pifithrin (BioDeep_00000842126)

   


代谢物信息卡片


pifithrin

化学式: C16H18N2OS (286.114)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N
InChI: InChI=1S/C16H18N2OS/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17/h6-9,17H,2-5,10H2,1H3

描述信息

同义名列表

1 个代谢物同义名

pifithrin



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ling Hao, Dandan Mu, Haitao Mu. Sakuranin represses the malignant biological behaviors of human bladder cancer cells by triggering autophagy via activating the p53/mTOR pathway. BMC urology. 2023 Oct; 23(1):170. doi: 10.1186/s12894-023-01334-2. [PMID: 37875863]
  • Hao Wu, Qian Liu, Xinyi Shan, Weihua Gao, Quan Chen. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4. Autophagy. 2023 Feb; ?(?):1-16. doi: 10.1080/15548627.2023.2170960. [PMID: 36752571]
  • Chen Yuqiang, Zhang Lisha, Wen Jiejun, Xue Qin, Wang Niansong. Pifithrin-α ameliorates glycerol induced rhabdomyolysis and acute kidney injury by reducing p53 activation. Renal failure. 2022 Dec; 44(1):473-481. doi: 10.1080/0886022x.2022.2048857. [PMID: 35285384]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Xiaobo Xie, Wanshun Wang, Jing Cheng, Haifeng Liang, Zefeng Lin, Tao Zhang, Yao Lu, Qi Li. Bilayer pifithrin-α loaded extracellular matrix/PLGA scaffolds for enhanced vascularized bone formation. Colloids and surfaces. B, Biointerfaces. 2020 Jun; 190(?):110903. doi: 10.1016/j.colsurfb.2020.110903. [PMID: 32120128]
  • Wei He, Weiwei Tao, Feng Zhang, Qian Jie, Yun He, Wei Zhu, Jiani Tan, Weixing Shen, Liu Li, Ye Yang, Haibo Cheng, Dongdong Sun. Lobetyolin induces apoptosis of colon cancer cells by inhibiting glutamine metabolism. Journal of cellular and molecular medicine. 2020 03; 24(6):3359-3369. doi: 10.1111/jcmm.15009. [PMID: 31990147]
  • Yueming Chen, Huachao Li, Weinan Zhang, Wanchen Qi, Changpeng Lu, Huiliang Huang, Zhicheng Yang, Bing Liu, Luyong Zhang. Sesamin suppresses NSCLC cell proliferation and induces apoptosis via Akt/p53 pathway. Toxicology and applied pharmacology. 2020 01; 387(?):114848. doi: 10.1016/j.taap.2019.114848. [PMID: 31809756]
  • Aicheng Yang, Fanna Liu, Baozhang Guan, Zhi Luo, Jiehua Lin, Wan Fang, Longhui Liu, Wanli Zuo. p53 induces miR-199a-3p to suppress mechanistic target of rapamycin activation in cisplatin-induced acute kidney injury. Journal of cellular biochemistry. 2019 10; 120(10):17625-17634. doi: 10.1002/jcb.29030. [PMID: 31148231]
  • Richard A Zager, Ali C M Johnson. Acute kidney injury induces dramatic p21 upregulation via a novel, glucocorticoid-activated, pathway. American journal of physiology. Renal physiology. 2019 04; 316(4):F674-F681. doi: 10.1152/ajprenal.00571.2018. [PMID: 30698046]
  • Anshulika Sable, Krishan M Rai, Amit Choudhary, Vikash K Yadav, Sudhir K Agarwal, Samir V Sawant. Inhibition of Heat Shock proteins HSP90 and HSP70 induce oxidative stress, suppressing cotton fiber development. Scientific reports. 2018 02; 8(1):3620. doi: 10.1038/s41598-018-21866-0. [PMID: 29483524]
