Carbovir Triphosphate (BioDeep_00000842091)
代谢物信息卡片
化学式: C11H16N5O11P3 (487.0059176)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C(C=CC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C11H16N5O11P3/c12-11-14-9-8(10(17)15-11)13-5-16(9)7-2-1-6(3-7)4-25-29(21,22)27-30(23,24)26-28(18,19)20/h1-2,5-7H,3-4H2,(H,21,22)(H,23,24)(H2,18,19,20)(H3,12,14,15,17)/t6-,7+/m1/s1
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:64174
- PubChem: 135499583
- ChEMBL: CHEMBL1201395
- CAS: 140850-29-9
- CAS: 129941-14-6
分类词条
相关代谢途径
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akil Jackson, Graeme Moyle, Laura Dickinson, David Back, Saye Khoo, Jessica Taylor, Keerti Gedela, George Abongomera, Brian Gazzard, Marta Boffito. Pharmacokinetics of abacavir and its anabolite carbovir triphosphate without and with darunavir/ritonavir or raltegravir in HIV-infected subjects.
Antiviral therapy.
2012; 17(1):19-24. doi:
10.3851/imp1910. [PMID: 22267465] - Graeme Moyle, Marta Boffito, Carl Fletcher, Chris Higgs, Phillip E Hay, Ivy H Song, Yu Lou, Geoffrey J Yuen, Sherene S Min, Elena M Guerini. Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1532-8. doi:
10.1128/aac.01000-08. [PMID: 19188387] - Nicholas A Boyle, Vivek K Rajwanshi, Marija Prhavc, Guangyi Wang, Patrick Fagan, Fu Chen, Gregory J Ewing, Jennifer L Brooks, Tiffany Hurd, Janet M Leeds, Thomas W Bruice, P Dan Cook. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase.
Journal of medicinal chemistry.
2005 Apr; 48(7):2695-700. doi:
10.1021/jm040101y. [PMID: 15801860] - David M Margolis, Stephen Kewn, Jason J Coull, Loyda Ylisastigui, Diana Turner, Holly Wise, Mohammed M Hossain, E Randall Lanier, Leslie M Shaw, David Back. The addition of mycophenolate mofetil to antiretroviral therapy including abacavir is associated with depletion of intracellular deoxyguanosine triphosphate and a decrease in plasma HIV-1 RNA.
Journal of acquired immune deficiency syndromes (1999).
2002 Sep; 31(1):45-9. doi:
10.1097/00126334-200209010-00006. [PMID: 12352149] - S M Daluge, S S Good, M B Faletto, W H Miller, M H St Clair, L R Boone, M Tisdale, N R Parry, J E Reardon, R E Dornsife, D R Averett, T A Krenitsky. 1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity.
Antimicrobial agents and chemotherapy.
1997 May; 41(5):1082-93. doi:
10.1128/aac.41.5.1082. [PMID: 9145874]