi, Akira Watanabe, Yoshihide Iwaki, Makoto Yanagisawa, Tatsuhiko Kodama, Osamu Cynshi, Etsuo Niki. Antioxidant action of 2,2,4,6-tetra-substituted 2,3-dihydro-5-hydroxybenzofuran against lipid peroxidation: effects of substituents and side chain.
Free radical research.
2002 Nov; 36(11):1171-8. doi:
10.1080/1071576021000016436. [PMID: 12592669] - Etsuo Niki, Noriko Noguchi. Effects of antioxidants against atherosclerosis.
Molecular and cellular biochemistry.
2002 May; 234-235(1-2):19-25. doi:
". [PMID: 12162433] - K Müller, K L Carpenter, M A Freeman, M J Mitchinson. Antioxidant BO-653 and human macrophage-mediated LDL oxidation.
Free radical research.
1999 Jan; 30(1):59-71. doi:
10.1080/10715769900300071. [PMID: 10193574] - N Noguchi, Y Okimoto, J Tsuchiya, O Cynshi, T Kodama, E Niki. Inhibition of oxidation of low-density lipoprotein by a novel antioxidant, BO-653, prepared by theoretical design.
Archives of biochemistry and biophysics.
1997 Nov; 347(1):141-7. doi:
10.1006/abbi.1997.0331. [PMID: 9344475] - K Koshiba, K Kumano, T Watanabe, Y Takashima, O Cynshi. [Effects of high fat diet and a novel antioxidant (BO653) on ischemia reperfusion injury of rat kidney].
Nihon Jinzo Gakkai shi.
1997 Jul; 39(5):455-63. doi:
NULL. [PMID: 9283210] - N Noguchi, Y Iwaki, M Takahashi, E Komuro, Y Kato, K Tamura, O Cynshi, T Kodama, E Niki. 2,3-Dihydro-5-hydroxy-2,2-dipentyl-4,6-di-tert-butylbenzofuran: design and evaluation as a novel radical-scavenging antioxidant against lipid peroxidation.
Archives of biochemistry and biophysics.
1997 Jun; 342(2):236-43. doi:
10.1006/abbi.1997.9994. [PMID: 9186484]