  • Tao Lu, Paul P Kim, Nigel H Greig, Yu Luo. Dopaminergic Neuron-Specific Deletion of p53 Gene Attenuates Methamphetamine Neurotoxicity. Neurotoxicity research. 2017 Aug; 32(2):218-230. doi: 10.1007/s12640-017-9723-z. [PMID: 28342134]
  • Kyuhwa Seo, Sung Hwan Ki, Eun Young Park, Sang Mi Shin. 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. Archives of pharmacal research. 2017 Feb; 40(2):231-239. doi: 10.1007/s12272-016-0878-6. [PMID: 28028695]
  • Jielu Hao, Qingqing Wei, Shuqin Mei, Lin Li, Yunchao Su, Changlin Mei, Zheng Dong. Induction of microRNA-17-5p by p53 protects against renal ischemia-reperfusion injury by targeting death receptor 6. Kidney international. 2017 01; 91(1):106-118. doi: 10.1016/j.kint.2016.07.017. [PMID: 27622990]
  • Jinwen Chen, Juan Wang, Huiling Li, Shixuan Wang, Xudong Xiang, Dongshan Zhang. p53 activates miR-192-5p to mediate vancomycin induced AKI. Scientific reports. 2016 12; 6(?):38868. doi: 10.1038/srep38868. [PMID: 27941921]
  • Di Li, Linli Wang, Jundi Hou, Qun Shen, Qianyu Chen, Xiaoshan Wang, Juan Du, Xiujuan Cai, Yongli Shan, Tian Zhang, Tiancheng Zhou, Xi Shi, Yuhua Li, Hua Zhang, Guangjin Pan. Optimized Approaches for Generation of Integration-free iPSCs from Human Urine-Derived Cells with Small Molecules and Autologous Feeder. Stem cell reports. 2016 05; 6(5):717-728. doi: 10.1016/j.stemcr.2016.04.001. [PMID: 27132887]
  • Jun Li, Wang He, Bo Liao, Jingyue Yang. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Scientific reports. 2015 Jul; 5(?):12724. doi: 10.1038/srep12724. [PMID: 26226833]
  • Reza Homayounfar, Mahmood Jeddi-Tehrani, Makan Cheraghpour, Asghar Ghorbani, Hamid Zand. Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin. General and comparative endocrinology. 2015 Apr; 214(?):134-9. doi: 10.1016/j.ygcen.2014.06.029. [PMID: 25016051]
  • Sandra Neitemeier, Goutham K Ganjam, Sebastian Diemert, Carsten Culmsee. Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition. Apoptosis : an international journal on programmed cell death. 2014 Dec; 19(12):1665-77. doi: 10.1007/s10495-014-1048-2. [PMID: 25343947]
  • Jason A Sprowl, Cynthia S Lancaster, Navjotsingh Pabla, Edwin Hermann, Ashley M Kosloske, Alice A Gibson, Lie Li, Dorothea Zeeh, Eberhard Schlatter, Laura J Janke, Giuliano Ciarimboli, Alex Sparreboom. Cisplatin-induced renal injury is independently mediated by OCT2 and p53. Clinical cancer research : an official journal of the American Association for Cancer Research. 2014 Aug; 20(15):4026-35. doi: 10.1158/1078-0432.ccr-14-0319. [PMID: 24916697]
  • He-Qi Bu, Dian-Lei Liu, Wei-Tian Wei, Liang Chen, Hai Huang, Ye Li, Jun-Hui Cui. Oridonin induces apoptosis in SW1990 pancreatic cancer cells via p53- and caspase-dependent induction of p38 MAPK. Oncology reports. 2014 Feb; 31(2):975-82. doi: 10.3892/or.2013.2888. [PMID: 24297112]
  • Rohan Samarakoon, Amy D Dobberfuhl, Catherine Cooley, Jessica M Overstreet, Samik Patel, Roel Goldschmeding, Kirstan K Meldrum, Paul J Higgins. Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species. Cellular signalling. 2013 Nov; 25(11):2198-209. doi: 10.1016/j.cellsig.2013.07.007. [PMID: 23872073]
