1H-Purine-2,6-dione, 7-(2-(4-(2-chlorophenyl)-1-piperazinyl)ethyl)-3,7-dihydro-1,3-dimethyl- (BioDeep_00000842084)
代谢物信息卡片
1H-Purine-2,6-dione, 7-(2-(4-(2-chlorophenyl)-1-piperazinyl)ethyl)-3,7-dihydro-1,3-dimethyl-
化学式: C19H23ClN6O2 (402.1571)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CCN3CCN(CC3)C4=CC=CC=C4Cl
InChI: InChI=1S/C19H23ClN6O2/c1-22-17-16(18(27)23(2)19(22)28)26(13-21-17)12-9-24-7-10-25(11-8-24)15-6-4-3-5-14(15)20/h3-6,13H,7-12H2,1-2H3
描述信息
D007476 - Ionophores > D061216 - Potassium Ionophores
D049990 - Membrane Transport Modulators
同义名列表
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
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INOH(0)
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0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Lian-Sheng Ren, Lei Zhang, Dan Zhu, Tong Li, Qi Wang, Xue-Ying Yuan, Li-Rong Hao. KMUP-1 regulates the vascular calcification in chronic renal failure by mediating NO/cGMP/PKG signaling pathway.
Life sciences.
2020 Jul; 253(?):117683. doi:
10.1016/j.lfs.2020.117683. [PMID: 32315727] - Meng-Luen Lee, Erna Sulistyowati, Jong-Hau Hsu, Bo-Yau Huang, Zen-Kong Dai, Bin-Nan Wu, Yu-Ying Chao, Jwu-Lai Yeh. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways.
Molecules (Basel, Switzerland).
2019 Apr; 24(7):. doi:
10.3390/molecules24071376. [PMID: 30965668] - Chung-Pin Liu, Pei-Chun Chau, Chain-Ting Chang, Li-Mei An, Jwu-Lai Yeh, Ing-Jun Chen, Bin-Nan Wu. KMUP-1, a GPCR Modulator, Attenuates Triglyceride Accumulation Involved MAPKs/Akt/PPARγ and PKA/PKG/HSL Signaling in 3T3-L1 Preadipocytes.
Molecules (Basel, Switzerland).
2018 Sep; 23(10):. doi:
10.3390/molecules23102433. [PMID: 30249030] - Chien-Hsing Lee, Zen-Kong Dai, Cheng-Ting Yen, Su-Ling Hsieh, Bin-Nan Wu. KMUP-1 protects against streptozotocin-induced mesenteric artery dysfunction via activation of ATP-sensitive potassium channels.
Pharmacological reports : PR.
2018 Aug; 70(4):746-752. doi:
10.1016/j.pharep.2018.02.017. [PMID: 29936361] - Chien-Hsing Lee, Chih-Sheng Chu, Han-Jie Tsai, Liang-Yin Ke, Hsiang-Chun Lee, Jwu-Lai Yeh, Chu-Huang Chen, Bin-Nan Wu. Xanthine-derived KMUP-1 reverses glucotoxicity-activated Kv channels through the cAMP/PKA signaling pathway in rat pancreatic β cells.
Chemico-biological interactions.
2018 Jan; 279(?):171-176. doi:
10.1016/j.cbi.2017.11.017. [PMID: 29183753] - Zen-Kong Dai, Chang-Ling Kao, Su-Ling Hsieh, Ing-Jun Chen, Bin-Nan Wu. Restoration of uridine 5'-triphosphate-suppressed delayed rectifying K+ currents by an NO activator KMUP-1 involves RhoA/Rho kinase signaling in pulmonary artery smooth muscle cells.
The Kaohsiung journal of medical sciences.
2016 Dec; 32(12):607-613. doi:
10.1016/j.kjms.2016.09.008. [PMID: 27914611] - Bin-Nan Wu, Kung-Kai Kuo, Yu-Hsun Chen, Chain-Ting Chang, Hung-Tu Huang, Chee-Yin Chai, Zen-Kong Dai, Ing-Jun Chen. Theophylline-Based KMUP-1 Improves Steatohepatitis via MMP-9/IL-10 and Lipolysis via HSL/p-HSL in Obese Mice.
International journal of molecular sciences.
2016 Aug; 17(8):. doi:
10.3390/ijms17081345. [PMID: 27548140] - Kung-Kai Kuo, Bin-Nan Wu, Chung-Pin Liu, Tzu-Yang Yang, Li-Pin Kao, Jiunn-Ren Wu, Wen-Ter Lai, Ing-Jun Chen. Xanthine-based KMUP-1 improves HDL via PPARγ/SR-B1, LDL via LDLRs, and HSL via PKA/PKG for hepatic fat loss.
