(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone (BioDeep_00000842089)

   


代谢物信息卡片


(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone

化学式: C13H15N3O2 (245.116421)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC(=O)NN=C1C2=CC=C(C=C2)NC(=O)C
InChI: InChI=1S/C13H15N3O2/c1-8-7-12(18)15-16-13(8)10-3-5-11(6-4-10)14-9(2)17/h3-6,8H,7H2,1-2H3,(H,14,17)(H,15,18)/t8-/m1/s1

描述信息

同义名列表

1 个代谢物同义名

(R)-N-Acetyl-6-(4-aminophenyl)-4,5-dihydro-5-methyl-3(2H)-pyridazinone



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Matti Kivikko, Stig Sundberg, Mats O Karlsson, Pasi Pohjanjousi, Wilson S Colucci. Acetylation status does not affect levosimendan's hemodynamic effects in heart failure patients. Scandinavian cardiovascular journal : SCJ. 2011 Apr; 45(2):86-90. doi: 10.3109/14017431.2010.540762. [PMID: 21133820]
  • M Louhelainen, S Merasto, P Finckenberg, E Vahtola, P Kaheinen, H Leskinen, J Levijoki, P Pollesello, H Haikala, E M A Mervaala. Effects of calcium sensitizer OR-1986 on a cardiovascular mortality and myocardial remodelling in hypertensive Dahl/Rapp rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2009 Sep; 60(3):41-7. doi: NULL. [PMID: 19826180]
  • Shao-rong Li, Xiao-yan Chen, Yi-fan Zhang, Guo-xin Li, Chun-mei Jiang, Da-fang Zhong. [Determination of levosimendan and its main metabolites in human plasma with HPLC-MS/MS method]. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Oct; 43(10):1053-9. doi: NULL. [PMID: 19127871]
  • V-P Harjola, L Oikarinen, L Toivonen, R Jurkko, J Puttonen, T Sarapohja, S Sundberg, M S Nieminen. The hemodynamic and pharmacokinetic interactions between chronic use of oral levosimendan and digoxin in patients with NYHA Classes II-III heart failure. International journal of clinical pharmacology and therapeutics. 2008 Aug; 46(8):389-99. doi: 10.5414/cpp46389. [PMID: 18793580]
  • M Koskinen, J Puttonen, M Pykäläinen, A Vuorela, T Lotta. Metabolism of OR-1896, a metabolite of levosimendan, in rats and humans. Xenobiotica; the fate of foreign compounds in biological systems. 2008 Feb; 38(2):156-70. doi: 10.1080/00498250701744658. [PMID: 18197557]
  • Patricia N Banfor, Lee C Preusser, Thomas J Campbell, Kennan C Marsh, James S Polakowski, Glenn A Reinhart, Bryan F Cox, Ryan M Fryer. Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs. American journal of physiology. Heart and circulatory physiology. 2008 Jan; 294(1):H238-48. doi: 10.1152/ajpheart.01181.2007. [PMID: 17982006]
  • Jaakko Puttonen, Tarmo Laine, Meri Ramela, Sari Häkkinen, Wenhui Zhang, Rajendra Pradhan, Pertti Pentikäinen, Mikko Koskinen. Pharmacokinetics and excretion balance of OR-1896, a pharmacologically active metabolite of levosimendan, in healthy men. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2007 Dec; 32(4-5):271-7. doi: 10.1016/j.ejps.2007.08.003. [PMID: 17888637]
  • Saila Antila, Ullamari Pesonen, Lasse Lehtonen, Pasi Tapanainen, Hanna Nikkanen, Katja Vaahtera, Harry Scheinin. Pharmacokinetics of levosimendan and its active metabolite OR-1896 in rapid and slow acetylators. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2004 Nov; 23(3):213-22. doi: 10.1016/j.ejps.2004.07.005. [PMID: 15489122]
  • Szabolcs Szilágyi, Piero Pollesello, Jouko Levijoki, Petri Kaheinen, Heimo Haikala, István Edes, Zoltán Papp. The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig. European journal of pharmacology. 2004 Feb; 486(1):67-74. doi: 10.1016/j.ejphar.2003.12.005. [PMID: 14751410]