  • Fang Cheng Wong, Chern Chiuh Woo, Annie Hsu, Benny Kwong Huat Tan. The anti-cancer activities of Vernonia amygdalina extract in human breast cancer cell lines are mediated through caspase-dependent and p53-independent pathways. PloS one. 2013; 8(10):e78021. doi: 10.1371/journal.pone.0078021. [PMID: 24205071]
  • Hidehisa Shimizu, Maimaiti Yisireyili, Fuyuhiko Nishijima, Toshimitsu Niwa. Indoxyl sulfate enhances p53-TGF-β1-Smad3 pathway in proximal tubular cells. American journal of nephrology. 2013; 37(2):97-103. doi: 10.1159/000346420. [PMID: 23363842]
  • Timothy A Sutton, Takashi Hato, Erik Mai, Momoko Yoshimoto, Sarah Kuehl, Melissa Anderson, Henry Mang, Zoya Plotkin, Rebecca J Chan, Pierre C Dagher. p53 is renoprotective after ischemic kidney injury by reducing inflammation. Journal of the American Society of Nephrology : JASN. 2013 Jan; 24(1):113-24. doi: 10.1681/asn.2012050469. [PMID: 23222126]
  • Rumpa Biswas Bhattacharjee, Thangima Zannat, Jnanankur Bag. Expression of the polyalanine expansion mutant of nuclear poly(A)-binding protein induces apoptosis via the p53 pathway. Cell biology international. 2012 Aug; 36(8):697-704. doi: 10.1042/cbi20110348. [PMID: 22519734]
  • Qi Zeng, Daxiang Lu, Qingliang Tang, Li Tian, Huadong Wang, Suisheng Tang, Chaofeng Hu. Functional characterization of the p53 binding site in the human PYNOD promoter. Human immunology. 2012 Apr; 73(4):355-63. doi: 10.1016/j.humimm.2012.01.010. [PMID: 22365966]
  • Jonathan C King, Qing-Yi Lu, Gang Li, Aune Moro, Hiroki Takahashi, Monica Chen, Vay Liang W Go, Howard A Reber, Guido Eibl, O Joe Hines. Evidence for activation of mutated p53 by apigenin in human pancreatic cancer. Biochimica et biophysica acta. 2012 Feb; 1823(2):593-604. doi: 10.1016/j.bbamcr.2011.12.008. [PMID: 22227579]
  • Pierre C Dagher, Erik M Mai, Takashi Hato, So-Young Lee, Melissa D Anderson, Stephanie C Karozos, Henry E Mang, Nicole L Knipe, Zoya Plotkin, Timothy A Sutton. The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury. American journal of physiology. Renal physiology. 2012 Jan; 302(2):F284-91. doi: 10.1152/ajprenal.00317.2011. [PMID: 22049400]
  • Hidehisa Shimizu, Dilinaer Bolati, Ayinuer Adijiang, Gulinuer Muteliefu, Atsushi Enomoto, Fuyuhiko Nishijima, Minori Dateki, Toshimitsu Niwa. NF-κB plays an important role in indoxyl sulfate-induced cellular senescence, fibrotic gene expression, and inhibition of proliferation in proximal tubular cells. American journal of physiology. Cell physiology. 2011 Nov; 301(5):C1201-12. doi: 10.1152/ajpcell.00471.2010. [PMID: 21832251]
  • Cora H Nijboer, Cobi J Heijnen, Michael A van der Kooij, Jitske Zijlstra, Cindy T J van Velthoven, Carsten Culmsee, Frank van Bel, Henrik Hagberg, Annemieke Kavelaars. Targeting the p53 pathway to protect the neonatal ischemic brain. Annals of neurology. 2011 Aug; 70(2):255-64. doi: 10.1002/ana.22413. [PMID: 21674585]
  • Pragathi Pallepati, Diana A Averill-Bates. Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free radical biology & medicine. 2011 Mar; 50(6):667-79. doi: 10.1016/j.freeradbiomed.2010.11.022. [PMID: 21130866]