Journal of lipid research.
2015 Nov; 56(11):2070-84. doi:
10.1194/jlr.m057547. [PMID: 26351364] - Chung-Pin Liu, Zen-Kong Dai, Chein-Heng Huang, Jwu-Lai Yeh, Bin-Nan Wu, Jiunn-Ren Wu, Ing-Jun Chen. Endothelial nitric oxide synthase-enhancing G-protein coupled receptor antagonist inhibits pulmonary artery hypertension by endothelin-1-dependent and endothelin-1-independent pathways in a monocrotaline model.
The Kaohsiung journal of medical sciences.
2014 Jun; 30(6):267-78. doi:
10.1016/j.kjms.2014.02.014. [PMID: 24835346] - Shu-Fen Liou, Jong-Hau Hsu, I-Ling Lin, Mei-Ling Ho, Pei-Chuan Hsu, Li-Wen Chen, Ing-Jun Chen, Jwu-Lai Yeh. KMUP-1 suppresses RANKL-induced osteoclastogenesis and prevents ovariectomy-induced bone loss: roles of MAPKs, Akt, NF-κB and calcium/calcineurin/NFATc1 pathways.
PloS one.
2013; 8(7):e69468. doi:
10.1371/journal.pone.0069468. [PMID: 23936022] - K K Kuo, B N Wu, E Y Chiu, C J Tseng, J L Yeh, C P Liu, C Y Chai, I J Chen. NO donor KMUP-1 improves hepatic ischemia-reperfusion and hypoxic cell injury by inhibiting oxidative stress and pro-inflammatory signaling.
International journal of immunopathology and pharmacology.
2013 Jan; 26(1):93-106. doi:
10.1177/039463201302600109. [PMID: 23527712] - Chung-Pin Liu, Chung-Han Hsieh, Bin-Nan Wu, Jwu-Lai Yeh, Zen-Kong Dai, Chee-Yin Chai, Ing-Jun Chen. Inhaled KMUP-1 Prevents Allergic Pulmonary Vascular Inflammation and Remodeling via NO and Suppressed MMP-9 and ICAM-1/VCAM-1.
Inflammation & allergy drug targets.
2012 Aug; 11(4):251-61. doi:
10.2174/187152812800958960. [PMID: 22452605] - Hui-Hsuan Chung, Zen-Kong Dai, Bin-Nan Wu, Jwu-Lai Yeh, Chee-Yin Chai, Koung-Shing Chu, Chung-Pin Liu, Ing-Jun Chen. KMUP-1 inhibits pulmonary artery proliferation by targeting serotonin receptors/transporter and NO synthase, inactivating RhoA and suppressing AKT/ERK phosphorylation.
Vascular pharmacology.
2010 Nov; 53(5-6):239-49. doi:
10.1016/j.vph.2010.09.003. [PMID: 20870034] - Hui-Hsuan Chung, Zen-Kong Dai, Bin-Nan Wu, Jwu-Lai Yeh, Chee-Yin Chai, Koung-Shing Chu, Chung-Pin Liu, Ing-Jun Chen. The xanthine derivative KMUP-1 inhibits models of pulmonary artery hypertension via increased NO and cGMP-dependent inhibition of RhoA/Rho kinase.
British journal of pharmacology.
2010 Jun; 160(4):971-86. doi:
10.1111/j.1476-5381.2010.00740.x. [PMID: 20590592] - Jwu-Lai Yeh, Jong-Hau Hsu, Ping-Ju Wu, Shu-Fen Liou, Chung-Pin Liu, Ing-Jun Chen, Bin-Nan Wu, Zen-Kong Dai, Jiunn-Ren Wu. KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways.
British journal of pharmacology.
2010 Mar; 159(5):1151-60. doi:
10.1111/j.1476-5381.2009.00587.x. [PMID: 20132211] - Ya-Yun Hsu, Chi-Ming Liu, Hsin-Hung Tsai, Yuh-Jyh Jong, Ing-Jun Chen, Yi-Ching Lo. KMUP-1 attenuates serum deprivation-induced neurotoxicity in SH-SY5Y cells: roles of PKG, PI3K/Akt and Bcl-2/Bax pathways.
Toxicology.
2010 Jan; 268(1-2):46-54. doi:
10.1016/j.tox.2009.11.021. [PMID: 19962417]
