Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-2-naphthalenecarboxylate (BioDeep_00000842112)

   


代谢物信息卡片


Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-2-naphthalenecarboxylate

化学式: C30H36O9 (540.2359206)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(CC)CC(=O)C1=C(C2=CC(=C(C(=C2C(=C1C(=O)OC)C3=CC(=C(C=C3)OC)OC)OC)OC)OC)O
InChI: InChI=1S/C30H36O9/c1-9-16(10-2)13-19(31)25-26(30(33)39-8)23(17-11-12-20(34-3)21(14-17)35-4)24-18(27(25)32)15-22(36-5)28(37-6)29(24)38-7/h11-12,14-16,32H,9-10,13H2,1-8H3

描述信息

同义名列表

1 个代谢物同义名

Methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-2-naphthalenecarboxylate



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Shingo Sakamoto, Hiroyuki Kusuhara, Kazutoshi Horie, Kohji Takahashi, Takahiko Baba, Jun Ishizaki, Yuichi Sugiyama. Identification of the transporters involved in the hepatobiliary transport and intestinal efflux of methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) glucuronide, a pharmacologically active metabolite of S-8921. Drug metabolism and disposition: the biological fate of chemicals. 2008 Aug; 36(8):1553-61. doi: 10.1124/dmd.108.020511. [PMID: 18474677]
  • Shingo Sakamoto, Hiroyuki Kusuhara, Kenji Miyata, Hiroyuki Shimaoka, Takushi Kanazu, Yumiko Matsuo, Kohji Nomura, Noboru Okamura, Seijiro Hara, Kazutoshi Horie, Takahiko Baba, Yuichi Sugiyama. Glucuronidation converting methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) to a potent apical sodium-dependent bile acid transporter inhibitor, resulting in a hypocholesterolemic action. The Journal of pharmacology and experimental therapeutics. 2007 Aug; 322(2):610-8. doi: 10.1124/jpet.106.116426. [PMID: 17470645]
  • Hitoshi Kurata, Sayaka Suzuki, Yasuo Ohhata, Takuya Ikeda, Toru Hasegawa, Ken Kitayama, Toshimori Inaba, Keita Kono, Takafumi Kohama. A novel class of apical sodium-dependent bile acid transporter inhibitors: the amphiphilic 4-oxo-1-phenyl-1,4-dihydroquinoline derivatives. Bioorganic & medicinal chemistry letters. 2004 Mar; 14(5):1183-6. doi: 10.1016/j.bmcl.2003.12.063. [PMID: 14980661]
  • Teruhisa Ichihashi. [Hypolipidemic drugs--ileal Na+/bile acid cotransporter inhibitors (S-8921 etc)]. Nihon rinsho. Japanese journal of clinical medicine. 2002 Jan; 60(1):130-6. doi: NULL. [PMID: 11808323]
  • M L Booker. S-8921 (Shionogi). Current opinion in investigational drugs (London, England : 2000). 2001 Mar; 2(3):393-5. doi: NULL. [PMID: 11575711]
  • T Yamaguchi, Y Nakajima, M Mizobuchi, K Inazawa, T Kanazu, K Kadono, T Ohkawa, K Iwatani. Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs. Arzneimittel-Forschung. 1998 Oct; 48(10):995-1006. doi: NULL. [PMID: 9825117]
  • J Higaki, S Hara, N Takasu, K Tonda, K Miyata, T Shike, K Nagata, T Mizui. Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arteriosclerosis, thrombosis, and vascular biology. 1998 Aug; 18(8):1304-11. doi: 10.1161/01.atv.18.8.1304. [PMID: 9714138]
  • T Ichihashi, M Izawa, K Miyata, T Mizui, K Hirano, Y Takagishi. Mechanism of hypocholesterolemic action of S-8921 in rats: S-8921 inhibits ileal bile acid absorption. The Journal of pharmacology and experimental therapeutics. 1998 Jan; 284(1):43-50. doi: NULL. [PMID: 9435159]
  • G Kominami, A Ueda, K Sakai, A Misaki. Radioimmunoassay for a novel lignan-related hypocholesterolemic agent, S-8921, in human plasma after high-performance liquid chromatography purification and in human urine after immunoaffinity extraction. Journal of chromatography. B, Biomedical sciences and applications. 1997 Dec; 704(1-2):243-50. doi: 10.1016/s0378-4347(97)00466-0. [PMID: 9518156]
  • S Hara, J Higaki, K Higashino, M Iwai, N Takasu, K Miyata, K Tonda, K Nagata, Y Goh, T Mizui. S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters. Life sciences. 1997; 60(24):PL 365-70. doi: 10.1016/s0024-3205(97)00242-7. [PMID: 9188770]