  • Eduardo Homsi, Sergio Mota da Silva, Silvano Machado de Brito, Elisa Bouçada Inácio Peixoto, Jose Butori Lopes de Faria, Patrícia Janino. p53-Mediated oxidative stress and tubular injury in rats with glycerol-induced acute kidney injury. American journal of nephrology. 2011; 33(1):49-59. doi: 10.1159/000322836. [PMID: 21178334]
  • Hidehisa Shimizu, Dilinaer Bolati, Ayinuer Adijiang, Atsushi Enomoto, Fuyuhiko Nishijima, Minori Dateki, Toshimitsu Niwa. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. American journal of physiology. Cell physiology. 2010 Nov; 299(5):C1110-7. doi: 10.1152/ajpcell.00217.2010. [PMID: 20720180]
  • Manujendra N Saha, Hua Jiang, Hong Chang. Molecular mechanisms of nutlin-induced apoptosis in multiple myeloma: evidence for p53-transcription-dependent and -independent pathways. Cancer biology & therapy. 2010 Sep; 10(6):567-78. doi: 10.4161/cbt.10.6.12535. [PMID: 20595817]
  • Shota Takumi, Masaharu Komatsu, Tatsuhiko Furukawa, Ryuji Ikeda, Tomoyuki Sumizawa, Hitomi Akenaga, Yuta Maeda, Kohji Aoyama, Koji Arizono, Seiichi Ando, Toru Takeuchi. p53 Plays an important role in cell fate determination after exposure to microcystin-LR. Environmental health perspectives. 2010 Sep; 118(9):1292-8. doi: 10.1289/ehp.1001899. [PMID: 20421190]
  • Rita S M Shih, Stephen H K Wong, Norberta W Schoene, Jun Jun Zhang, Kai Y Lei. Enhanced Gadd45 expression and delayed G2/M progression are p53-dependent in zinc-supplemented human bronchial epithelial cells. Experimental biology and medicine (Maywood, N.J.). 2010 Aug; 235(8):932-40. doi: 10.1258/ebm.2010.010076. [PMID: 20660093]
  • Li Zhou, Ping Fu, Xiao R Huang, Fei Liu, Kar Neng Lai, Hui Y Lan. Activation of p53 promotes renal injury in acute aristolochic acid nephropathy. Journal of the American Society of Nephrology : JASN. 2010 Jan; 21(1):31-41. doi: 10.1681/asn.2008111133. [PMID: 19892935]
  • Nana Asare, Xavier Tekpli, Mary Rissel, Anita Solhaug, Nina Landvik, Valerie Lecureur, Normand Podechard, Gunnar Brunborg, Marit Låg, Dominique Lagadic-Gossmann, Jørn A Holme. Signalling pathways involved in 1-nitropyrene (1-NP)-induced and 3-nitrofluoranthene (3-NF)-induced cell death in Hepa1c1c7 cells. Mutagenesis. 2009 Nov; 24(6):481-93. doi: 10.1093/mutage/gep032. [PMID: 19703935]
  • Pankaj Kumar Singh, Raj Kumar, Ashok Sharma, Rajesh Arora, Swatantra Kumar Jain, Rakesh Kumar Sharma. Pifithrin-alpha decreases the radioprotective efficacy of a Podophyllum hexandrum Himalayan mayapple fraction REC-2006 in HepG2 cells. Biotechnology and applied biochemistry. 2009 Jul; 54(1):53-64. doi: 10.1042/ba20080250. [PMID: 19409072]
  • Timothy A Sutton, Jared Wilkinson, Henry E Mang, Nicole L Knipe, Zoya Plotkin, Maya Hosein, Katelyn Zak, Jeremy Wittenborn, Pierre C Dagher. p53 regulates renal expression of HIF-1{alpha} and pVHL under physiological conditions and after ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2008 Dec; 295(6):F1666-77. doi: 10.1152/ajprenal.90304.2008. [PMID: 18815219]
  • Mary L García-Cazarín, Jennifer L Smith, Daret K St Clair, Michael T Piascik. The alpha1D-adrenergic receptor induces vascular smooth muscle apoptosis via a p53-dependent mechanism. Molecular pharmacology. 2008 Oct; 74(4):1000-7. doi: 10.1124/mol.108.047993. [PMID: 18628404]
  • Sudharsan Periyasamy-Thandavan, Man Jiang, Qingqing Wei, Robert Smith, Xiao-Ming Yin, Zheng Dong. Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney international. 2008 Sep; 74(5):631-40. doi: 10.1038/ki.2008.214. [PMID: 18509315]
  • Kuei-Chuan Chan, Chau-Jong Wang, Hsieh-Hsun Ho, Hsiang-Mei Chen, Chien-Ning Huang. Simvastatin inhibits cell cycle progression in glucose-stimulated proliferation of aortic vascular smooth muscle cells by up-regulating cyclin dependent kinase inhibitors and p53. Pharmacological research. 2008 Sep; 58(3-4):247-56. doi: 10.1016/j.phrs.2008.08.005. [PMID: 18804536]
  • Sanjeev Shukla, Sanjay Gupta. Apigenin-induced prostate cancer cell death is initiated by reactive oxygen species and p53 activation. Free radical biology & medicine. 2008 May; 44(10):1833-45. doi: 10.1016/j.freeradbiomed.2008.02.007. [PMID: 18342637]
  • William Davidson, Qing Ren, Gabor Kari, Ori Kashi, Adam P Dicker, Ulrich Rodeck. Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos. Cell cycle (Georgetown, Tex.). 2008 May; 7(9):1224-30. doi: 10.4161/cc.7.9.5786. [PMID: 18418056]
  • Shu-Jing Wu, Lean-Teik Ng. MAPK inhibitors and pifithrin-alpha block cinnamaldehyde-induced apoptosis in human PLC/PRF/5 cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2007 Dec; 45(12):2446-53. doi: 10.1016/j.fct.2007.05.032. [PMID: 17673346]
  • Qingqing Wei, Guie Dong, Tianxin Yang, Judit Megyesi, Peter M Price, Zheng Dong. Activation and involvement of p53 in cisplatin-induced nephrotoxicity. American journal of physiology. Renal physiology. 2007 Oct; 293(4):F1282-91. doi: 10.1152/ajprenal.00230.2007. [PMID: 17670903]
  • Takahisa Yano, Yoshinori Itoh, Misaki Matsuo, Takehiro Kawashiri, Nobuaki Egashira, Ryozo Oishi. Involvement of both tumor necrosis factor-alpha-induced necrosis and p53-mediated caspase-dependent apoptosis in nephrotoxicity of cisplatin. Apoptosis : an international journal on programmed cell death. 2007 Oct; 12(10):1901-9. doi: 10.1007/s10495-007-0110-8. [PMID: 17701360]
  • Kathrin Hochegger, Christian Koppelstaetter, Andrea Tagwerker, Julia M Huber, Dorothea Heininger, Gert Mayer, Alexander R Rosenkranz. p21 and mTERT are novel markers for determining different ischemic time periods in renal ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2007 Feb; 292(2):F762-8. doi: 10.1152/ajprenal.00084.2006. [PMID: 16968891]
  • Peitan Liu, Baohuan Xu, Thomas A Cavalieri, Carl E Hock. Pifithrin-alpha attenuates p53-mediated apoptosis and improves cardiac function in response to myocardial ischemia/reperfusion in aged rats. Shock (Augusta, Ga.). 2006 Dec; 26(6):608-14. doi: 10.1097/01.shk.0000232273.11225.af. [PMID: 17117137]
  • Aurora M Nedelcu. Evidence for p53-like-mediated stress responses in green algae. FEBS letters. 2006 May; 580(13):3013-7. doi: 10.1016/j.febslet.2006.04.044. [PMID: 16678168]
  • Rohit Seth, Cheng Yang, Varsha Kaushal, Sudhir V Shah, Gur P Kaushal. p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. The Journal of biological chemistry. 2005 Sep; 280(35):31230-9. doi: 10.1074/jbc.m503305200. [PMID: 15983031]
  • Martina Plísková, Jan Vondrácek, Borivoj Vojtesek, Alois Kozubík, Miroslav Machala. Deregulation of cell proliferation by polycyclic aromatic hydrocarbons in human breast carcinoma MCF-7 cells reflects both genotoxic and nongenotoxic events. Toxicological sciences : an official journal of the Society of Toxicology. 2005 Feb; 83(2):246-56. doi: 10.1093/toxsci/kfi040. [PMID: 15548639]
  • Pao-Chen Kuo, Huei-Fang Liu, Jui-I Chao. Survivin and p53 modulate quercetin-induced cell growth inhibition and apoptosis in human lung carcinoma cells. The Journal of biological chemistry. 2004 Dec; 279(53):55875-85. doi: 10.1074/jbc.m407985200. [PMID: 15456784]
  • Man Jiang, Xiaolan Yi, Stephen Hsu, Cong-Yi Wang, Zheng Dong. Role of p53 in cisplatin-induced tubular cell apoptosis: dependence on p53 transcriptional activity. American journal of physiology. Renal physiology. 2004 Dec; 287(6):F1140-7. doi: 10.1152/ajprenal.00262.2004. [PMID: 15315938]
  • Patrick J M Murphy, Mario D Galigniana, Yoshihiro Morishima, Jennifer M Harrell, Roland P S Kwok, Mats Ljungman, William B Pratt. Pifithrin-alpha inhibits p53 signaling after interaction of the tumor suppressor protein with hsp90 and its nuclear translocation. The Journal of biological chemistry. 2004 Jul; 279(29):30195-201. doi: 10.1074/jbc.m403539200. [PMID: 15145929]
  • Xuwan Liu, Chu C Chua, Jinping Gao, Zhongyi Chen, Cathy L C Landy, Ronald Hamdy, Balvin H L Chua. Pifithrin-alpha protects against doxorubicin-induced apoptosis and acute cardiotoxicity in mice. American journal of physiology. Heart and circulatory physiology. 2004 Mar; 286(3):H933-9. doi: 10.1152/ajpheart.00759.2003. [PMID: 14766674]
  • Cristine Alves da Costa, Mark P Mattson, Karine Ancolio, Frederic Checler. The C-terminal fragment of presenilin 2 triggers p53-mediated staurosporine-induced apoptosis, a function independent of the presenilinase-derived N-terminal counterpart. The Journal of biological chemistry. 2003 Apr; 278(14):12064-9. doi: 10.1074/jbc.m212379200. [PMID: 12556443]
  • K J Kelly, Zoya Plotkin, Stacey L Vulgamott, Pierre C Dagher. P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor. Journal of the American Society of Nephrology : JASN. 2003 Jan; 14(1):128-38. doi: 10.1097/01.asn.0000040596.23073.01. [PMID: 12506145]
  • Brian S Cummings, Rick G Schnellmann. Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. The Journal of pharmacology and experimental therapeutics. 2002 Jul; 302(1):8-17. doi: 10.1124/jpet.302.1.8. [PMID: 12065694]
  • A Lakkaraju, J M Dubinsky, W C Low, Y E Rahman. Neurons are protected from excitotoxic death by p53 antisense oligonucleotides delivered in anionic liposomes. The Journal of biological chemistry. 2001 Aug; 276(34):32000-7. doi: 10.1074/jbc.m100138200. [PMID: 11406618]